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  1. Article ; Online: Open clinical trial evaluating the efficacy of a novel eyelash growth enhancer with peptides and glycosaminoglycans.

    Fernandez-Gonzalez, Pablo / Truchuelo-Díez, Maria Teresa / Gómez-Sánchez, Maria José

    Journal of cosmetic dermatology

    2024  

    Abstract: Background: Eyelashes play a crucial role in self-image and ocular protection. Enhancements to their structure are of both cosmetic and clinical interest.: Aims: To assess the efficacy of a peptide and glycosaminoglycan-based eyelash enhancer serum ... ...

    Abstract Background: Eyelashes play a crucial role in self-image and ocular protection. Enhancements to their structure are of both cosmetic and clinical interest.
    Aims: To assess the efficacy of a peptide and glycosaminoglycan-based eyelash enhancer serum in improving eyelash structure.
    Patients/methods: This open-label clinical trial involved 30 females aged 25-65. Eyelashes were assessed at baseline (D0), 4 weeks (D28), and 12 weeks (D84) using specialized software and high-resolution imagery. Measurements included lash number, width, length, volume, arc, and angle.
    Results: At 12 weeks, significant increases were observed in lash length (+8.3%), number (+5%), width (+10.1%), volume (+14.1%), arc (+13.4%), and angle (+28.3%) compared to baseline. Global Eyelash Assessment (GEA) scores significantly improved, and patient treatment satisfaction increased from 73.34% at D28 to 84.33% at D84. No adverse effects were reported.
    Conclusions: The eyelash growth enhancer serum demonstrated significant efficacy in improving eyelash structure by Week 12, with early signs of improvement evident by Week 4. The high patient satisfaction levels underscore the perceived effectiveness of the product.
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.16265
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  2. Article ; Online: Visual Dermatology: A Rare Case of Habit-Tic Deformity in All Fingernails.

    Jimenez-Cauhe, Juan / Fernandez-Gonzalez, Pablo

    Journal of cutaneous medicine and surgery

    2020  Volume 24, Issue 6, Page(s) 637

    MeSH term(s) Fingers ; Habits ; Humans ; Nail Diseases/etiology ; Nails, Malformed/etiology ; Tic Disorders/complications ; Tics/complications
    Language English
    Publishing date 2020-06-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1361720-5
    ISSN 1615-7109 ; 1203-4754
    ISSN (online) 1615-7109
    ISSN 1203-4754
    DOI 10.1177/1203475420931777
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    Zs.A 4987: Show issues Location:
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  3. Article ; Online: Early and maintained application of the secretion of Cryptomphalus aspersa (SCA) 40% improves cutaneous healing after ablative fractional laser in skin aging.

    Fernandez-Gonzalez, Pablo / Vitale, Maria / Truchuelo, M Teresa

    Journal of cosmetic dermatology

    2020  Volume 20, Issue 4, Page(s) 1140–1145

    Abstract: Background: Ablative fractional laser generates a regulated skin damage, which secondarily improves skin aging.: Aims: The main objective of the present study was to figure out if the adverse effects induced by laser and the skin recovery could ... ...

    Abstract Background: Ablative fractional laser generates a regulated skin damage, which secondarily improves skin aging.
    Aims: The main objective of the present study was to figure out if the adverse effects induced by laser and the skin recovery could improve with the application of a cosmetic product based on the secretion of Cryptomphalus aspersa (SCA).
    Patients/methods: A prospective double-blind controlled study with vehicle in 10 patients with skin aging. The patients received one session of fractional ablative CO
    Results: Significant greater decrease in the density of microcolumns produced by laser was detected on the active-treated side, indicating greater and faster postprocedure recovery compared to the vehicle-treated side. In addition, side effects were reduced and some antiaging effects were more apparent on the side treated with SCA 40%.
    Conclusion: SCA 40% applied immediately after ablative laser, and during the next days, it can accelerate laser-induced damage regeneration. In addition, SCA improves the cosmetic outcome after laser application.
    MeSH term(s) Administration, Cutaneous ; Female ; Humans ; Laser Therapy ; Lasers, Gas/adverse effects ; Prospective Studies ; Skin ; Skin Aging
    Language English
    Publishing date 2020-09-24
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.13720
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  4. Article ; Online: The fungal-derived compound AM3 modulates pro-inflammatory cytokine production and skews the differentiation of human monocytes.

    Geckin, Büsra / Kilic, Gizem / Debisarun, Priya A / Föhse, Konstantin / Rodríguez-Luna, Azahara / Fernández-González, Pablo / Sánchez, Ana López / Domínguez-Andrés, Jorge

    Frontiers in immunology

    2023  Volume 14, Page(s) 1165683

    Abstract: The proper functioning of the immune system depends on an appropriate balance between pro-inflammation and anti-inflammation. When the balance is disrupted and the system is excessively biased towards inflammation, immune responses cannot return within ... ...

