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Article ; Online: Healthcare network for patients with acute aortic syndrome.

Fernández, Ángel L / El-Diasty, Mohammad M

Revista espanola de cardiologia (English ed.)

2022 Volume 75, Issue 9, Page(s) 774

MeSH term(s)	Acute Disease ; Aneurysm, Dissecting ; Aorta ; Aortic Diseases/diagnosis ; Aortic Diseases/therapy ; Delivery of Health Care ; Humans ; Syndrome
Language	Spanish
Publishing date	2022-06-03
Publishing country	Spain
Document type	Letter
ZDB-ID	2592481-3
ISSN	1885-5857 ; 1885-5857
ISSN (online)	1885-5857
ISSN	1885-5857
DOI	10.1016/j.rec.2022.06.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Ischemic ventricular septal rupture with patent coronary bypass grafts due to occluded septal branch, a case report.

El Diasty, Mohammad / Fatima, Rubab / Fernandez, Angel L / Ribeiro, Igo

Portuguese journal of cardiac thoracic and vascular surgery

2022 Volume 29, Issue 2, Page(s) 57–58

Abstract: Background: Ischemic ventricular septal rupture (VSR) is a lethal complication that occurs either after spontaneous or iatrogenic occlusion of one of the major epicardial coronary vessels. To the best of our knowledge, this is the first reported case of ...

Abstract	Background: Ischemic ventricular septal rupture (VSR) is a lethal complication that occurs either after spontaneous or iatrogenic occlusion of one of the major epicardial coronary vessels. To the best of our knowledge, this is the first reported case of a VSD after a septal branch occlusion in a patient with patent coronary artery grafts to both the left anterior descending and posterior descending arteries. Methods: We present a rare case of anterior ischemic VSR due to the occlusion of a major septal branch. The patient had previous coronary artery bypass grafts and his left internal mammary artery conduit to the anterior descending artery was patent. The culprit lesion that resulted in the development of the VSR was the occlusion of a major septal branch. Discussion: The presence of collateral circulation in chronic coronary occlusive disease may provide a protective effect against the development of transmural myocardial necrosis which may reduce the risk of septal rupture. This case highlights the fact that patent coronary artery grafts may not protect from future ischemic VSR. Conclusion: Major septal branches with significant disease should be assessed for percutaneous options if technically feasible as dictated by the Heart Team.
MeSH term(s)	Collateral Circulation ; Coronary Angiography ; Coronary Vessels ; Humans ; Myocardial Infarction/complications ; Ventricular Septal Rupture/diagnostic imaging
Language	English
Publishing date	2022-07-03
Publishing country	Portugal
Document type	Case Reports ; Journal Article
ISSN	2184-9927
ISSN	2184-9927
DOI	10.48729/pjctvs.243
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Article ; Online: Wildlife susceptibility to infectious diseases at global scales.

Robles-Fernández, Ángel L / Santiago-Alarcon, Diego / Lira-Noriega, Andrés

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 35, Page(s) e2122851119

Abstract: Disease transmission prediction across wildlife is crucial for risk assessment of emerging infectious diseases. Susceptibility of host species to pathogens is influenced by the geographic, environmental, and phylogenetic context of the specific system ... ...

Abstract	Disease transmission prediction across wildlife is crucial for risk assessment of emerging infectious diseases. Susceptibility of host species to pathogens is influenced by the geographic, environmental, and phylogenetic context of the specific system under study. We used machine learning to analyze how such variables influence pathogen incidence for multihost pathogen assemblages, including one of direct transmission (coronaviruses and bats) and two vector-borne systems (West Nile Virus [WNV] and birds, and malaria and birds). Here we show that this methodology is able to provide reliable global spatial susceptibility predictions for the studied host-pathogen systems, even when using a small amount of incidence information (i.e., [Formula: see text] of information in a database). We found that avian malaria was mostly affected by environmental factors and by an interaction between phylogeny and geography, and WNV susceptibility was mostly influenced by phylogeny and by the interaction between geographic and environmental distances, whereas coronavirus susceptibility was mostly affected by geography. This approach will help to direct surveillance and field efforts providing cost-effective decisions on where to invest limited resources.
MeSH term(s)	Animals ; Animals, Wild/parasitology ; Animals, Wild/virology ; Bird Diseases/epidemiology ; Bird Diseases/transmission ; Chiroptera/virology ; Communicable Diseases, Emerging/epidemiology ; Communicable Diseases, Emerging/transmission ; Communicable Diseases, Emerging/veterinary ; Coronavirus ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Coronavirus Infections/veterinary ; Databases, Factual ; Disease Susceptibility ; Environment ; Epidemiological Monitoring ; Geography ; Host-Pathogen Interactions ; Incidence ; Machine Learning ; Malaria/epidemiology ; Malaria/transmission ; Malaria/veterinary ; Phylogeny ; Risk Assessment ; West Nile Fever/epidemiology ; West Nile Fever/transmission ; West Nile Fever/veterinary ; West Nile virus
Language	English
Publishing date	2022-08-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2122851119
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Article ; Online: Accumulation of Inflammatory Mediators in the Normal Pericardial Fluid.

