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  1. Article ; Online: Current Issues in Fungal Infections and COVID-19.

    Fernández-Cruz, Ana / Magira, Eleni

    Journal of fungi (Basel, Switzerland)

    2022  Volume 8, Issue 11

    Abstract: The COVID-19 pandemic has brought up a new host for fungal invasive infections [ ... ]. ...

    Abstract The COVID-19 pandemic has brought up a new host for fungal invasive infections [...].
    Language English
    Publishing date 2022-10-23
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8111115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clinical experience in the treatment of COVID-19 with monoclonal antibodies in solid organ transplant recipients.

    Múñez-Rubio, E / Calderón-Parra, J / Gutiérrez-Villanueva, A / Fernández-Cruz, A / Ramos-Martínez, A

    Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia

    2023  Volume 36 Suppl 1, Page(s) 25–28

    Abstract: Solid organ transplant (SOT) recipients are at high risk for complications from coronavirus disease 2019 (COVID-19). SOT recipients mount lower immunological responses to vaccines than general population and are at high risk for breakthrough COVID-19 ... ...

    Abstract Solid organ transplant (SOT) recipients are at high risk for complications from coronavirus disease 2019 (COVID-19). SOT recipients mount lower immunological responses to vaccines than general population and are at high risk for breakthrough COVID-19 infections. Passive immunotherapy in the form of anti-Spike monoclonal antibodies (MoAbs) may be an alternative for the prophylaxis and treatment of COVID-19 in these patients. SARS-CoV-2 has evolved by accumulating resistance mutations that have escaped the neutralizing action of most MoAbs. However, MoAbs directed at more conserved epitopes and that maintain effector functions could maintain efficacy in the treatment of these patients. According to published data, SOT recipients with low anti-spike antibody responses to vaccination could benefit from the use of MoAbs in pre-exposure prophylaxis, in the treatment of COVID-19 mild to moderate and severe COVID-19 with less than 15 days of symptom duration and low oxygen requirements. Combination therapy could be more effective than monotherapy for the treatment of mild-to-moderate SARS-CoV-2 infection.
    MeSH term(s) Humans ; COVID-19 ; Antibodies, Monoclonal/therapeutic use ; SARS-CoV-2 ; Organ Transplantation/adverse effects
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2023-11-24
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 1018135-0
    ISSN 1988-9518 ; 0214-3429
    ISSN (online) 1988-9518
    ISSN 0214-3429
    DOI 10.37201/req/s01.07.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2833: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Identification of Predictive Markers of Response to Immunomodulators in the Treatment of COVID-19 Patients.

    Caballero-Bermejo, A F / Sancho-Lopez, A / Ferrer-Armengou, L / Jimenez-Martin, M L / Fernandez-Cruz, A / Ruiz-Antoran, B

    Clinical laboratory

    2022  Volume 68, Issue 9

    Abstract: Background: Proper identification of patients at risk of developing serious disease in the context of SARS-CoV-2 infection, as well as the initiation of early treatment, is one of the fundamental elements for successful management of COVID-19. The main ... ...

    Abstract Background: Proper identification of patients at risk of developing serious disease in the context of SARS-CoV-2 infection, as well as the initiation of early treatment, is one of the fundamental elements for successful management of COVID-19. The main objective of this study was to evaluate the usefulness of serum biomarkers (neutrophils, lymphocytes, C-reactive protein, lactate dehydrogenase, D-dimer, ferritin, and interleukin-6) to predict the early response to immunosuppressant therapy in COVID-19 patients.
    Methods: This is a case-control study nested in a retrospective cohort, which included hospitalized patients with interstitial pneumonia and with elevation of some proinflammatory parameters. Each of the individuals who died during the 28-day follow-up was defined as a case. For each case, 4 controls were selected, matched by age, gender, and comorbidities.
    Results: The initial cohort included 856 patients. The incidence of therapeutic failure in the cohort was 14%, thus we identified a total of 120 cases. After the application of a Cox regression model, high serum concentrations of LDH (> 451 IU/L), ferritin (> 1,014 ng/mL) and D-Dimer (> 1,300 ng/mL) were identified as predictors of poor response to treatment. Highly-specific cut-off points could not be established for any of these biomarkers.
    Conclusions: Some inflammatory biomarkers, such as LDH, ferritin, and D-dimer, may be helpful in identifying patients for whom an early immunomodulatory therapeutic intervention should be considered in the treatment of COVID-19 patients with pneumonia.
    MeSH term(s) Biomarkers ; C-Reactive Protein/analysis ; COVID-19/drug therapy ; Case-Control Studies ; Ferritins ; Humans ; Immunologic Factors/therapeutic use ; Immunosuppressive Agents/therapeutic use ; Interleukin-6 ; L-Lactate Dehydrogenase ; Retrospective Studies ; SARS-CoV-2
    Chemical Substances Biomarkers ; Immunologic Factors ; Immunosuppressive Agents ; Interleukin-6 ; C-Reactive Protein (9007-41-4) ; Ferritins (9007-73-2) ; L-Lactate Dehydrogenase (EC 1.1.1.27)
    Language English
    Publishing date 2022-09-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1307629-2
    ISSN 1433-6510 ; 0941-2131
    ISSN 1433-6510 ; 0941-2131
    DOI 10.7754/Clin.Lab.2022.211233
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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.170: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 25: Show issues

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  4. Article ; Online: Fosfomycin in antimicrobial stewardship programs.

