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Article ; Online: Understanding the Cellular Sources of the Fractional Exhaled Nitric Oxide (FeNO) and Its Role as a Biomarker of Type 2 Inflammation in Asthma.

Escamilla-Gil, Jose M / Fernandez-Nieto, Mar / Acevedo, Nathalie

2022 Volume 2022, Page(s) 5753524

Abstract: Fractional exhaled nitric oxide (FeNO) has gained great clinical importance as a biomarker of type 2 inflammation in chronic airway diseases such as asthma. FeNO originates primarily in the bronchial epithelium and is produced in large quantities by the ... ...

Abstract	Fractional exhaled nitric oxide (FeNO) has gained great clinical importance as a biomarker of type 2 inflammation in chronic airway diseases such as asthma. FeNO originates primarily in the bronchial epithelium and is produced in large quantities by the enzyme inducible nitric oxide synthase (iNOS). It should be noted that nitric oxide (NO) produced at femtomolar to picomolar levels is fundamental for respiratory physiology. This basal production is induced in the bronchial epithelium by interferon gamma (IFN
MeSH term(s)	Asthma/drug therapy ; Biomarkers/metabolism ; Breath Tests ; Exhalation ; Fractional Exhaled Nitric Oxide Testing ; Humans ; Inflammation ; Nitric Oxide/metabolism
Chemical Substances	Biomarkers ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2022-05-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2022/5753524
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Article ; Online: Moderate-High Blood Eosinophilia Is Associated with Increased Hospitalization and Other Asthma Comorbidities.

Naharro-González, Sara / Lorente-Sorolla, Clara / Rodrigo-Muñoz, José Manuel / Valverde-Monge, Marcela / Pinillos-Robles, Erwin Javier / Betancor, Diana / Fernández-Nieto, Mar / Sánchez-Mellado, Diana / Gil-Martínez, Marta / Santillán-Coello, Jessica Mireya / Villacampa-Aubá, José Miguel / Mahillo-Fernandez, Ignacio / Herrero-González, Antonio / Perez-González, Alejandro / Rodríguez-Nieto, María Jesús / Del Pozo, Victoria

Biomolecules

2024 Volume 14, Issue 1

Abstract: 1) Background: Eosinophilia has traditionally been linked to eosinophilic asthma, for which it is the gold-standard prognostic biomarker. However, the association between eosinophilia and the presence of other diseases and comorbidities is yet unclear. ( ...

Abstract	(1) Background: Eosinophilia has traditionally been linked to eosinophilic asthma, for which it is the gold-standard prognostic biomarker. However, the association between eosinophilia and the presence of other diseases and comorbidities is yet unclear. (2) Methods: For this retrospective study, we reviewed the electronic medical records of 49,909 subjects with blood eosinophilia to gather data on the presence of asthma, COPD, sleep apnea, tuberculosis, dyslipidemia, hypertension, and other cardiovascular diseases and severe CRSwNP among these subjects. Demographic features including age, sex, and smoking habits were collected, as well as the number of hospitalizations and emergency department visits. T-tests, ANOVA, Fisher test, and logistic regression models were used. (3) Results: For all age groups studied, eosinophilia was significantly more prevalent among asthmatic subjects than nonasthmatics, especially in patients also presenting CRSwNP, hypertension, and dyslipidemia. The likelihood of developing asthma, COPD, and CRSwNP, and hospitalization, was increased when BEC was above 600 eosinophils/μL. The association between asthma, CRSwNP, and BEC was corroborated by multiple logistic regressions models. (4) Conclusions: We demonstrated the association of having over 600 blood eosinophils/μL with a higher number of hospitalizations and comorbidities (CRSwNP and COPD), which proves that BEC is a highly useful parameter to consider in subjects who present blood eosinophilia.
MeSH term(s)	Humans ; Animals ; Retrospective Studies ; Asthma/complications ; Asthma/epidemiology ; Hypertension ; Hospitalization ; Mustelidae ; Pulmonary Eosinophilia ; Dyslipidemias/epidemiology ; Pulmonary Disease, Chronic Obstructive/epidemiology
Language	English
Publishing date	2024-01-18
Publishing country	Switzerland
Document type	Review ; Journal Article
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom14010126
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Article: Shared Decision-Making in Allergen Immunotherapy (AIT) Options Using a Questionnaire for Respiratory Allergic Patients: A Delphi Consensus Study.

