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  1. Article ; Online: Oral amoxicillin/clavulanate for the prevention of bacteremia following dental extractions.

    Diniz Freitas, Márcio / Álvarez Fernández, Maximiliano / Vasallo Vidal, Francisco Jose / Limeres Posse, Jacobo / Diz Dios, Pedro / Fernández Feijoo, Javier

    Oral diseases

    2022  Volume 29, Issue 5, Page(s) 2272–2276

    Abstract: This study aimed to evaluate the effectiveness of oral amoxicillin/clavulanate (AMX-CL) for the prevention of bacteremia following dental extractions. The study group (AMX-CLG) comprised 40 adults requiring dental extractions under general anesthesia who ...

    Abstract This study aimed to evaluate the effectiveness of oral amoxicillin/clavulanate (AMX-CL) for the prevention of bacteremia following dental extractions. The study group (AMX-CLG) comprised 40 adults requiring dental extractions under general anesthesia who were administered a prophylactic regimen of 1875/125 mg of AMX-CL orally 1-2 h prior to the surgery. Venous blood samples were collected from each patient at baseline and at 30 s and 15 min after dental extractions. Samples were inoculated into BACTEC Plus culture bottles and processed in the BACTEC 9240. Conventional microbiological techniques were used for subcultures and further identification of the isolated bacteria. The results for the AMX-CLG were compared with those of a control group (CG; no prophylaxis) and an amoxicillin group (AMXG; 2 g of amoxicillin orally), consisting of randomly selected patients from among those participating in two clinical trials that we have previously published. The prevalence of bacteremia in the CG, AMXG, and AMX-CLG was 97%, 50%, and 15%, respectively, at 30 s after completing the extractions, and 67%, 10%, and 4% at 15 min, respectively, after the last extraction. The prevalence of bacteremia in the AMXG and the AMX-CLG at 30 s and at 15 min after completing the extractions was significantly lower than that in the CG (p < 0.001 and p < 0.001, respectively; Fisher's exact test). The prevalence of bacteremia in the AMX-CLG at 30 s after completing the extractions was significantly lower than that in the AMXG (p < 0.001; Fisher's exact test). Based in the results of this preliminary study, oral AMX-CL could be an excellent option for preventing bacteremia secondary to dental procedures in patients at risk.
    MeSH term(s) Adult ; Humans ; Tooth Extraction/adverse effects ; Amoxicillin/therapeutic use ; Amoxicillin-Potassium Clavulanate Combination/therapeutic use ; Bacteremia/prevention & control ; Bacteremia/epidemiology ; Bacteria ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Amoxicillin (804826J2HU) ; Amoxicillin-Potassium Clavulanate Combination (74469-00-4) ; Anti-Bacterial Agents
    Language English
    Publishing date 2022-05-13
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.14221
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  2. Article ; Online: Severe tongue protrusion dyskinesia after dental extractions.

    Diniz Freitas, Márcio / Diz Dios, Pedro / Fernández Feijoo, Javier / Limeres Posse, Jacobo / Outumuro Rial, Mercedes

    Journal of the American Dental Association (1939)

    2022  Volume 154, Issue 5, Page(s) e1–e3

    MeSH term(s) Humans ; Dyskinesias ; Tongue Diseases/diagnosis ; Tongue Diseases/etiology ; Tongue ; Tooth Extraction/adverse effects
    Language English
    Publishing date 2022-05-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 220622-5
    ISSN 1943-4723 ; 0002-8177 ; 1048-6364
    ISSN (online) 1943-4723
    ISSN 0002-8177 ; 1048-6364
    DOI 10.1016/j.adaj.2022.03.010
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  3. Article ; Online: Development of a new tool for predicting the behavior of individuals with intellectual disability in the dental office: A pilot study.

    Varela, Iván / Fernández-Feijoo, Javier / García, Eliane / Diniz-Freitas, Márcio / Martínez, Isabel / Roca, Javier / Diz, Pedro / Limeres, Jacobo

    Disability and health journal

    2021  Volume 15, Issue 2, Page(s) 101229

    Abstract: Background: The dental treatment of individuals with intellectual disability can represent a considerable professional challenge.: Objective: To develop a model for predicting the behavior of patients with intellectual disability in the dental office. ...

