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  1. Article ; Online: The mediating role of reflective functioning in the association between childhood trauma and suicide attempt.

    Andreo-Jover, J / Curto Ramos, J / Bobes, J / Bravo-Ortiz, M / Cebria, A I / Crespo-Facorro, B / De la Torre-Luque, A / Díaz-Marsa, M / Fernández-Rodrigues, V / Garrido-Torres, N / Grande, I / López Peña, M P / Pemau, A / Roberto, N / Ruiz-Veguilla, M / Saiz, P / Rodríguez-Vega, B / Pérez-Sola, V

    Journal of psychiatric research

    2024  Volume 171, Page(s) 30–37

    Abstract: Background: Childhood trauma is intimately related with suicidal behaviour. Patients who have suffered childhood trauma develop impaired Reflective Functioning (RF), which refers to the capacity to understand ourselves and others in terms of intentional ...

    Abstract Background: Childhood trauma is intimately related with suicidal behaviour. Patients who have suffered childhood trauma develop impaired Reflective Functioning (RF), which refers to the capacity to understand ourselves and others in terms of intentional mental states. An improvement in RF has been associated with a reduction in suicidal attempts, but the mediating role of RF between childhood trauma and suicidal behaviour has not been addressed so far.
    Objective: We aim to examine the potential mediating effect of RF among childhood trauma and suicide attempts.
    Method: We included 748 patients who had attempted suicide at least once. They were asked to complete the Reflective Functioning Questionnaire (RFQ-8), the Columbia-Suicide Severity Rating scale (CSSRS), and the Childhood Trauma Questionnaire-Short Form (CTQ-SF). We conducted linear regressions by simple mediating model to examine the role of RF in the indirect association between childhood trauma and the number of suicide attempts.
    Results: Our results show significant indirect effects through hypo and hypermentalizing between Emotional Abuse (EA) and Sexual Abuse (SA) in childhood and the number of suicide attempts in lifetime. These results indicate that ineffective RF significantly mediates the association between childhood trauma and suicidality.
    Conclusion: This is the first study supporting the mediational role of RF in the relationship between EA and SA, and the number of suicide attempt in lifetime. These findings have important implications for reducing suicide rates and preventing future re-attempts. Further studies analysing this mediating role and focusing efforts on increasing RF-based interventions are required.
    MeSH term(s) Humans ; Suicide, Attempted ; Adverse Childhood Experiences ; Self Report ; Suicidal Ideation ; Risk Factors ; Psychological Tests
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 3148-3
    ISSN 1879-1379 ; 0022-3956
    ISSN (online) 1879-1379
    ISSN 0022-3956
    DOI 10.1016/j.jpsychires.2024.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Suicide mortality in a Spanish police force: The case of the civil guard.

    Garcia-Ramos, Adriana / Gonzalez-Weiss, Rogelio / Lopez, Daniel J / Perez-Diez, Ivan / Fernandez-Rodrigues, Veronica / Torre-Luque, Alejandro de la

    Spanish journal of psychiatry and mental health

    2023  Volume 16, Issue 2, Page(s) 131–132

    MeSH term(s) Humans ; Police ; Suicide ; Suicide Prevention
    Language English
    Publishing date 2023-01-21
    Publishing country Spain
    Document type Case Reports
    ISSN 2950-2853
    ISSN (online) 2950-2853
    DOI 10.1016/j.rpsm.2023.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Neurocognitive profile associated with borderline personality disorder: building specific indices of executive function.

    Lopez-Villatoro, Jose Manuel / Diaz-Marsá, Marina / Rico-Perez, Ana / Fernandez-Rodrigues, Veronica / Ayad-Ahmed, Wala / Galvez-Merlin, Alejandra / Carrasco, Jose Luis

    Actas espanolas de psiquiatria

    2023  Volume 51, Issue 5, Page(s) 220–228

    Abstract: The objective of this work is the creation of specific indices of the different executive functions (EF). ...

    Abstract The objective of this work is the creation of specific indices of the different executive functions (EF).
    MeSH term(s) Humans ; Borderline Personality Disorder/complications ; Executive Function
    Language English
    Publishing date 2023-09-01
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1480971-0
    ISSN 1578-2735 ; 1575-071X ; 1139-9287
    ISSN (online) 1578-2735
    ISSN 1575-071X ; 1139-9287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Inflammatory profiles in women with eating disorder: Linking inflammatory biomarkers to clinical phenotypes.

