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Article: Adult Stem Cells and Induced Pluripotent Stem Cells for Stroke Treatment.

Fernández-Susavila, Héctor / Bugallo-Casal, Ana / Castillo, José / Campos, Francisco

2019 Volume 10, Page(s) 908

Abstract: Stroke is the main cause of disability and death in the world within neurological diseases. Despite such a huge impact, enzymatic, and mechanical recanalization are the only treatments available so far for ischemic stroke, but only <20% of patients can ... ...

Abstract	Stroke is the main cause of disability and death in the world within neurological diseases. Despite such a huge impact, enzymatic, and mechanical recanalization are the only treatments available so far for ischemic stroke, but only <20% of patients can benefit from them. The use of stem cells as a possible cell therapy in stroke has been tested for years. The results obtained from these studies, although conflicting or controversial in some aspects, are promising. In the last few years, the recent development of the induced pluripotent stem cells has opened new possibilities to find new cell therapies against stroke. In this review, we will provide an overview of the state of the art of cell therapy in stroke. We will describe the current situation of the most employed stem cells and the use of induced pluripotent stem cells in stroke pathology. We will also present a summary of the different clinical trials that are being carried out or that already have results on the use of stem cells as a potential therapeutic intervention for stroke.
Language	English
Publishing date	2019-08-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2019.00908
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Article ; Online: Inclusion criteria update for the rat intraluminal ischaemic model for preclinical studies.

Fernández-Susavila, Héctor / Iglesias-Rey, Ramón / Dopico-López, Antonio / Pérez-Mato, María / Sobrino, Tomás / Castillo, José / Campos, Francisco

Disease models & mechanisms

2017 Volume 10, Issue 12, Page(s) 1433–1438

Abstract: Proper occlusion of the medial cerebral artery, as determined by laser Doppler monitoring, during cerebral ischaemia in rat models is an important inclusion criterion in experimental studies. However, successful occlusion of the artery does not always ... ...

Abstract	Proper occlusion of the medial cerebral artery, as determined by laser Doppler monitoring, during cerebral ischaemia in rat models is an important inclusion criterion in experimental studies. However, successful occlusion of the artery does not always guarantee a reproducible infarct volume, which is crucial for validating the efficacy of new protective drugs. In a rat intraluminal ischaemic model, laser Doppler monitoring alone was compared with laser Doppler monitoring in combination with magnetic resonance angiography (MRA) and diffusion-weighted imaging (DWI). Twenty-eight animals showed successful occlusion and reperfusion determined with Doppler monitoring, with an infarct size at 24 h of 16.7±11.5% (determined as ischaemic damage with respect to the ipsilateral hemisphere volume). However, when arterial occlusion and infarct damage were analysed in these animals using MRA and DWI, respectively, 15 animals were excluded and only 13 animals were included, with an infarct size at 24 h of 21.6±6.1%, showing a variability in the infarct size significantly lower (
MeSH term(s)	Angiography ; Animals ; Brain Ischemia/pathology ; Diffusion Magnetic Resonance Imaging ; Disease Models, Animal ; Male ; Rats, Sprague-Dawley
Language	English
Publishing date	2017--19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1754-8411
ISSN (online)	1754-8411
DOI	10.1242/dmm.029868
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Article ; Online: Model of Disc Degeneration in Rat Tail Induced Through a Vascular Isolation of Vertebral Endplates.

Fernández-Susavila, Héctor / Pardo-Seco, Juan Pablo / Iglesias-Rey, Ramón / Sobrino, Tomás / Campos, Francisco / Díez-Ulloa, Máximo Alberto

Journal of investigative surgery : the official journal of the Academy of Surgical Research

2017 Volume 31, Issue 4, Page(s) 265–274

Abstract: Back pain is a major health problem. The degenerative cascade of the spine begins in the intervertebral disc, due to an impairment in the blood supply through the vertebral endplates. Our objective was to develop a novel disc degeneration model based on ... ...

