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  1. Article ; Online: Measurement of cerebrospinal fluid lactate levels in pediatric patients with suspected ventriculoperitoneal shunt infection: A retrospective cohort study.

    Fernandez V, Jose Pablo / Acosta G, Natalia / Flores S, Tamara / Fernández, Gabriela

    Clinical neurology and neurosurgery

    2024  Volume 240, Page(s) 108256

    Abstract: Introduction: Ventriculoperitoneal shunt (VPS) infection is a severe complication. Early diagnosis could help to decrease morbidity and treatment costs. Lactate has been used for the diagnosis of other central nervous system infections. The aim of this ... ...

    Abstract Introduction: Ventriculoperitoneal shunt (VPS) infection is a severe complication. Early diagnosis could help to decrease morbidity and treatment costs. Lactate has been used for the diagnosis of other central nervous system infections. The aim of this study is to determine the usefulness of lactate for the diagnosis of VPS infection.
    Methodology: Retrospective cohort study. Lactate was measured in patients who consulted with VPS dysfunction between May 2019 and May 2022. Mean were compared according to culture results. A Receiver Operating Characteristic (ROC) curve was performed to determine the appropriate cut-off point.
    Result: Lactate has a high negative predictive value but a low positive predictive value for the diagnosis of ventriculitis.
    MeSH term(s) Humans ; Ventriculoperitoneal Shunt/adverse effects ; Retrospective Studies ; Female ; Male ; Lactic Acid/cerebrospinal fluid ; Child ; Child, Preschool ; Infant ; Cohort Studies ; Adolescent ; Cerebral Ventriculitis/cerebrospinal fluid ; Cerebral Ventriculitis/diagnosis
    Chemical Substances Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2024-03-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2024.108256
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    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.53: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Significant myocardial perfusion defect during stress visible in prone but not in supine imaging.

    Andersson, Yvonne / Fernandez, Gabriela / Mars, Peter / Lindow, Thomas

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2022  Volume 30, Issue 5, Page(s) 2209–2212

    MeSH term(s) Humans ; Coronary Artery Disease/diagnostic imaging ; Diagnostic Imaging ; Perfusion ; Prone Position ; Supine Position ; Tomography, Emission-Computed, Single-Photon/methods ; Myocardial Perfusion Imaging/methods
    Language English
    Publishing date 2022-08-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-022-03080-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4121: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Preferences of Patients with Amyotrophic Lateral Sclerosis for Intrathecal Drug Delivery: Choosing between an Implanted Drug-Delivery Device and Therapeutic Lumbar Puncture.

    Seo, Jaein / Saurkar, Sandeep / Fernandez, Gabriela S / Das, Anup / Goutman, Stephen A / Heidenreich, Sebastian

    The patient

    2023  Volume 17, Issue 2, Page(s) 161–177

    Abstract: Background: Novel intrathecal treatments for amyotrophic lateral sclerosis (ALS) may require delivery using lumbar puncture (LP). Implanted drug-delivery devices (IDDDs) could be an alternative but little is known about patients' preferences for ... ...

    Abstract Background: Novel intrathecal treatments for amyotrophic lateral sclerosis (ALS) may require delivery using lumbar puncture (LP). Implanted drug-delivery devices (IDDDs) could be an alternative but little is known about patients' preferences for intrathecal drug-delivery methods.
    Objective: We aimed to elicit preferences of patients with ALS for routine LP and IDDD use.
    Methods: A discrete choice experiment (DCE) and a threshold technique (TT) exercise were conducted online among patients with ALS in the US and Europe. In the DCE, patients made trade-offs between administration attributes. Attributes were identified from qualitative interviews. The TT elicited maximum acceptable risks (MARs) of complications from device implantation surgery. DCE data were analyzed using mixed logit to quantify relative attribute importance (RAI) as the maximum contribution of each attribute to a preference, and to estimate MARs of device failure. TT data were analyzed using interval regression. Four scenarios of LP and IDDD were compared.
    Results: Participants (N = 295) had a mean age of 57.7 years; most (74.2%) were diagnosed < 3 years ago. Preferences were affected by device failure risk (RAI 28.6%), administration frequency (26.4%), administration risk (19.7%), overall duration (17.8%), and appointment location (7.5%). Patients accepted a 5.6% device failure risk to reduce overall duration from 2 h to 30 min and a 3.6% risk for administration in a local clinic instead of a hospital. The average MAR of complications from implantation surgery was 29%. Patients preferred IDDD over LP in three of four scenarios.
    Conclusion: Patients considered an IDDD as a valuable alternative to LP in multiple clinical settings.
    MeSH term(s) Humans ; Middle Aged ; Choice Behavior ; Amyotrophic Lateral Sclerosis/drug therapy ; Spinal Puncture/adverse effects ; Patient Preference ; Europe
    Language English
    Publishing date 2023-12-14
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2466680-4
    ISSN 1178-1661 ; 1178-1653
    ISSN (online) 1178-1661
    ISSN 1178-1653
    DOI 10.1007/s40271-023-00665-4
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  4. Article ; Online: Botánicas

