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Article ; Online: Six new iridoid glycosides from the whole plants of

Gao, Huan-Huan / Qin, Ling-Feng / Zhang, Xu / Yuan, Xiang / Feng, Zi-Ming / Jiang, Jian-Shuang / Zhang, Pei-Cheng / Yang, Ya-Nan

Journal of Asian natural products research

2024 Volume 26, Issue 1, Page(s) 112–119

Abstract: Six new iridoid glycosides were isolated from the ethyl acetate fraction of the whole plants ... ...

Abstract	Six new iridoid glycosides were isolated from the ethyl acetate fraction of the whole plants of
MeSH term(s)	Iridoid Glycosides/pharmacology ; Hedyotis/chemistry ; Antioxidants ; Magnetic Resonance Spectroscopy ; Esters ; Glycosides/pharmacology ; Coumaric Acids
Chemical Substances	Iridoid Glycosides ; Antioxidants ; E-6-O-p-coumaroyl scandoside methyl ester ; Esters ; Glycosides ; Coumaric Acids
Language	English
Publishing date	2024-01-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2077926-4
ISSN	1477-2213 ; 1028-6020
ISSN (online)	1477-2213
ISSN	1028-6020
DOI	10.1080/10286020.2023.2293068
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Six undescribed lavandulylated flavonoids with PTP1B inhibition from the roots of Sophora flavescens.

Zhang, Xu / Lu, Kai-Zhou / Yang, Ya-Nan / Feng, Zi-Ming / Yuan, Xiang / Jiang, Jian-Shuang / Zhang, Pei-Cheng

Phytochemistry

2023 Volume 216, Page(s) 113889

Abstract: Six undescribed lavandulylated flavonoids (1-6) were isolated from the roots of Sophora flavescens. Remarkably, compounds 1 and 2, which were composed of a flavane unit and a phloroglucinol unit, were the first reported dimers. Compounds 3 and 4 were the ...

Abstract	Six undescribed lavandulylated flavonoids (1-6) were isolated from the roots of Sophora flavescens. Remarkably, compounds 1 and 2, which were composed of a flavane unit and a phloroglucinol unit, were the first reported dimers. Compounds 3 and 4 were the first reported neoflavonoids with lavandulyl units. Compounds 5 and 6 were chalcone with oxidized lavandulyl units. Their structures were fully characterized by cumulative analyses of UV, IR, HRESIMS, NMR and ECD spectroscopic data, along with computational calculations through density functional theory. Compounds 1 and 2 showed significant protein tyrosine phosphatase-1B inhibitory activities with IC
MeSH term(s)	Flavonoids/chemistry ; Sophora flavescens ; Sophora/chemistry ; Plant Extracts/chemistry ; Plant Roots/chemistry
Chemical Substances	Flavonoids ; Plant Extracts
Language	English
Publishing date	2023-10-09
Publishing country	England
Document type	Journal Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2023.113889
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Article ; Online: The tanshinones from the plant of Salvia miltiorrhiza.

Jiang, Jian-Shuang / Gu, Quan-Chang / Feng, Zi-Ming / Yuan, Xiang / Zhang, Xu / Zhang, Pei-Cheng / Yang, Ya-Nan

Phytochemistry

2023 Volume 210, Page(s) 113673

Abstract: Six undescribed tanshinones, (+)-2-Cl-tanshindiol C (1), (-)-2-Cl-tanshindiol C (2), (+)-tanshinoic acid D (3), (-)-tanshinoic acid D (4), (-)-tanshinoic acid E (5), and (+)-tanshinoic acid E (6), were isolated from the rhizome of Salvia miltiorrhiza ... ...