    Díaz-Marsá, Marina / Ayad-Ahmed, Wala / López-Villatoro, José Manuel / Fernández-Rodrigues, Verónica / Ruiz-Guerrero, Francisco / Gómez Del Barrio, Andrés / Beato-Fernández, Luis / Polo-Montes, Filomena / León-Velasco, Magdalena / Torre-Luque, Alejandro de la / Carrasco, José Luis / Caso, Javier R / MacDowell, Karina S / Leza, Juan C

    Psychoneuroendocrinology

    2024  Volume 162, Page(s) 106956

    Abstract: Introduction: Eating disorders (ED) represent a group of very complex and serious diagnoses characterized by emotional dysregulation and impulsivity. New approaches are necessary to achieve effective diagnosis and treatments. Shifting biomarker research ...

    Abstract Introduction: Eating disorders (ED) represent a group of very complex and serious diagnoses characterized by emotional dysregulation and impulsivity. New approaches are necessary to achieve effective diagnosis and treatments. Shifting biomarker research away from the constraints of diagnostic categories may effectively contribute to a dimensional differentiation across disorders according to neurobiology (e.g., inflammatory biomarkers). Thus, the aim of our study was to identify inflammatory profiles in patients with ED.
    Methods: A sample of 100 women with an ED (23.4 ± 8.55 years) and 59 healthy controls (HC) (20.22 ± 4.18 years) was used. K-means cluster analysis was followed to identify inflammatory clusters considering seven blood biomarkers (iNOS, TNFα, COX2, p38, ERK, TBARS and PPARγ). Moreover, a wide assessment of clinical features was conducted.
    Results: Two distinct clusters were identified. Cluster 1 patients were characterized by higher inflammatory levels of TNF-α, COX2, p38, and ERK, and had more restrictive anorexia diagnosis than cluster 2. Cluster 2 participants showed higher inflammatory levels of iNOS and were older than cluster 1 and controls and had lower BMI than HC. In addition, they had higher levels of bulimic symptoms than those from the cluster 1 and HC, and higher impulsivity than HC. All ED patients (regardless of cluster) showed higher ED symptoms and more trauma than HC.
    Conclusions: Our study revealed that inflammatory dysfunction may be linked with clinical endophenotypes in ED, one more restrictive (cluster 1) with an inflammation/oxidative endophenotype more cytokine and MAPK/ERK mediated, and the other more impulsive, with more bulimic symptoms (cluster 2) with NO free radical high output source iNOS. Trauma seems to be a vulnerability factor for both endophenotypes.
    MeSH term(s) Humans ; Female ; Bulimia/diagnosis ; Bulimia/psychology ; Cyclooxygenase 2 ; Feeding and Eating Disorders ; Biomarkers ; Phenotype
    Chemical Substances Cyclooxygenase 2 (EC 1.14.99.1) ; Biomarkers
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 197636-9
    ISSN 1873-3360 ; 0306-4530
    ISSN (online) 1873-3360
    ISSN 0306-4530
    DOI 10.1016/j.psyneuen.2023.106956
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Risk factors for suicidal behaviour in late-life depression: A systematic review.

    Fernandez-Rodrigues, Veronica / Sanchez-Carro, Yolanda / Lagunas, Luisa Natalia / Rico-Uribe, Laura Alejandra / Pemau, Andres / Diaz-Carracedo, Patricia / Diaz-Marsa, Marina / Hervas, Gonzalo / de la Torre-Luque, Alejandro

    World journal of psychiatry

    2022  Volume 12, Issue 1, Page(s) 187–203

    Abstract: Background: Suicide is a leading cause of preventable death worldwide, with its peak of maximum incidence in later life. Depression often puts an individual at higher risk for suicidal behaviour. In turn, depression deserves particular interest in old ... ...