    Brenes, Francisco / Goldstein, Evan V / Sarduy, Ernesto Lázaro / Lazarus, Richard / Fernandez, Gabriela / Henriquez, Federico / Asgarali, Dariel

    Hispanic health care international : the official journal of the National Association of Hispanic Nurses

    2024  , Page(s) 15404153241247261

    Abstract: As the U.S. population becomes more racially/ethnically diverse, the Hispanic American immigrant population has slowly grown in recent years. In the face of anti-immigrant policies, limited access to care, fear of deportation, discrimination, ... ...

    Abstract As the U.S. population becomes more racially/ethnically diverse, the Hispanic American immigrant population has slowly grown in recent years. In the face of anti-immigrant policies, limited access to care, fear of deportation, discrimination, stigmatization, poverty, and other stressors, Hispanic American immigrants seek services from
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ISSN 1938-8993
    ISSN (online) 1938-8993
    DOI 10.1177/15404153241247261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Redefining the Distributional Boundaries and Phylogenetic Relationships for Ctenomids From Central Argentina.

    Carnovale, Cecilia Soledad / Fernández, Gabriela Paula / Merino, Mariano Lisandro / Mora, Matías Sebastián

    Frontiers in genetics

    2021  Volume 12, Page(s) 698134

    Abstract: With about 68 recognized living species, subterranean rodents of the ... ...

    Abstract With about 68 recognized living species, subterranean rodents of the genus
    Language English
    Publishing date 2021-08-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2021.698134
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  6. Article: Effect of Pretreatment on Nutrient Leaching and Phytotoxicity of Biosolids from Anaerobic Digestion in Silty Loam Soil

    Fernández, Gabriela / Venegas, María / Vidal, Gladys

    Water, air, and soil pollution. 2020 Nov., v. 231, no. 11

    2020  

    Abstract: The aim of this study was to evaluate the effect of pretreatment on the phytotoxicity and leaching of nitrogen and phosphorus in biosolids from anaerobic digestion in silty loam soil. Soil columns filled with silty loam soil and biosolids (BS) stabilized ...

    Abstract The aim of this study was to evaluate the effect of pretreatment on the phytotoxicity and leaching of nitrogen and phosphorus in biosolids from anaerobic digestion in silty loam soil. Soil columns filled with silty loam soil and biosolids (BS) stabilized by conventional (CAD) and advanced (AAD) anaerobic digestion were installed. AAD consisted of the application of sequential pretreatments: ultrasound followed by a low thermal process. The BS loads were equivalent to 30 ton/ha (CAD30 and AAD30) and 90 ton/ha (CAD90 and AAD90), and the soil columns were watered with 29 mL/day of distilled water. Phytotoxicity was evaluated by germination and root growth inhibition and by the germination index (GI) of Triticum aestivum, Lactuca sativa, and Raphanus sativus seeds. Nitrogen leaching varied from 0 to 9 mg/week, while phosphate leaching did not exceed 0.01 mg/week. The nutrient leaching rate depended on the BS application rate and not on the use of pretreatment (p < 0.05). Regarding phytotoxicity, BS application presented a tendency to attenuate the inhibition caused by the silty loam soil, with GI values ranging from 31 to 50%, 62 to 63%, and 70 to 82% for L. sativa, R. sativus, and T. aestivum, respectively.Graphical abstract
    Keywords Lactuca sativa ; Raphanus sativus ; Triticum aestivum ; air ; anaerobic digestion ; application rate ; biosolids ; germination ; growth retardation ; nitrogen ; phosphates ; phosphorus ; phytotoxicity ; root growth ; silt loam soils ; soil pollution ; ultrasonics ; water
    Language English
    Dates of publication 2020-11
    Size p. 549.
    Publishing place Springer International Publishing
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 120499-3
    ISSN 1573-2932 ; 0049-6979 ; 0043-1168
    ISSN (online) 1573-2932
    ISSN 0049-6979 ; 0043-1168
    DOI 10.1007/s11270-020-04876-5
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2719: Show issues

