Article ; Online: Overweight and obesity in men with prostate cancer do not constitute risk factors for biochemical recurrence.
The aging male : the official journal of the International Society for the Study of the Aging Male
2020 Volume 23, Issue 5, Page(s) 1283–1288
Abstract: Aim: To investigate if overweight and obesity were associated with a higher degree of biochemical recurrence (BCR) after radical prostatectomy, in Mexican men with prostate cancer (PCa).: Methods: We included 180 men with PCa, who underwent radical ... ...
Abstract | Aim: To investigate if overweight and obesity were associated with a higher degree of biochemical recurrence (BCR) after radical prostatectomy, in Mexican men with prostate cancer (PCa). Methods: We included 180 men with PCa, who underwent radical prostatectomy (RP). Body mass index (BMI) was determined and the degree of PCa aggressiveness was established according to the D'Amico classification. Postoperative follow-up of all patients was performed with PSA quantification every/6 weeks after surgery and then at 3-month intervals for 1 year, followed every/6 months for 5 years. Postoperative BCR was defined as two consecutive increases in PSA levels ≥0.4 ng/mL, after RP. Results: Sixty eight percent of the patients presented overweight or obesity. We found that only intermediate/high risk patients presented an increased risk factor for BCR-free survival (HR = 4.39; 95% CI = 1.74-11.24; Conclusions: The overweight and obesity do not represent a risk factor to present BCR after RP for PCa. However, an intermediate/high risk, according to the D'Amico's classification, constitutes a risk factor to present BCR after radical prostatectomy, which is not related to the BMI. |
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MeSH term(s) | Humans ; Male ; Neoplasm Recurrence, Local/epidemiology ; Obesity/complications ; Overweight/complications ; Overweight/epidemiology ; Prostate-Specific Antigen ; Prostatic Neoplasms/complications ; Prostatic Neoplasms/surgery ; Retrospective Studies ; Risk Factors |
Chemical Substances | Prostate-Specific Antigen (EC 3.4.21.77) |
Language | English |
Publishing date | 2020-05-15 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 2108146-3 |
ISSN | 1473-0790 ; 1368-5538 |
ISSN (online) | 1473-0790 |
ISSN | 1368-5538 |
DOI | 10.1080/13685538.2020.1764523 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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