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Article ; Online: Exploring clues pointing toward the existence of a brain-gut microbiota-hair follicle axis.

Feng, Yang

Current research in translational medicine

2023 Volume 72, Issue 1, Page(s) 103408

Abstract: Proposing the concept of a brain-gut-skin axis has led some researchers to recognize the relationship among brain activity, gut microbiota, and the skin. Hair follicles are skin accessory organs, a previously unnoticed target tissue for classical ... ...

Abstract	Proposing the concept of a brain-gut-skin axis has led some researchers to recognize the relationship among brain activity, gut microbiota, and the skin. Hair follicles are skin accessory organs, a previously unnoticed target tissue for classical neurohormones, neurotrophins, and neuropeptides. Some studies have shown a relationship between the central nervous system and hair follicles that an imbalance in the gut bacteria can affect hair follicle density. This review summarizes existing evidence from literature and explores clues supporting a connection linking the brain, gut microbiota, and hair follicles. It amalgamates previously proposed partial concepts into a new, unified concept-the "brain-gut microbiota-hair follicle" axis, -which suggests that modulation of the microbiome via probiotics can have positive effects on hair follicles. This review also explores how preclinical research on hair follicles can propel novel and clinically untapped applications.
MeSH term(s)	Humans ; Hair Follicle ; Gastrointestinal Microbiome ; Microbiota ; Brain/physiology ; Skin
Language	English
Publishing date	2023-09-10
Publishing country	France
Document type	Journal Article ; Review
ISSN	2452-3186
ISSN (online)	2452-3186
DOI	10.1016/j.retram.2023.103408
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Innovative digital technology design and game healing-Serious Game's innovative design for children with special needs

Feng Yang

E3S Web of Conferences, Vol 236, p

2021 Volume 05076

Abstract: Digital technology promotes the innovation and development of design. With the development of science and technology, design has changed the traditional design mode. We must stimulate the innovative potential of design and let digital technology play a ... ...

Abstract	Digital technology promotes the innovation and development of design. With the development of science and technology, design has changed the traditional design mode. We must stimulate the innovative potential of design and let digital technology play a greater driving force.The current era of "internet of all things" is also a new challenge to the development of human civilization. Game design as an important part of modern design, its design innovation is worth thinking about: How to use the rapidly changing Science and Technology; how to organically connect the real world with the virtual world; how to skillfully integrate human care into the game design; how to use the game to pay attention to special groups; how to make the function of the game get multi-dimensional presentation and other aspects are worth discussing.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Enhanced knee joint treatment using a hybrid hyaluronic acid-alginate filler reinforced with hydroxyapatite-titanium nanoparticles for sports-related injuries

Feng Yang / A. Ranjbar / D.T. Semirumi

Arabian Journal of Chemistry, Vol 17, Iss 1, Pp 105387- (2024)

1481

Abstract: Sports injuries, particularly bone injuries, have become increasingly prevalent in recent years. As athletes push themselves harder and become more competitive, the risk of injury rises. Additionally, the aging population has contributed to the increased ...

Abstract	Sports injuries, particularly bone injuries, have become increasingly prevalent in recent years. As athletes push themselves harder and become more competitive, the risk of injury rises. Additionally, the aging population has contributed to the increased prevalence of bone injuries, including those related to the knee joint. As a result, significant research efforts have focused on developing new techniques for knee joint repair. In this study, a novel hyaluronic acid-Alginate filler composition containing hydroxyapatite-titanium nanoparticles (HA/Ti-NPs) was prepared through freeze-drying. The crystalline properties of the porous scaffolds were analyzed using X-ray diffraction (XRD), while scanning electron microscope (SEM) images were used to visualize the scaffold structure. The morphological investigation demonstrated that adding 15 wt% Ti-NP to the scaffold reduces percentages of porosity to about 76.5 ± 5, while increasing the elastic modulus. Furthermore, the presence of nanoparticles decreased the rate of degradation, increased crystallinity, reduced pore size, and promoted calcium release, creating a favorable environment for bone tissue growth. The scaffold's degradation pH is close to neutral, which is ideal for bone tissue treatment. Adding 15 wt% Ti-NP reduces the contact angle from 120° to 93°. The composite scaffolds promote the proliferation and growth of osteoblast cells, and after 48 h, degraded material improved cell viability, growth, and proliferation. The three-component hyaluronic acid-Alginate/HA scaffolds with 15 wt% Ti-NP exhibited suitable morphological, mechanical, physical, and chemical properties for bone applications, as well as high potential for joint bonding. These porous scaffolds have the potential to be used as bone fillers of sport injuries and further research is needed to confirm their efficacy.
Keywords	Hyaluronic acid ; Sport injuries ; Titanium nanoparticles ; Knee Joint ; Scaffold morphology ; Osteoblast cell proliferation ; Chemistry ; QD1-999
Subject code	796
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A comparative study on the development of Chinese and English abilities of Chinese primary school students through two bilingual reading modes: human-AI robot interaction and paper books.