    Abstract Background: The dental treatment of individuals with intellectual disability can represent a considerable professional challenge.
    Objective: To develop a model for predicting the behavior of patients with intellectual disability in the dental office.
    Methods: The study group comprised 250 patients with Down syndrome (DS), autism spectrum disorder (ASD), cerebral palsy (CP), idiopathic cognitive impairment or rare disorders. We collected their demographic, medical, social and behavioral information and identified potential predictors (chi-squared test). We developed stratified models (Akaike information criterion) to anticipate the patients'behavior during intraoral examinations and to discern whether the dental treatment should be performed under general anesthesia. These models were validated in a new study group consisting of 80 patients. Goodness of fit was quantified with sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and area under the receiver operating characteristic curve (AUC). We developed a mathematical algorithm for executing the models and developed software for its practical implementation (PREdictors of BEhavior in Dentistry, "PREBED").
    Results: For patients with DS, ASD and CP, the model predicting the need for physical restraint during examination achieved a PPV of 0.90, 0.85 and 1.00, respectively, and an NPV of 0.66, 0.76 and 1.00, respectively. The model predicting the need for performing treatment under general anesthesia achieved a PPV of 0.63, 1.00 and 1.00, respectively, and an NPV of 1.00, 1.00 and 0.73, respectively. However, when validating the stratified models, the percentage of poorly classified individuals (false negatives + false positives) ranged from 24% to 46.6%.
    Conclusions: The results of the PREBED tool open the door to establishing new models implementing other potentially predictive variables.
    MeSH term(s) Autism Spectrum Disorder/complications ; Autism Spectrum Disorder/psychology ; Dental Offices ; Disabled Persons ; Humans ; Intellectual Disability/complications ; Pilot Projects
    Language English
    Publishing date 2021-11-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2414615-8
    ISSN 1876-7583 ; 1936-6574
    ISSN (online) 1876-7583
    ISSN 1936-6574
    DOI 10.1016/j.dhjo.2021.101229
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  4. Article ; Online: The effect of dentist experience on the treatment of individuals with disability under general anesthesia.

    Fernández-Feijoo, Javier / Carro, Beatriz / Branco, Ana / García-Caballero, Lucía / Diniz, Márcio / Limeres, Jacobo

    Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry

    2019  Volume 39, Issue 3, Page(s) 281–286

    Abstract: Aims: The aim of the present work was to assess in patients with severe disability operated under general anesthesia whether the progressive acquisition of experience by the dental team affects the type of procedure performed and the duration of ... ...

    Abstract Aims: The aim of the present work was to assess in patients with severe disability operated under general anesthesia whether the progressive acquisition of experience by the dental team affects the type of procedure performed and the duration of operations.
    Methods and results: A study group of 911 patients who underwent dental treatment under general anesthesia between 1997 and 2014 was conformed. Information was collected from every patient including: dental diagnosis, dental procedures and duration of the operating times. To analyze the impact of the operators' experience, the study period was divided into three 6-year periods. The most prevalent systemic diagnosis was "mental disease and behavior disorders" (42.9%). The most common dental procedures were extractions and fillings. Fewer extractions were performed during the third 6-year period (p = .000). Compared with the other two periods, during the first period fewer composite fillings (p = .000 and p = .000, respectively) and more fissure sealants (p = .001 and p = .023, respectively) were performed. The number of amalgam fillings decreased progressively (p = .000). There was a statistically significant reduction in the mean duration of the operations between the first and third period (p = .002).
    Conclusion: The dental team's experience entailed a significant reduction in the duration of operations.
    MeSH term(s) Anesthesia, General ; Dental Care ; Dentists ; Humans ; Pit and Fissure Sealants ; Tooth Extraction
    Chemical Substances Pit and Fissure Sealants
    Language English
    Publishing date 2019-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604118-8
    ISSN 1754-4505 ; 0275-1879
    ISSN (online) 1754-4505
    ISSN 0275-1879
    DOI 10.1111/scd.12380
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  5. Article ; Online: Denosumab-related osteonecrosis of the jaw following non-surgical periodontal therapy: A case report.

    Diniz-Freitas, Márcio / Fernández-Feijoo, Javier / Diz Dios, Pedro / Pousa, Xiana / Limeres, Jacobo

    Journal of clinical periodontology

    2018  Volume 45, Issue 5, Page(s) 570–577

    Abstract: Introduction: Osteonecrosis of the jaw associated with bisphosphonates is currently called medication-related osteonecrosis of the jaw (MRONJ), given that in addition to bisphosphonates, jaw osteonecrosis has been related to the administration of other ... ...