    Múñez Rubio, E / Ramos Martínez, A / Fernández Cruz, A

    Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia

    2019  Volume 32 Suppl 1, Page(s) 62–66

    Abstract: Due to the increase in antimicrobial resistance, strategies such as antimicrobial stewardship programs (ASP) have been developed to improve the clinical results, decrease the adverse effects and the development of resistances and ensure cost-effective ... ...

    Abstract Due to the increase in antimicrobial resistance, strategies such as antimicrobial stewardship programs (ASP) have been developed to improve the clinical results, decrease the adverse effects and the development of resistances and ensure cost-effective therapies. Fosfomycin has a unique mechanism of action against Gram-positive and Gram-negative bacteria. Cross-resistance is uncommon; however, fosfomycin should be used in combination in severe infections to avoid selecting resistant mutations. Fosfomycin's oral formulation facilitates sequential treatment, has low toxicity and high tissue penetration, even in the central nervous system and bone. Fosfomycin is active against resistant Gram-positive bacteria such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin- resistant enterococci and penicillin-resistant Streptococcus pneumoniae, as well as against resistant Gram-negative bacteria such as extended-spectrum beta-lactamase-producing and carbapenemase-producing enterobacteria. Fosfomycin is therefore useful for cases of persistent bacteremia, skin and soft tissue infections, as a glycopeptide-sparing and carbapenem-sparing drug for healthcare-associated infections and for polymicrobial infections. Published studies have demonstrated the synergy between fosfomycin and beta-lactams, daptomycin and glycopeptides against MSSA and MRSA; with linezolid in biofilm-associated infections and with aminoglycosides and colistin against Gram-negative bacteria, providing a nephroprotective effect.
    MeSH term(s) Animals ; Anti-Bacterial Agents/therapeutic use ; Antimicrobial Stewardship ; Bacterial Infections/drug therapy ; Bacterial Infections/microbiology ; Drug Resistance, Multiple, Bacterial ; Fosfomycin/therapeutic use ; Gram-Negative Bacterial Infections/drug therapy ; Gram-Negative Bacterial Infections/microbiology ; Gram-Positive Bacterial Infections/drug therapy ; Gram-Positive Bacterial Infections/microbiology ; Humans
    Chemical Substances Anti-Bacterial Agents ; Fosfomycin (2N81MY12TE)
    Language English
    Publishing date 2019-05-27
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 1018135-0
    ISSN 1988-9518 ; 0214-3429
    ISSN (online) 1988-9518
    ISSN 0214-3429
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    Zs.A 2833: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article ; Online: How Long Do We Need to Treat an Invasive Mold Disease in Hematology Patients? Factors Influencing Duration of Therapy and Future Questions.

    Fernández-Cruz, Ana / Lewis, Russell E / Kontoyiannis, Dimitrios P

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 71, Issue 3, Page(s) 685–692

    Abstract: Treatment duration for invasive mold disease (IMD) in patients with hematological malignancy is not standardized and is a challenging subject in antifungal stewardship. Concerns for IMD relapse during subsequent reinduction or consolidation chemotherapy ... ...

    Abstract Treatment duration for invasive mold disease (IMD) in patients with hematological malignancy is not standardized and is a challenging subject in antifungal stewardship. Concerns for IMD relapse during subsequent reinduction or consolidation chemotherapy or graft versus host disease treatment in hematopoietic stem cell transplant recipients often results in prolonged or indefinite antifungal treatment. There are no validated criteria that predict when it is safe to stop antifungals. Decisions are individualized and depend on the offending fungus, site and extent of IMD, comorbidities, hematologic disease prognosis, and future plans for chemotherapy or transplantation. Recent studies suggest that FDG-PET/CT could help discriminate between active and residual fungal lesions to support decisions for safely stopping antifungals. Validation of noninvasive biomarkers for monitoring treatment response, tests for quantifying the "net state of immunosuppression," and genetic polymorphisms associated with poor fungal immunity could lead to a personalized assessment for the continued need for antifungal therapy.
    MeSH term(s) Antifungal Agents/therapeutic use ; Duration of Therapy ; Fungi/genetics ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/drug therapy ; Hematology ; Hematopoietic Stem Cell Transplantation ; Humans ; Positron Emission Tomography Computed Tomography
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2020-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciz1195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1505: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 480: Show issues

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  6. Article: Usefulness of

    Gutiérrez-Villanueva, Andrea / Quintana-Reyes, Claudia / Martínez de Antonio, Elena / Rodríguez-Alfonso, Begoña / Velásquez, Karina / de la Iglesia, Almudena / Bautista, Guiomar / Escudero-Gómez, Cristina / Duarte, Rafael / Fernández-Cruz, Ana

    Microorganisms

    2024  Volume 12, Issue 2

    Abstract: Febrile neutropenia (FN) is a complication of hematologic malignancy therapy. An early diagnosis would allow optimization of antimicrobials. ... ...