Feng, Yang / Wang, Xiya

Frontiers in psychology

2023 Volume 14, Page(s) 1200675

Abstract: To address the challenges encountered by Chinese primary school students, particularly left-behind and migrant children, who exhibit a preference for animations, video games, and short videos over reading books and struggle with Chinese-English bilingual ...

Abstract	To address the challenges encountered by Chinese primary school students, particularly left-behind and migrant children, who exhibit a preference for animations, video games, and short videos over reading books and struggle with Chinese-English bilingual skills, this study introduces an educational robot AI-assisted method for simultaneous bilingual reading. To assess the effectiveness of this method, a 6-month Chinese-English bilingual extracurricular reading comparative experiment was conducted involving 85 grade 5 students from two classes in a primary school in Hangzhou, China. The AI-assisted class freely read 100 bilingual/English electronic picture books and 200 Chinese electronic classic serial picture books by employing the AI-assisted human-computer interactive electronic reading mode of the "Educational Robot+Audio Electronic Picture Book+Character-play Based Reading." In contrast, the paper book group read the same content presented in the traditional paper book format, following the "regular independent reading" mode. Post-experimental analyses were conducted employing
Language	English
Publishing date	2023-10-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1200675
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Traditional Chinese exercises on depression: A network meta-analysis.

Feng, Yang / Liu, Jin / Liu, Peng / Teng, Jing

Medicine

2024 Volume 103, Issue 13, Page(s) e37319

Abstract: Background: Exercise is an important factor for the treatment and rehabilitation of depression. Traditional Chinese exercise is considered as an effective treatment for depression. In recent years, many studies have shown that Chinese exercise therapy ... ...

Abstract	Background: Exercise is an important factor for the treatment and rehabilitation of depression. Traditional Chinese exercise is considered as an effective treatment for depression. In recent years, many studies have shown that Chinese exercise therapy may be safe in the treatment of depression. To evaluate the therapeutic effect of traditional Chinese exercise on depression using network meta-analysis. Methods: PubMed, Cochrane Library, Web of Science, China National Knowledge Infrastructure, VIP shop Database, China Biomedical Literature Database, and Wan Fang Data Knowledge Service Platform were included in randomized controlled studies on traditional Chinese exercises for the treatment of depression from the establishment of the library to July 2023. The literature was extracted and assessed for risk of bias using the Cochrane Risk of Bias Assessment and statistically analyzed using Review Manager 5.4 and Stata 14.2. Results: A total of 25 studies involving 3 exercises with a total of 1605 cases were included. The results of the network meta-analysis showed that each exercise significantly reduced the 24-item Hamilton Depression Scale (HAMD-24), Hamilton Anxiety Scale, Beck Depression Inventory, and Self-rating Depression Scale scores. However, conventional treatments have the advantage of improving the sleep quality of patients with depression. Conclusions: The 3 exercises included in this study were effective for depression. Baduanjin and Tai Chi were better at improving the outcomes related to depression and anxiety. The effect of sleep quality intervention was slightly worse. Larger, high-quality randomized controlled trials are needed to compare interventions across exercises in a more granular manner.
MeSH term(s)	Humans ; Depression/drug therapy ; Network Meta-Analysis ; Exercise Therapy/methods ; Exercise ; Tai Ji
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Meta-Analysis ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037319
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The impact of boarding school on student development in primary and secondary schools: a meta-analysis.