El-Diasty, Mohammad M / Rodríguez, Javier / Pérez, Luis / Eiras, Sonia / Fernández, Angel L

International journal of molecular sciences

2023 Volume 25, Issue 1

Abstract: There is paucity of studies that focus on the composition of pericardial fluid under resting conditions. The purpose of this study is to determine the levels of inflammatory mediators in pericardial fluid and their correlation with plasma levels in ... ...

Abstract	There is paucity of studies that focus on the composition of pericardial fluid under resting conditions. The purpose of this study is to determine the levels of inflammatory mediators in pericardial fluid and their correlation with plasma levels in patients undergoing elective cardiac surgery. We conducted a prospective cohort study on candidates for elective aortic valve replacement surgery. Pericardial fluid and peripheral venous blood samples were collected after opening the pericardium. Levels of interleukin 1α (IL-1α); interleukin 1β (IL-1β); interleukin 2 (IL-2) interleukin 4 (IL-4); interleukin 6 (IL-6); interleukin 8 (IL8); interleukin 10 (IL10); tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), vascular endothelial growth factor (VEGF), monocyte chemotactic protein-1 (MCP-1) epidermal growth factor (EGF), soluble E-selectin, L-selectin, P-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) were determined in both pericardial fluid and serum samples. A total of 45 patients with a mean age of 74 years were included of which 66% were males. Serum levels of all study mediators were within normal limits. Serum and pericardial levels of IL-1 α, IL-1 β, IL-2, IL-4, and IL-10 were similar. Levels of VEGF, EGF, VCAM-2, ICAM 1, E-selectin, P-selectin, and L-selectin were significantly lower in pericardial fluid than in serum. However, levels of IL-6, IL-8, TNF-α, IFN-γ, MCP-1, and MCP-1 were significantly higher in the pericardial fluid than in serum. Under normal conditions, the pattern of distribution of different inflammatory mediators in the pericardial fluid does not reflect serum levels. This may either reflect the condition of the underlying myocardium and epicardial fat or the activity of the mesothelial and mononuclear cells present in pericardial fluid.
MeSH term(s)	Male ; Humans ; Aged ; Female ; Pericardial Fluid ; Interleukin-2 ; P-Selectin ; Interleukin-4 ; Vascular Endothelial Growth Factor A ; Epidermal Growth Factor ; Interleukin-6 ; Prospective Studies ; Tumor Necrosis Factor-alpha ; Pericardium
Chemical Substances	Interleukin-2 ; P-Selectin ; Interleukin-4 (207137-56-2) ; Vascular Endothelial Growth Factor A ; Epidermal Growth Factor (62229-50-9) ; Interleukin-6 ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2023-12-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25010157
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Article: Left Ventricular Papillary Fibroelastoma.

Balboa, Cristina / Souaf, Souhayla / Suárez, José M / El-Diasty, Mohammad M / Fernandez, Angel L

Portuguese journal of cardiac thoracic and vascular surgery

2023 Volume 30, Issue 1, Page(s) 49–52

Abstract: Introduction: Cardiac papillary fibroelastoma is a rare benign primary cardiac tumor typically found on the valvular structures of the heart. Nonvalvular papillary fibroelastomas are exceedingly rare. We report the case of a 66-year-old male who ... ...

Abstract	Introduction: Cardiac papillary fibroelastoma is a rare benign primary cardiac tumor typically found on the valvular structures of the heart. Nonvalvular papillary fibroelastomas are exceedingly rare. We report the case of a 66-year-old male who presented with cerebellar infarctions and was found to have a mobile mass attached to the endocardial surface of the anteroseptal wall of the left ventricle. Cardiac magnetic resonance imaging demonstrated late gadolinium enhancement. Surgical excision of the cardiac mass was performed via the transaortic approach without intra-operative complications. Histopathologic examination confirmed the diagnosis of a papillary fibroelastoma. Some aspects related to the etiology, diagnosis and management of this entity are discussed.
MeSH term(s)	Male ; Humans ; Aged ; Heart Ventricles/diagnostic imaging ; Cardiac Papillary Fibroelastoma/complications ; Echocardiography, Transesophageal ; Contrast Media ; Gadolinium ; Heart Neoplasms/diagnostic imaging
Chemical Substances	Contrast Media ; Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2023-04-04
Publishing country	Portugal
Document type	Case Reports ; Journal Article
ISSN	2184-9927
ISSN	2184-9927
DOI	10.48729/pjctvs.332
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Article: American Mammals Susceptibility to Dengue According to Geographical, Environmental, and Phylogenetic Distances.

