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Article ; Online: Current Issues in Fungal Infections and COVID-19.

Fernández-Cruz, Ana / Magira, Eleni

2022 Volume 8, Issue 11

Abstract: The COVID-19 pandemic has brought up a new host for fungal invasive infections [ ... ]. ...

Abstract	The COVID-19 pandemic has brought up a new host for fungal invasive infections [...].
Language	English
Publishing date	2022-10-23
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof8111115
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Article ; Online: How Long Do We Need to Treat an Invasive Mold Disease in Hematology Patients? Factors Influencing Duration of Therapy and Future Questions.

Fernández-Cruz, Ana / Lewis, Russell E / Kontoyiannis, Dimitrios P

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2020 Volume 71, Issue 3, Page(s) 685–692

Abstract: Treatment duration for invasive mold disease (IMD) in patients with hematological malignancy is not standardized and is a challenging subject in antifungal stewardship. Concerns for IMD relapse during subsequent reinduction or consolidation chemotherapy ... ...

Abstract	Treatment duration for invasive mold disease (IMD) in patients with hematological malignancy is not standardized and is a challenging subject in antifungal stewardship. Concerns for IMD relapse during subsequent reinduction or consolidation chemotherapy or graft versus host disease treatment in hematopoietic stem cell transplant recipients often results in prolonged or indefinite antifungal treatment. There are no validated criteria that predict when it is safe to stop antifungals. Decisions are individualized and depend on the offending fungus, site and extent of IMD, comorbidities, hematologic disease prognosis, and future plans for chemotherapy or transplantation. Recent studies suggest that FDG-PET/CT could help discriminate between active and residual fungal lesions to support decisions for safely stopping antifungals. Validation of noninvasive biomarkers for monitoring treatment response, tests for quantifying the "net state of immunosuppression," and genetic polymorphisms associated with poor fungal immunity could lead to a personalized assessment for the continued need for antifungal therapy.
MeSH term(s)	Antifungal Agents/therapeutic use ; Duration of Therapy ; Fungi/genetics ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/drug therapy ; Hematology ; Hematopoietic Stem Cell Transplantation ; Humans ; Positron Emission Tomography Computed Tomography
Chemical Substances	Antifungal Agents
Language	English
Publishing date	2020-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciz1195
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Article: Relationship between reward-related evoked potentials and real-world motivation in older people living with human immunodeficiency virus.

Castaneda, Gloria / Fernandez Cruz, Ana-Lucia / Brouillette, Marie-Josée / Mayo, Nancy E / Fellows, Lesley K

Frontiers in aging neuroscience

2022 Volume 14, Page(s) 927209

Abstract: Apathy, a clinical disorder characterized by low motivation, is prevalent in people living with Human Immunodeficiency Virus (HIV). It affects mental and physical health-related quality-of-life, medication adherence, and is associated with cognitive ... ...

Abstract	Apathy, a clinical disorder characterized by low motivation, is prevalent in people living with Human Immunodeficiency Virus (HIV). It affects mental and physical health-related quality-of-life, medication adherence, and is associated with cognitive decline. However, the causes of apathy and the underlying brain mechanisms in HIV are unknown. Brain responses to reward may be relevant to understanding apathy and might serve as biomarkers for diagnosis or treatment response. Electroencephalogram (EEG) responses to gain and loss feedback in simple guessing tasks have been related to apathy in neurodegenerative conditions and healthy individuals. The primary aim of this study is to contribute evidence regarding the relationship between two EEG correlates of reward processing, the Reward Positivity, and the Feedback-P300, and real-world motivated behavior indicated by self-reported hours engaged in goal-directed leisure activities per week, in older individuals with well-controlled HIV infection. High-density EEG was collected from 75 participants while they performed a guessing task with gain or loss feedback. We found that a later component of reward processing, the Feedback-P300, was related to real-world engagement, while the earlier Reward Positivity was not. The Feedback-P300 measured with EEG holds promise as a biomarker for motivated behavior in older people living with HIV. These findings lay the groundwork for a better understanding of the neurobiology of apathy in this condition.
Language	English
Publishing date	2022-09-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2022.927209
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Article: Usefulness of

