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  1. Article ; Online: One-year readmissions for circulatory diseases and in-hospital mortality after an index episode of heart failure in elderly patients. A nationwide data from public hospitals in Spain between 2016 and 2018.

    Esteban-Fernández, Alberto / Anguita-Sánchez, Manuel / Bonilla-Palomas, Juan Luis / Anguita-Gámez, María / Rosillo, Nicolás / Del Prado, Náyade / Bernal, José Luis / Fernández-Pérez, Cristina / Fernández-Rozas, Inmaculada / Gómez-Doblas, Juan José / Pérez-Villacastin, Julián / Elola, Francisco Javier

    Clinical research in cardiology : official journal of the German Cardiac Society

    2023  Volume 112, Issue 8, Page(s) 1119–1128

    Abstract: Introduction: Heart failure (HF) is one of the leading causes of hospitalization and death in elderly patients. However, there is limited evidence on readmission and mortality 1-year after discharge for HF.: Methods: Retrospective analysis of the ... ...

    Abstract Introduction: Heart failure (HF) is one of the leading causes of hospitalization and death in elderly patients. However, there is limited evidence on readmission and mortality 1-year after discharge for HF.
    Methods: Retrospective analysis of the Minimum Basic Data Set, including HF episodes, discharged from Spanish hospitals between 2016 and 2018 in ≥ 75 years. We calculated: (a) the rate of readmissions due to circulatory system diseases (CSD) 365 days after index episode; (b) in-hospital mortality in readmissions; and (c) predictors of mortality and readmission.
    Results: We included 178,523 patients (59.2% women) aged 85.1 ± 5.5 years. The most frequent comorbidities were arrhythmias (56.0%) and renal failure (39.5%). During the follow-up, 48,932 patients (27.4%) had at least one readmission for CSD and a crude rate of 40.2%, the most frequent one HF (52.8%). The median between the date of readmission and discharge from the last admission was 70 days [IQI 24; 171] for the first readmission. The most relevant predictors of the number of readmissions were valvular heart disease and myocardial ischemia. During the readmissions, 26,757 patients (79.1%) died, representing a cumulative in-hospital mortality of 47,945 (26.9%). The factors in the index episode predictors of mortality during readmissions were cardio-respiratory failure and stroke. The number of readmissions was a risk factor for in-hospital mortality (OR 1.13; 95% CI 1.11-1.14).
    Conclusions: The readmission rate for CSD 1-year after the index episode of HF in patients ≥ 75 years was 28.4%. The cumulative in-hospital mortality rate during the readmissions was 26.9%, and the number of rehospitalizations was identified as one of the main predictors of mortality.
    MeSH term(s) Aged ; Humans ; Female ; Male ; Patient Readmission ; Retrospective Studies ; Hospital Mortality ; Spain/epidemiology ; Heart Failure/therapy ; Risk Factors ; Hospitals, Public
    Language English
    Publishing date 2023-04-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2213295-8
    ISSN 1861-0692 ; 1861-0684
    ISSN (online) 1861-0692
    ISSN 1861-0684
    DOI 10.1007/s00392-023-02202-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The COVID-19 curve, health system overload, and mortality.

    Núñez-Gil, Iván J / Estrada, Vicente / Fernández-Pérez, Cristina / Fernández-Rozas, Inmaculada / Martín-Sánchez, Francisco Javier / Macaya, Carlos

    Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias

    2020  Volume 32, Issue 4, Page(s) 293–295

    Title translation Curva pandémica COVID-19, sobrecarga sanitaria y mortalidad.
    MeSH term(s) Adolescent ; Adult ; Age Distribution ; Age Factors ; Aged ; Betacoronavirus ; COVID-19 ; Cardiovascular Diseases/mortality ; Child ; China/epidemiology ; Cohort Studies ; Comorbidity ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Female ; Health Services Accessibility/statistics & numerical data ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Pandemics ; Patient Discharge/statistics & numerical data ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; SARS-CoV-2 ; Sex Distribution ; Spain/epidemiology ; Symptom Assessment ; United States/epidemiology ; Young Adult
    Keywords covid19
    Language Spanish
    Publishing date 2020-07-21
    Publishing country Spain
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2127173-2
    ISSN 2386-5857 ; 1137-6821
    ISSN (online) 2386-5857
    ISSN 1137-6821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Clinical Profile and Prognosis of a Real-World Cohort of Patients With Moderate or Severe Cancer Therapy-Induced Cardiac Dysfunction.