Robles-Fernández, Ángel L / Santiago-Alarcon, Diego / Lira-Noriega, Andrés

Frontiers in veterinary science

2021 Volume 8, Page(s) 604560

Abstract: Many human emergent and re-emergent diseases have a sylvatic cycle. Yet, little effort has been put into discovering and modeling the wild mammal reservoirs of dengue (DENV), particularly in the Americas. Here, we show a species-level susceptibility ... ...

Abstract	Many human emergent and re-emergent diseases have a sylvatic cycle. Yet, little effort has been put into discovering and modeling the wild mammal reservoirs of dengue (DENV), particularly in the Americas. Here, we show a species-level susceptibility prediction to dengue of wild mammals in the Americas as a function of the three most important biodiversity dimensions (ecological, geographical, and phylogenetic spaces), using machine learning protocols. Model predictions showed that different species of bats would be highly susceptible to DENV infections, where susceptibility mostly depended on phylogenetic relationships among hosts and their environmental requirement. Mammal species predicted as highly susceptible coincide with sets of species that have been reported infected in field studies, but it also suggests other species that have not been previously considered or that have been captured in low numbers. Also, the environment (i.e., the distance between the species' optima in bioclimatic dimensions) in combination with geographic and phylogenetic distance is highly relevant in predicting susceptibility to DENV in wild mammals. Our results agree with previous modeling efforts indicating that temperature is an important factor determining DENV transmission, and provide novel insights regarding other relevant factors and the importance of considering wild reservoirs. This modeling framework will aid in the identification of potential DENV reservoirs for future surveillance efforts.
Language	English
Publishing date	2021-03-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2021.604560
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Article ; Online: Does Pacemaker Implantation After Surgical Aortic Valve Replacement Impact Long-Term Morbidity and Mortality? A Focused Review.

El Diasty, Mohammad / Davies, Mark / Fernandez, Angel L / Ribeiro, Igo / Payne, Darrin / Petsikas, Dimitri

Texas Heart Institute journal

2022 Volume 49, Issue 5

Abstract: Permanent pacing remains a serious complication that can occur in the postoperative period of surgical aortic valve replacement. The reported incidence is variable, and there are many perioperative factors that have been linked with a greater need for ... ...

Abstract	Permanent pacing remains a serious complication that can occur in the postoperative period of surgical aortic valve replacement. The reported incidence is variable, and there are many perioperative factors that have been linked with a greater need for permanent pacing. Permanent pacing can also be associated with late lead-related and cardiac complications that can affect late outcome. However, the degree of late dependence on pacemakers is varied, and some studies have shown that a substantial proportion of patients do not need long-term pacing. Some groups have found that permanent pacing was associated with a negative impact on long-term survival in these patients. A common finding among these studies is that the groups of patients with pacemakers had higher preoperative surgical risk and comorbidity status. This makes it difficult to establish whether permanent pacing on its own represents a risk factor for late mortality or whether it is simply a marker that reflects the higher complexity and comorbidities in this group of patients.
MeSH term(s)	Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Cardiac Pacing, Artificial/adverse effects ; Humans ; Incidence ; Pacemaker, Artificial ; Retrospective Studies ; Risk Factors ; Transcatheter Aortic Valve Replacement ; Treatment Outcome
Language	English
Publishing date	2022-10-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	604761-0
ISSN	1526-6702 ; 0730-2347
ISSN (online)	1526-6702
ISSN	0730-2347
DOI	10.14503/THIJ-20-7518
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Zs.A 1452: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 484: Show issues

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Article ; Online: Surgicel-Related Uptake on Positron Emission Tomography Scan Mimicking Prosthetic Valve Endocarditis.

Martínez, Amparo / Pubul, Virgina / Jokh, Estephany Abou / Martínez, Anxo / El-Diasty, Mohamed / Fernández, Angel L

The Annals of thoracic surgery

2021 Volume 112, Issue 5, Page(s) e317–e319

Abstract: A 78-year-old patient who underwent an aortic valve replacement presented 6 months later with clinical symptoms suspicious for prosthetic valve endocarditis. Echocardiography showed no features suggestive of endocarditis, but a positron emission ... ...