Gutiérrez-Villanueva, Andrea / Quintana-Reyes, Claudia / Martínez de Antonio, Elena / Rodríguez-Alfonso, Begoña / Velásquez, Karina / de la Iglesia, Almudena / Bautista, Guiomar / Escudero-Gómez, Cristina / Duarte, Rafael / Fernández-Cruz, Ana

Microorganisms

2024 Volume 12, Issue 2

Abstract: Febrile neutropenia (FN) is a complication of hematologic malignancy therapy. An early diagnosis would allow optimization of antimicrobials. ... ...

Abstract	Febrile neutropenia (FN) is a complication of hematologic malignancy therapy. An early diagnosis would allow optimization of antimicrobials. The
Language	English
Publishing date	2024-01-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms12020307
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Article: A Response to: Letter to the Editor Regarding Combination of Tocilizumab and Steroids to Improve Mortality in Patients with Severe COVID-19 Infection: A Spanish, Multicenter, Cohort.

Ruiz-Antorán, Belén / Sancho-López, Aránzazu / Torres, Ferrán / Fernández-Cruz, Ana

Infectious diseases and therapy

2021 Volume 10, Issue 3, Page(s) 1811–1813

Language	English
Publishing date	2021-04-29
Publishing country	New Zealand
Document type	Letter
ZDB-ID	2701611-0
ISSN	2193-6382 ; 2193-8229
ISSN (online)	2193-6382
ISSN	2193-8229
DOI	10.1007/s40121-021-00444-4
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Article ; Online: Does effort-cost decision-making relate to real-world motivation in people living with HIV?

Castaneda, Gloria / Fernandez Cruz, Ana Lucia / Sefranek, Marcus / Yau, Yvonne H C / Brouillette, Marie-Josée / Mayo, Nancy E / Fellows, Lesley K

Journal of clinical and experimental neuropsychology

2022 Volume 43, Issue 10, Page(s) 1032–1043

Abstract: Introduction: Low motivation is frequent in older people with HIV, yet poorly understood. Effort-cost decision-making (ECDM) tasks inspired by behavioral economics have shown promise as indicators of motivation or apathy. These tasks assess the ... ...

Abstract	Introduction: Low motivation is frequent in older people with HIV, yet poorly understood. Effort-cost decision-making (ECDM) tasks inspired by behavioral economics have shown promise as indicators of motivation or apathy. These tasks assess the willingness to exert effort to earn a monetary reward, providing an estimate of the subjective "cost" of effort for each participant. Here we sought evidence for a relationship between ECDM task performance and self-reported motivation in a cross-sectional study involving 80 middle-aged and older people with well-controlled HIV infection, a chronic health condition with a high burden of mental and cognitive health challenges. Methods: Participants attending a regular follow-up visit for a Canadian longitudinal study of brain health in HIV completed a computerized ECDM task and a self-report measure of motivation. Other brain health measures were available, collected for the parent study (cognition, depression, anxiety, and vitality, as well as self-reported time spent on real-world leisure activities). Results: Contrary to our hypothesis, we found no relationship between ECDM performance and self-reported motivation. However, those willing to accept higher effort in the ECDM task also reported more time engaged in real-world activities. This association had a small-to-moderate effect size. Conclusions: The behavioral economics construct of subjective cost of effort, measured with a laboratory ECDM task, does not relate to motivation in people living with chronic HIV. However, the task shows some relationship with real-world goal-directed behavior, suggesting this construct has potential clinical relevance. More work is needed to understand how the subjective cost of effort plays out in clinical symptoms and everyday activities.
MeSH term(s)	Aged ; Canada ; Cross-Sectional Studies ; Decision Making ; HIV Infections ; Humans ; Longitudinal Studies ; Middle Aged ; Motivation ; Reward
Language	English
Publishing date	2022-03-31
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	605982-x
ISSN	1744-411X ; 0168-8634 ; 1380-3395
ISSN (online)	1744-411X
ISSN	0168-8634 ; 1380-3395
DOI	10.1080/13803395.2022.2058464
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Article ; Online: Re: 'the unique COVID-19 presentation of patients with B cell depletion' by Belkin et al.