    Abstract Febrile neutropenia (FN) is a complication of hematologic malignancy therapy. An early diagnosis would allow optimization of antimicrobials. The
    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12020307
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  7. Article: Pathology and clinic of fibrositis; the problems of its diagnosis and treatment.

    FERNANDEZ CRUZ, A

    Medicamenta

    2007  Volume 7, Issue 159, Page(s) 93–96

    Title translation Patologia y clinica de las fibrositis; los problemas de su diagnóstico y tratamiento.
    MeSH term(s) Humans ; Panniculitis
    Language Spanish
    Publishing date 2007-12-15
    Publishing country Spain
    Document type Journal Article
    ISSN 0025-7648
    ISSN 0025-7648
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  8. Article: The doctrine of functional lung and its meaning for the pathology, clinic and therapy of acute lung diseases.

    FERNANDEZ CRUZ, A

    La Medicina colonial

    2007  Volume 13, Issue 4, Page(s) 219; passim

    Title translation La doctrina del pulmón funcional y su significado para la patologia, clinica y terapéutica de las neumopatias agudas.
    MeSH term(s) Humans ; Lung/physiology ; Respiratory Function Tests ; Respiratory Physiological Phenomena
    Language Spanish
    Publishing date 2007-12-15
    Publishing country Spain
    Document type Journal Article
    ISSN 0368-931X
    ISSN 0368-931X
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  9. Article: The doctrine of functional lung and its meaning for the pathology, clinic and therapy of acute lung diseases.

    FERNANDEZ CRUZ, A

    La Medicina colonial

    2007  Volume 13, Issue 5, Page(s) 323

    Title translation La doctrina del pulmón funcional y su significado para la patologia, clinica y terapéutica de las neumopatias agudas.
    MeSH term(s) Humans ; Lung
    Language Spanish
    Publishing date 2007-12-15
    Publishing country Spain
    Document type Journal Article
    ISSN 0368-931X
    ISSN 0368-931X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Bronchoalveolar Lavage Fluid Cytology in Culture-Documented Invasive Pulmonary Aspergillosis in Patients with Hematologic Diseases: Analysis of 67 Episodes.

    Fernández-Cruz, A / Magira, E / Heo, S T / Evans, S / Tarrand, J / Kontoyiannis, D P

    Journal of clinical microbiology

    2018  Volume 56, Issue 10

    Abstract: There is a paucity of studies on the yield of Gomori-methenamine-silver (GMS) staining in bronchoalveolar lavage (BAL) fluid cytology and its comparison with fluorescent dye staining for the diagnosis of invasive pulmonary aspergillosis (IPA) in patients ...

    Abstract There is a paucity of studies on the yield of Gomori-methenamine-silver (GMS) staining in bronchoalveolar lavage (BAL) fluid cytology and its comparison with fluorescent dye staining for the diagnosis of invasive pulmonary aspergillosis (IPA) in patients with hematologic malignancies. To that end, we analyzed the yield of direct fungal visualization in BAL fluid cytology with GMS staining, in a series of culture-positive IPA cases in 67 patients with hematologic malignancies, and we compared the results with those of direct examination with calcofluor white staining and BAL fluid galactomannan assays, when available. GMS staining in BAL fluid cytology was positive in 42% of the 67 cases and revealed coinfections in 7 cases. In contrast, only 2/67 (3.6%) BAL fluid samples were positive in direct smears stained with the fluorescent dye calcofluor white. Positive GMS staining results were significantly more frequent in IPA cases with cavitary lesions and IPA cases caused by >1
    MeSH term(s) Adult ; Aspergillus/isolation & purification ; Aspergillus/metabolism ; Bronchoalveolar Lavage Fluid/microbiology ; Fluorescent Dyes/metabolism ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/microbiology ; Humans ; Invasive Pulmonary Aspergillosis/complications ; Invasive Pulmonary Aspergillosis/diagnosis ; Invasive Pulmonary Aspergillosis/pathology ; Methenamine/metabolism ; Retrospective Studies ; Sensitivity and Specificity ; Staining and Labeling/methods
    Chemical Substances Fluorescent Dyes ; Methenamine (J50OIX95QV)
    Language English
    Publishing date 2018-09-25
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.00962-18
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    Zs.A 1188: Show issues Location:
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