Artikel ; Online: Comparative Analysis of Cyclization Techniques in Stapled Peptides: Structural Insights into Protein-Protein Interactions in a SARS-CoV-2 Spike RBD/hACE2 Model System.
International journal of molecular sciences
2023 Band 25, Heft 1
Abstract: Medicinal chemistry is constantly searching for new approaches to develop more effective and targeted therapeutic molecules. The design of peptidomimetics is a promising emerging strategy that is aimed at developing peptides that mimic or modulate the ... ...
| Abstract | Medicinal chemistry is constantly searching for new approaches to develop more effective and targeted therapeutic molecules. The design of peptidomimetics is a promising emerging strategy that is aimed at developing peptides that mimic or modulate the biological activity of proteins. Among these, stapled peptides stand out for their unique ability to stabilize highly frequent helical motifs, but they have failed to be systematically reported. Here, we exploit chemically diverse helix-inducing |
|---|---|
| Mesh-Begriff(e) | Humans ; COVID-19 ; Cyclization ; Lactams ; Peptides/pharmacology ; SARS-CoV-2 ; Triazoles |
| Chemische Substanzen | Lactams ; Peptides ; Triazoles |
| Sprache | Englisch |
| Erscheinungsdatum | 2023-12-21 |
| Erscheinungsland | Switzerland |
| Dokumenttyp | Comparative Study ; Journal Article |
| ZDB-ID | 2019364-6 |
| ISSN | 1422-0067 ; 1422-0067 ; 1661-6596 |
| ISSN (online) | 1422-0067 |
| ISSN | 1422-0067 ; 1661-6596 |
| DOI | 10.3390/ijms25010166 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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