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Article ; Online: Long COVID across SARS-CoV-2 variants, lineages, and sublineages.

Padilla, Sergio / Ledesma, Christian / García-Abellán, Javier / García, José Alberto / Fernández-González, Marta / de la Rica, Alba / Galiana, Antonio / Gutiérrez, Félix / Masiá, Mar

iScience

2024 Volume 27, Issue 4, Page(s) 109536

Abstract: This prospective study aimed to determine the prevalence of long COVID in patients hospitalized for SARS-CoV-2 infection from March 2020 to July 2022 and assess the impact of different viral lineages. A total of 2,524 patients were followed up for 12 ... ...

Abstract	This prospective study aimed to determine the prevalence of long COVID in patients hospitalized for SARS-CoV-2 infection from March 2020 to July 2022 and assess the impact of different viral lineages. A total of 2,524 patients were followed up for 12 months, with persistent symptoms reported in 35.2% at one month, decreasing thereafter. Omicron variant patients initially showed higher symptom intensity, but this trend diminished over time. Certain viral lineages, notably Delta lineages AY.126 and AY.43, and Omicron sublineages BA.1.17, BA.2.56, and BA.5.1, consistently correlated with more severe symptoms. Overall, long COVID prevalence and severity were similar across SARS-CoV-2 variants. Specific lineages may influence post-COVID sequelae persistence and severity.
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2024.109536
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Conference proceedings: Beeinflusst das Alter die Ergebnisse der Implantation einer intraokularen Collamer-Linse (V5 ICL) in einem myopen Kollektiv?

Pahlitzsch, Milena / Pahlitzsch, Marie-Luise / Fernandez-Gonzalez, Marta Julia / Pahlitzsch, Thomas

2022 , Page(s) WK 6.1

Event/congress	34. Internationaler Kongress der Deutschen Ophthalmochirurgen; Nürnberg; 2022
Keywords	Medizin, Gesundheit
Publishing date	2022-06-03
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/22doc066
Database	German Medical Science

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Article ; Online: Incidence of delayed asymptomatic COVID-19 recurrences in a 6-month longitudinal study.

Masiá, Mar / Padilla, Sergio / Galiana, Antonio / Fernández-González, Marta / Gutiérrez, Félix

The Journal of infection

2021 Volume 82, Issue 6, Page(s) 276–316

MeSH term(s)	COVID-19 ; Humans ; Incidence ; Longitudinal Studies ; Recurrence ; Reinfection ; SARS-CoV-2
Language	English
Publishing date	2021-03-29
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2021.03.020
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Article ; Online: Human Immunodeficiency Virus Type 1 RNA Levels in Rectal and Seminal Compartments After Switching to Long-Acting Cabotegravir Plus Rilpivirine: A Longitudinal Study.

Masiá, Mar / Fernández-González, Marta / Agulló, Vanesa / Mascarell, Paula / Padilla, Sergio / García-Abellán, Javier / Gutiérrez, Félix

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2022 Volume 76, Issue 3, Page(s) e748–e751

Abstract: Human immunodeficiency virus type 1 RNA levels were longitudinally evaluated in 211 rectal and 152 seminal samples from 12 virologically suppressed participants switching to monthly long-acting cabotegravir plus rilpivirine or continuing with daily ... ...

Abstract	Human immunodeficiency virus type 1 RNA levels were longitudinally evaluated in 211 rectal and 152 seminal samples from 12 virologically suppressed participants switching to monthly long-acting cabotegravir plus rilpivirine or continuing with daily dolutegravir-abacavir-lamivudine. Maintenance of viral suppression in rectal and seminal compartments was comparable, and blips occurred with similar frequency with both treatment regimens. Clinical trials registration: NCT02938520.
MeSH term(s)	Humans ; Anti-HIV Agents/therapeutic use ; Anti-Retroviral Agents/therapeutic use ; HIV Infections/drug therapy ; HIV-1/genetics ; Longitudinal Studies ; Rilpivirine/therapeutic use ; RNA/therapeutic use
Chemical Substances	Anti-HIV Agents ; Anti-Retroviral Agents ; cabotegravir (HMH0132Z1Q) ; Rilpivirine (FI96A8X663) ; RNA (63231-63-0)
Language	English
Publishing date	2022-08-16
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciac676
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Article ; Online: Sperm and testicular tissue cryopreservation and assisted reproductive technology outcomes in male cancer patients: a 15-year experience.