Antón, Mónica / Cabañes, Nieves / Fernández-Meléndez, Salvador / Fernández-Nieto, Mar / Jiménez-Ferrera, Gloria / Letrán, Antonio / Méndez-Brea, Paula / Montoro, Javier / Moreno, Francisco / Mur-Gimeno, Pilar / Rodríguez-Vázquez, Virginia / Rosado, Ana / Sánchez-Guerrero, Inmaculada / Vega-Chicote, Jose Mª / Vidal, Carmen

Patient preference and adherence

2023 Volume 17, Page(s) 1771–1782

Abstract: Purpose: The objective of this study was to develop and validate a questionnaire, through a Delphi consensus, to be used by allergists in their routine clinical practice to assess the preferences of patients starting allergen immunotherapy (AIT) ... ...

Abstract	Purpose: The objective of this study was to develop and validate a questionnaire, through a Delphi consensus, to be used by allergists in their routine clinical practice to assess the preferences of patients starting allergen immunotherapy (AIT) treatment using an objective approach. Patients and methods: A Delphi consensus-driven process was used. The scientific committee, composed of 15 allergists, led the study and participated in the preparation of the questionnaire. Two-hundred panelists from different Spanish regions were invited to complete a 16-item questionnaire on a nine-point Likert scale covering six topic blocks. Consensus was achieved if ≥66.6% of panelists reached agreement or disagreement. Results: Of the 200 experts invited to participate in the Delphi process, a total of 195 (97.5%) answered the questionnaire. The panel experts reached a consensus on "agreement" on a total of 12 of the 16 (75.0%) items, covering a total of six categories: (a) patient knowledge (2 questions), (b) barriers to patient adherence (3 questions), (c) patient behavior (4 questions), (d) future actions (3 questions), (e) treatment costs (2 questions), and (f) final patient preferences (2 questions). Conclusion: This Delphi consensus study validated a set of twelve recommended questions for patients objectively assessing their preferences and suitability for the most common AIT options available. The questionnaire intends to assist allergists in making an objective, unconditioned decision regarding the best AIT option for each patient, after informing them about the different routes.
Language	English
Publishing date	2023-07-24
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2455848-5
ISSN	1177-889X
ISSN	1177-889X
DOI	10.2147/PPA.S409466
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Article ; Online: Comparison of impulse oscillometry and spirometry for detection of airway hyperresponsiveness to methacholine, mannitol, and eucapnic voluntary hyperventilation in children.

Jara-Gutierrez, Pamela / Aguado, Erika / Del Potro, Manuela García / Fernandez-Nieto, Mar / Mahillo, Ignacio / Sastre, Joaquin

Pediatric pulmonology

2019 Volume 54, Issue 8, Page(s) 1162–1172

Abstract: Background: Forced expiratory maneuvers are usually difficult in young children. Impulse oscillometry (IOS) requires no active cooperation, is noninvasive, rapid, and easy to perform. This study aimed to compare IOS indexes and forced expiratory volume ... ...

Abstract	Background: Forced expiratory maneuvers are usually difficult in young children. Impulse oscillometry (IOS) requires no active cooperation, is noninvasive, rapid, and easy to perform. This study aimed to compare IOS indexes and forced expiratory volume in 1 second (FEV1) in children for the assessment of bronchial hyperreactivity to methacholine, mannitol, and eucapnic voluntary hyperventilation (EVH). Materials: Children aged 3-14 years (mean 10.0 ± 3.1) with symptoms suggestive of asthma were recruited. IOS measurements were taken before spirometry. Methacholine, mannitol, and EVH tests were performed without a specific order. Results: We included 190 children, whose mean age was 10.0 ± 3.1 years. Changes in FEV1 correlated significantly with variation in IOS indexes (P < .05). The indexes with the greatest discriminative capacity were Z5, R5, and X5. Optimal cut-offs were: for methacholine tests, ≧22% in R5, ≧82% for reactance area (AX), and ≦41% for X5; for the mannitol test, ≧18% in R5, ≧40% in AX, and ≦21% for X5. In the EVH test, ≧23% for R5, ≧40% for AX, and a fall of 29% for X5. When using the optimal cut-off points obtained from IOS, the mean number of steps and doses required for methacholine and mannitol tests to induce significant bronchoconstriction were significantly lower compared with spirometry ( P < .05). Conclusions: The effectiveness of R5, X5, and AX indexes were comparable to FEV1 in assessing bronchial obstruction during bronchial challenge testing. Therefore, IOS may be useful in assessing bronchial obstruction in children who cannot reliably perform spirometric maneuvers during bronchial challenge testing.
MeSH term(s)	Adolescent ; Bronchial Diseases/diagnosis ; Bronchial Diseases/physiopathology ; Bronchial Provocation Tests ; Child ; Child, Preschool ; Female ; Forced Expiratory Volume ; Humans ; Hyperventilation/diagnosis ; Male ; Mannitol/administration & dosage ; Methacholine Chloride/administration & dosage ; Oscillometry ; Respiratory Hypersensitivity/diagnosis ; Respiratory Hypersensitivity/physiopathology ; Spirometry
Chemical Substances	Methacholine Chloride (0W5ETF9M2K) ; Mannitol (3OWL53L36A)
Language	English
Publishing date	2019-06-18
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.24409
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Article ; Online: Jellyfish collagen: A new allergen in the beach.

