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  1. Article ; Online: Research news in clinical context.

    Fernández-Huerta, Miguel / Solomon, Danielle / Tan, Rayner Kay Jin

    Sexually transmitted infections

    2021  Volume 97, Issue 6, Page(s) 395–396

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Ceftriaxone/therapeutic use ; Female ; Gonorrhea/complications ; Gonorrhea/drug therapy ; HIV/genetics ; HIV Infections/diagnosis ; HIV Infections/drug therapy ; Humans ; Male ; Neisseria gonorrhoeae/drug effects ; Pregnancy ; RNA, Viral/genetics
    Chemical Substances Anti-Bacterial Agents ; RNA, Viral ; Ceftriaxone (75J73V1629)
    Language English
    Publishing date 2021-08-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1420303-0
    ISSN 1472-3263 ; 1368-4973
    ISSN (online) 1472-3263
    ISSN 1368-4973
    DOI 10.1136/sextrans-2020-054858
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mycoplasma genitalium

    Fernández-Huerta, Miguel / Espasa, Mateu

    Sexually transmitted infections

    2019  Volume 95, Issue 5, Page(s) 391

    MeSH term(s) Adolescent ; Adult ; Anti-Bacterial Agents/pharmacology ; Asymptomatic Diseases/psychology ; Asymptomatic Diseases/therapy ; Chlamydia Infections/drug therapy ; Chlamydia Infections/microbiology ; Chlamydia trachomatis/drug effects ; Chlamydia trachomatis/physiology ; Coinfection/drug therapy ; Coinfection/microbiology ; Coinfection/psychology ; Drug Resistance, Bacterial ; Gonorrhea/drug therapy ; Gonorrhea/microbiology ; Gonorrhea/psychology ; Humans ; Macrolides/pharmacology ; Male ; Middle Aged ; Mycoplasma Infections/drug therapy ; Mycoplasma Infections/microbiology ; Mycoplasma Infections/psychology ; Mycoplasma genitalium/drug effects ; Mycoplasma genitalium/physiology ; Neisseria gonorrhoeae/drug effects ; Neisseria gonorrhoeae/physiology ; Retrospective Studies ; Sexual Partners ; Young Adult
    Chemical Substances Anti-Bacterial Agents ; Macrolides
    Language English
    Publishing date 2019-07-18
    Publishing country England
    Document type Letter
    ZDB-ID 1420303-0
    ISSN 1472-3263 ; 1368-4973
    ISSN (online) 1472-3263
    ISSN 1368-4973
    DOI 10.1136/sextrans-2018-053848
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prevalence of Respiratory Viral Infections in Deceased Persons during the COVID-19 Pandemic Season 2021-2022: A Population-Based Observational Study.

    Trobajo-Sanmartín, Camino / Navascués, Ana / Fernández-Huerta, Miguel / Martínez-Baz, Iván / Casado, Itziar / Ezpeleta, Carmen / Castilla, Jesús

    Viruses

    2024  Volume 16, Issue 4

    Abstract: Although the omicron variant of SARS-CoV-2 circulated intensely during the 2021-2022 season, many patients with severe acute respiratory disease tested negative for COVID-19. The aim of this study was to assess the presence of different respiratory ... ...

    Abstract Although the omicron variant of SARS-CoV-2 circulated intensely during the 2021-2022 season, many patients with severe acute respiratory disease tested negative for COVID-19. The aim of this study was to assess the presence of different respiratory viruses in deceased persons. The proportion of deceased persons with respiratory viral infections in the 2021-2022 season in Navarre, Spain, was estimated considering all deaths caused by confirmed COVID-19 according to the epidemiological surveillance and the results of multiplex PCR tests for respiratory viruses performed in a sample of deceased persons with a cause of death other than COVID-19. Of 3578 deaths, 324 (9.1%) were initially reported as caused by pre-mortem confirmed COVID-19. A sample of 242 persons who died by causes other than COVID-19 were tested post-mortem; 64 (26.4%) of them were positive for any respiratory virus: 11.2% for SARS-CoV-2, 5.8% for rhinovirus, 3.7% for human coronavirus, 2.5% for metapneumovirus, 1.7% for respiratory syncytial virus, 1.7% for parainfluenza, 1.2% for influenza, and less than 1% each for adenovirus and bocavirus. Combining both approaches, we estimated that 34.4% of all deceased persons during the study period had a respiratory viral infection and 19.2% had SARS-CoV-2. Only 33.3% (9/27) of SARS-CoV-2 and 5.0% (2/40) of other viruses detected post-mortem had previously been confirmed pre-mortem. In a period with very intense circulation of SARS-CoV-2 during the pandemic, other respiratory viruses were also frequently present in deceased persons. Some SARS-CoV-2 infections and most other viral infections were not diagnosed pre-mortem. Several respiratory viruses may contribute to excess mortality in winter.
    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19/mortality ; COVID-19/virology ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/virology ; Respiratory Tract Infections/mortality ; Spain/epidemiology ; Male ; Female ; Aged ; Middle Aged ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Aged, 80 and over ; Prevalence ; Adult ; Young Adult ; Seasons ; Adolescent ; Pandemics
    Language English
    Publishing date 2024-03-29
    Publishing country Switzerland
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16040533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Perspectives.