Abstract	Back pain is a major health problem. The degenerative cascade of the spine begins in the intervertebral disc, due to an impairment in the blood supply through the vertebral endplates. Our objective was to develop a novel disc degeneration model based on these premises, akin to the process in humans, in contrast to other proposed models (puncture, enzyme injection, aberrant loads,…) Material and methods: 37 Sprague-Dawley rats, 2 arms: (a) histological (n = 17, one died), en- bloc sections, Van Gieson staining, (Nisimura-Mochida criteria) and also collagen VI staining (tissue oxidative stress), four animals were euthanized every 2 weeks (2-8); and (b) imaging (n = 20, six wound sloughs), MRI 9.4 Tesla protocol, sequential disc volumetric analysis (24 h-8 weeks) in all animals. Disc degeneration was induced by means of vascular isolation of tail discs endplates either from one side or both. Results: Isolation from both sides caused a progressive degeneration of the disc (p < 0.001 vs. controls), bigger than isolation from one side (p < 0.01 vs. both sides and p < 0.05 vs. controls), as rated by volumetric reduction; furthermore, tissue structural changes (Nisimura-Mochida) and collagen VI deposition confirmed these results. Conclusion: the model here described represents a novel and translational tool that reproduces the intervertebral disc degeneration in a similar way to that taking place in human beings.
MeSH term(s)	Animals ; Collagen Type VI/metabolism ; Disease Models, Animal ; Humans ; Intervertebral Disc/blood supply ; Intervertebral Disc Degeneration/etiology ; Intervertebral Disc Degeneration/pathology ; Male ; Oxidative Stress ; Rats ; Rats, Sprague-Dawley ; Reproducibility of Results ; Tail
Chemical Substances	Collagen Type VI
Language	English
Publishing date	2017-05-25
Publishing country	United States
Document type	Journal Article ; Validation Studies
ZDB-ID	639444-9
ISSN	1521-0553 ; 0894-1939
ISSN (online)	1521-0553
ISSN	0894-1939
DOI	10.1080/08941939.2017.1317373
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Article ; Online: Neddylation orchestrates the complex transcriptional and posttranscriptional program that drives Schwann cell myelination.

Ayuso-García, Paula / Sánchez-Rueda, Alejandro / Velasco-Avilés, Sergio / Tamayo-Caro, Miguel / Ferrer-Pinós, Aroa / Huarte-Sebastian, Cecilia / Alvarez, Vanesa / Riobello, Cristina / Jiménez-Vega, Selene / Buendia, Izaskun / Cañas-Martin, Jorge / Fernández-Susavila, Héctor / Aparicio-Rey, Adrián / Esquinas-Román, Eva M / Ponte, Carlos Rodríguez / Guhl, Romane / Laville, Nicolas / Pérez-Andrés, Encarni / Lavín, José L /

González-Lopez, Monika / Cámara, Nuria Macías / Aransay, Ana M / Lozano, Juan José / Sutherland, James D / Barrio, Rosa / Martinez-Chantar, María Luz / Azkargorta, Mikel / Elortza, Félix / Soriano-Navarro, Mario / Matute, Carlos / Sánchez-Gómez, María Victoria / Bayón-Cordero, Laura / Pérez-Samartín, Alberto / Bravo, Susana B / Kurz, Thimo / Lama-Díaz, Tomas / Blanco, Miguel G / Haddad, Saif / Record, Christopher J / van Hasselt, Peter M / Reilly, Mary M / Varela-Rey, Marta / Woodhoo, Ashwin

Science advances

2024 Volume 10, Issue 15, Page(s) eadm7600

Abstract: Myelination is essential for neuronal function and health. In peripheral nerves, >100 causative mutations have been identified that cause Charcot-Marie-Tooth disease, a disorder that can affect myelin sheaths. Among these, a number of mutations are ... ...

Abstract	Myelination is essential for neuronal function and health. In peripheral nerves, >100 causative mutations have been identified that cause Charcot-Marie-Tooth disease, a disorder that can affect myelin sheaths. Among these, a number of mutations are related to essential targets of the posttranslational modification neddylation, although how these lead to myelin defects is unclear. Here, we demonstrate that inhibiting neddylation leads to a notable absence of peripheral myelin and axonal loss both in developing and regenerating mouse nerves. Our data indicate that neddylation exerts a global influence on the complex transcriptional and posttranscriptional program by simultaneously regulating the expression and function of multiple essential myelination signals, including the master transcription factor EGR2 and the negative regulators c-Jun and Sox2, and inducing global secondary changes in downstream pathways, including the mTOR and YAP/TAZ signaling pathways. This places neddylation as a critical regulator of myelination and delineates the potential pathogenic mechanisms involved in CMT mutations related to neddylation.
MeSH term(s)	Animals ; Mice ; Schwann Cells ; Myelin Sheath/genetics ; Charcot-Marie-Tooth Disease/genetics ; Mutation ; Protein Processing, Post-Translational
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adm7600
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Article ; Online: Cold stress protein RBM3 responds to hypothermia and is associated with good stroke outcome.