Cañas, José Antonio / Rodrigo-Muñoz, José Manuel / Rondon-Cepeda, Stalyn Humberto / Bordehore, Cesar / Fernández-Nieto, Mar / Del Pozo, Victoria

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

2018 Volume 120, Issue 4, Page(s) 430–431

MeSH term(s)	Aged ; Allergens/immunology ; Animals ; Bites and Stings/complications ; Collagen/immunology ; Humans ; Hypersensitivity, Immediate/diagnosis ; Hypersensitivity, Immediate/etiology ; Hypersensitivity, Immediate/immunology ; Immunoglobulin E/blood ; Male ; Scyphozoa/immunology
Chemical Substances	Allergens ; Immunoglobulin E (37341-29-0) ; Collagen (9007-34-5)
Language	English
Publishing date	2018-02-02
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1228189-x
ISSN	1534-4436 ; 0003-4738 ; 1081-1206
ISSN (online)	1534-4436
ISSN	0003-4738 ; 1081-1206
DOI	10.1016/j.anai.2018.01.018
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Article: Serum microRNAs as Tool to Predict Early Response to Benralizumab in Severe Eosinophilic Asthma.

Cañas, José A / Valverde-Monge, Marcela / Rodrigo-Muñoz, José M / Sastre, Beatriz / Gil-Martínez, Marta / García-Latorre, Raquel / Rial, Manuel J / Gómez-Cardeñosa, Aida / Fernández-Nieto, Mar / Pinillos-Robles, Erwin J / Rodríguez-Nieto, María J / González-Mangado, Nicolás / Sastre, Joaquín / Pozo, Victoria Del

Journal of personalized medicine

2021 Volume 11, Issue 2

Abstract: Severe eosinophilic asthma poses a serious health and economic problem, so new therapy approaches have been developed to control it, including biological drugs such as benralizumab, which is a monoclonal antibody that binds to IL-5 receptor alpha subunit ...

Abstract	Severe eosinophilic asthma poses a serious health and economic problem, so new therapy approaches have been developed to control it, including biological drugs such as benralizumab, which is a monoclonal antibody that binds to IL-5 receptor alpha subunit and depletes peripheral blood eosinophils rapidly. Biomarkers that predict the response to this drug are needed so that microRNAs (miRNAs) can be useful tools. This study was performed with fifteen severe eosinophilic asthmatic patients treated with benralizumab, and serum miRNAs were evaluated before and after treatment by semi-quantitative PCR (qPCR). Patients showed a clinical improvement after benralizumab administration. Additionally, deregulation of miR-1246, miR-5100 and miR-338-3p was observed in severe asthmatic patients after eight weeks of therapy, and a correlation was found between miR-1246 and eosinophil counts, including a number of exacerbations per year in these severe asthmatics. In silico pathway analysis revealed that these three miRNAs are regulators of the MAPK signaling pathway, regulating target genes implicated in asthma such as
Language	English
Publishing date	2021-01-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm11020076
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Article ; Online: New developments in work-related asthma.

Quirce, Santiago / Campo, Paloma / Domínguez-Ortega, Javier / Fernández-Nieto, Mar / Gómez-Torrijos, Elisa / Martínez-Arcediano, Ana / Mur, Pilar / Delgado, Julio

Expert review of clinical immunology

2017 Volume 13, Issue 3, Page(s) 271–281

Abstract: Introduction: Work-related asthma includes two subtypes: occupational asthma or asthma caused by specific agents (sensitizers or irritants) in the workplace, and work-exacerbated asthma or pre-existing asthma worsened by workplace exposures. Areas ... ...

