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Article ; Online: Commentary: Evaluation of the Educational Quality of the Top 30 Most Viewed Laparoscopic Distal Pancreatectomy Videos on YouTube by Tan

Feo, Claudio F / Porcu, Alberto

Journal of laparoendoscopic & advanced surgical techniques. Part A

2023 Volume 33, Issue 4, Page(s) 320

MeSH term(s)	Humans ; Social Media ; Pancreatectomy ; Laparoscopy ; Video Recording ; Educational Status
Language	English
Publishing date	2023-03-01
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1381909-4
ISSN	1557-9034 ; 1092-6429
ISSN (online)	1557-9034
ISSN	1092-6429
DOI	10.1089/lap.2023.29046.cff
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Article ; Online: S-Adenosylmethionine: From the Discovery of Its Inhibition of Tumorigenesis to Its Use as a Therapeutic Agent.

Pascale, Rosa M / Simile, Maria M / Calvisi, Diego F / Feo, Claudio F / Feo, Francesco

Cells

2022 Volume 11, Issue 3

Abstract: Alterations of methionine cycle in steatohepatitis, cirrhosis, and hepatocellular carcinoma induce MAT1A decrease and MAT2A increase expressions with the consequent decrease of S-adenosyl-L-methionine (SAM). This causes non-alcoholic fatty liver disease ( ...

Abstract	Alterations of methionine cycle in steatohepatitis, cirrhosis, and hepatocellular carcinoma induce MAT1A decrease and MAT2A increase expressions with the consequent decrease of S-adenosyl-L-methionine (SAM). This causes non-alcoholic fatty liver disease (NAFLD). SAM administration antagonizes pathological conditions, including galactosamine, acetaminophen, and ethanol intoxications, characterized by decreased intracellular SAM. Positive therapeutic effects of SAM/vitamin E or SAM/ursodeoxycholic acid in animal models with NAFLD and intrahepatic cholestasis were not confirmed in humans. In in vitro experiments, SAM and betaine potentiate PegIFN-alpha-2a/2b plus ribavirin antiviral effects. SAM plus betaine improves early viral kinetics and increases interferon-stimulated gene expression in patients with viral hepatitis non-responders to pegIFNα/ribavirin. SAM prevents hepatic cirrhosis, induced by CCl4, inhibits experimental tumors growth and is proapoptotic for hepatocellular carcinoma and MCF-7 breast cancer cells. SAM plus Decitabine arrest cancer growth and potentiate doxorubicin effects on breast, head, and neck cancers. Furthermore, SAM enhances the antitumor effect of gemcitabine against pancreatic cancer cells, inhibits growth of human prostate cancer PC-3, colorectal cancer, and osteosarcoma LM-7 and MG-63 cell lines; increases genomic stability of SW480 cells. SAM reduces colorectal cancer progression and inhibits the proliferation of preneoplastic rat liver cells in vivo. The discrepancy between positive results of SAM treatment of experimental tumors and modest effects against human disease may depend on more advanced human disease stage at moment of diagnosis.
MeSH term(s)	Animals ; Antiviral Agents/therapeutic use ; Betaine ; Carcinogenesis ; Carcinoma, Hepatocellular/pathology ; Cell Transformation, Neoplastic ; Colorectal Neoplasms/drug therapy ; Humans ; Liver Neoplasms/pathology ; Male ; Methionine Adenosyltransferase ; Non-alcoholic Fatty Liver Disease/drug therapy ; Rats ; Ribavirin/therapeutic use ; S-Adenosylmethionine/metabolism ; S-Adenosylmethionine/pharmacology ; S-Adenosylmethionine/therapeutic use
Chemical Substances	Antiviral Agents ; Betaine (3SCV180C9W) ; Ribavirin (49717AWG6K) ; S-Adenosylmethionine (7LP2MPO46S) ; MAT2A protein, human (EC 2.5.1.6) ; Methionine Adenosyltransferase (EC 2.5.1.6)
Language	English
Publishing date	2022-01-25
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11030409
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Article ; Online: Open Hemorrhoidectomy With Ligasure™ Under Local or Spinal Anesthesia: A Comparative Study.

Feo, Claudio F / Ninniri, Chiara / Tanda, Cinzia / Deiana, Giulia / Porcu, Alberto

The American surgeon

2021 Volume 89, Issue 4, Page(s) 671–675

Abstract: Background: There is increasing evidence that many anorectal surgical procedures may be performed under local anesthesia. The aim of the present study was to evaluate the safety and efficacy of local anesthesia in the outpatient clinic vs spinal ... ...