Ávila-Gómez, Paulo / Vieites-Prado, Alba / Dopico-López, Antonio / Bashir, Saima / Fernández-Susavila, Héctor / Gubern, Carme / Pérez-Mato, María / Correa-Paz, Clara / Iglesias-Rey, Ramón / Sobrino, Tomás / Bustamante, Alejandro / Wellmann, Sven / Montaner, Joan / Serena, Joaquín / Castillo, José / Hervella, Pablo / Campos, Francisco

Brain communications

2020 Volume 2, Issue 2, Page(s) fcaa078

Abstract: RNA-binding motif protein 3 is a molecular marker of hypothermia that has proved neuroprotective in neurodegenerative disease models. However, its relationship to the well-recognized therapeutic effect of hypothermia in ischaemic stroke had not been ... ...

Abstract	RNA-binding motif protein 3 is a molecular marker of hypothermia that has proved neuroprotective in neurodegenerative disease models. However, its relationship to the well-recognized therapeutic effect of hypothermia in ischaemic stroke had not been studied. In this work, the expression of RNA-binding motif protein 3 was investigated in ischaemic animal models subjected to systemic and focal brain hypothermia, specifically the effects of RNA-binding motif protein 3 silencing and overexpression on ischaemic lesions. Moreover, the association of RNA-binding motif protein 3 levels with body temperature and clinical outcome was evaluated in two independent cohorts of acute ischaemic stroke patients (
Language	English
Publishing date	2020-06-04
Publishing country	England
Document type	Journal Article
ISSN	2632-1297
ISSN (online)	2632-1297
DOI	10.1093/braincomms/fcaa078
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Article ; Online: Generation and characterization of the human iPSC line IDISi001-A isolated from blood cells of a CADASIL patient carrying a NOTCH3 mutation.

Fernández-Susavila, Héctor / Mora, Cristina / Aramburu-Núñez, Marta / Quintas-Rey, Rita / Arias, Susana / Collado, Manuel / López-Arias, Esteban / Sobrino, Tomás / Castillo, José / Dell'Era, Patrizia / Campos, Francisco

Stem cell research

2018 Volume 28, Page(s) 16–20

Abstract: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common form of hereditary stroke disorder. It is caused by mutations in NOTCH3 that lead to progressive degeneration of the smooth muscle ... ...

Abstract	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common form of hereditary stroke disorder. It is caused by mutations in NOTCH3 that lead to progressive degeneration of the smooth muscle cells in blood vessels. There is currently no treatment for this disorder. We reprogrammed to pluripotency blood mononuclear cells isolated from a patient carrying a NOTCH3 mutation by using a commercially available non-integrating system. The success in the generation of this iPSC line (IDISi001-A) suggests that the NOTCH3 mutation did not limit cell reprogramming and offers an unprecedented opportunity for studying and modeling CADASIL pathology.
MeSH term(s)	Aged ; Base Sequence ; Blood Cells/metabolism ; CADASIL/blood ; CADASIL/pathology ; Cell Culture Techniques/methods ; Cell Separation ; Humans ; Induced Pluripotent Stem Cells/cytology ; Male ; Mutation/genetics ; Receptor, Notch3/genetics ; Reproducibility of Results
Chemical Substances	NOTCH3 protein, human ; Receptor, Notch3
Language	English
Publishing date	2018-01-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1876-7753
ISSN (online)	1876-7753
DOI	10.1016/j.scr.2018.01.023
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Article ; Online: Heads and Tails of Natriuretic Peptides: Neuroprotective Role of Brain Natriuretic Peptide.

Fernández-Susavila, Héctor / Rodríguez-Yáñez, Manuel / Dopico-López, Antonio / Arias, Susana / Santamaría, María / Ávila-Gómez, Paulo / Doval-García, Juan M / Sobrino, Tomás / Iglesias-Rey, Ramón / Castillo, José / Campos, Francisco

Journal of the American Heart Association

2017 Volume 6, Issue 12

Abstract: Background: Besides the relevant role of brain-type natriuretic peptide (BNP) as biomarker of cardioembolic strokes, new experimental evidences suggest that this peptide may mediate neuroprotective effects. In this study, we have evaluated for the first ...