Abstract	Six undescribed tanshinones, (+)-2-Cl-tanshindiol C (1), (-)-2-Cl-tanshindiol C (2), (+)-tanshinoic acid D (3), (-)-tanshinoic acid D (4), (-)-tanshinoic acid E (5), and (+)-tanshinoic acid E (6), were isolated from the rhizome of Salvia miltiorrhiza Bunge. Their structures were elucidated based on the spectroscopic data (UV, IR, HR-ESI-MS, and NMR). The bioactive assays of all these compounds for the antioxidant activities in cardiomyocytes upon hypoxia stimulation were evaluated. The results suggested that compounds 5 and 6 exhibited good antioxidant activities in cardiomyocytes and the cell survival rates were 46.3% and 57.9% (10
MeSH term(s)	Salvia miltiorrhiza/chemistry ; Antioxidants/pharmacology ; Abietanes/pharmacology ; Abietanes/chemistry ; Rhizome/chemistry ; Plant Roots/chemistry
Chemical Substances	tanshinone (03UUH3J385) ; Antioxidants ; Abietanes
Language	English
Publishing date	2023-04-06
Publishing country	England
Document type	Journal Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2023.113673
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Article ; Online: Seventeen undescribed iridoid derivatives with anti-inflammatory effects from Hedyotis diffusa and their structure-activity relationships.

Qin, Ling-Feng / Gao, Huan-Huan / Zhang, Xu / Yuan, Xiang / Feng, Zi-Ming / Zhang, Pei-Cheng / Jiang, Jian-Shuang / Yang, Ya-Nan

Phytochemistry

2023 Volume 217, Page(s) 113904

Abstract: Seventeen undescribed iridoid derivatives (1-17) and four known compounds (18-21) were isolated from the whole plant of Hedyotis diffusa Willd. Their structures were elucidated based on unambiguous spectroscopic data (UV, IR, HRESIMS, CD, and 1D and 2D ... ...

Abstract	Seventeen undescribed iridoid derivatives (1-17) and four known compounds (18-21) were isolated from the whole plant of Hedyotis diffusa Willd. Their structures were elucidated based on unambiguous spectroscopic data (UV, IR, HRESIMS, CD, and 1D and 2D NMR). It is noteworthy that compounds 1-8, which possess unique long-chain aliphatic acid moiety, were reported for the first time among the iridoid natural products. All compounds were evaluated for their anti-inflammatory activities in lipopolysaccharide-induced RAW 264.7 cells. Compounds 2, 4, and 6 showed significant suppression effects on nitric oxide production, with IC
MeSH term(s)	Iridoids/pharmacology ; Iridoids/chemistry ; Hedyotis/chemistry ; Plant Extracts/chemistry ; Structure-Activity Relationship ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/chemistry
Chemical Substances	Iridoids ; Plant Extracts ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-11-04
Publishing country	England
Document type	Journal Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2023.113904
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Article ; Online: The tanshinones from the plant of Salvia miltiorrhiza

Jiang, Jian-Shuang / Gu, Quan-chang / Feng, Zi-Ming / Yuan, Xiang / Zhang, Xu / Zhang, Pei-Cheng / Yang, Ya-Nan

Phytochemistry. 2023 June, v. 210 p.113673-

2023

Abstract: Six undescribed tanshinones, (+)-2-Cl-tanshindiol C (1), (−)-2-Cl-tanshindiol C (2), (+)-tanshinoic acid D (3), (−)-tanshinoic acid D (4), (−)-tanshinoic acid E (5), and (+)-tanshinoic acid E (6), were isolated from the rhizome of Salvia miltiorrhiza ... ...

Abstract	Six undescribed tanshinones, (+)-2-Cl-tanshindiol C (1), (−)-2-Cl-tanshindiol C (2), (+)-tanshinoic acid D (3), (−)-tanshinoic acid D (4), (−)-tanshinoic acid E (5), and (+)-tanshinoic acid E (6), were isolated from the rhizome of Salvia miltiorrhiza Bunge. Their structures were elucidated based on the spectroscopic data (UV, IR, HR-ESI-MS, and NMR). The bioactive assays of all these compounds for the antioxidant activities in cardiomyocytes upon hypoxia stimulation were evaluated. The results suggested that compounds 5 and 6 exhibited good antioxidant activities in cardiomyocytes and the cell survival rates were 46.3% and 57.9% (10⁻⁵ mol/L), respectively.
Keywords	Salvia miltiorrhiza ; antioxidants ; cardiomyocytes ; cell viability ; hypoxia ; plant biochemistry ; rhizomes ; spectral analysis ; Labiatae ; Isolation and purification ; Tanshinone ; Structural elucidation ; Antioxidant activities
Language	English
Dates of publication	2023-06
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2023.113673
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Bioactive amides from

Zhang, Xu / Liu, Fu / Feng, Zi-Ming / Jiang, Jian-Shuang / Yang, Ya-Nan / Zhang, Pei-Cheng

Journal of Asian natural products research

2021 Volume 23, Issue 3, Page(s) 228–234

Abstract: One pair of new amides enantiomers ( ...