    Daskalopoulou, Marina / Fernández-Huerta, Miguel / Chung, Emily

    Sexually transmitted infections

    2020  Volume 96, Issue 5, Page(s) 318–319

    Language English
    Publishing date 2020-07-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1420303-0
    ISSN 1472-3263 ; 1368-4973
    ISSN (online) 1472-3263
    ISSN 1368-4973
    DOI 10.1136/sextrans-2019-054273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Research news in clinical context.

    Desai, Monica / Fernández-Huerta, Miguel / Daskalopoulou, Marina

    Sexually transmitted infections

    2020  Volume 96, Issue 2, Page(s) 157–158

    Language English
    Publishing date 2020-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1420303-0
    ISSN 1472-3263 ; 1368-4973
    ISSN (online) 1472-3263
    ISSN 1368-4973
    DOI 10.1136/sextrans-2019-054270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Hospitalisations and Deaths Averted by COVID-19 Vaccination in Navarre, Spain, 2021-2022.

    Martínez-Baz, Iván / Trobajo-Sanmartín, Camino / Miqueleiz, Ana / Egüés, Nerea / García Cenoz, Manuel / Casado, Itziar / Navascués, Ana / Fernández-Huerta, Miguel / Echeverría, Aitziber / Guevara, Marcela / Ezpeleta, Carmen / Castilla, Jesús

    Vaccines

    2024  Volume 12, Issue 1

    Abstract: In 2021-2022, most of the Spanish population received COVID-19 vaccines and a high proportion of them had SARS-CoV-2 infection. We estimated the rate of hospitalisations and deaths that were averted by risk reduction among vaccinated COVID-19 cases. ... ...

    Abstract In 2021-2022, most of the Spanish population received COVID-19 vaccines and a high proportion of them had SARS-CoV-2 infection. We estimated the rate of hospitalisations and deaths that were averted by risk reduction among vaccinated COVID-19 cases. Hospitalisations and deaths were analysed among COVID-19 cases confirmed in 2021 and 2022 in Navarre, Spain. To calculate the number of prevented outcomes by sex, age, comorbidities, and semester, the difference in the risk of each outcome between unvaccinated and vaccinated cases was multiplied by the number of vaccinated cases. COVID-19 vaccination coverage with any dose reached 88%, 86% with full vaccination, and 56% with a booster dose. The cumulative rates per 1000 inhabitants were 382 COVID-19 confirmed cases, 6.70 hospitalisations, and 1.15 deaths from COVID-19. The estimated rates of prevented events by vaccination were 16.33 hospitalisations and 3.39 deaths per 1000 inhabitants, which was 70.9% and 74.7% of expected events without vaccination, respectively. People aged 80 years and older or with major chronic conditions accounted for the majority of hospitalizations and deaths prevented by COVID-19 vaccination. One hospitalisation and death due to COVID-19 were averted for every 53 and 258 people vaccinated, respectively. The high COVID-19 vaccine effect in reducing the risk of severe outcomes and the high vaccination coverage in risk populations prevented three out of four hospitalisations and deaths due to COVID-19 during a period of intense circulation of SARS-CoV-2.
    Language English
    Publishing date 2024-01-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines12010058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Utility of a commercial RT-qPCR assay to detect SARS-CoV-2 gene variations as an indicator of lineages

    Trobajo-Sanmartín, Camino / Miqueleiz, Ana / Portillo, María Eugenia / Fernández-Huerta, Miguel / Navascués, Ana / Castilla, Jesús / Ezpeleta, Carmen

    Journal of Virological Methods. 2022 Feb., v. 300 p.114428-

    2022  

    Abstract: The World Health Organization (WHO) recommended RT-qPCR tests as the reference technique for SARS-CoV-2 molecular detection, however with the rapid spread of the infection, mutations in specific RT-qPCR target regions have been widely described could ... ...