Abstract	A 78-year-old patient who underwent an aortic valve replacement presented 6 months later with clinical symptoms suspicious for prosthetic valve endocarditis. Echocardiography showed no features suggestive of endocarditis, but a positron emission tomography/computed tomography with fluorine-18-fluorodeoxyglucose (
MeSH term(s)	Aged ; Aortic Valve/surgery ; Cellulose, Oxidized/adverse effects ; Diagnosis, Differential ; Endocarditis/diagnostic imaging ; Fluorodeoxyglucose F18 ; Heart Valve Prosthesis ; Humans ; Male ; Positron Emission Tomography Computed Tomography ; Postoperative Complications/diagnostic imaging ; Radiopharmaceuticals
Chemical Substances	Cellulose, Oxidized ; Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Surgicel (82347-53-3)
Language	English
Publishing date	2021-03-04
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2021.02.046
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Zs.A 252: Show issues

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Article ; Online: Biomechanical characteristics of different methods of neo-chordal fixation to the papillary muscles.

Fernández, Luis / Monzonís, Amparo Martínez / El-Diasty, Mohammad M / Álvarez-Lorenzo, Carmen / Concheiro, Ángel / Fernández, Ángel L

Journal of cardiac surgery

2022 Volume 37, Issue 12, Page(s) 4408–4415

Abstract: Background and aim of the study: Several techniques have been described for neo-chordal fixation to the papillary muscles without any reported clinical differences. The objective of this study is to compare in vitro the biomechanical properties of four ... ...

Abstract	Background and aim of the study: Several techniques have been described for neo-chordal fixation to the papillary muscles without any reported clinical differences. The objective of this study is to compare in vitro the biomechanical properties of four of these common techniques. Methods: We studied the biomechanical properties of expanded polytetrafluoroethylene neo-chordal fixation using four techniques: nonknotted simple stitch, nonknotted figure-of-eight stitch, knotted pledgeted mattress stitch, and knotted pledgeted stitch using commercially available prefabricated loops. Neo-chordae were submitted to a total of 20 traction-relaxation cycles with incremental loads of 1, 2, and 4 N. We calculated the elongation, the force-strain curve, elasticity, and the maximum tolerated load before neo-chordal failure. Results: The elongation of the neo-chordae was lowest in the simple stitch followed by the figure-of-eight, the pledgeted mattress, and he commercially prefabricated loops (p < .001). Conversely, the elastic modulus was highest in the simple stitch followed by the figure-of-eight, the pledgeted mattress, and the prefabricated loops (p < .001). The maximum tolerated load was similar with the simple stitch (28.87 N) and with the figure-of-eight stitch (31.39 N) but was significantly lower with the pledgeted mattress stitch (20.51 N) and with the prefabricated loops (7.78 N). Conclusion: In vitro, neo-chordal fixation by nonknotted simple or nonknotted figure-of-eight stitches resulted in less compliance as opposed to the use of knotted pledgeted stitches. Fixation technique seemed to influence neo-chordal biomechanical properties, however, it did not seem to affect the strength of the suture when subjected to loads within physiological ranges.
MeSH term(s)	Male ; Humans ; Papillary Muscles/surgery ; Biomechanical Phenomena ; Suture Techniques ; Sutures
Language	English
Publishing date	2022-10-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	639059-6
ISSN	1540-8191 ; 0886-0440
ISSN (online)	1540-8191
ISSN	0886-0440
DOI	10.1111/jocs.17027
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Zs.A 2221: Show issues

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Article ; Online: Postoperative hyperbilirubinemia and Gilbert's syndrome in patients undergoing cardiac surgery.

Fernández, Angel L / Baluja, Aurora / Al-Hamwy, Zaid / Alvarez, Julian

Annals of cardiac anaesthesia

2019 Volume 22, Issue 2, Page(s) 207–209

Abstract: We report a series of seven patients with Gilbert's syndrome undergoing cardiac surgery. Early and transient increase of total, direct, and indirect bilirubin without other complications was observed. Although this is a benign process, we believe that ... ...

Abstract	We report a series of seven patients with Gilbert's syndrome undergoing cardiac surgery. Early and transient increase of total, direct, and indirect bilirubin without other complications was observed. Although this is a benign process, we believe that this disease should be routinely included in the differential diagnosis of postoperative jaundice after cardiopulmonary bypass.
MeSH term(s)	Cardiac Surgical Procedures ; Diagnosis, Differential ; Female ; Gilbert Disease/blood ; Gilbert Disease/diagnosis ; Humans ; Hyperbilirubinemia/blood ; Hyperbilirubinemia/diagnosis ; Male ; Middle Aged ; Postoperative Complications/blood ; Postoperative Complications/diagnosis
Language	English
Publishing date	2019-04-10
Publishing country	India
Document type	Case Reports ; Journal Article
ZDB-ID	2106866-5
ISSN	0974-5181 ; 0971-9784
ISSN (online)	0974-5181
ISSN	0971-9784
DOI	10.4103/aca.ACA_48_18
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