    Esteban-Fernández, Alberto / Carvajal Estupiñan, Juan Fernando / Gavira-Gómez, Juan José / Pernas, Sonia / Moliner, Pedro / Garay, Alberto / Sánchez-González, Álvaro / Fernández-Rozas, Inmaculada / González-Costello, José

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 721080

    Abstract: Introduction and Objectives: ...

    Abstract Introduction and Objectives:
    Language English
    Publishing date 2021-10-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.721080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comprehensive Assessment of Myocardial Ischemia Mechanisms in the Catheterization Laboratory: Design and Rationale of the Advanced Invasive Diagnosis Strategy for Patients with Stable Coronary Syndromes Undergoing Coronary ANGIOgraphy - the AID-ANGIO Study.

    Jeronimo, Adrian / Travieso, Alejandro / Paredes-Vázquez, José G / Finocchiaro, Francesca / Shabbir, Asad / Faria, Daniel / Gómez-Polo, Juan Carlos / Fernández-Rozas, Inmaculada / Grande-Ingelmo, Juan Manuel / García-Romo, Eva / Pérez-Velasco, Javier García / García-Lledó, Alberto / Curcio, Alejandro / Alonso-Bello, Javier / Gonzalo, Nieves / Mejía-Rentería, Hernán / Escaned, Javier

    Cardiovascular revascularization medicine : including molecular interventions

    2023  Volume 53, Page(s) 45–50

    Abstract: Background: The diagnostic yield of invasive coronary angiography (ICA) to identify obstructive coronary artery disease in the context of chronic coronary syndromes (CCS) is very low. Furthermore, myocardial ischemia may have a non-obstructive origin, ... ...

    Abstract Background: The diagnostic yield of invasive coronary angiography (ICA) to identify obstructive coronary artery disease in the context of chronic coronary syndromes (CCS) is very low. Furthermore, myocardial ischemia may have a non-obstructive origin, which cannot be detected by ICA.
    Methods: AID-ANGIO is an observational, prospective, single-cohort, multicenter study, intended to evaluate the diagnostic yield of adopting a hierarchical strategy to assess obstructive and non-obstructive causes of myocardial ischemia in an all-comers population of patients with CCS at the time of ICA. The primary endpoint will investigate the additional diagnostic value of such strategy over angiography alone regarding the identification of ischemia-generating mechanisms.
    Summary: An estimated sample of consecutive 260 patients with CCS referred by their clinicians to ICA, will be enrolled. In a stepwise manner, a conventional ICA will be performed as the initial diagnostic tool. Those patients with severe-grade stenosis will not undergo further assessment and an obstructive origin for myocardial ischemia will be assumed. Subsequently, the remainder with intermediate-grade stenosis will be assessed with pressure guidewires. Those with a negative result from physiological evaluation and those without epicardial coronary stenosis will be further studied for ischemia of non-obstructive origin, including microvascular dysfunction and vasomotor disorders. The study will be conducted in two steps. Firstly, ICA images will be displayed to patient's referring clinicians, who will be asked to identify the existent epicardial stenosis, their angiographic severity and probable physiological relevance, together with a tentative therapeutic approach. Then, the diagnostic algorithm will continue to be applied and, considering the whole gathered information, a definite therapeutic plan will be consensually established by the interventional cardiologist and patient's referring clinicians.
    Conclusion: The AID-ANGIO study will assess the additional diagnostic yield of a hierarchical strategy over ICA alone to identify ischemia-generating mechanisms in patients with CCS and its impact on therapeutic approach. Positive results of the study might support a streamlined invasive diagnostic process for patients with CCS.
    MeSH term(s) Humans ; Coronary Artery Disease ; Coronary Angiography/methods ; Prospective Studies ; Constriction, Pathologic ; Syndrome ; Myocardial Ischemia/diagnostic imaging ; Myocardial Ischemia/therapy ; Coronary Stenosis ; Catheterization ; Predictive Value of Tests ; Computed Tomography Angiography/methods
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2212113-4
    ISSN 1878-0938 ; 1553-8389
    ISSN (online) 1878-0938
    ISSN 1553-8389
    DOI 10.1016/j.carrev.2023.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Curva pandémica COVID-19, sobrecarga sanitaria y mortalidad./ Curva pandémica COVID-19, sobrecarga sanitaria y mortalidad./ The COVID-19 curve, health system overload, and mortality

