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  1. Article: A distal renal tubular acidosis showing hyperammonemia and hyperlactacidemia.

    Ripoli, C / Pinna, A / Marras, S / Fenu, M L / Nurchi, A M

    La Pediatria medica e chirurgica : Medical and surgical pediatrics

    2012  Volume 34, Issue 4, Page(s) 198–201

    Abstract: Introduction: distal renal tubular acidosis (dRTA) presents itself with variable clinical manifestations and often with late expressions that impact on prognosis.: Case report: A 45-day-old male infant was admitted with stopping growth, difficult ... ...

    Abstract Introduction: distal renal tubular acidosis (dRTA) presents itself with variable clinical manifestations and often with late expressions that impact on prognosis.
    Case report: A 45-day-old male infant was admitted with stopping growth, difficult feeding and vomiting after meals. Clinical tests and labs revealed a type 1 renal tubular acidosis, even if the first blood tests showed ammonium and lactate increase. We had to exclude metabolic diseases before having a certain diagnosis.
    Conclusions: blood and urine investigations and genetic tests are fundamental to formulate dRTA diagnosis and to plan follow-up, according to possible phenotypic expressions of recessive and dominant autosomal forms in patients with dRTA.
    MeSH term(s) Acidosis, Renal Tubular/blood ; Acidosis, Renal Tubular/complications ; Acidosis, Renal Tubular/diagnosis ; Acidosis, Renal Tubular/genetics ; Acidosis, Renal Tubular/therapy ; Growth Disorders/etiology ; Humans ; Hyperammonemia/blood ; Hyperammonemia/diagnosis ; Hyperammonemia/etiology ; Hyperammonemia/genetics ; Infant ; Lactates/blood ; Male ; Mutation ; Phenotype ; Potassium Citrate/administration & dosage ; Sodium Bicarbonate/administration & dosage ; Treatment Outcome ; Vomiting/etiology
    Chemical Substances Lactates ; Sodium Bicarbonate (8MDF5V39QO) ; Potassium Citrate (EE90ONI6FF)
    Language English
    Publishing date 2012-07
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 605942-9
    ISSN 2420-7748 ; 0391-5387
    ISSN (online) 2420-7748
    ISSN 0391-5387
    DOI 10.4081/pmc.2012.74
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A comparison of two blood culture procedures for the isolation of staphylococci in a paediatric intensive care unit.

    Belli, M L / Ugolotti, E / Fenu, M L / Mantero, E / Ceccarelli, R

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2005  Volume 11, Issue 12, Page(s) 1035–1037

    Abstract: Blood culture results obtained between January 2000 and July 2003 were reviewed for 1360 patients in a paediatric intensive care unit (PICU). The BacT/Alert FA aerobic medium was used with a blood volume of 1.5 mL for the first 23 months, and the BacT/ ... ...

    Abstract Blood culture results obtained between January 2000 and July 2003 were reviewed for 1360 patients in a paediatric intensive care unit (PICU). The BacT/Alert FA aerobic medium was used with a blood volume of 1.5 mL for the first 23 months, and the BacT/Alert PF paediatric medium was used with a 0.5-mL volume for the remaining 18 months. The isolation rates were similar during both periods (13.4% vs. 13.1%), and staphylococci were the most common isolates (72.8%). There was a shorter time to detection of staphylococci with the smaller-volume (PF) procedure, which thus seems suitable for use in the diagnosis of staphylococcal bacteraemia in the PICU.
    MeSH term(s) Adolescent ; Bacteremia/diagnosis ; Bacteriological Techniques ; Child ; Child, Preschool ; Culture Media ; Culture Techniques ; Humans ; Infant ; Intensive Care Units, Pediatric ; Staphylococcal Infections/diagnosis ; Staphylococcus/isolation & purification
    Chemical Substances Culture Media
    Language English
    Publishing date 2005-12
    Publishing country England
    Document type Comparative Study ; Evaluation Studies ; Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1198-743X ; 1470-9465
    ISSN (online) 1469-0691
    ISSN 1198-743X ; 1470-9465
    DOI 10.1111/j.1469-0691.2005.01269.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Use of the E test to assess synergy of antibiotic combinations against isolates of Burkholderia cepacia-complex from patients with cystic fibrosis.

    Manno, G / Ugolotti, E / Belli, M L / Fenu, M L / Romano, L / Cruciani, M

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2003  Volume 22, Issue 1, Page(s) 28–34

    Abstract: Treatment of Burkholderia cepacia-complex infections in cystic fibrosis patients is problematic, since the microorganism is often resistant to most antimicrobial agents. In this study, the Epsilometer test, or E test, was used to assess the activity of ... ...