Fernández-González, Marta J / Radauer-Plank, Anne-Catherine / Stelzer, Cornelia / Geiger, Waldemar / Goranova, Irena / Borgmann-Staudt, Anja / Balcerek, Magdalena / Wilkemeyer, Ina

Journal of cancer research and clinical oncology

2022 Volume 149, Issue 8, Page(s) 5321–5330

Abstract: Objective: To explore the characteristics of cancer patients who cryopreserved sperm/testicular tissue samples in the Cryobank of Charité-Universitätsmedizin Berlin between 2004 and 2019, and the ART utilization rate with associated outcomes.: Methods! ...

Abstract	Objective: To explore the characteristics of cancer patients who cryopreserved sperm/testicular tissue samples in the Cryobank of Charité-Universitätsmedizin Berlin between 2004 and 2019, and the ART utilization rate with associated outcomes. Methods: Retrospective data were available for 506 cancer patients, of which 46 (9.1%) had used their samples for artificial reproductive technologies (ART). Corresponding cycle information was collected from external fertility centers. Results: Our cohort included 53/506 (10.5%) patients aged < 18 years at diagnosis. While adolescents and adults mainly banked sperm, adolescents showed higher rates of testicular tissue cryopreservation before (11.8%, 6/51 vs. 6.4%, 26/406) and after treatment (16.7%, 4/24 vs. 7.8%, 13/167). At study conduction, storage had been ended for 44.8% (269/601) of samples. The majority of samples used for ART were requested within the first 3 years after cryopreservation (71.5%, 28/39, range = 0-12 years). Pregnancy rate was 51.4% (19/37 cycles), resulting in 11 singleton births, 3 twin pairs, and 4 miscarriages. Conclusion: With the new advantage of public health insurance coverage of fertility preservation (FP) in Germany, an increased utilization has already been noticed in our center, emphasizing the necessity of further knowledge for individual counseling. Adolescent cancer patients need to be addressed specifically, as these patients show especially low cryopreservation rates.
MeSH term(s)	Adult ; Pregnancy ; Adolescent ; Female ; Humans ; Male ; Retrospective Studies ; Semen ; Reproductive Techniques, Assisted ; Cryopreservation ; Neoplasms/therapy ; Neoplasms/complications ; Spermatozoa
Language	English
Publishing date	2022-11-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-022-04488-y
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Article ; Online: Lack of detrimental effect of corticosteroids on antibody responses to SARS-CoV-2 and viral clearance in patients hospitalized with COVID-19.

Masiá, Mar / Fernández-González, Marta / García, José Alberto / Padilla, Sergio / Gutiérrez, Félix

The Journal of infection

2020 Volume 82, Issue 3, Page(s) 414–451

MeSH term(s)	Adrenal Cortex Hormones/adverse effects ; Antibodies, Viral ; Antibody Formation ; COVID-19 ; Humans ; SARS-CoV-2
Chemical Substances	Adrenal Cortex Hormones ; Antibodies, Viral
Keywords	covid19
Language	English
Publishing date	2020-10-25
Publishing country	England
Document type	Letter
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2020.10.018
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Article ; Online: Integrating SARS-CoV-2-specific interferon-γ release assay testing in the evaluation of patients hospitalized with COVID-19.

Masiá, Mar / de la Rica, Alba / Fernández-González, Marta / García, José Alberto / Padilla, Sergio / García-Abellán, Javier / Botella, Ángela / Mascarell, Paula / Gutiérrez, Félix

Microbiology spectrum

2023 Volume 11, Issue 6, Page(s) e0241923

Abstract: Importance: The cellular immune response is essential in the protection against severe disease in patients with established SARS-CoV-2 infection. The novelty of this study lies in the evaluation of the overall performance of a standardized assay to ... ...