Abstract	Introduction: Work-related asthma includes two subtypes: occupational asthma or asthma caused by specific agents (sensitizers or irritants) in the workplace, and work-exacerbated asthma or pre-existing asthma worsened by workplace exposures. Areas covered: This review provides an update on the definitions and the clinical features of the different work-related asthma subtypes as well as new insights into their etiology and the pathophysiological mechanisms involved. The diagnosis of work-related asthma should be made on objective basis using a constellation of clinical, physiologic and allergologic tests. Specific inhalation challenge with the suspected occupational agent(s) remains as the reference standard for diagnosis. A literature search was performed using the following terms: work-related asthma, occupational asthma, work-exacerbated asthma, irritant-induced asthma and etiological agents. Expert commentary: Studies focusing on the biological effects and mechanisms of environmental exposures in the development of sensitizer-induced or irritant-induced asthma in various workplace settings are of greatest interest. An integrative approach that combines clinical parameters with component-resolved diagnosis as well as inflammatory biomarkers appears to be very promising. Occupational allergy provides a good opportunity to understand the complex relationships between exposure to allergens in the workplace, interaction with genes and the co-exposures to other factors in the working environment.
MeSH term(s)	Allergens/immunology ; Animals ; Asthma, Occupational/diagnosis ; Biomarkers/metabolism ; Bronchial Provocation Tests ; Dermatitis, Allergic Contact/diagnosis ; Humans ; Inflammation Mediators/metabolism ; Irritants/immunology ; Occupational Exposure/adverse effects
Chemical Substances	Allergens ; Biomarkers ; Inflammation Mediators ; Irritants
Language	English
Publishing date	2017-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2274260-8
ISSN	1744-8409 ; 1744-666X
ISSN (online)	1744-8409
ISSN	1744-666X
DOI	10.1080/1744666X.2017.1239529
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Article ; Online: Medical and economic impact of misdiagnosis of drug hypersensitivity in hospitalized patients.

Sastre, Joaquín / Manso, Luis / Sanchez-García, Silvia / Fernández-Nieto, Mar

The Journal of allergy and clinical immunology

2012 Volume 129, Issue 2, Page(s) 566–567

MeSH term(s)	Anti-Bacterial Agents/adverse effects ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Contrast Media/adverse effects ; Diagnostic Errors/economics ; Diagnostic Errors/statistics & numerical data ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/economics ; Female ; Hospitals, University/economics ; Hospitals, University/statistics & numerical data ; Humans ; Male ; Skin Tests
Chemical Substances	Anti-Bacterial Agents ; Anti-Inflammatory Agents, Non-Steroidal ; Contrast Media
Language	English
Publishing date	2012-02
Publishing country	United States
Document type	Letter
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2011.09.028
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Article ; Online: Asthma induced by a thermal printer.

Sánchez-Garcia, Silvia / Fernández-Nieto, Mar / Sastre, Joaquín

The New England journal of medicine

2009 Volume 360, Issue 22, Page(s) 2375–2376

MeSH term(s)	Acrylates/adverse effects ; Asthma/etiology ; Computer Peripherals ; Female ; Forced Expiratory Volume ; Humans ; Middle Aged ; Occupational Diseases/etiology ; Printing/instrumentation
Chemical Substances	Acrylates ; trimethylolpropane triacrylate (4B67KGL96S)
Language	English
Publishing date	2009-05-28
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc0901008
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Article ; Online: Acute generalized exanthematic pustulosis due to ibuprofen.

Arochena, Lourdes / Zafra, María Paz / Fariña, Ma Carmen / Del Pozo, Victoria / Fernández-Nieto, Mar

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

2013 Volume 110, Issue 5, Page(s) 386–387

MeSH term(s)	Acute Generalized Exanthematous Pustulosis/chemically induced ; Acute Generalized Exanthematous Pustulosis/immunology ; Analgesics, Non-Narcotic/adverse effects ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Basophils/immunology ; Drug Eruptions/etiology ; Drug Eruptions/immunology ; Humans ; Ibuprofen/adverse effects ; Male ; Middle Aged
Chemical Substances	Analgesics, Non-Narcotic ; Anti-Inflammatory Agents, Non-Steroidal ; Ibuprofen (WK2XYI10QM)
Language	English
Publishing date	2013-05
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	1228189-x
ISSN	1534-4436 ; 0003-4738 ; 1081-1206
ISSN (online)	1534-4436
ISSN	0003-4738 ; 1081-1206
DOI	10.1016/j.anai.2013.01.020
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