Múñez-Rubio, Elena / Calderón-Parra, Jorge / Fernández-Cruz, Ana / Moreno-Torres, Víctor / Blanco-Alonso, Silvia / Ramos-Martínez, Antonio

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2022 Volume 29, Issue 2, Page(s) 272–273

MeSH term(s)	Humans ; COVID-19/diagnosis ; SARS-CoV-2
Language	English
Publishing date	2022-10-27
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2022.10.025
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Efficacy and safety of antiviral plus anti-spike monoclonal antibody combination therapy vs. monotherapy for high-risk immunocompromised patients with mild-to-moderate SARS-CoV2 infection during the Omicron era: A prospective cohort study.

Calderón-Parra, Jorge / Gutiérrez-Villanueva, Andrea / Ronda-Roca, Gerard / Jimenez, Maria Luisa Martín / de la Torre, Helena / Ródenas-Baquero, María / Paniura-Pinedo, María / Lozano-Llano, Carla / Pintos-Pascual, Ilduara / Fernández-Cruz, Ana / Ramos-Martínez, Antonio / Muñez-Rubio, Elena

International journal of antimicrobial agents

2024 Volume 63, Issue 3, Page(s) 107095

Abstract: Introduction: Antivirals and monoclonal antibodies lower the risk of progression in immunocompromised patients. However, combination therapy with both types of agents has not been studied.: Patients and methods: This was a single-centre, prospective, ...

Abstract	Introduction: Antivirals and monoclonal antibodies lower the risk of progression in immunocompromised patients. However, combination therapy with both types of agents has not been studied. Patients and methods: This was a single-centre, prospective, cohort study. All immunocompromised patients who received treatment for mild-to-moderate COVID-19 from 1 January 2022 to 30 October 2022 were enrolled. The primary endpoint was COVID-19 progression at 90 days, defined as hospital admission or death due to COVID-19 and/or seronegative persistent COVID-19. Results: A total of 304 patients were included: 43 patients (14.1%) received sotrovimab plus a direct-acting antiviral, and 261 (85.9%) received monotherapy. Primary outcome occurred more frequently after monotherapy (4.6% vs. 0%, P=0.154). Among patients with anti-spike immunoglobulin G (anti-S IgG) titre <750 BAU/mL, COVID-19 progression was more common after monotherapy (23.9% vs. 0%, P=0.001), including more frequent COVID-related admission (15.2% vs. 0%, P=0.014) and seronegative persistent COVID-19 (10.9% vs. 0%, P=0.044). Combination therapy was associated with lower risk of progression (odds ratio [OR] 0.08, 95% confidence interval [95% CI] 0.01-0.64). Anti-S IgG titre <750 BAU/mL and previous anti-CD20 were associated with higher risk of progression (OR 13.70, 95% CI 2.77-67.68; and OR 3.05, 95% CI 1.20-10.94, respectively). Conclusions: In immunocompromised patients, combination therapy with sotrovimab plus an antiviral may be more effective than monotherapy for SARS-CoV2.
MeSH term(s)	Humans ; Prospective Studies ; RNA, Viral ; Antiviral Agents/therapeutic use ; Cohort Studies ; COVID-19 ; Hepatitis C, Chronic ; SARS-CoV-2 ; Antibodies, Monoclonal/adverse effects ; Immunocompromised Host ; Immunoglobulin G
Chemical Substances	RNA, Viral ; Antiviral Agents ; Antibodies, Monoclonal ; Immunoglobulin G
Language	English
Publishing date	2024-01-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2024.107095
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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 500: Show issues

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Article ; Online: Performance of the beta-glucan test for the diagnosis of invasive fusariosis and scedosporiosis: a meta-analysis.