Abstract	Background: There is increasing evidence that many anorectal surgical procedures may be performed under local anesthesia. The aim of the present study was to evaluate the safety and efficacy of local anesthesia in the outpatient clinic vs spinal anesthesia in the operating room for open hemorrhoidectomy. Methods: Sixty-two patients with grade III or IV hemorrhoids underwent open hemorrhoidectomy with LigaSure™ between 2018 and 2020. Of them, 32 procedures were performed in the operating room under spinal anesthesia with hyperbaric bupivacaine and other 30 procedures were undertaken in the outpatient clinic under local anesthesia with ropivacaine. Results: There were no significant differences regarding age, gender, American Society of Anesthesiologists class, and Goligher's grade in between groups. No significant differences were observed in postoperative pain score (P = .85), perioperative complications (P = .51), and reoperation rate (P = .96). No recurrences and no differences in patients' satisfaction degree (P = .76) were documented at long-term follow-up in both study groups. Discussion: Our results suggest that open hemorrhoidectomy with LigaSure™ performed in selected patients under local anesthesia in the outpatient clinic is a well-tolerated, safe, and effective procedure.
MeSH term(s)	Humans ; Hemorrhoidectomy/methods ; Anesthesia, Spinal ; Hemorrhoids/surgery ; Ropivacaine ; Pain, Postoperative/prevention & control ; Anesthesia, Local ; Treatment Outcome
Chemical Substances	Ropivacaine (7IO5LYA57N)
Language	English
Publishing date	2021-08-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/00031348211038590
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Article: Hepatopancreatoduodenectomy for the treatment of extrahepatic cholangiocarcinoma.

Porcu, Alberto / Deiana, Giulia / Feo, Claudio F / Ninniri, Chiara / Turilli, Davide / Tanda, Lorena / Fancellu, Alessandro

Hepatobiliary & pancreatic diseases international : HBPD INT

2022 Volume 22, Issue 4, Page(s) 430–433

MeSH term(s)	Humans ; Cholangiocarcinoma/surgery ; Cholangiocarcinoma/pathology ; Bile Ducts, Intrahepatic ; Bile Duct Neoplasms/surgery ; Bile Duct Neoplasms/pathology ; Bile Ducts, Extrahepatic
Language	English
Publishing date	2022-08-21
Publishing country	Singapore
Document type	Letter
ZDB-ID	2241386-8
ISSN	1499-3872
ISSN	1499-3872
DOI	10.1016/j.hbpd.2022.08.011
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Article: Jejunal adenocarcinoma after biliopancreatic diversion. Report of a case.

Cossu, Maria L / Fancellu, Alessandro / Feo, Claudio F / Ginesu, Giorgio C / Sogos, Sebastiano / Ariu, Maria L / Porcu, Alberto

Obesity research & clinical practice

2022 Volume 16, Issue 3, Page(s) 269–271

Abstract: The effects of bariatric surgery on the development of gastrointestinal cancers remain ill defined. We present a case of jejunal adenocarcinoma developing 19 years after biliopancreatic diversion (BPD) procedure according to Scopinaro's technique. The ... ...

Abstract	The effects of bariatric surgery on the development of gastrointestinal cancers remain ill defined. We present a case of jejunal adenocarcinoma developing 19 years after biliopancreatic diversion (BPD) procedure according to Scopinaro's technique. The patient developed a marked distension of the biliopancreatic limb caused by a jejunal mass, evolving towards the so called "duodenal blowout". Emergency jejunal resection of the biliopancreatic limb, with creation of a new end-to-side jejunal-ileal anastomosis was necessary. The histological examination resulted in a moderately-differentiated ulcerated adenocarcinoma, with reactive lymph nodes and tumor-free resection margins. Tumors of the gastrointestinal system can arise following malabsorptive operations for morbid obesity, and they may be difficult to diagnose, since the symptoms are often attributed to the anatomical-functional changes resulting from this type of surgery. The case reported herein suggests that there is a need for surveillance in patients complaining of digestive symptoms after malabsorptive bariatric surgery.
MeSH term(s)	Adenocarcinoma/etiology ; Adenocarcinoma/surgery ; Anastomosis, Surgical ; Biliopancreatic Diversion/adverse effects ; Biliopancreatic Diversion/methods ; Duodenum/surgery ; Humans ; Obesity, Morbid/surgery
Language	English
Publishing date	2022-05-11
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	2274031-4
ISSN	1878-0318 ; 1871-403X
ISSN (online)	1878-0318
ISSN	1871-403X
DOI	10.1016/j.orcp.2022.05.002
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Article ; Online: Current management of incidental gallbladder cancer: A review.

