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  1. Article ; Online: Burden of Respiratory Syncytial Virus in the European Union: estimation of RSV-associated hospitalizations in children under 5 years.

    Del Riccio, Marco / Spreeuwenberg, Peter / Osei-Yeboah, Richard / Johannesen, Caroline K / Fernandez, Liliana Vazquez / Teirlinck, Anne C / Wang, Xin / Heikkinen, Terho / Bangert, Mathieu / Caini, Saverio / Campbell, Harry / Paget, John

    The Journal of infectious diseases

    2023  Volume 228, Issue 11, Page(s) 1528–1538

    Abstract: Background: No overall estimate of respiratory syncytial virus (RSV)-associated hospitalizations in children aged under 5 years has been published for the European Union (EU). We aimed to estimate the RSV hospitalization burden in children aged under 5 ... ...

    Abstract Background: No overall estimate of respiratory syncytial virus (RSV)-associated hospitalizations in children aged under 5 years has been published for the European Union (EU). We aimed to estimate the RSV hospitalization burden in children aged under 5 years in EU countries and Norway, by age group.
    Methods: We collated national RSV-associated hospitalization estimates calculated using linear regression models via the RESCEU project for Denmark, England, Finland, Norway, the Netherlands, and Scotland, 2006-2018. Additional estimates were obtained from a systematic review. Using multiple imputation and nearest neighbor matching methods, we estimated overall RSV-associated hospitalizations and rates in the EU.
    Results: Additional estimates for 2 countries (France and Spain) were found in the literature. In the EU, an average of 245 244 (95% confidence interval [CI], 224 688-265 799) yearly hospital admissions with a respiratory infection per year were associated with RSV in children aged under 5 years, with most cases occurring among children aged under 1 year (75%). Infants aged under 2 months represented the most affected group (71.6 per 1000 children; 95% CI, 66.6-76.6).
    Conclusions: Our findings will help support decisions regarding prevention efforts and represent an important benchmark to understand changes in the RSV burden following the introduction of RSV immunization programs in Europe.
    MeSH term(s) Child ; Child, Preschool ; Humans ; Infant ; European Union ; Hospitalization ; Respiratory Syncytial Virus Infections/epidemiology ; Respiratory Syncytial Virus, Human ; Respiratory Tract Infections ; Systematic Reviews as Topic
    Language English
    Publishing date 2023-05-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiad188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Risk factors associated with severe disease in respiratory syncytial virus infected children under 5 years of age.

    Havdal, Lise Beier / Bøås, Håkon / Bekkevold, Terese / Bakken Kran, Anne-Marte / Rojahn, Astrid Elisabeth / Størdal, Ketil / Debes, Sara / Døllner, Henrik / Nordbø, Svein Arne / Barstad, Bjørn / Haarr, Elisebet / Fernández, Liliana Vázquez / Nakstad, Britt / Inchley, Christopher / Flem, Elmira

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 1004739

    Abstract: Objective: To evaluate risk factors for severe disease in children under 59 months of age hospitalized with respiratory syncytial virus (RSV) infection.: Study design: We prospectively enrolled 1,096 cases of laboratory confirmed RSV infection during ...

    Abstract Objective: To evaluate risk factors for severe disease in children under 59 months of age hospitalized with respiratory syncytial virus (RSV) infection.
    Study design: We prospectively enrolled 1,096 cases of laboratory confirmed RSV infection during three consecutive RSV seasons in 2015-2018. Potential risk factors for severe disease were retrieved through patient questionnaires and linkage to national health registries. Need for respiratory support (invasive ventilation, bi-level positive airway pressure, or continuous positive airway pressure), and length of stay exceeding 72 h were used as measures of disease severity. Associations were investigated using multivariable logistic regression analyses. Multiple imputation was used to avoid bias and inference induced by missing data.
    Results: Risk factors associated with a need for respiratory support included age younger than 3 months of age [aOR: 6.73 (95% CI 2.71-16.7)], having siblings [aOR: 1.65 (95% CI 1.05-2.59)] and comorbidity [aOR: 2.40 (95% CI 1.35-4.24)]. The length of hospital stay >72 h was significantly associated with being younger than 3 months of age [aOR: 3.52 (95% CI 1.65-7.54)], having siblings [aOR: 1.45 (95% CI 1.01-2.08)], and comorbidity [aOR: 2.18 (95% CI 1.31-3.61)]. Sub-group analysis of children younger than 6 months of age confirmed the association between both young age and having siblings and the need for respiratory support.
    Conclusion: In a large cohort of children <59 months hospitalized with RSV infection, young age, comorbidity, and having siblings were associated with more severe disease.
    Language English
    Publishing date 2022-08-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.1004739
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Corrigendum to 'The burden of respiratory syncytial virus in children under 5 years of age in Norway' [Journal of Infection Volume 84, Issue 2 (2022) Pages 205-215].