    Abstract Introduction: Osteonecrosis of the jaw associated with bisphosphonates is currently called medication-related osteonecrosis of the jaw (MRONJ), given that in addition to bisphosphonates, jaw osteonecrosis has been related to the administration of other antiresorptive and antiangiogenic drugs, such as denosumab, sunitinib, bevacizumab and ipilimumab.
    Case presentation: A 77-year-old patient with osteoporosis treated with subcutaneous injections of denosumab at an interval of 6 months is presented. The patient developed MRONJ after receiving a non-surgical periodontal therapy. Although the MRONJ was initially classified as a stage I lesion in this patient, cone beam computed tomography images confirmed the presence of a significant osteolytic lesion. Treatment consisted of the administration of chlorhexidine mouthwash and systemic doxycycline, exodontia of the involved teeth, sequestrectomy and complete surgical debridement of the necrotic bone.
    Conclusion: To our knowledge, this is the first case reported in the literature of MRONJ following non-surgical periodontal therapy in a patient with osteoporosis treated with denosumab. The risk of MRONJ development after a periodontal procedure and how to prevent this complication are still unknown.
    MeSH term(s) Aged ; Bisphosphonate-Associated Osteonecrosis of the Jaw/diagnostic imaging ; Bisphosphonate-Associated Osteonecrosis of the Jaw/therapy ; Bone Density Conservation Agents/adverse effects ; Combined Modality Therapy ; Denosumab/adverse effects ; Female ; Humans ; Periodontitis/complications ; Periodontitis/therapy ; Risk Factors
    Chemical Substances Bone Density Conservation Agents ; Denosumab (4EQZ6YO2HI)
    Language English
    Publishing date 2018-04-16
    Publishing country United States
    Document type Case Reports
    ZDB-ID 188647-2
    ISSN 1600-051X ; 0303-6979
    ISSN (online) 1600-051X
    ISSN 0303-6979
    DOI 10.1111/jcpe.12882
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  6. Article ; Online: Bibliometric Analysis of Medication-Related Osteonecrosis of the Jaw: High Citation Rates but Low Evidence.

    Diniz-Freitas, Márcio / Pena-Cristobal, Maite / Pérez-López, Daniel / Lago-Méndez, Lucía / Fernández-Feijoo, Javier / Limeres-Posse, Jacobo

    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

    2019  Volume 77, Issue 8, Page(s) 1655.e1–1655.e17

    Abstract: Purpose: Citation analysis is one of the most commonly used bibliometric tools for measuring the academic importance of a report in a specific area of knowledge. The objective of the present study was to identify the 100 most cited reports on medication- ...

    Abstract Purpose: Citation analysis is one of the most commonly used bibliometric tools for measuring the academic importance of a report in a specific area of knowledge. The objective of the present study was to identify the 100 most cited reports on medication-related osteonecrosis of the jaw (MRONJ), determine their main bibliometric characteristics, and identify the bibliometric variables that affected the citation rates.
    Materials and methods: We performed a data search in the Scopus database to determine the number of MRONJ article citations up to September 30, 2018. We next selected the 100 most referenced studies and recorded the following information: ranking according to the number of citations; citation density; number and names of authors; language and year of publication; country and institution of origin; financial support; journal name, impact factor, category, and quartile; type of research; evidence level; and area of study.
    Results: The 100 most cited reports had a mean citation density of 21.7 ± 20.7 (range, 6.2 to 99.4) and an h-index of 96. The 100 most cited reports on MRONJ had been published in 42 scientific journals, classified into 10 separate categories of the Journal Citation Reports; 56% of the articles were in the first quartile of their category. Most of the studies had been classified with a level of evidence of 4 (n = 45) or 5 (n = 29). In the bivariate analyses, only the conflict of interest (P = .002) was associated with citation density. After adjusting for numerous variables, conflict of interest (r = 0.27; P = .020) and country of the first author (r = 0.23; P = .043) were significantly associated with citation density.
    Conclusions: The 100 most cited studies of MRONJ had a large number of citations and had been reported in journals with a high impact factor; however, the studies had a generally low evidence level and randomized clinical trials were lacking.
    MeSH term(s) Bibliometrics ; Bisphosphonate-Associated Osteonecrosis of the Jaw ; Databases, Factual ; Evidence-Based Dentistry ; Humans ; Periodicals as Topic
    Language English
    Publishing date 2019-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392404-x
    ISSN 1531-5053 ; 0278-2391
    ISSN (online) 1531-5053
    ISSN 0278-2391
    DOI 10.1016/j.joms.2019.04.015
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  7. Article ; Online: A practical approach to dental care for patients with Wolf-Hirschhorn syndrome.

    Serrano Martín, Candela / Fernández Feijoo, Javier / García Mato, Eliane / Varela Aneiros, Iván / Diniz Freitas, Marcio / Vázquez García, Emma / Limeres Posse, Jacobo

    Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry

    2021  Volume 42, Issue 2, Page(s) 137–142

    Abstract: Wolf-Hirschhorn syndrome is a polymalformative chromosomal disorder caused by a deletion in the distal region of the short arm of chromosome 4. The disease is considered rare (1/50,000 births) and predominantly affects females (2:1). In addition to the ... ...