Zhong, Zhiyong / Feng, Yang / Xu, Yongqi

Frontiers in psychology

2024 Volume 15, Page(s) 1359626

Abstract: As a long-established model of schooling, the boarding system is commonly practiced in countries around the world. Numerous scholars have conducted a great deal of research on the relationship between the boarding school and student development, but the ... ...

Abstract	As a long-established model of schooling, the boarding system is commonly practiced in countries around the world. Numerous scholars have conducted a great deal of research on the relationship between the boarding school and student development, but the results of the research are quite divergent. In order to clarify the real effects of boarding school on students' development, this study used meta-analysis to quantify 49 (91 effect sizes) experimental or quasi-experimental studies on related topics at home and abroad. The results find that: (1) Overall, boarding school has no significant predictive effect on student development, with a combined effect size of 0.002 (
Language	English
Publishing date	2024-03-28
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2024.1359626
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Article ; Online: RaSE: A Variable Screening Framework via Random Subspace Ensembles

Tian, Ye / Feng, Yang

Journal of the American Statistical Association. 2023 Jan. 2, v. 118, no. 541 p.457-468

2023

Abstract: Variable screening methods have been shown to be effective in dimension reduction under the ultra-high dimensional setting. Most existing screening methods are designed to rank the predictors according to their individual contributions to the response. ... ...

Abstract	Variable screening methods have been shown to be effective in dimension reduction under the ultra-high dimensional setting. Most existing screening methods are designed to rank the predictors according to their individual contributions to the response. As a result, variables that are marginally independent but jointly dependent with the response could be missed. In this work, we propose a new framework for variable screening, random subspace ensemble (RaSE), which works by evaluating the quality of random subspaces that may cover multiple predictors. This new screening framework can be naturally combined with any subspace evaluation criterion, which leads to an array of screening methods. The framework is capable to identify signals with no marginal effect or with high-order interaction effects. It is shown to enjoy the sure screening property and rank consistency. We also develop an iterative version of RaSE screening with theoretical support. Extensive simulation studies and real-data analysis show the effectiveness of the new screening framework.
Keywords	Americans ; design ; dimensions ; journals ; screening ; Ensemble learning ; High-dimensional data ; Random subspace method ; Rank consistency ; Sure screening property ; Variable screening ; Variable selection
Language	English
Dates of publication	2023-0102
Size	p. 457-468.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2064981-2
ISSN	1537-274X
ISSN	1537-274X
DOI	10.1080/01621459.2021.1938084
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Susceptibility Evaluation of Debris Flow Disaster in Plateau Hydropower Cascade Development Reservoir Area

Feng Yang, Xudong Hu, Zhenyao Xia, Lei Cui and Qi Yang

Nature Environment and Pollution Technology, Vol 22, Iss 1, Pp 229-

2023 Volume 236

Abstract: The Rumei Hydropower Station is a typical cascade hydropower development project in a plateau area. The dam site is located in an area with complex topography, lithology, and geological structure. Geological disasters are developed in the area, mainly ... ...

Abstract	The Rumei Hydropower Station is a typical cascade hydropower development project in a plateau area. The dam site is located in an area with complex topography, lithology, and geological structure. Geological disasters are developed in the area, mainly debris flow. Thus, taking the dam site and the surrounding areas as key evaluation objects, the engineering geological characteristics, geological environment characteristics, and the susceptibility and risk of geological disasters that may be caused are predicted and evaluated. The main methods used in this assessment are the binary logistic regression model and expert evaluation. The results show that the susceptibility to geological disasters is small and medium. The results of this study could provide a scientific basis for the rationality of the general layout and site selection of the project construction in the plateau water elevator level development reservoir area.
Keywords	rumei hydropower station ; debris flow ; binary logistic regression model susceptibility ; Environmental effects of industries and plants ; TD194-195 ; Science (General) ; Q1-390
Subject code	550
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Technoscience Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical study on low-frequency repetitive transcranial magnetic atimulation combined with fasudil in the treatment of acute cerebral infarction

Yun-Feng Yang

Journal of Hainan Medical University, Vol 25, Iss 23, Pp 25-

2020 Volume 29

Abstract: Objective: To investigate the effect of low-frequency rTMS combined with fasudil on neurological function in patients with acute cerebral infarction and its mechanism. Method:120 patients with acute cerebral infarction admitted from January 2016 to ... ...

