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  1. Article: Mesenchymal stem cells-based therapies for severe ARDS with ECMO: a review.

    Cao, Jing-Ke / Hong, Xiao-Yang / Feng, Zhi-Chun / Li, Qiu-Ping

    Intensive care medicine experimental

    2024  Volume 12, Issue 1, Page(s) 12

    Abstract: Acute respiratory distress syndrome (ARDS) is the primary cause of respiratory failure in critically ill patients. Despite remarkable therapeutic advances in recent years, ARDS remains a life-threatening clinical complication with high morbidity and ... ...

    Abstract Acute respiratory distress syndrome (ARDS) is the primary cause of respiratory failure in critically ill patients. Despite remarkable therapeutic advances in recent years, ARDS remains a life-threatening clinical complication with high morbidity and mortality, especially during the global spread of the coronavirus disease 2019 (COVID-19) pandemic. Previous studies have demonstrated that mesenchymal stem cell (MSC)-based therapy is a potential alternative strategy for the treatment of refractory respiratory diseases including ARDS, while extracorporeal membrane oxygenation (ECMO) as the last resort treatment to sustain life can help improve the survival of ARDS patients. In recent years, several studies have explored the effects of ECMO combined with MSC-based therapies in the treatment of ARDS, and some of them have demonstrated that this combination can provide better therapeutic effects, while others have argued that some critical issues need to be solved before it can be applied to clinical practice. This review presents an overview of the current status, clinical challenges and future prospects of ECMO combined with MSCs in the treatment of ARDS.
    Language English
    Publishing date 2024-02-09
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2740385-3
    ISSN 2197-425X
    ISSN 2197-425X
    DOI 10.1186/s40635-024-00596-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Candida utilis

    Li, Qiuping / Zhuang, Lu / Zhang, Sheng / Feng, Zhichun

    BMJ paediatrics open

    2023  Volume 7, Issue 1

    Abstract: This retrospective study was conducted in a neonatal intensive care unit in Beijing. Patients whose blood culture ... ...

    Abstract This retrospective study was conducted in a neonatal intensive care unit in Beijing. Patients whose blood culture yielded
    MeSH term(s) Infant ; Humans ; Infant, Newborn ; Candida ; Infant, Premature ; Retrospective Studies ; Antifungal Agents/therapeutic use ; Candidemia/diagnosis ; Candidemia/drug therapy ; Candidemia/microbiology
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2023-11-15
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ISSN 2399-9772
    ISSN (online) 2399-9772
    DOI 10.1136/bmjpo-2023-002245
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  3. Article ; Online: The influence of the COVID-19 pandemic on the spectrum of neonatal disease in a tertiary hospital in China: A retrospective analysis.

    Wang, Yi / Song, Linhong / Ma, Ning / Li, Hao / Hu, Siqi / Feng, Zhichun

    Health science reports

    2024  Volume 7, Issue 2, Page(s) e1928

    Abstract: Background and aims: Neonatal diseases are a significant threat to global public health, affecting the homeostasis and well-being of patients and reflecting the status of, and challenges to, regional, national, and global healthcare systems. This study ... ...

    Abstract Background and aims: Neonatal diseases are a significant threat to global public health, affecting the homeostasis and well-being of patients and reflecting the status of, and challenges to, regional, national, and global healthcare systems. This study sought to investigate how the disease spectrum observed among neonatal inpatients changed after the onset of the coronavirus disease 2019 (COVID-19) pandemic.
    Methods: The present hospital-based retrospective study analyzed the demographic and clinical characteristics of 19,943 hospitalized newborns from January 2018 to December 2022 using data derived from pediatric department registers.
    Results: According to the International Classification of Diseases 11th Revision (ICD-11) classification criteria, the two most common neonatal disorders during this study period were "Certain conditions originating in the perinatal period" and "Disease of the respiratory system." Following the start of the COVID-19 pandemic (2020 onwards), the number of neonatal patients declined markedly (5742 per year vs. 2820 per year), and the incidence of "Disease of the respiratory system" was significantly lower than in 2018-2019 (25.72% vs. 17.46%).
    Conclusion: The study offers detailed insights into the shifts in neonatal disease patterns at the Seventh Medical Center of the PLA General Hospital following the onset of the COVID-19 pandemic, providing a foundation for future research and policymaking efforts.
    Language English
    Publishing date 2024-02-25
    Publishing country United States
    Document type Journal Article
    ISSN 2398-8835
    ISSN (online) 2398-8835
    DOI 10.1002/hsr2.1928
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  4. Article: Veno-arterial extracorporeal membrane oxygenation for respiratory and cardiac support in neonates: a single center experience.