    Abstract Background: Suicide is a leading cause of preventable death worldwide, with its peak of maximum incidence in later life. Depression often puts an individual at higher risk for suicidal behaviour. In turn, depression deserves particular interest in old age due to its high prevalence and dramatic impact on health and wellbeing.
    Aim: To gather integrated evidence on the potential risk factors for suicide behaviour development in depressive older adults, and to examine the effects of depression treatment to tackle suicide behaviour in this population.
    Methods: A systematic review of empirical studies, published from 2000 onwards, was conducted. Suicidal behaviour was addressed considering its varying forms (
    Results: Thirty-five papers were selected for review, comprising both clinical and epidemiological studies. Most of studies focused on suicidal ideation (60%). The studies consistently pointed out that the risk was related to depressive episode severity, psychiatric comorbidity (anxiety or substance use disorders), poorer health status, and loss of functionality. Reduced social support and loneliness were also associated with suicide behaviour in depressive older adults. Finally, the intervention studies showed that suicidal behaviour was a robust predictor of depression treatment response. Reductions in suicidal ideation were moderated by reductions in risk factors for suicide symptoms.
    Conclusion: To sum up, common and age-specific risk factors seem to be involved in suicide development in depressive older adults. A major effort should be made to tackle this serious public health concern so as to promote older people to age healthily and well.
    Language English
    Publishing date 2022-01-19
    Publishing country United States
    Document type Journal Article
    ISSN 2220-3206
    ISSN 2220-3206
    DOI 10.5498/wjp.v12.i1.187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Psychiatric profiles in suicidal attempters: Relationships with suicide behaviour features.

    Sánchez-Carro, Yolanda / de la Torre-Luque, Alejandro / Díaz-Marsá, Marina / Aguayo-Estremera, Raimundo / Andreo-Jover, Jorge / Ayad-Ahmed, Wala / Bobes, Julio / Bobes-Bascarán, Teresa / Bravo-Ortiz, María Fé / Canal-Rivero, Manuel / Cebrià, Ana Isabel / Crespo-Facorro, Benedicto / Elices, Matilde / Fernández-Rodrigues, Verónica / Lopez-Peña, Purificacion / Grande, Iría / Palao-Tarrero, Ángela / Pemau, Andrés / Roberto, Natalia /
    Ruiz-Veguilla, Miguel / Pérez-Solà, Víctor

    Spanish journal of psychiatry and mental health

    2024  

    Abstract: Background: Suicide constitutes a major health concern worldwide, being a significant contributor of death, globally. The diagnosis of a mental disorder has been extensively linked to the varying forms of suicidal ideation and behaviour. The aim of our ... ...

    Abstract Background: Suicide constitutes a major health concern worldwide, being a significant contributor of death, globally. The diagnosis of a mental disorder has been extensively linked to the varying forms of suicidal ideation and behaviour. The aim of our study was to identify the varying diagnostic profiles in a sample of suicide attempters.
    Methods: A sample of 683 adults (71.3% females, 40.10±15.74 years) admitted at a hospital emergency department due to a suicide attempt was recruited. Latent class analysis was used to identify diagnostic profiles and logistic regression to study the relationship between comorbidity profile membership and sociodemographic and clinical variables.
    Results: Two comorbidity profiles were identified (Class I: low comorbidity class, 71.3% of attempters; Class II: high comorbidity class, 28.7% of attempters). Class I members were featured by the diagnosis of depression and general anxiety disorder, and low comorbidity; by contrast, the high comorbidity profile was characterized by a higher probability of presenting two or more coexisting psychiatric disorders. Class II included more females, younger, with more depressive symptoms and with higher impulsivity levels. Moreover, Class II members showed more severe suicidal ideation, higher number of suicide behaviours and a greater number of previous suicide attempts (p<.01, for all the outcomes), compared to Class I members.
    Conclusions: Psychiatric profiles may be considered for treatment provision and personalized psychiatric treatment in suicidal attempters as well as tackle suicide risk.
    Language English
    Publishing date 2024-02-07
    Publishing country Spain
    Document type Journal Article
    ISSN 2950-2853
    ISSN (online) 2950-2853
    DOI 10.1016/j.sjpmh.2024.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Anxious and depressive symptoms and health-related quality of life in a cohort of people who recently attempted suicide: A network analysis.

    Oliva, Vincenzo / Roberto, Natalia / Andreo-Jover, Jorge / Bobes, Teresa / Canal Rivero, Manuel / Cebriá, Anabel / Crespo-Facorro, Benedicto / de la Torre-Luque, Alejandro / Díaz-Marsá, Marina / Elices, Matilde / Fernández-Rodrigues, Verónica / Gonzalez-Pinto, Ana / Palao Tarrero, Angela / Pérez-Diez, Iván / Rodríguez-Vega, Beatriz / Ruiz-Veguilla, Miguel / Saiz, Pilar A / Seijo-Zazo, Elisa / Toll-Privat, Alba /
    McIntyre, Roger S / Vieta, Eduard / Grande, Iria / Pérez-Solà, Víctor

    Journal of affective disorders

    2024  Volume 355, Page(s) 210–219

    Abstract: Background: Suicide is an international health concern with immeasurable impact from the perspective of human and social suffering. Prior suicide attempts, anxious and depressive symptoms, and relatively lower health-related quality of life (HRQoL) are ... ...