Abstract	One pair of new amides enantiomers (
MeSH term(s)	Amides/pharmacology ; Fallopia japonica ; Molecular Structure ; Plant Extracts ; Polygonum ; Rhizome
Chemical Substances	Amides ; Plant Extracts
Language	English
Publishing date	2021-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2077926-4
ISSN	1477-2213 ; 1028-6020
ISSN (online)	1477-2213
ISSN	1028-6020
DOI	10.1080/10286020.2021.1873298
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Article ; Online: Synthesis of 4-thiosubstituted flavan derivatives and their hypoglycemic activities.

Zhang, Xu / Yun, Ju-Ping / Yang, Ya-Nan / Feng, Zi-Ming / Jiang, Jian-Shuang / Yuan, Xiang / Liu, Wei / Zhang, Pei-Cheng

Fitoterapia

2022 Volume 161, Page(s) 105255

Abstract: A series of 4-thiosubstituted flavan derivatives (1-44) were designed and synthesized. The target compounds were assayed for inhibitory activity against α-glucosidase in vitro, and the results indicated that all compounds displayed significant effects in ...

Abstract	A series of 4-thiosubstituted flavan derivatives (1-44) were designed and synthesized. The target compounds were assayed for inhibitory activity against α-glucosidase in vitro, and the results indicated that all compounds displayed significant effects in the range of IC
MeSH term(s)	Acarbose/pharmacology ; Animals ; Glycoside Hydrolase Inhibitors/pharmacology ; Hypoglycemic Agents/pharmacology ; Mice ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship ; alpha-Glucosidases/metabolism
Chemical Substances	Glycoside Hydrolase Inhibitors ; Hypoglycemic Agents ; alpha-Glucosidases (EC 3.2.1.20) ; Acarbose (T58MSI464G)
Language	English
Publishing date	2022-07-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	412385-2
ISSN	1873-6971 ; 0367-326X
ISSN (online)	1873-6971
ISSN	0367-326X
DOI	10.1016/j.fitote.2022.105255
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Article ; Online: Eight new arnebinol B-based meroterpenoids with planar chirality in the constrained 6/10/5 tricyclic skeleton from Arnebia euchroma and their cytotoxicities.

Yan, Hai-Wei / Yang, Ya-Nan / Zhang, Xu / Jiang, Jian-Shuang / Yuan, Xiang / Feng, Zi-Ming / Zhang, Pei-Cheng

Bioorganic chemistry

2022 Volume 128, Page(s) 106091

Abstract: Eight new arnebinol B-based meroterpenoids ((-)-1, 2, 3, (-)-5, and 7-10) with a constrained 6/10/5 tricyclic backbone were isolated from the roots of Arnebia euchroma. The planar and steric structures of these new compounds were unambiguously elucidated ...

Abstract	Eight new arnebinol B-based meroterpenoids ((-)-1, 2, 3, (-)-5, and 7-10) with a constrained 6/10/5 tricyclic backbone were isolated from the roots of Arnebia euchroma. The planar and steric structures of these new compounds were unambiguously elucidated by extensive spectroscopic analyses, X-ray diffraction crystallography, and ECD calculations. The predominant relative orientation between H-7 and the Z double bond with a methyl substituent in the rigid 10-membered carbocycle, along with the planar chirality of the Z double bond was analyzed and discussed for the first time. The illustration of the planar chirality derived from the Z double bond should be paid great importance during the structure elucidation on these homologous meroterpenoids. All the isolated meroterpenoids were screened for their cytotoxicities against the HCT-8, PANC-1, HGC-27, HepG2, and PC9 cell lines, and compounds (+)-5 and (-)-5 exhibited the most potent cytotoxicity.
MeSH term(s)	Boraginaceae/chemistry ; Molecular Structure ; Plant Roots/chemistry ; Skeleton ; Terpenes/chemistry ; Terpenes/pharmacology
Chemical Substances	Terpenes ; arnebinol (87064-17-3)
Language	English
Publishing date	2022-08-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2022.106091
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Article ; Online: The phenolic acids from the plant of Salvia miltiorrhiza.

