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  1. Article ; Online: Who is HOT and who is LOT? Detailed characterization of prescription opioid-induced changes in behavior between 129P3/J and 129S1/SvlmJ mouse substrains.

    Szumlinski, Karen K / Coelho, Michal A / Tran, Tori / Stailey, Nicholas / Lieberman, Dylan / Gabriella, Ivette / Swauncy, Isaiah / Brewin, Lindsey W / Ferdousian, Sami

    Genes, brain, and behavior

    2019  Volume 19, Issue 5, Page(s) e12609

    Abstract: Genetic factors are theorized to contribute to the substantial inter-individual variability in opioid abuse/addiction. To advance the behavioral genetics of prescription opioid abuse, our prior work identified the 129S1/SvlmJ (S1) and related 129P3/J (P3) ...

    Abstract Genetic factors are theorized to contribute to the substantial inter-individual variability in opioid abuse/addiction. To advance the behavioral genetics of prescription opioid abuse, our prior work identified the 129S1/SvlmJ (S1) and related 129P3/J (P3) mouse substrains, respectively, as low and high opioid-taking. Herein, we related our prior results to measures of sucrose reward/reinforcement, basal anxiety, opioid-induced place-conditioning, locomotor activity and Straub tail reaction, as well as behavioral and physiological signs of withdrawal. Substrains were also re-examined for higher-dose oxycodone and fentanyl intake under limited-access drinking procedures. S1 mice failed to acquire sucrose self-administration under various operant-conditioning procedures and exhibited lower sucrose intake in the home-cage. However, sucrose intake under limited-access procedures escalated in both substrains with repeated sucrose experience. S1 mice exhibited less spontaneous locomotor activity, as well as less opioid-induced locomotor activity and Straub tail reaction, than P3 mice and failed to exhibit an oxycodone-induced place-preference. The lack of conditioned behavior by S1 mice was unrelated to behavioral signs of withdrawal-induced negative affect or dependence severity, but might reflect high levels of basal anxiety-like behavior. Intriguingly, S1 and P3 mice initially exhibited equivalent oxycodone and fentanyl consumption in the home-cage; however opioid intake escalated only in P3 mice with repeated opioid experience. No sex differences were observed for any of our measures. These data provide additional evidence for robust differences in opioid addiction-related behaviors between P3 and S1 substrains and suggest that anxiety, learning, and/or motivational impairments might confound interpretation of operant- and place-conditioning studies employing the S1 substrain.
    MeSH term(s) Analgesics, Opioid/toxicity ; Animals ; Anxiety/etiology ; Anxiety/genetics ; Anxiety/physiopathology ; Choice Behavior ; Conditioning, Operant ; Female ; Fentanyl/toxicity ; Genotype ; Locomotion ; Male ; Mice ; Mice, Inbred C57BL ; Motivation ; Opioid-Related Disorders/complications ; Opioid-Related Disorders/genetics ; Opioid-Related Disorders/physiopathology ; Oxycodone/toxicity ; Spatial Behavior
    Chemical Substances Analgesics, Opioid ; Oxycodone (CD35PMG570) ; Fentanyl (UF599785JZ)
    Language English
    Publishing date 2019-10-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2075819-4
    ISSN 1601-183X ; 1601-1848
    ISSN (online) 1601-183X
    ISSN 1601-1848
    DOI 10.1111/gbb.12609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Bipolar Bone Loss of the Shoulder Joint due to Recurrent Instability: Use of Fresh Osteochondral Distal Tibia and Humeral Head Allografts.

    Haber, Daniel B / Sanchez, Anthony / Sanchez, George / Ferrari, Marcio B / Ferdousian, Sami / Provencher, Matthew T

    Arthroscopy techniques

    2017  Volume 6, Issue 3, Page(s) e893–e899

    Abstract: With increasing shoulder instability events, the likelihood of a bony lesion of the glenoid and/or humeral head rises. Although bone loss of either the glenoid or humeral head may result in recurrent instability, bipolar lesions have been shown, in ... ...