    Wang, Gang / Li, Qiuping / Zhou, Gengxu / Hong, Xiaoyang / Zhao, Zhe / Meng, Qiang / Feng, Zhichun

    Frontiers in cardiovascular medicine

    2024  Volume 11, Page(s) 1322231

    Abstract: Objective: Extracorporeal membrane oxygenation (ECMO) is an advanced life support that has been utilized in the neonate for refractory respiratory and circulatory failure. Striving for the best outcomes and understanding optimal surgical techniques ... ...

    Abstract Objective: Extracorporeal membrane oxygenation (ECMO) is an advanced life support that has been utilized in the neonate for refractory respiratory and circulatory failure. Striving for the best outcomes and understanding optimal surgical techniques continue to be at the forefront of discussion and research. This study presents a single-center experience of cervically cannulated neonatal patients on V-A ECMO, a description of our cannulation/decannulation techniques and our patient outcomes.
    Methods: Single center retrospective review of neonates who received neck V-A ECMO support from January 2012 to December 2022. The data and outcomes of the patients were retrospectively analyzed.
    Results: A total of 78 neonates received V-A ECMO support. There were 66 patients that received ECMO for respiratory support, the other 12 patients that received ECMO for cardiac support. The median duration of ECMO support was 109 (32-293) hours for all patients. During ECMO support, 20 patients died and 5 patients discontinued treatment due to poor outcome or the cost. A total of 53 (68%) patients were successfully weaned from ECMO, but 3 of them died in the subsequent treatment. Overall 50 (64%) patients survived to hospital discharge. In this study, 48 patients were cannulated using the vessel sparing technique, the other 30 patients were cannulated using the ligation technique. We found no significant difference in the rates of normal cranial MRI at discharge between survivors with and without common carotid artery ligation.
    Conclusion: We achieved satisfactory outcomes of neonatal ECMO in 11-year experience. This study found no significant difference in early neuroimaging between survivors with and without common carotid artery ligation. The long-term neurological function of ECMO survivors warranted further follow-up and study.
    Language English
    Publishing date 2024-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2024.1322231
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  5. Article ; Online: Retraction notice to "MicroRNA-375-3p in endothelial progenitor cells-derived extracellular vesicles relieves myocardial injury in septic rats via BRD4-mediated PI3K/AKT signaling pathway" [Int. Immunopharmacol. 96 (2021) 107740].

    Hong, Xiaoyang / Wang, Jie / Li, Shuanglei / Zhao, Zhe / Feng, Zhichun

    International immunopharmacology

    2023  Volume 117, Page(s) 109857

    Language English
    Publishing date 2023-02-21
    Publishing country Netherlands
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2023.109857
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    In stock of ZB MED Cologne/Königswinter

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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Ventricular septal intramyocardial dissection after cardiac tumor excision.

    Wang, Gang / Wang, Jianhua / Zhou, Gengxu / Feng, Zhichun

    Journal of cardiac surgery

    2022  Volume 37, Issue 9, Page(s) 2864–2866

    Abstract: We reported a rare case: an infant underwent cardiac tumor resection, and postoperative transthoracic echocardiography revealed a cystic dissection located in the interventricular septum. ...

    Abstract We reported a rare case: an infant underwent cardiac tumor resection, and postoperative transthoracic echocardiography revealed a cystic dissection located in the interventricular septum.
    MeSH term(s) Echocardiography ; Heart Neoplasms/diagnostic imaging ; Heart Neoplasms/surgery ; Humans ; Infant ; Ventricular Septum/diagnostic imaging ; Ventricular Septum/surgery
    Language English
    Publishing date 2022-06-04
    Publishing country United States
    Document type Case Reports
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.16665
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    Zs.A 2221: Show issues Location:
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  7. Article ; Online: Pectoralis major muscle turnover flap reconstruction for treatment of deep sternal wound infection in infants and children.