    Núñez-Gil, Iván J / Estrada, Vicente / Fernández-Pérez, Cristina / Fernández-Rozas, Inmaculada / Martín-Sánchez, Francisco Javier / Macaya, Carlos

    Emergencias

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #660178
    Database COVID19

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  6. Article: The COVID-19 curve, health system overload, and mortality/ Curva pandemica COVID-19, sobrecarga sanitaria y mortalidad

    Nunez-Gil, Ivan J. / Estrada, Vicente / Fernandez-Perez, Cristina / Fernandez-Rozas, Inmaculada / Martin-Sanchez, Francisco Javier / Macaya, Carlos

    Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #679946
    Database COVID19

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  7. Article ; Online: Clinical profile and prognosis in patients on oral anticoagulation before admission for COVID-19.

    Rivera-Caravaca, José Miguel / Núñez-Gil, Iván J / Vivas, David / Viana-Llamas, María C / Uribarri, Aitor / Becerra-Muñoz, Víctor Manuel / Trabattoni, Daniela / Fernández Rozas, Inmaculada / Feltes, Gisela / López-Pais, Javier / El-Battrawy, Ibrahim / Macaya, Carlos / Fernandez-Ortiz, Antonio / Estrada, Vicente / Marín, Francisco

    European journal of clinical investigation

    2020  Volume 51, Issue 1, Page(s) e13436

    Abstract: Background: The coronavirus disease 2019 (COVID-19) shows high morbidity and mortality, particularly in patients with concomitant cardiovascular diseases. Some of these patients are under oral anticoagulation (OAC) at admission, but to date, there are ... ...

    Abstract Background: The coronavirus disease 2019 (COVID-19) shows high morbidity and mortality, particularly in patients with concomitant cardiovascular diseases. Some of these patients are under oral anticoagulation (OAC) at admission, but to date, there are no data on the clinical profile, prognosis and risk factors of such patients during hospitalization for COVID-19.
    Design: Subanalysis of the international 'real-world' HOPE COVID-19 registry. All patients with prior OAC at hospital admission for COVID-19 were suitable for the study. All-cause mortality was the primary endpoint.
    Results: From 1002 patients included, 110 (60.9% male, median age of 81.5 [IQR 75-87] years, median Short-Form Charlson Comorbidity Index [CCI] of 1 [IQR 1-3]) were on OAC at admission, mainly for atrial fibrillation and venous thromboembolism. After propensity score matching, 67.9% of these patients died during hospitalization, which translated into a significantly higher mortality risk compared to patients without prior OAC (HR 1.53, 95% CI 1.08-2.16). After multivariate Cox regression analysis, respiratory insufficiency during hospitalization (HR 6.02, 95% CI 2.18-16.62), systemic inflammatory response syndrome (SIRS) during hospitalization (HR 2.29, 95% CI 1.34-3.91) and the Short-Form CCI (HR 1.24, 95% CI 1.03-1.49) were the main risk factors for mortality in patients on prior OAC.
    Conclusions: Compared to patients without prior OAC, COVID-19 patients on OAC therapy at hospital admission showed lower survival and higher mortality risk. In these patients on OAC therapy, the prevalence of several comorbidities is high. Respiratory insufficiency and SIRS during hospitalization, as well as higher comorbidity, pointed out those anticoagulated patients with increased mortality risk.
    MeSH term(s) Aged ; Aged, 80 and over ; Anticoagulants/therapeutic use ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/epidemiology ; COVID-19/mortality ; Comorbidity ; Factor Xa Inhibitors/therapeutic use ; Female ; Heart Failure/epidemiology ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation ; Heparin/therapeutic use ; Heparin, Low-Molecular-Weight/therapeutic use ; Hospital Mortality ; Humans ; Intensive Care Units ; Male ; Multivariate Analysis ; Prognosis ; Propensity Score ; Proportional Hazards Models ; Renal Insufficiency/epidemiology ; Respiration, Artificial ; Respiratory Insufficiency/epidemiology ; Risk Factors ; SARS-CoV-2 ; Sepsis/epidemiology ; Systemic Inflammatory Response Syndrome/epidemiology ; Thromboembolism/epidemiology ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/epidemiology
    Chemical Substances Anticoagulants ; Factor Xa Inhibitors ; Heparin, Low-Molecular-Weight ; Heparin (9005-49-6)
    Keywords covid19
    Language English
    Publishing date 2020-11-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13436
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Chronic Oral Anticoagulation Therapy and Prognosis of Patients Admitted to Hospital for COVID-19: Insights from the HOPE COVID-19 Registry.