Jiang, Jian-Shuang / Gu, Quan-Chang / Feng, Zi-Ming / Yuan, Xiang / Zhang, Xu / Zhang, Pei-Cheng / Yang, Ya-Nan

Fitoterapia

2022 Volume 159, Page(s) 105180

Abstract: Seven new phenolic acids, 7, 8-epiblechnic acid (1), 8-epiblechnic acid 9-ehthyl-9'-methyl ester (2), 9'-ehyl-isolithospermate (3), 9''-methyl-isolithospermate (4), 9'-ethyl-9''-methyl-isolithospermate (5), 9', 9''-dimethyl-isolithospermate (6), ... ...

Abstract	Seven new phenolic acids, 7, 8-epiblechnic acid (1), 8-epiblechnic acid 9-ehthyl-9'-methyl ester (2), 9'-ehyl-isolithospermate (3), 9''-methyl-isolithospermate (4), 9'-ethyl-9''-methyl-isolithospermate (5), 9', 9''-dimethyl-isolithospermate (6), sebesteniod E (7), were isolated from the roots of Salvia miltiorrhiza. Their structures were elucidated by detailed spectroscopic means including UV, IR, HRESIMS, and NMR data spectra. The bioactive assays of compounds 1-7 against neuroprotection activities were determined. The results suggested that compound 4 exhibited a moderate glutamate-induced neuroprotective activity and the cell survival rate was 24.0% (10
MeSH term(s)	Hydroxybenzoates/pharmacology ; Molecular Structure ; Plant Roots ; Salvia miltiorrhiza/chemistry
Chemical Substances	Hydroxybenzoates
Language	English
Publishing date	2022-03-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	412385-2
ISSN	1873-6971 ; 0367-326X
ISSN (online)	1873-6971
ISSN	0367-326X
DOI	10.1016/j.fitote.2022.105180
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Article: Enhancement of autophagy flux by isopsoralen ameliorates interleukin-1β-stimulated apoptosis in rat chondrocytes

Chen, Zhi / Li, Chen / Qian, Yi-Hong / Fu, Yang / Feng, Zi-Ming

Journal of Asian natural products research. 2020 Feb. 1, v. 22, no. 2

2020

Abstract: Chondrocyte apoptosis contributes to the pathogenesis of cartilage degeneration in osteoarthritis (OA). We found that isopsoralen pretreatment significantly reversed the increase in DNA fragmentation and apoptosis rate, and significantly decreased the ... ...

Abstract	Chondrocyte apoptosis contributes to the pathogenesis of cartilage degeneration in osteoarthritis (OA). We found that isopsoralen pretreatment significantly reversed the increase in DNA fragmentation and apoptosis rate, and significantly decreased the caspase-3 activity and PARP cleavage in IL-1β-treated chondrocytes. Isopsoralen pretreatment markedly inhibited disruption of matrix proteins. Moreover, the expressions of LC3-II and LAMP-1 were markedly increased but the expression of p62/SQSTM1 was remarkably decreased by isopsoralen pretreatment. Importantly, the protective effects of isopsoralen against IL-1β were blocked by pretreatment with autophagy inhibitor 3-MA and bafilomycin A1. These results suggest that isopsoralen ameliorates chondrocyte apoptosis by promoting autophagy flux.
Keywords	DNA fragmentation ; apoptosis ; autophagy ; cartilage ; caspase-3 ; chondrocytes ; enzyme activity ; interleukin-1beta ; osteoarthritis ; pathogenesis ; protective effect ; proteins ; rats
Language	English
Dates of publication	2020-0201
Size	p. 179-192.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2077926-4
ISSN	1477-2213 ; 1028-6020
ISSN (online)	1477-2213
ISSN	1028-6020
DOI	10.1080/10286020.2018.1537265
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