    Abstract Wolf-Hirschhorn syndrome is a polymalformative chromosomal disorder caused by a deletion in the distal region of the short arm of chromosome 4. The disease is considered rare (1/50,000 births) and predominantly affects females (2:1). In addition to the characteristic facial phenotype ("Greek warrior helmet"), its clinical manifestations include epilepsy, developmental and psychomotor delay, intellectual disability, cardiac and respiratory complications, and eating problems. The most prevalent oral manifestations are hypodontia, delayed tooth eruption, morphological dental abnormalities, dental malocclusions, cleft lip/palate and ogival palate. Based on our clinical experience, Wolf-Hirschhorn syndrome does not represent an absolute contraindication for any type of dental procedure. The feasibility of dental treatment will depend mainly on the degree of epilepsy control and on the level of collaboration, this latter conditioned by the severity of the intellectual disability and communication difficulties.
    MeSH term(s) Cleft Lip ; Cleft Palate ; Dental Care ; Female ; Humans ; Intellectual Disability ; Wolf-Hirschhorn Syndrome/complications ; Wolf-Hirschhorn Syndrome/genetics
    Language English
    Publishing date 2021-09-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604118-8
    ISSN 1754-4505 ; 0275-1879
    ISSN (online) 1754-4505
    ISSN 0275-1879
    DOI 10.1111/scd.12644
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  8. Article ; Online: Brief Report: Estimating the Dental Age of Children with Autism Spectrum Disorders.

    Limeres, Jacobo / Diz, Pedro / Abeleira, María Teresa / Outumuro, Mercedes / Fernández-Feijoo, Javier / Diniz-Freitas, Márcio / García-Caballero, Lucía

    Journal of autism and developmental disorders

    2019  Volume 49, Issue 6, Page(s) 2612–2617

    Abstract: Determining a patient's dental age is essential from the dental standpoint but can also have connotations of a forensic, anthropological and medicolegal nature. In this study, we assessed the correspondence between dental age and chronological age in a ... ...

    Abstract Determining a patient's dental age is essential from the dental standpoint but can also have connotations of a forensic, anthropological and medicolegal nature. In this study, we assessed the correspondence between dental age and chronological age in a group of 50 children with autism spectrum disorders, with a chronological age range of 3-17 years. The dental age was calculated using panoramic radiography images, applying linear regression models derived from the classical indices by Nolla and Demirjian. In 2 of every 3 boys, the dental age was ahead of the chronological age, and in almost 1 of every 3 cases, the difference was ≥ 12 months. In the girls, conversely, we found no significant differences between dental age and chronological age.
    MeSH term(s) Adolescent ; Age Determination by Teeth ; Autism Spectrum Disorder/diagnostic imaging ; Child ; Child, Preschool ; Female ; Humans ; Male ; Radiography, Panoramic ; Tooth
    Language English
    Publishing date 2019-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391999-7
    ISSN 1573-3432 ; 0162-3257
    ISSN (online) 1573-3432
    ISSN 0162-3257
    DOI 10.1007/s10803-019-04007-y
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  9. Article ; Online: Why refer possible oral cancer to the dentist for assessment?

    Fernández-Feijoo, Javier / Fernández-Varela, Marta / Diniz-Freitas, Márcio / Diz-Dios, Pedro / Limeres-Posse, Jacobo

    Oral oncology

    2019  Volume 94, Page(s) 123–124

    MeSH term(s) Aged ; Dentists ; Humans ; Male ; Mouth Mucosa/pathology ; Mouth Neoplasms/diagnosis ; Physician's Role ; Primary Health Care ; Referral and Consultation
    Language English
    Publishing date 2019-05-14
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2019.05.008
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  10. Article ; Online: Perforaciones de los guantes durante procedimientos rutinarios del higienista dental en una consulta de atención primaria.

    Pérez-Serrano, María Esther / Diniz-Freitas, Márcio / Fernández-Feijoo, Javier / Limeres-Posse, Jacobo

    Atencion primaria

    2017  Volume 50, Issue 2, Page(s) 130–131

    Title translation Glove perforations during routine dental hygienist procedures in a primary care setting.
    MeSH term(s) Dental Prophylaxis ; Equipment Failure/statistics & numerical data ; Gloves, Protective ; Primary Health Care
    Language Spanish
    Publishing date 2017-09-18
    Publishing country Spain
    Document type Letter
    ZDB-ID 1200787-0
    ISSN 1578-1275 ; 0212-6567
    ISSN (online) 1578-1275
    ISSN 0212-6567
    DOI 10.1016/j.aprim.2017.04.007
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