    Havdal, Lise Beier / Bøås, Håkon / Bekkevold, Terese / Kran, Anne-Marte Bakken / Rojahn, Astrid Elisabeth / Størdal, Ketil / Debes, Sara / Døllner, Henrik / Nordbø, Svein Arne / Barstad, Bjørn / Haarr, Elisebet / Fernández, Liliana Vázquez / Nakstad, Britt / Inchley, Christopher / Flem, Elmira

    The Journal of infection

    2022  Volume 86, Issue 4, Page(s) 420

    Language English
    Publishing date 2022-12-24
    Publishing country England
    Document type Published Erratum
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2022.12.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The burden of respiratory syncytial virus in children under 5 years of age in Norway.

    Havdal, Lise Beier / Bøås, Håkon / Bekkevold, Terese / Kran, Anne-Marte Bakken / Rojahn, Astrid Elisabeth / Størdal, Ketil / Debes, Sara / Døllner, Henrik / Nordbø, Svein Arne / Barstad, Bjørn / Haarr, Elisebet / Fernández, Liliana Vázquez / Nakstad, Britt / Inchley, Christopher / Flem, Elmira

    The Journal of infection

    2021  Volume 84, Issue 2, Page(s) 205–215

    Abstract: Objectives: To estimate age-specific incidence of medically attended respiratory syncytial virus (RSV) infections in hospitalised Norwegian children and describe disease epidemiology.: Methods: Active prospective hospital surveillance for RSV in ... ...

    Abstract Objectives: To estimate age-specific incidence of medically attended respiratory syncytial virus (RSV) infections in hospitalised Norwegian children and describe disease epidemiology.
    Methods: Active prospective hospital surveillance for RSV in children <59 months of age was conducted during 2015-2018. All febrile children 12-59 months of age were enrolled, whereas children <12 months were enrolled based on respiratory symptoms regardless of fever. Surveillance data were linked to national registry data to estimate the clinical burden of RSV.
    Results: Of the children enrolled, 1096 (40%) were infected with RSV. The highest incidence rates were found in children 1 month of age, with a peak incidence of 43 per 1000 during the 2016-2017 season. In comparison, children 24-59 months of age had an infection rate of 1.4 per 1000 during the same winter season. The peak season was during the 2016-2017 winter, with an incidence rate of 6.0 per 1000 children 0-59 months of age. In the study population a total of 168 (15%) of the infected children had pre-existing medical conditions predisposing for more severe disease. High infection rates were found in this population.
    Conclusions: Children with comorbidities showed high hospital contact rates, but the majority of children in need of medical attention associated with RSV infection were previously healthy.
    MeSH term(s) Child ; Child, Preschool ; Hospitalization ; Humans ; Incidence ; Infant ; Prospective Studies ; Respiratory Syncytial Virus Infections ; Respiratory Syncytial Virus, Human
    Language English
    Publishing date 2021-12-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2021.12.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Respiratory Syncytial Virus-Associated Hospital Admissions in Children Younger Than 5 Years in 7 European Countries Using Routinely Collected Datasets.

    Reeves, Rachel M / van Wijhe, Maarten / Tong, Sabine / Lehtonen, Toni / Stona, Luca / Teirlinck, Anne C / Fernandez, Liliana Vazquez / Li, You / Giaquinto, Carlo / Fischer, Thea Kølsen / Demont, Clarisse / Heikkinen, Terho / Speltra, Irene / van Boven, Michiel / Bøås, Håkon / Campbell, Harry

    The Journal of infectious diseases

    2020  Volume 222, Issue Suppl 7, Page(s) S599–S605

    Abstract: Background: Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infection (RTI) in young children. Registries provide opportunities to explore RSV epidemiology and burden.: Methods: We explored routinely collected hospital data ... ...

    Abstract Background: Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infection (RTI) in young children. Registries provide opportunities to explore RSV epidemiology and burden.
    Methods: We explored routinely collected hospital data on RSV in children aged < 5 years in 7 European countries. We compare RSV-associated admission rates, age, seasonality, and time trends between countries.
    Results: We found similar age distributions of RSV-associated hospital admissions in each country, with the highest burden in children < 1 years old and peak at age 1 month. Average annual rates of RTI admission were 41.3-112.0 per 1000 children aged < 1 year and 8.6-22.3 per 1000 children aged < 1 year. In children aged < 5 years, 57%-72% of RTI admissions with specified causal pathogen were coded as RSV, with 62%-87% of pathogen-coded admissions in children < 1 year coded as RSV.
    Conclusions: Our results demonstrate the benefits and limitations of using linked routinely collected data to explore epidemiology and burden of RSV. Our future work will use these data to generate estimates of RSV burden using time-series modelling methodology, to inform policymaking and regulatory decisions regarding RSV immunization strategy and monitor the impact of future vaccines.
    MeSH term(s) Child, Preschool ; Europe/epidemiology ; Female ; Hospitalization/statistics & numerical data ; Hospitals ; Humans ; Infant ; Infant, Newborn ; Male ; Respiratory Syncytial Virus Infections/epidemiology ; Respiratory Syncytial Virus Infections/prevention & control ; Respiratory Syncytial Virus Infections/virology ; Respiratory Syncytial Virus, Human ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/prevention & control ; Vaccination
    Language English
    Publishing date 2020-08-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiaa360
    Database MEDical Literature Analysis and Retrieval System OnLINE

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