Feo, Claudio F / Ginesu, Giorgio C / Fancellu, Alessandro / Perra, Teresa / Ninniri, Chiara / Deiana, Giulia / Scanu, Antonio M / Porcu, Alberto

International journal of surgery (London, England)

2022 Volume 98, Page(s) 106234

Abstract: Early-stage gallbladder cancer (GBC) is mostly discovered incidentally by the pathologist after cholecystectomy for a presumed benign disease. It is the most common malignancy of the biliary tract with a variable incidence rate all over the World. The ... ...

Abstract	Early-stage gallbladder cancer (GBC) is mostly discovered incidentally by the pathologist after cholecystectomy for a presumed benign disease. It is the most common malignancy of the biliary tract with a variable incidence rate all over the World. The majority of patients with GBC remain asymptomatic for a long time and diagnosis is usually late when the disease is at an advanced stage. Radical surgery consisting in resection of the gallbladder liver bed and regional lymph nodes seems to be the best treatment option for incidental GBC. However, recurrence rates after salvage surgery are still high and the addition of neoadjuvant/adjuvant chemotherapy may improve outcomes. The aim of the present review is to evaluate current literature for advances in management of incidental GBC, with particular focus on staging techniques and surgical options.
MeSH term(s)	Cholecystectomy ; Gallbladder Neoplasms/diagnosis ; Gallbladder Neoplasms/epidemiology ; Gallbladder Neoplasms/surgery ; Humans ; Incidental Findings ; Lymph Node Excision ; Neoplasm Staging
Language	English
Publishing date	2022-01-21
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1016/j.ijsu.2022.106234
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Article: The Warburg Effect 97 Years after Its Discovery.

Pascale, Rosa Maria / Calvisi, Diego Francesco / Simile, Maria Maddalena / Feo, Claudio Francesco / Feo, Francesco

Cancers

2020 Volume 12, Issue 10

Abstract: The deregulation of the oxidative metabolism in cancer, as shown by the increased aerobic glycolysis and impaired oxidative phosphorylation (Warburg effect), is coordinated by genetic changes leading to the activation of oncogenes and the loss of ... ...

Abstract	The deregulation of the oxidative metabolism in cancer, as shown by the increased aerobic glycolysis and impaired oxidative phosphorylation (Warburg effect), is coordinated by genetic changes leading to the activation of oncogenes and the loss of oncosuppressor genes. The understanding of the metabolic deregulation of cancer cells is necessary to prevent and cure cancer. In this review, we illustrate and comment the principal metabolic and molecular variations of cancer cells, involved in their anomalous behavior, that include modifications of oxidative metabolism, the activation of oncogenes that promote glycolysis and a decrease of oxygen consumption in cancer cells, the genetic susceptibility to cancer, the molecular correlations involved in the metabolic deregulation in cancer, the defective cancer mitochondria, the relationships between the Warburg effect and tumor therapy, and recent studies that reevaluate the Warburg effect. Taken together, these observations indicate that the Warburg effect is an epiphenomenon of the transformation process essential for the development of malignancy.
Language	English
Publishing date	2020-09-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers12102819
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Article ; Online: Laparoscopic treatment of colo-colic intussusception secondary to a lipomatous polyp.

Feo, Carlo V / Marcello, Daniele / Feo, Claudio F

Annali italiani di chirurgia

2017 Volume 6

Abstract: Introduction: Colo-colic intussusception is extremely rare in adults and few cases have been described secondary to a lypomatous polyp.: Case report: We present the case of a 50-year old man with chronic abdominal pain who was diagnosed a colo-colic ... ...

