Article ; Online: Albuminuria and proteinuria in dogs infected with Dirofilaria repens
Journal of Veterinary Internal Medicine, Vol 37, Iss 3, Pp 992-
A cross‐sectional study
2023 Volume 997
Abstract: Abstract Background It is unknown whether Dirofilaria repens is capable of causing similar glomerular lesions, as does Dirofilaria immitis. Objective To determine whether D. repens infection could cause albuminuria or proteinuria. Animals Sixty‐five ... ...
| Abstract | Abstract Background It is unknown whether Dirofilaria repens is capable of causing similar glomerular lesions, as does Dirofilaria immitis. Objective To determine whether D. repens infection could cause albuminuria or proteinuria. Animals Sixty‐five clinically healthy laboratory beagle dogs. Methods In this cross‐sectional study, dogs were tested for D. repens infection (modified Knott test, PCR test, D. immitis antigen test) and were grouped as “D. repens infected” or “control” dogs. Urinary albumin‐to‐creatinine ratio (UAC) and urinary protein‐to‐creatinine ratio (UPC) were measured from samples taken by cystocentesis. Results Forty‐three (26 infected, 17 control) dogs were included in the final study group. UAC but not UPC level was significantly higher in the infected group (UAC median 12.5; range, 0‐700 mg/g and UPC median 0.15; range, 0.06‐1.06) than in the control group (UAC median 6.3; range, 0‐28 mg/g and UPC median 0.13; range, 0.05‐0.64; P = .02 and P = .65). Overt proteinuria (UPC > 0.5) was present in 6/26 (23%) of the infected dogs and 1/17 (6%) of the control dogs. Albuminuria (UAC > 19 mg/g) was detected in 9/26 (35%) dogs in the infected group, and 2/17 dogs (12%) in the control group. Conclusions and Clinical Importance D. repens might cause similar glomerular lesions to those caused by D. immitis. |
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| Keywords | canine ; glomerulopathy ; subcutaneous dirofilariasis ; urinary albumin ; Veterinary medicine ; SF600-1100 |
| Subject code | 630 |
| Language | English |
| Publishing date | 2023-05-01T00:00:00Z |
| Publisher | Wiley |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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