    Abstract Treatment of Burkholderia cepacia-complex infections in cystic fibrosis patients is problematic, since the microorganism is often resistant to most antimicrobial agents. In this study, the Epsilometer test, or E test, was used to assess the activity of antimicrobial combinations against Burkholderia cepacia-complex. In a preliminary evaluation, the E test was compared to the checkerboard method using 10 test organisms. Synergy testing by the E test was then performed on 131 clinical isolates of Burkholderia cepacia-complex using various combinations of antimicrobial agents. Agreement between the E test and the checkerboard method was 90%. The rate of resistance to individual agents ranged from 48% for meropenem to 100% for tobramycin, chloramphenicol, and rifampin. In 71.6%, 15.6%, and 12.6% of the test evaluations performed, the combinations tested resulted in additivity/indifference, synergism, and antagonism, respectively. The highest rates of synergy were observed with combinations of ciprofloxacin-piperacillin (44%), rifampin-ceftazidime (33%), chloramphenicol-ceftazidime (22%), cotrimoxazole-piperacillin/tazobactam (22%), and ciprofloxacin-ceftazidime (21%). Rates of antagonism for cotrimoxazole and chloramphenicol in combination with beta-lactam agents were higher than those observed for ciprofloxacin plus beta-lactam agents. These results suggest that the E test is a valuable and practical method to be considered for improving the identification of possible therapeutic options in cystic fibrosis patients infected with organisms belonging to the Burkholderia cepacia-complex.
    MeSH term(s) Bacteriological Techniques ; Burkholderia Infections/drug therapy ; Burkholderia Infections/etiology ; Burkholderia cepacia/drug effects ; Burkholderia cepacia/isolation & purification ; Ceftazidime/pharmacology ; Chi-Square Distribution ; Child ; Child, Preschool ; Ciprofloxacin/pharmacology ; Cystic Fibrosis/complications ; Cystic Fibrosis/drug therapy ; Drug Resistance, Microbial ; Drug Synergism ; Drug Therapy, Combination/pharmacology ; Female ; Humans ; Lactams/pharmacology ; Male ; Microbial Sensitivity Tests/methods ; Piperacillin/pharmacology ; Rifampin/pharmacology ; Sensitivity and Specificity
    Chemical Substances Lactams ; Ciprofloxacin (5E8K9I0O4U) ; Ceftazidime (9M416Z9QNR) ; Rifampin (VJT6J7R4TR) ; Piperacillin (X00B0D5O0E)
    Language English
    Publishing date 2003-01
    Publishing country Germany
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-002-0852-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Epidemiologia e sensibilita agli antibiotici in infezioni respiratorie di pazienti pediatrici in un periodo di 4 anni. Studio retrospettivo su 460 ceppi di H. influenzae, S. pneumoniae e M. catarrhalis.

    Manno, G. / Belli, M.L. / Bassetti, M. / Ugolotti, E. / Fenu, M.L. / Piana, S. / Bassetti, D.

    Le infezioni in medicina

    2000  Volume 8, Issue 2, Page(s) 95–100

    Abstract: H. influenzae, S. pneumoniae and M. catarrhalis are the most common bacterial pathogens causing respiratory infections in children. Resistance to antibiotics may vary according to the geographical area. It is therefore important that the resistance ... ...

    Title translation Epidemiology and sensitivity to antibiotics in paediatric respiratory infections over a 4-year period. Retrospective study of 460 H. influenzae, S. pneumoniae and M. catarrhalis strains
    Abstract H. influenzae, S. pneumoniae and M. catarrhalis are the most common bacterial pathogens causing respiratory infections in children. Resistance to antibiotics may vary according to the geographical area. It is therefore important that the resistance pattern of such pathogens is determined by surveillance studies carried out both on a national scale and by individual laboratories. In this study, we determined retrospectively the prevalence of H. influenzae, S. pneumoniae and M. catarrhalis in upper respiratory tract infections involving subjects of paediatric age, with reference to the type of clinical sample (pharingeal swab and nasal swab), symptomatology and age group. Moreover, for the above micro-organisms the pattern of sensitivity to antibiotics was assessed. In the observation period (January 1996-December 1999), at the day hospital of the Paediatric Pneumology Division of the Gaslini Institute in Genova, in 476 patients between 0 and 15 years of age a total of 460 respiratory pathogens were isolated: 164 S. pneumoniae strains, 163 of H. influenzae (96 belonging to type B and 67 non-attributable to any type) and 133 of M. catarrhalis. As regards sensitivity to antibiotics, ceftriaxone and amoxycillin/clavulanic acid proved to be the most active molecules in all the studied strains.
    Language Italian
    Publishing date 2000
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2041081-5
    ISSN 1124-9390
    ISSN 1124-9390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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