Abstract	Importance: The cellular immune response is essential in the protection against severe disease in patients with established SARS-CoV-2 infection. The novelty of this study lies in the evaluation of the overall performance of a standardized assay to measure cellular immune response, the SARS-CoV-2-specific interferon-γ release assay (IGRA), in hospitalized patients with severe COVID-19. The SARS-CoV-2 IGRA was shown to accurately classify patients based on disease severity and prognosis, and the study revealed that test performance was not affected by the SARS-CoV-2 variant or control tube results. We identified an assay cut-off point with a high negative predictive value against mortality. The SARS-CoV-2 IGRA in patients hospitalized for COVID-19 may be a useful tool to assess cellular immunity and adopt targeted therapeutic and preventive measures.
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19/diagnosis ; Interferon-gamma Release Tests ; Immunity, Cellular ; Antibodies, Viral
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2023-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.02419-23
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Article ; Online: T-Cell Immunity Against Severe Acute Respiratory Syndrome Coronavirus 2 Measured by an Interferon-γ Release Assay Is Strongly Associated With Patient Outcomes in Vaccinated Persons Hospitalized With Delta or Omicron Variants.

Fernández-González, Marta / Agulló, Vanesa / García, José Alberto / Padilla, Sergio / García-Abellán, Javier / de la Rica, Alba / Mascarell, Paula / Masiá, Mar / Gutiérrez, Félix

The Journal of infectious diseases

2023 Volume 228, Issue 9, Page(s) 1240–1252

Abstract: Background: We measured T-cell and antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vaccinated patients hospitalized for coronavirus disease 2019 (COVID-19) and explored their potential value to predict outcomes.: ... ...

Abstract	Background: We measured T-cell and antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vaccinated patients hospitalized for coronavirus disease 2019 (COVID-19) and explored their potential value to predict outcomes. Methods: This was a prospective, longitudinal study including vaccinated patients hospitalized with Delta and Omicron SARS-CoV-2 variants. TrimericS-IgG antibodies and SARS-CoV-2 T-cell response were measured using a specific quantitative interferon-γ release assay (IGRA). Primary outcome was all-cause 28-day mortality or need for intensive care unit (ICU) admission. Cox models were used to assess associations with outcomes. Results: Of 181 individuals, 158 (87.3%) had detectable SARS-CoV-2 antibodies, 92 (50.8%) showed SARS-CoV-2-specific T-cell responses, and 87 (48.1%) had both responses. Patients who died within 28 days or were admitted to ICU were less likely to have both unspecific and specific T-cell responses in IGRA. In adjusted analyses (adjusted hazard ratio [95% confidence interval]), for the entire cohort, having both T-cell and antibody responses at admission (0.16 [.05-.58]) and Omicron variant (0.38 [.17-.87]) reduced the hazard of 28-day mortality or ICU admission, whereas higher Charlson comorbidity index score (1.27 [1.07-1.51]) and lower oxygen saturation to fraction of inspired oxygen ratio (2.36 [1.51-3.67]) increased the risk. Conclusions: Preexisting immunity against SARS-CoV-2 is strongly associated with patient outcomes in vaccinated individuals requiring hospital admission for COVID-19. Persons showing both T-cell and antibody responses have the lowest risk of severe outcomes.
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19/diagnosis ; Interferon-gamma Release Tests ; Longitudinal Studies ; Prospective Studies ; T-Lymphocytes
Language	English
Publishing date	2023-07-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiad260
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Article ; Online: The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors.

Borgmann-Staudt, Anja / Michael, Simon / Sommerhaeuser, Greta / Fernández-González, Marta-Julia / Friedrich, Lucía Alacán / Klco-Brosius, Stephanie / Kepak, Tomas / Kruseova, Jarmila / Michel, Gisela / Panasiuk, Anna / Schmidt, Sandrin / Lotz, Laura / Balcerek, Magdalena

Current oncology (Toronto, Ont.)

2022 Volume 29, Issue 8, Page(s) 5748–5762

Abstract: CCS often wish to have biological children yet harbour concerns about fertility impairment, pregnancy risks and the general health risks of prospective offspring. To clarify these concerns, health outcomes in survivor offspring born following ART (n = 74, ...