    Rivera-Caravaca, José Miguel / Núñez-Gil, Iván J / Lip, Gregory Y H / Uribarri, Aitor / Viana-Llamas, María C / Gonzalez, Adelina / Castro-Mejía, Alex F / Alonso González, Berta / Alfonso, Emilio / García Prieto, Juan Fortunato / Cavallino, Chiara / Cortese, Bernardo / Feltes, Gisela / Fernández-Rozas, Inmaculada / Signes-Costa, Jaime / Huang, Jia / García Aguado, Marcos / Pepe, Martino / Romero, Rodolfo /
    Cerrato, Enrico / Becerra-Muñoz, Víctor Manuel / Raposeiras Roubin, Sergio / Santoro, Francesco / Bagur, Rodrigo / Sposato, Luciano / El-Battrawy, Ibrahim / López Masjuan, Alvaro / Fernandez-Ortiz, Antonio / Estrada, Vicente / Macaya, Carlos / Marín, Francisco

    International journal of clinical practice

    2022  Volume 2022, Page(s) 7325060

    Abstract: Background: Most evidence regarding anticoagulation and COVID-19 refers to the hospitalization setting, but the role of oral anticoagulation (OAC) before hospital admission has not been well explored. We compared clinical outcomes and short-term ... ...

    Abstract Background: Most evidence regarding anticoagulation and COVID-19 refers to the hospitalization setting, but the role of oral anticoagulation (OAC) before hospital admission has not been well explored. We compared clinical outcomes and short-term prognosis between patients with and without prior OAC therapy who were hospitalized for COVID-19.
    Methods: Analysis of the whole cohort of the HOPE COVID-19 Registry which included patients discharged (deceased or alive) after hospital admission for COVID-19 in 9 countries. All-cause mortality was the primary endpoint. Study outcomes were compared after adjusting variables using propensity score matching (PSM) analyses.
    Results: 7698 patients were suitable for the present analysis (675 (8.8%) on OAC at admission: 427 (5.6%) on VKAs and 248 (3.2%) on DOACs). After PSM, 1276 patients were analyzed (638 with OAC; 638 without OAC), without significant differences regarding the risk of thromboembolic events (OR 1.11, 95% CI 0.59-2.08). The risk of clinically relevant bleeding (OR 3.04, 95% CI 1.92-4.83), as well as the risk of mortality (HR 1.22, 95% CI 1.01-1.47; log-rank
    Conclusion: Hospitalized COVID-19 patients on prior OAC therapy had a higher risk of mortality and worse clinical outcomes compared to patients without prior OAC therapy, even after adjusting for comorbidities using a PSM. There were no differences in clinical outcomes in patients previously taking VKAs or DOACs. This trial is registered with NCT04334291/EUPAS34399.
    MeSH term(s) Administration, Oral ; Anticoagulants/adverse effects ; Atrial Fibrillation/drug therapy ; COVID-19/drug therapy ; Hemorrhage/chemically induced ; Hospitalization ; Hospitals ; Humans ; Prognosis ; Registries ; Thromboembolism/prevention & control
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2022-05-26
    Publishing country India
    Document type Journal Article
    ZDB-ID 1386246-7
    ISSN 1742-1241 ; 1368-5031
    ISSN (online) 1742-1241
    ISSN 1368-5031
    DOI 10.1155/2022/7325060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Clinical profile and prognosis in patients on oral anticoagulation before admission for COVID-19