Abstract	Introduction: Colo-colic intussusception is extremely rare in adults and few cases have been described secondary to a lypomatous polyp. Case report: We present the case of a 50-year old man with chronic abdominal pain who was diagnosed a colo-colic intussusception secondary to a lipoma of the left colon. The patient underwent laparoscopic resection of the splenic flexure without reduction, which occurred spontaneously after induction of the pneumoperitoneum, and final histology confirmed a submucosal lipoma with no evidence of malignancy. Conclusion: The traditional treatment of choice for adult intussusception is bowel resection without reduction. More recently, however, preoperative reduction of the invaginated bowel segment has been reconsidered in order to: 1) avoid emergency surgery, 2) allow radical surgery for cancer, and 3) reduce the extent of the intestinal resection. To the best of our knowledge, this is the first case of adult colonic intussusception secondary to a lipoma treated by laparoscopy. Key words: Colon, Intussusception, Laparoscopy, Lipoma.
MeSH term(s)	Abdominal Pain/etiology ; Colonic Diseases/diagnostic imaging ; Colonic Diseases/etiology ; Colonic Diseases/surgery ; Colonic Neoplasms/complications ; Colonic Neoplasms/diagnostic imaging ; Colonic Neoplasms/surgery ; Colonic Polyps/complications ; Colonic Polyps/diagnostic imaging ; Colonic Polyps/pathology ; Colonic Polyps/surgery ; Colonoscopy ; Humans ; Intussusception/diagnostic imaging ; Intussusception/etiology ; Intussusception/surgery ; Laparoscopy/methods ; Lipoma/complications ; Lipoma/diagnostic imaging ; Lipoma/surgery ; Male ; Middle Aged ; Tomography, X-Ray Computed
Language	English
Publishing date	2017-06-12
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
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Article: Deregulation of methionine metabolism as determinant of progression and prognosis of hepatocellular carcinoma.

Pascale, Rosa M / Feo, Claudio F / Calvisi, Diego F / Feo, Francesco

Translational gastroenterology and hepatology

2018 Volume 3, Page(s) 36

Abstract: The under-regulation of liver- ... ...

Abstract	The under-regulation of liver-specific
Language	English
Publishing date	2018-06-29
Publishing country	China
Document type	Journal Article ; Review
ISSN	2415-1289
ISSN	2415-1289
DOI	10.21037/tgh.2018.06.04
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Article: Nuclear localization dictates hepatocarcinogenesis suppression by glycine N-methyltransferase.

Simile, Maria M / Cigliano, Antonio / Paliogiannis, Panagiotis / Daino, Lucia / Manetti, Roberto / Feo, Claudio F / Calvisi, Diego F / Feo, Francesco / Pascale, Rosa M

Translational oncology

2021 Volume 15, Issue 1, Page(s) 101239

Abstract: Background: GNMT (glycine N-methyltransferase) is a tumor suppressor gene, but the mechanisms mediating its suppressive activity are not entirely known.: Methods: We investigated the oncosuppressive mechanisms of GNMT in human hepatocellular ... ...

Abstract	Background: GNMT (glycine N-methyltransferase) is a tumor suppressor gene, but the mechanisms mediating its suppressive activity are not entirely known. Methods: We investigated the oncosuppressive mechanisms of GNMT in human hepatocellular carcinoma (HCC). GNMT mRNA and protein levels were evaluated by quantitative RT-PCR and immunoblotting. GNMT effect in HCC cell lines was modulated through GNMT cDNA induced overexpression or anti-GNMT siRNA transfection. Results: GNMT was expressed at low level in human HCCs with a better prognosis (HCCB) while it was almost absent in fast-growing tumors (HCCP). In HCCB, the nuclear localization of the GNMT protein was much more pronounced than in HCCP. In Huh7 and HepG2 cell lines, GNMT forced expression inhibited the proliferation and promoted apoptosis. At the molecular level, GNMT overexpression inhibited the expression of CYP1A (Cytochrome p450, aromatic compound-inducible), PREX2 (Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2), PARP1 [Poly (ADP-ribose) polymerase 1], and NFKB (nuclear factor-kB) genes. By chromatin immunoprecipitation, we found GNMT binding to the promoters of CYP1A1, PREX2, PARP1, and NFKB genes resulting in their strong inhibition. These genes are implicated in hepatocarcinogenesis, and are involved in the GNMT oncosuppressive action. Conclusion: Overall, the present data indicate that GNMT exerts a multifaceted suppressive action by interacting with various cancer-related genes and inhibiting their expression.
Language	English
Publishing date	2021-10-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2443840-6
ISSN	1936-5233
ISSN	1936-5233
DOI	10.1016/j.tranon.2021.101239
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