Abstract	CCS often wish to have biological children yet harbour concerns about fertility impairment, pregnancy risks and the general health risks of prospective offspring. To clarify these concerns, health outcomes in survivor offspring born following ART (n = 74, 4.5%) or after spontaneous conception (n = 1585) were assessed in our European offspring study by descriptive and bivariate analysis. Outcomes were compared to a sibling offspring cohort (n = 387) in a 4:1 matched-pair analysis (n = 1681). (i) Survivors were more likely to employ ART than their siblings (4.5% vs. 3.7%, p = 0.501). Successful pregnancies were achieved after a median of one cycle with, most commonly, intracytoplasmic sperm injection (ICSI) using non-cryopreserved oocytes/sperm. (ii) Multiple-sibling births (p < 0.001, 29.7% vs. 2.5%), low birth weight (p < 0.001; OR = 3.035, 95%-CI = 1.615−5.706), and preterm birth (p < 0.001; OR = 2.499, 95%-CI = 1.401−4.459) occurred significantly more often in survivor offspring following ART utilisation than in spontaneously conceived children. ART did not increase the prevalence of childhood cancer, congenital malformations or heart defects. (iii) These outcomes had similar prevalences in the sibling population. In our explorative study, we could not detect an influence on health outcomes when known confounders, such as multiple births, were taken into account.
MeSH term(s)	Cancer Survivors ; Child ; Female ; Humans ; Infant, Newborn ; Male ; Neoplasms/epidemiology ; Pregnancy ; Pregnancy Outcome ; Premature Birth/epidemiology ; Prospective Studies ; Reproductive Techniques, Assisted/adverse effects ; Semen
Language	English
Publishing date	2022-08-15
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol29080453
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Article ; Online: Robust long-term immunity to SARS-CoV-2 in patients recovered from severe COVID-19 after interleukin-6 blockade.

Masiá, Mar / Fernández-González, Marta / García, José Alberto / Padilla, Sergio / García-Abellán, Javier / Botella, Ángela / Mascarell, Paula / Agulló, Vanesa / Gutiérrez, Félix

EBioMedicine

2022 Volume 82, Page(s) 104153

Abstract: Background: Whether interleukin-6 (IL-6) blockade in patients with COVID-19 will affect the protective immunity against SARS-CoV-2 has become an important concern for anti-IL-6 therapy. We aimed to investigate the effects of IL-6 blockade on long-term ... ...

Abstract	Background: Whether interleukin-6 (IL-6) blockade in patients with COVID-19 will affect the protective immunity against SARS-CoV-2 has become an important concern for anti-IL-6 therapy. We aimed to investigate the effects of IL-6 blockade on long-term immunity to SARS-CoV-2. Methods: Prospective, longitudinal cohort study conducted in patients hospitalized for severe or critical COVID-19 with laboratory confirmed SARS-CoV-2 infection. We assessed humoral (anti-S1 domain of the spike [S], anti-nucleocapsid [N], anti-trimeric spike [TrimericS] IgG, and neutralizing antibodies [Nab]) and T-cell (interferon-γ release assay [IGRA]) responses and evaluated the incidence of reinfections over one year after infection in patients undergoing IL-6 blockade with tocilizumab and compared them with untreated subjects. Findings: From 150 adults admitted with confirmed SARS-CoV-2 infection, 78 were 1:1 propensity score-matched. Patients receiving anti-IL6 therapy showed a shorter time to S-IgG seropositivity and stronger S-IgG and N-IgG antibody responses. Among unvaccinated subjects one year after infection, median (Q1-Q3) levels of TrimericS-IgG (295 vs 121 BAU/mL; p = 0.011) and Nab (74.7 vs 41.0 %IH; p = 0.012) were higher in those undergoing anti-IL6 therapy, and a greater proportion of them had Nab (80.6% vs 57.7%; p = 0.028). T-cell immunity was also better in those treated with anti-IL6, with higher median (Q1-Q3) interferon-γ responses (1760 [702-3992] vs 542 [35-1716] mIU/mL; p = 0.013) and more patients showing positive T-cell responses in the IGRA one year after infection. Patients treated with anti-IL6 had fewer reinfections during follow-up and responded to vaccination with robust increase in both antibody and T-cell immunity. Interpretation: IL-6 blockade in patients with severe COVID-19 does not have deleterious effects on long-term immunity to SARS-CoV-2. The magnitude of both antibody and T-cell responses was stronger than the observed in non-anti-cytokine-treated patients with no increase in the risk of reinfections. Funding: Instituto de Salud Carlos-III (Spain).
MeSH term(s)	Adult ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19/drug therapy ; Humans ; Immunity, Humoral ; Immunoglobulin G ; Interleukin-6 ; Longitudinal Studies ; Prospective Studies ; Reinfection ; SARS-CoV-2
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin G ; Interleukin-6
Language	English
Publishing date	2022-07-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2022.104153
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