    Abstract The World Health Organization (WHO) recommended RT-qPCR tests as the reference technique for SARS-CoV-2 molecular detection, however with the rapid spread of the infection, mutations in specific RT-qPCR target regions have been widely described could allow the presumptive identification. In this study, we evaluated the analytical performance of the Allplex™SARS-CoV-2/FluA/FluB/RSV assay for the additional presumptive identification of SARS-CoV-2 variants in a real-life setting. We observed gene-specific changes in the cycle threshold (Ct) of the N and RdRp genes compared with the Ct yielded for the S gene when the SARS-CoV-2 testing was performed Allplex™SARS-CoV-2/FluA/FluB/RSV assay. Seventeen samples showed Ct variations in the N and/or RdRp. In 10 cases, the N gene was affected, delayed or negative and in 14 cases, the RdRp gene showed a delay or negative concerning the S gene. A delay in the Ct of both genes (RdRp and N) was observed in six cases. Sequencing determined that all samples identified as B.1.1.7 showed changes in the PCR curves of the N and RdRp. However, samples identified as B.1.177 only showed variations for the RdRp gene. Allplex™SARS-CoV-2/FluA/FluB/RSV assay, the diagnosis could presumably allow the rapid assignment of lineages B.1.1.7 and B.1.177, and emphasizes the importance of exhaustive surveillance for circulating variants of the SARS-CoV-2 virus to reduce community transmission.
    Keywords Severe acute respiratory syndrome coronavirus 2 ; World Health Organization ; genes ; monitoring ; viruses ; SARS-CoV-2 ; RdRp gene ; N gene ; Variants
    Language English
    Dates of publication 2022-02
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 8013-5
    ISSN 1879-0984 ; 0166-0934
    ISSN (online) 1879-0984
    ISSN 0166-0934
    DOI 10.1016/j.jviromet.2021.114428
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Research news in clinical context.

    Ceccherini-Silberstein, Francesca / Fernández-Huerta, Miguel / Geretti, Anna Maria

    Sexually transmitted infections

    2020  Volume 96, Issue 7, Page(s) 471–472

    MeSH term(s) Biomedical Research/trends ; Gastrointestinal Microbiome ; Humans ; Mass Screening ; Sexually Transmitted Diseases/diagnosis ; Sexually Transmitted Diseases/drug therapy ; Sexually Transmitted Diseases/epidemiology ; Sexually Transmitted Diseases/prevention & control ; Vaccination
    Language English
    Publishing date 2020-10-19
    Publishing country England
    Document type News
    ZDB-ID 1420303-0
    ISSN 1472-3263 ; 1368-4973
    ISSN (online) 1472-3263
    ISSN 1368-4973
    DOI 10.1136/sextrans-2019-054275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Comment on: Lower mgpB diversity in macrolide-resistant Mycoplasma genitalium infecting men visiting two sexually transmitted infection clinics in Montpellier, France.

    Fernández-Huerta, Miguel / Serra-Pladevall, Judit / Pumarola, Tomàs / Pich, Oscar Q / Espasa, Mateu

    The Journal of antimicrobial chemotherapy

    2021  Volume 76, Issue 6, Page(s) 1649–1650

    Language English
    Publishing date 2021-03-03
    Publishing country England
    Document type Letter
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkab041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 124: Show issues

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  10. Article ; Online: Mycoplasma genitalium and fluoroquinolone resistance: From genotype to phenotype.

    Fernández-Huerta, Miguel / Serra-Pladevall, Judit / Esperalba, Juliana / Espasa, Mateu

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2019  Volume 38, Issue 1, Page(s) 44–45

    Title translation Mycoplasma genitalium y resistencia a fluoroquinolonas: del genotipo al fenotipo.
    MeSH term(s) Anti-Bacterial Agents ; Drug Resistance, Bacterial ; Fluoroquinolones ; Genotype ; Humans ; Macrolides ; Mutation/drug effects ; Mycoplasma Infections ; Mycoplasma genitalium/drug effects ; Phenotype
    Chemical Substances Anti-Bacterial Agents ; Fluoroquinolones ; Macrolides
    Language Spanish
    Publishing date 2019-05-20
    Document type Letter ; Comment
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimc.2019.04.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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