    Wang, Gang / Gao, Yongshun / Zhou, Gengxu / Feng, Zhichun

    Journal of cardiac surgery

    2022  Volume 37, Issue 8, Page(s) 2309–2314

    Abstract: Objective: The aim of the study is to assess the therapeutic effect and applicability of pectoralis major muscle turnover flap (PMMTF) reconstruction for treatment of deep sternal wound infection (DSWI) after cardiac surgery in infants and children.: ... ...

    Abstract Objective: The aim of the study is to assess the therapeutic effect and applicability of pectoralis major muscle turnover flap (PMMTF) reconstruction for treatment of deep sternal wound infection (DSWI) after cardiac surgery in infants and children.
    Methods: From March 2013 to October 2021, 23 patients with DSWI after cardiac surgery underwent PMMTF reconstruction. The data and outcomes of the patients were retrospectively analyzed.
    Results: Twenty patients were treated with unilateral PMMTF reconstruction, and three patients were treated by bilateral PMMTF. All of the sternal wounds healed successfully. All patients survived and were discharged without evidence of infection. In a follow-up period, ranging from 15 to 83 months (mean 32.6 months), all patients demonstrated normal development with no limitations to limb movements. There were no signs of chronic sternal infection in all of them.
    Conclusion: PMMTF reconstruction is a simple, feasible, and effective treatment of DSWI after cardiac surgery in infants and children, with minimal developmental problems.
    MeSH term(s) Child ; Humans ; Infant ; Pectoralis Muscles/transplantation ; Reconstructive Surgical Procedures ; Retrospective Studies ; Sternum/surgery ; Surgical Flaps/surgery ; Surgical Wound Infection/surgery ; Treatment Outcome
    Language English
    Publishing date 2022-05-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.16567
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    Zs.A 2221: Show issues Location:
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  8. Article: A Novel Variant of the

    Zhu, Lina / Peng, Fujun / Deng, Zengwen / Feng, Zhichun / Ma, Xiuwei

    Frontiers in genetics

    2022  Volume 13, Page(s) 761178

    Abstract: Pathogenic variants ... ...

    Abstract Pathogenic variants in
    Language English
    Publishing date 2022-02-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.761178
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  9. Article ; Online: Window anastomosis technique for repair of supracardiac total anomalous pulmonary venous connection in infants.

    Wang, Gang / Zhou, Gengxu / Wang, Jieqiong / Wang, Hui / Feng, Zhichun

    Journal of cardiac surgery

    2022  Volume 37, Issue 11, Page(s) 3988–3990

    Abstract: Outcomes of operations for total anomalous pulmonary venous connection (TAPVC) have improved. However, postoperative pulmonary venous obstruction remains the most significant complication with high morbidity and mortality. We introduce a window ... ...

    Abstract Outcomes of operations for total anomalous pulmonary venous connection (TAPVC) have improved. However, postoperative pulmonary venous obstruction remains the most significant complication with high morbidity and mortality. We introduce a window anastomosis technique for repair of supracardiac TAPVC in infants. The mainstay of the surgical technique is to resect the anterior wall of the pulmonary vein confluence and part of the posterior wall of the left atrium to form a large and undistorted "window to window" anastomosis.
    MeSH term(s) Anastomosis, Surgical/methods ; Heart Atria/surgery ; Heart Defects, Congenital/surgery ; Humans ; Infant ; Pulmonary Veins/abnormalities ; Pulmonary Veins/surgery ; Scimitar Syndrome/surgery ; Vascular Diseases
    Language English
    Publishing date 2022-08-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.16871
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  10. Article ; Online: Comment on "A Pumpless Microfluidic Neonatal Lung Assist Device for Support of Preterm Neonates in Respiratory Distress".

    Wang, Li / Li, Fang / Feng, Zhichun / Shi, Yuan

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2021  Volume 8, Issue 12, Page(s) 2004382

    Language English
    Publishing date 2021-05-03
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202004382
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