Article ; Online: Differential expression of TOB/BTG family members in patients with plaque psoriasis: cross-sectional study.
2023 Volume 72, Issue 2, Page(s) 234–241
Abstract: TOB/BTG is a family of antiproliferative proteins that play an important role in the regulation of immune responses, acting as lymphocyte activators and macrophage-mediated cytotoxicity. No previous studies have explored their role in patients with ... ...
| Abstract | TOB/BTG is a family of antiproliferative proteins that play an important role in the regulation of immune responses, acting as lymphocyte activators and macrophage-mediated cytotoxicity. No previous studies have explored their role in patients with psoriasis. The aim of this study was to characterize the expression of TOB/BTG family and their co-localization in skin from patients with psoriasis. This is an exploratory, observational, and cross-sectional study that included 24 plaque psoriasis patients and 15 controls. Gene expression of TOB/BTG family was determinate by RT-PCR. Protein products of TOB/BTG were evaluated by immunohistochemistry and compared with control skin tissues. Holm-Sidak's multiple comparisons test was performed. TOB/BTG family mRNA levels and protein expression were significantly decreased in psoriatic skin tissue compared to non-inflammatory control skin tissue. Double-positive cell TOB1/2, BTG1,2 and BTG4/CD16 expressions were found in normal control skin tissues through epidermis and dermis (p < 0.001) and lesser percentage in patients with mild, almost absent in moderate-severe plaque psoriasis. This is the first report of the TOB/BTG family gene and protein expression in skin tissues by a CD16 + subpopulation in plaque psoriasis. TOB/BTG family protein might represent a new therapeutic target among immune-mediated inflammatory diseases. |
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| MeSH term(s) | Humans ; Tumor Suppressor Proteins/genetics ; Cross-Sectional Studies ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Protein Processing, Post-Translational ; Psoriasis/genetics | |||||
| Chemical Substances | Tumor Suppressor Proteins ; Cell Cycle Proteins | |||||
| Language | English | |||||
| Publishing date | 2023-10-24 | |||||
| Publishing country | United States | |||||
| Document type | Observational Study ; Journal Article | |||||
| ZDB-ID | 632857-x | |||||
| ISSN | 1559-0755 ; 0257-277X | |||||
| ISSN (online) | 1559-0755 | |||||
| ISSN | 0257-277X | |||||
| DOI | 10.1007/s12026-023-09427-8 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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