    Rivera-Caravaca, José Miguel / Núñez-Gil, Iván J / Vivas, David / Viana-Llamas, María C / Uribarri, Aitor / Becerra-Muñoz, Víctor Manuel / Trabattoni, Daniela / Fernández Rozas, Inmaculada / Feltes, Gisela / López-Pais, Javier / El-Battrawy, Ibrahim / Macaya, Carlos / Fernandez-Ortiz, Antonio / Estrada, Vicente / Marín, Francisco

    Eur J Clin Invest

    Abstract: BACKGROUND: The coronavirus disease 2019 (COVID-19) shows high morbidity and mortality, particularly in patients with concomitant cardiovascular diseases. Some of these patients are under oral anticoagulation (OAC) at admission, but to date, there are no ...

    Abstract BACKGROUND: The coronavirus disease 2019 (COVID-19) shows high morbidity and mortality, particularly in patients with concomitant cardiovascular diseases. Some of these patients are under oral anticoagulation (OAC) at admission, but to date, there are no data on the clinical profile, prognosis and risk factors of such patients during hospitalization for COVID-19. DESIGN: Subanalysis of the international 'real-world' HOPE COVID-19 registry. All patients with prior OAC at hospital admission for COVID-19 were suitable for the study. All-cause mortality was the primary endpoint. RESULTS: From 1002 patients included, 110 (60.9% male, median age of 81.5 [IQR 75-87] years, median Short-Form Charlson Comorbidity Index [CCI] of 1 [IQR 1-3]) were on OAC at admission, mainly for atrial fibrillation and venous thromboembolism. After propensity score matching, 67.9% of these patients died during hospitalization, which translated into a significantly higher mortality risk compared to patients without prior OAC (HR 1.53, 95% CI 1.08-2.16). After multivariate Cox regression analysis, respiratory insufficiency during hospitalization (HR 6.02, 95% CI 2.18-16.62), systemic inflammatory response syndrome (SIRS) during hospitalization (HR 2.29, 95% CI 1.34-3.91) and the Short-Form CCI (HR 1.24, 95% CI 1.03-1.49) were the main risk factors for mortality in patients on prior OAC. CONCLUSIONS: Compared to patients without prior OAC, COVID-19 patients on OAC therapy at hospital admission showed lower survival and higher mortality risk. In these patients on OAC therapy, the prevalence of several comorbidities is high. Respiratory insufficiency and SIRS during hospitalization, as well as higher comorbidity, pointed out those anticoagulated patients with increased mortality risk.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #880897
    Database COVID19

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  10. Article ; Online: Clinical profile and prognosis in patients on oral anticoagulation before admission for COVID‐19

    Rivera‐Caravaca, José Miguel / Núñez‐Gil, Iván J. / Vivas, David / Viana‐Llamas, María C. / Uribarri, Aitor / Becerra‐Muñoz, Víctor Manuel / Trabattoni, Daniela / Fernández Rozas, Inmaculada / Feltes, Gisela / López‐Pais, Javier / El‐Battrawy, Ibrahim / Macaya, Carlos / Fernandez‐Ortiz, Antonio / Estrada, Vicente / Marín, Francisco

    European Journal of Clinical Investigation ; ISSN 0014-2972 1365-2362

    2020  

    Keywords Clinical Biochemistry ; Biochemistry ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1111/eci.13436
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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