    Abstract The proper functioning of the immune system depends on an appropriate balance between pro-inflammation and anti-inflammation. When the balance is disrupted and the system is excessively biased towards inflammation, immune responses cannot return within the normal range, which favors the onset of diseases of autoimmune or inflammatory nature. In this scenario, it is fundamental to find new compounds that can help restore this balance and contribute to the normal functioning of the immune system in humans. Here, we show the properties of a fungal compound with a strong safety profile in humans, AM3, as an immunomodulatory molecule to decrease excessive cytokine production in human cells. Our results present that AM3 treatment of human peripheral blood mononuclear cells and monocytes decreased their pro-inflammatory cytokine secretion following the challenge with bacterial lipopolysaccharide. Additionally, AM3 skewed the differentiation profile of human monocytes to macrophages towards a non-inflammatory phenotype without inducing tolerance, meaning these cells kept their capacity to respond to different stimuli. These effects were similar in young and elderly individuals. Thus, the fungal compound, AM3 may help reduce excessive immune activation in inflammatory conditions and keep the immune responses within a normal homeostatic range, regardless of the age of the individual.
    MeSH term(s) Humans ; Aged ; Monocytes ; Leukocytes, Mononuclear ; Inflammation ; Cell Differentiation ; Cytokines
    Chemical Substances Immunoferon (87139-86-4) ; Cytokines
    Language English
    Publishing date 2023-10-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1165683
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Monkeypox Infection Mimicking Oral Primary Syphilis.

    Naharro-Rodríguez, Jorge / Selda-Enríquez, Gerald / García-Mouronte, Emilio / Pérez-González, Luis Alfonso / Teresa-Dianzo, Ileana / Fernández-González, Pablo

    Dermatology practical & conceptual

    2023  Volume 13, Issue 4

    Language English
    Publishing date 2023-10-01
    Publishing country Austria
    Document type Letter
    ZDB-ID 2685397-8
    ISSN 2160-9381
    ISSN 2160-9381
    DOI 10.5826/dpc.1304a222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pellagra linked to maize consumption in Gambo, Ethiopia: A call for awareness.

    Fernandez-Gonzalez, Pablo / Seijas-Pereda, Laura / Tefasmariam, Abraham / Balcha, Seble / Fernandez-Zarzoso, Miguel / Onoda, Mamiko / Quiles-Recuenco, Ana / Pérez-Tanoira, Ramón / Malmierca, Eduardo

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2024  

    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.19829
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    Zs.A 3492: Show issues Location:
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    Zs.MO 413: Show issues

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  7. Article: Case report: From monkeypox pharyngitis to myopericarditis and atypical skin lesions.

    Sanromán Guerrero, María Ascensión / Sánchez, Elena Hernández / Ruanes, Belén de Nicolás / Fernández-González, Pablo / Ugalde, Sonia Antoñana / Leal, Alejandra González / Fernández, Marcelo Sanmartín / Rodríguez, Jose Javier Alarcón / Martinez Garcia, Laura / Escudero, Rosa / Méndez, Maria Ángeles Fernández / Zamorano Gómez, Jose Luis / Llorente, Beatriz Montero / Vivancos-Gallego, Maria Jesús

    Frontiers in cardiovascular medicine

    2023  Volume 9, Page(s) 1046498

    Abstract: Background: A global outbreak of the human monkeypox virus (HMPXV), first identified in May 2022, was declared a health emergency of international concern on 23 July 2022. Before the global outbreak, monkeypox cases were mostly confined to central and ... ...

    Abstract Background: A global outbreak of the human monkeypox virus (HMPXV), first identified in May 2022, was declared a health emergency of international concern on 23 July 2022. Before the global outbreak, monkeypox cases were mostly confined to central and west African countries, where this virus is prevalent. Close contact, mainly sexual contact, is supposed to be the main route of transmission, and it is remarkable that the incidence is higher in men who have sexual relationships with other men.
    Case summary: A 40-year-old Caucasian man arrived at the emergency department complaining of oppressive epigastric pain extending to the chest after a diagnosis of pharyngitis, which was suspected to be caused by the human monkeypox virus. Based on the clinical symptoms, physical examination, serum cardiac biomarkers, and electrocardiographic findings, he was diagnosed with myopericarditis. The real-time PCR for human monkeypox in skin lesions, urine, plasma, and the oropharyngeal swab was positive. The peak of troponin I was 20.6 ng/ml, and the electrocardiogram showed an upward concavity in the ST segment in diffuse leads, which was in agreement with the previous diagnosis. The presence of edema, subepicardial, and myocardial late gadolinium enhancement, and increased values on T1 mapping in the cardiac MRI were in agreement with the diagnosis of myopericarditis. Antiviral treatment with tecovirimat was started with excellent tolerability. After 6 days, the patient recovered and was discharged.
    Discussion: To our knowledge, this is one of the first reported cases of myopericarditis due to human monkeypox infection, which was confirmed by a cardiac MRI following modified Lake Louise criteria. The short span between the onset of the mucocutaneous symptoms and the myocardial damage suggests a pathogenic association. Furthermore, the active viral replication in plasma samples and the negative results on real-time PCR for other viruses support this clinical association.
    Language English
    Publishing date 2023-01-05
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.1046498
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  8. Article ; Online: Immunomodulation with AM3 and antioxidants creates an adequate framework for skin repair and decreases the monocyte proinflammatory stage in smoker women.