Abstract	Objective: To investigate the effect of low-frequency rTMS combined with fasudil on neurological function in patients with acute cerebral infarction and its mechanism. Method:120 patients with acute cerebral infarction admitted from January 2016 to January 2019 were randomly divided into four groups: control group (n = 30), fasudil group (n = 30), rTMS group (n = 30), fasudil + rTMS group (n = 30). The changes of NIHSS score, ADL score, serum GAP- 43, serum RhoA and serum ROCK-II were observed and recorded before and after treatment. Results: The ADL scores and serum GAP-43 levels of the four groups after treatment were higher than those before treatment (P < 0.05); the NIHSS scores, serum RhoA and serum ROCK-II levels of the four groups after treatment were lower than those before treatment (P < 0.05); After treatment, ADL score and serum GAP-43 level in fasudil+rTMS group were higher than those in other three groups (P < 0.05); After treatment, NIHSS score, serum RhoA and serum ROCK-II levels in fasudil+rTMS group were lower than those in other three groups (P < 0.05). After treatment, NIHSS score was positively correlated with RhoA and ROCK-II content, negatively correlated with GAP-43 content and ADL score. Conclusions: Low-frequency rTMS combined with fasudil in the treatment of acute cerebral infarction can significantly improve neurological deficits, improve daily living ability, promote axonal remodeling and regeneration. It may be one of its mechanisms by increasing the expression of GAP-43 in serum and reducing the expression levels of RhoA and ROCK-II in serum. It has high clinical value.
Keywords	low-frequency rtms ; fasudil cerebral infarction ; gap-43 ; rhoa ; rock-ⅱ ; Medicine ; R
Subject code	630
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Editorial Board of Journal of Hainan Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Expanding the Analytical Toolbox

Y. Diana Liu / Michelle Irwin Beardsley / Feng Yang

Pharmaceuticals, Vol 16, Iss 1327, p

Developing New Lys-C Peptide Mapping Methods with Minimized Assay-Induced Artifacts to Fully Characterize Antibodies

2023 Volume 1327

Abstract: Peptide mapping is an important tool used to confirm that the correct sequence has been expressed for a protein and to evaluate protein post-translational modifications (PTMs) that may arise during the production, processing, or storage of protein drugs. ...

Abstract	Peptide mapping is an important tool used to confirm that the correct sequence has been expressed for a protein and to evaluate protein post-translational modifications (PTMs) that may arise during the production, processing, or storage of protein drugs. Our new orally administered drug (Ab-1), a single-domain antibody, is highly stable and resistant to proteolysis. Analysis via the commonly used tryptic mapping method did not generate sufficient sequence coverage. Alternative methods were needed to study the Ab-1 drug substance (75 mg/mL) and drug product (3 mg/mL). To meet these analytical needs, we developed two new peptide mapping methods using lysyl endopeptidase (Lys-C) digestion. These newly developed protein digestion protocols do not require desalting/buffer-exchange steps, thereby reducing sample preparation time and improving method robustness. Additionally, the protein digestion is performed under neutral pH with methionine acting as a scavenger to minimize artifacts, such as deamidation and oxidation, which are induced during sample preparation. Further, the method for low-concentration samples performs comparably to the method for high-concentration samples. Both methods provide 100% sequence coverage for Ab-1, and, therefore, enable comprehensive characterization for its product quality attribute (PQA) assessment. Both methods can be used to study other antibody formats.
Keywords	biopharmaceuticals ; drug substances ; sample preparation ; enzymatic digestion ; mass spectrometry ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
Subject code	500
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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