    Abstract Background: Suicide is an international health concern with immeasurable impact from the perspective of human and social suffering. Prior suicide attempts, anxious and depressive symptoms, and relatively lower health-related quality of life (HRQoL) are among the most replicated risk factors for suicide. Our goal was to visualize the distribution of these features and their interconnections with use of a network analysis approach in individuals who recently attempted suicide.
    Methods: Individuals with a recent suicide attempt were recruited from nine University Hospitals across Spain as part of the SURVIVE cohort study. Anxious and depressive symptoms, and perceived HRQoL were included in the network analysis. Network structures were estimated with the EBICglasso model. Centrality measures and bridge symptoms connecting communities were explored. Subnetworks comparing younger and older individuals, and women and men were analyzed.
    Results: A total of 1106 individuals with a recent suicide attempt were included. Depressed mood was the symptom with the greatest influence in the overall network, followed by anxiety symptoms such as feeling nervous, worrying, restless, and having difficulties to relax. Perceived general health was associated with increased suicidal ideation in the whole sample. Older people showed a specific connection between perceived general health and depressed mood.
    Limitations: The cross-sectional design does not allow determination of established causality.
    Conclusions: Depressed mood was the core network's symptom and, therefore, an important target in the management and prevention of suicide. HRQoL had more influence on the network of older populations, in which it should be a primary focus.
    MeSH term(s) Male ; Humans ; Female ; Aged ; Suicide, Attempted ; Depression/epidemiology ; Quality of Life ; Cohort Studies ; Cross-Sectional Studies ; Anxiety/epidemiology ; Suicidal Ideation ; Risk Factors
    Language English
    Publishing date 2024-03-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2024.03.109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Clinical predictors and psychosocial risk factors of suicide attempt severity.

    González-Ortega, Itxaso / Diaz-Marsa, Marina / López-Peña, Purificación / Fernández-Sevillano, Jessica / Andreo-Jover, Jorge / Bobes, Julio / Bravo-Ortiz, María Fe / Cebria, Ana Isabel / Crespo-Facorro, Benedicto / de la Torre-Luque, Alejandro / Elices, Matilde / Fernández-Rodrigues, Verónica / Garrido-Torres, Nathalia / Grande, Iria / Palao-Tarrero, Ángela / Pemau, Andrés / Roberto, Natalia / Ruiz-Veguilla, Miguel / Seijo-Zazo, Elisa /
    Alberich, Susana / González-Pinto, Ana / Pérez, Víctor

    Spanish journal of psychiatry and mental health

    2023  

    Abstract: Background: Suicide attempts are an important predictor of completed suicide and may differ in terms of severity of medical consequences or medical lethality. There is little evidence on serious suicide attempt (SSA) and very few studies have compared ... ...

    Abstract Background: Suicide attempts are an important predictor of completed suicide and may differ in terms of severity of medical consequences or medical lethality. There is little evidence on serious suicide attempt (SSA) and very few studies have compared SSA with non-SSA.
    Objective: The aim of this multisite, coordinated, cohort study was to analyze the role of clinical variables and the sociodemographic and psychological risk factors of SSA.
    Method: In this multisite, coordinated, cohort study, 684 participants (222 for the mild suicide attempt group, 371 for the moderate suicide attempt group and 91 for the SSA group) were included in the study. Ordinal regression models were performed to analyze the predictor variables of SSA.
    Results: Early physical abuse (OR=1.231) and impulsivity (OR=1.036) were predictors of SSA, while depressive symptoms were associated with a lower risk of SSA.
    Conclusion: Environmental and psychological factors as physical abuse and impulsivity are related with severe suicide severity. These findings will help to develop strategies to prevent suicide and may be considered for the treatment and management of suicide.
    Language English
    Publishing date 2023-09-29
    Publishing country Spain
    Document type Journal Article
    ISSN 2950-2853
    ISSN (online) 2950-2853
    DOI 10.1016/j.sjpmh.2023.07.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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