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  7. Article ; Online: Obesity in Cystic fibrosis: prevalence, trends and associated factors data from the US cystic fibrosis foundation patient registry.

    Szentpetery, Sylvia / Fernandez, Gabriela S / Schechter, Michael S / Jain, Raksha / Flume, Patrick A / Fink, Aliza K

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2022  Volume 21, Issue 5, Page(s) 777–783

    Abstract: Strong emphasis has been placed historically on increasing weight and improving nutritional status in cystic fibrosis patients. Due to correlation between nutritional indices (e.g. BMI) and lung function, CF Nutrition Guidelines have recommended BMI ... ...

    Abstract Strong emphasis has been placed historically on increasing weight and improving nutritional status in cystic fibrosis patients. Due to correlation between nutritional indices (e.g. BMI) and lung function, CF Nutrition Guidelines have recommended BMI percentile goals at the 50th percentile or higher. Trends in increasing BMI across CF programs suggest significantly increasing proportions of overweight and obese status in recent years. We identify that between 2000 and 2019 there has been a relative decrease in underweight status by ∼40%, simultaneously with a > 300% increase in overweight status, and >400% increase in obesity. Patient specific factors associated with higher prevalence of obesity included age ≥46, living in a zip code where the median income was < $20,000, having at least one allele with a class IV or V mutation, a ppFEV
    MeSH term(s) Cystic Fibrosis/complications ; Cystic Fibrosis/epidemiology ; Cystic Fibrosis/genetics ; Humans ; Obesity/complications ; Obesity/epidemiology ; Overweight/epidemiology ; Prevalence ; Registries
    Language English
    Publishing date 2022-04-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2022.03.010
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6028: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 459: Show issues

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  8. Article: Combined Vertebral Augmentation for Vertebral Body Fracture With Contraindications for Traditional Techniques.

    Baabor, Marcos G / Valenzuela Cecchi, Bayron / Fernández, Gabriela / Gonzáles J, Lucas / Peña, Alann / Delso, Hernán / Vázquez, Pedro

    Cureus

    2023  Volume 15, Issue 11, Page(s) e48517

    Abstract: Introduction and objective: A vertebral compression fracture (VCF) can be found in trauma, osteoporosis, and tumor pathology. The most frequent is the pathological fracture in osteoporotic vertebrae in the elderly. Percutaneous techniques of vertebral ... ...

    Abstract Introduction and objective: A vertebral compression fracture (VCF) can be found in trauma, osteoporosis, and tumor pathology. The most frequent is the pathological fracture in osteoporotic vertebrae in the elderly. Percutaneous techniques of vertebral cementation allow treatment of A1-A2 AO spine fractures, improving pain control and spine stabilization and decreasing mobility and mortality. Traditionally, the selection of patients is fundamental for spine surgery success, with an absolute contraindication being posterior wall involvement (A3-A4 AO spine fractures) or VCF with a loss of height greater than 50%. In this report, we present a variant surgical technique combining percutaneous spine surgery with cementoplasty for patients with classical spine surgery contraindications.
    Methods: Five patients with complex symptomatic VCF or A3-A4 AO spine fractures in pathologic bone with MRI short tau inversion recovery (STIR) sequence (+) were operated on with a combined technique (percutaneous kyphoplasty (KP) and vesselplasty). The visual analog scale
    Results: The procedure was performed within 60 days of the fracture in all patients. The mean hospital stay was two days. No patient developed major complications. All the patients had a satisfactory clinical (improvement in pain control) and radiological response at the perioperative period and at a 30-day follow-up.
    Conclusions: The combined percutaneous technique allows surgical resolution of cases previously considered contraindicated, especially in elderly patients and those with comorbidities, without involving higher cost, complications, surgical time, and hospital stay. We suggest a novel, safe, and effective variation of the vertebral cementoplasty technique.
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.48517
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  9. Article: The Impact of Substantial Improvements in HbA1c and Weight Loss on the Medication Preferences of People with Type 2 Diabetes.