Lamoth, Frederic / Nucci, Marcio / Fernandez-Cruz, Ana / Azoulay, Elie / Lanternier, Fanny / Bremerich, Jens / Einsele, Hermann / Johnson, Elizabeth / Lehrnbecher, Thomas / Mercier, Toine / Porto, Luciana / Verweij, Paul E / White, Lewis / Maertens, Johan / Alanio, Alexandre

Medical mycology

2023 Volume 61, Issue 7

Abstract: The (1→3)-β-D-glucan (BDG) is a component of the fungal cell wall that can be detected in serum and used as an adjunctive tool for the diagnosis of invasive mold infections (IMI) in patients with hematologic cancer or other immunosuppressive conditions. ... ...

Abstract	The (1→3)-β-D-glucan (BDG) is a component of the fungal cell wall that can be detected in serum and used as an adjunctive tool for the diagnosis of invasive mold infections (IMI) in patients with hematologic cancer or other immunosuppressive conditions. However, its use is limited by modest sensitivity/specificity, inability to differentiate between fungal pathogens, and lack of detection of mucormycosis. Data about BDG performance for other relevant IMI, such as invasive fusariosis (IF) and invasive scedosporiosis/lomentosporiosis (IS) are scarce. The objective of this study was to assess the sensitivity of BDG for the diagnosis of IF and IS through systematic literature review and meta-analysis. Immunosuppressed patients diagnosed with proven or probable IF and IS, with interpretable BDG data were eligible. A total of 73 IF and 27 IS cases were included. The sensitivity of BDG for IF and IS diagnosis was 76.7% and 81.5%, respectively. In comparison, the sensitivity of serum galactomannan for IF was 27%. Importantly, BDG positivity preceded the diagnosis by conventional methods (culture or histopathology) in 73% and 94% of IF and IS cases, respectively. Specificity was not assessed because of lacking data. In conclusion, BDG testing may be useful in patients with suspected IF or IS. Combining BDG and galactomannan testing may also help differentiating between the different types of IMI.
MeSH term(s)	Animals ; Fusariosis/diagnosis ; Fusariosis/veterinary ; beta-Glucans ; Invasive Fungal Infections/diagnosis ; Invasive Fungal Infections/veterinary ; Sensitivity and Specificity
Chemical Substances	beta-Glucans
Language	English
Publishing date	2023-06-30
Publishing country	England
Document type	Systematic Review ; Meta-Analysis ; Journal Article
ZDB-ID	1421796-x
ISSN	1460-2709 ; 1369-3786
ISSN (online)	1460-2709
ISSN	1369-3786
DOI	10.1093/mmy/myad061
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Article ; Online: Determining the usefulness of systematic

Gutiérrez, Andrea / Rodriguez, Begoña / Velasquez, Karina / Gutiérrez, Isabel / García, Sonia / Múñez, Elena / Calderón-Parra, Jorge / Callejas-Diaz, Alejandro / Ramos-Martinez, Antonio / Fernandez-Cruz, Ana

BMJ open

2023 Volume 13, Issue 6, Page(s) e074240

Abstract: Introduction: The evaluation of staging and activity of invasive fungal infection (IFI) is used to adjust the type and duration of antifungal therapy (AT). Typically anatomy-based imaging is used. Positron emission tomography/CT with : Methods and ... ...

Abstract	Introduction: The evaluation of staging and activity of invasive fungal infection (IFI) is used to adjust the type and duration of antifungal therapy (AT). Typically anatomy-based imaging is used. Positron emission tomography/CT with Methods and analysis: Multicentre prospective cohort study of IFI with performance of systematic Ethics and dissemination: The Clinical Research Ethics Committee of Puerta de Hierro-Majadahonda University Hospital approved the protocol of the study at the primary site. We plan to publish the results in high-impact journals. Trial registration number: NCT05688592.
MeSH term(s)	Humans ; Fluorodeoxyglucose F18 ; Invasive Fungal Infections/diagnostic imaging ; Invasive Fungal Infections/drug therapy ; Multicenter Studies as Topic ; Neoplasm Staging ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Prospective Studies ; Radiopharmaceuticals
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
Language	English
Publishing date	2023-06-23
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-074240
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