    Abstract With increasing shoulder instability events, the likelihood of a bony lesion of the glenoid and/or humeral head rises. Although bone loss of either the glenoid or humeral head may result in recurrent instability, bipolar lesions have been shown, in particular, to result in a negative and additive effect on glenohumeral stability. In the case of a bipolar lesion comprising severe glenoid bone loss and an engaging, "off-track" Hill-Sachs lesion, the bony foundation of the glenohumeral joint is compromised and bony augmentation is necessary. We present our preferred technique, made up of the application of a distal tibia allograft to address the glenoid bone loss and humeral head allograft to address the Hill-Sachs lesion, for the treatment of a severe bipolar lesion in the setting of recurrent anterior shoulder instability after a failed Latarjet procedure.
    Language English
    Publishing date 2017-06-28
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2212-6287
    ISSN 2212-6287
    DOI 10.1016/j.eats.2017.02.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Medial Patellofemoral Ligament Reconstruction in a Revision Setting: Anchor and Interference Screw Fixation.

    Ferrari, Marcio B / Sanchez, George / Chang, Angela / Ferdousian, Sami / Provencher, Matthew T

    Arthroscopy techniques

    2017  Volume 6, Issue 4, Page(s) e927–e932

    Abstract: Recurrent patellar instability is a common pathology and typically affects younger and more active patients. To prevent complete lateral dislocation of the patella, several osseous and soft-tissue procedures have been previously described, including ... ...

    Abstract Recurrent patellar instability is a common pathology and typically affects younger and more active patients. To prevent complete lateral dislocation of the patella, several osseous and soft-tissue procedures have been previously described, including reconstruction of the medial patellofemoral ligament (MPFL), which has been identified as the primary medial stabilizer of the patella. Several techniques have been reported for reconstruction of the MPFL, sometimes in conjunction with other procedures, with the majority showing success in the treatment and resolution of patellar instability. However, MPFL reconstruction is not free of complications, with previous reports of recurrence of medial patellar instability and patellar fracture after surgery. The objective of this Technical Note is to describe our preferred technique, comprising anchor as well as interference screw fixation, for reconstruction of the MPFL in a primary or revision setting.
    Language English
    Publishing date 2017-07-03
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2212-6287
    ISSN 2212-6287
    DOI 10.1016/j.eats.2017.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Transgenic Analyses of Homer2 Function Within Nucleus Accumbens Subregions in the Regulation of Methamphetamine Reward and Reinforcement in Mice.

    Brown, Chelsea N / Fultz, Elissa K / Ferdousian, Sami / Rogers, Sarina / Lustig, Elijah / Page, Ariana / Shahin, John R / Flaherty, Daniel M / Von Jonquieres, Georg / Bryant, Camron D / Kippin, Tod E / Szumlinski, Karen K

    Frontiers in psychiatry

    2020  Volume 11, Page(s) 11

    Abstract: Problems associated with the abuse of amphetamine-type stimulants, including methamphetamine (MA), pose serious health and socioeconomic issues world-wide. While it is well-established that MA's psychopharmacological effects involve interactions with ... ...

    Abstract Problems associated with the abuse of amphetamine-type stimulants, including methamphetamine (MA), pose serious health and socioeconomic issues world-wide. While it is well-established that MA's psychopharmacological effects involve interactions with monoamine neurotransmission, accumulating evidence from animal models implicates dysregulated glutamate in MA addiction vulnerability and use disorder. Recently, we discovered an association between genetic vulnerability to MA-taking and increased expression of the glutamate receptor scaffolding protein Homer2 within both the shell and core subregions of the nucleus accumbens (NAC) and demonstrated a necessary role for Homer2 within the shell subregion in MA reward and reinforcement in mice. This report extends our earlier work by interrogating the functional relevance of Homer2 within the NAC core for the conditioned rewarding and reinforcing properties of MA. C57BL/6J mice with a virus-mediated knockdown of Homer2b expression within the NAC core were first tested for the development and expression of a MA-induced conditioned place-preference/CPP (four pairings of 2 mg/kg MA) and then were trained to self-administer oral MA under operant-conditioning procedures (5-80 mg/L). Homer2b knockdown in the NAC core augmented a MA-CPP and shifted the dose-response function for MA-reinforced responding, above control levels. To determine whether Homer2b within NAC subregions played an active role in regulating MA reward and reinforcement, we characterized the MA phenotype of constitutive
    Language English
    Publishing date 2020-02-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2020.00011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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