    Jimenez-Gómez, Natalia / López-Suárez, Andrea / Haro, Sergio / Fernández-González, Pablo / Monserrat, Jorge / Eraña-Tomás, Itziar / Cuevas-Santos, Jesus / Rodríguez-Luna, Azahara / Ortega, Miguel A / Gómez-Sánchez, María José / Díaz, David / Jaén-Olasolo, Pedro / Álvarez-Mon, Melchor

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 170, Page(s) 115929

    Abstract: Smoking has been considering a crucial factor in promoting skin and systemic aging that is associated with the development of a low-level, systemic, chronic inflammation known as "inflammaging" in which monocytes play a pivotal role. Our aim was to ... ...

    Abstract Smoking has been considering a crucial factor in promoting skin and systemic aging that is associated with the development of a low-level, systemic, chronic inflammation known as "inflammaging" in which monocytes play a pivotal role. Our aim was to investigate the effects of AM3 plus antioxidants vs placebo in the activation status, function of monocytes and cutaneous aging parameters in healthy smoker middle-aged women. A total of 32 women were 1:1 randomly assigned to AM3 plus antioxidants or placebo for three months. Peripheral mononuclear blood cells and cutaneous biopsy were obtained and flow cytometry and immunohistological studies, respectively, were performed before and after the treatment. AM3 plus antioxidants treatment compared with placebo significantly reduced the monocyte production of the proinflammatory interleukin 1 (IL-1), tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) cytokines as well as increased the regulatory IL-10 in middle-aged smoker women. Furthermore, AM3 and antioxidants did not modify ROS production by monocytes and granulocytes but increased their phagocytic activity. The active combination also stimulated a significative increase in reticular dermis depth as well as an increase in the expression of CD117 and CD31. Thus, AM3 and antioxidants treatment reduces the systemic proinflammatory monocyte disturbance of heathy smoker middle-aged women and encourage skin repair mechanisms.
    MeSH term(s) Female ; Humans ; Middle Aged ; Antioxidants/pharmacology ; Cytokines ; Immunomodulation ; Interleukin-6 ; Monocytes ; Smokers ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Antioxidants ; Cytokines ; Immunoferon (87139-86-4) ; Interleukin-6 ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2023-12-08
    Publishing country France
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.115929
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  9. Article ; Online: Monkeypox virus infection with a syphilitic-roseola-like rash and its histopathologic characterization during 2022 outbreak.

    Berna-Rico, Emilio / Perna, Cristian / Azcarraga-Llobet, Carlos / Garcia-Mouronte, Emilio / de Nicolas-Ruanes, Belen / Melendez-Gispert, Maria Rosa / Vivancos, Maria J / Martinez-Garcia, Laura / Fernandez-Gonzalez, Pablo

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2022  Volume 37, Issue 3, Page(s) e400–e402

    MeSH term(s) Humans ; Monkeypox virus ; Mpox (monkeypox)/diagnosis ; Mpox (monkeypox)/epidemiology ; Mpox (monkeypox)/pathology ; Exanthema/epidemiology ; Disease Outbreaks
    Language English
    Publishing date 2022-11-05
    Publishing country England
    Document type Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.18708
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    Zs.A 3492: Show issues Location:
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    Zs.MO 413: Show issues

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  10. Article ; Online: Keratosis pilaris-like eruption induced by nilotinib.

    Jimenez-Cauhe, Juan / Fernandez-Gonzalez, Pablo / Ortega-Quijano, Daniel / Fernandez-Nieto, Diego / Saceda-Corralo, David

    Italian journal of dermatology and venereology

    2019  Volume 156, Issue Suppl. 1 to No. 6, Page(s) 47–48

    MeSH term(s) Abnormalities, Multiple ; Darier Disease/chemically induced ; Eyebrows/abnormalities ; Humans ; Pyrimidines/adverse effects
    Chemical Substances Pyrimidines ; nilotinib (F41401512X)
    Language English
    Publishing date 2019-07-12
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3065415-4
    ISSN 2784-8450
    ISSN (online) 2784-8450
    DOI 10.23736/S2784-8671.19.06333-8
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