    Gelhorn, Heather L / Osumili, Beatrice / Brown, Katelyn / Ross, Melissa M / Schulz, Andrea / Fernandez, Gabriela / Boye, Kristina S

    Patient preference and adherence

    2023  Volume 17, Page(s) 793–805

    Abstract: Purpose: To quantify the preferences of people with type 2 diabetes (T2D) for treatment attributes of a glucose-dependent insulinotropic polypeptide (GIP)/glucagon-like peptide-1 (GLP-1) receptor agonist (RA) versus an injectable GLP-1 RA medication ... ...

    Abstract Purpose: To quantify the preferences of people with type 2 diabetes (T2D) for treatment attributes of a glucose-dependent insulinotropic polypeptide (GIP)/glucagon-like peptide-1 (GLP-1) receptor agonist (RA) versus an injectable GLP-1 RA medication profile.
    Patients and methods: Injection-naive people taking oral medications for T2D in the US and UK completed a web survey including a discrete choice experiment to quantify patients' preferences for five treatment attributes: delivery system, frequency of nausea, frequency of hypoglycemia, HbA1c reduction, and weight reduction. Attributes and levels were based on head-to-head clinical trial data of tirzepatide 5mg, 10mg, and 15mg versus semaglutide 1mg. Preference data were analyzed separately by country using multinomial mixed logit (MXL) models. MXL parameters were used to estimate the predicted preference for each tirzepatide dose versus semaglutide 1mg. Direct preferences for each dose of tirzepatide versus semaglutide 1mg were elicited.
    Results: Participants (N=620) in the US (N=301) and UK (N=319) were 50.8% and 50.5% female with mean ages of 60.7 years and 58.9 years, respectively. The order and magnitude of relative attribute importance (RAI) scores differed between countries. HbA1c reduction (26.3%) had the greatest impact on US participants' preferences, and hypoglycemia (32.8%) did among UK participants. Attribute-level marginal utility results indicated preferences for greater HbA1c improvements, the single-use pre-filled pen, lower hypoglycemia, greater weight reductions, and lower frequency of nausea. Assuming the availability of only tirzepatide or semaglutide 1mg, the predicted preference for tirzepatide (5, 10, and 15mg) in the US is 95.6% (vs 4.4% for semaglutide 1mg) and in the UK was 86.3% (vs 13.7% for semaglutide 1mg).
    Conclusion: HbA1c reduction, frequency of hypoglycemia, and weight reduction are key drivers of preferences among people with T2D when considering medication options. Overall, people with T2D are likely to prefer the tirzepatide over the semaglutide 1mg medication profiles.
    Language English
    Publishing date 2023-03-22
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2455848-5
    ISSN 1177-889X
    ISSN 1177-889X
    DOI 10.2147/PPA.S401465
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  10. Article ; Online: Multivariate data analysis: Validation of an instrument for the evaluation of teaching digital competence.

    Cisneros-Barahona, Andrés Santiago / Marqués-Molías, Luis / Samaniego-Erazo, Nicolay / Mejía-Granizo, Catalina / De la Cruz-Fernández, Gabriela

    F1000Research

    2023  Volume 12, Page(s) 866

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Reproducibility of Results ; Cross-Sectional Studies ; Learning ; Surveys and Questionnaires ; Ecuador
    Language English
    Publishing date 2023-11-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.135194.2
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