Abstract	Background: Besides the relevant role of brain-type natriuretic peptide (BNP) as biomarker of cardioembolic strokes, new experimental evidences suggest that this peptide may mediate neuroprotective effects. In this study, we have evaluated for the first time the clinical association between BNP (by means of proBNP) and good outcome in ischemic stroke patients, and analyzed the effect of blood BNP increase in an ischemic animal model. Methods and results: A retrospective study with 2 different cohorts (262 patients in cohort I and 610 in cohort II) from the same prospective stroke registry was performed. proBNP concentration was analyzed within the first 12 hours from stroke onset. The primary predictor variable was functional outcome evaluated by modified Rankin Scale at 3 months. For the experimental study, BNP pretreatment was tested in an ischemic animal model subjected to a transient occlusion of the cerebral artery, and the infarct volume and sensorimotor deficit were evaluated for 14 days. Cardioembolic strokes presented a positive correlation between proBNP concentration and modified Rankin Scale at 3 months; however, noncardioembolic strokes presented a negative correlation. In the logistic regression analysis, noncardioembolic strokes with concentrations of proBNP ≥340 pg/mL were associated with a good outcome. In line with these clinical findings, the experimental study revealed that those BNP pretreated animals presented a reduction on infarct volumes at 24 hours and functional recovery at days 7 and 14 compared with the control groups. Conclusions: These clinical and experimental evidences support the potential role of BNP as a protective factor against cerebral ischemia.
MeSH term(s)	Animals ; Biomarkers/blood ; Brain Ischemia/blood ; Brain Ischemia/diagnosis ; Brain Ischemia/physiopathology ; Brain Ischemia/prevention & control ; Chi-Square Distribution ; Disability Evaluation ; Disease Models, Animal ; Infarction, Middle Cerebral Artery/blood ; Infarction, Middle Cerebral Artery/diagnosis ; Infarction, Middle Cerebral Artery/physiopathology ; Infarction, Middle Cerebral Artery/prevention & control ; Logistic Models ; Male ; Motor Activity ; Natriuretic Peptide, Brain/administration & dosage ; Natriuretic Peptide, Brain/blood ; Natriuretic Peptide, Brain/pharmacokinetics ; Neuroprotective Agents/administration & dosage ; Odds Ratio ; Prognosis ; Protective Factors ; Rats, Sprague-Dawley ; Recovery of Function ; Registries ; Retrospective Studies ; Risk Factors ; Sensory Thresholds ; Stroke/blood ; Stroke/diagnosis ; Stroke/physiopathology ; Stroke/prevention & control ; Time Factors
Chemical Substances	Biomarkers ; Neuroprotective Agents ; Natriuretic Peptide, Brain (114471-18-0)
Language	English
Publishing date	2017-12-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.117.007329
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Article ; Online: Protective Effects and Magnetic Resonance Imaging Temperature Mapping of Systemic and Focal Hypothermia in Cerebral Ischemia.

Vieites-Prado, Alba / Iglesias-Rey, Ramón / Fernández-Susavila, Héctor / da Silva-Candal, Andrés / Rodríguez-Castro, Emilio / Gröhn, Olli H J / Wellmann, Sven / Sobrino, Tomás / Castillo, José / Campos, Francisco

Stroke

2016 Volume 47, Issue 9, Page(s) 2386–2396

Abstract: Background and purpose: Hypothermia is potentially the most effective protective therapy for brain ischemia; however, its use is limited because of serious side effects. Although focal hypothermia (FH) has a significantly lower stress profile than ... ...

Abstract	Background and purpose: Hypothermia is potentially the most effective protective therapy for brain ischemia; however, its use is limited because of serious side effects. Although focal hypothermia (FH) has a significantly lower stress profile than systemic hypothermia (SH), its efficacy in ischemia has been poorly studied. We aimed to compare the therapeutic effects of each treatment on various short- and long-term clinically relevant end points. Methods: Sprague-Dawley rats were subjected to transient (45 minutes) occlusion of the middle cerebral artery. One hour after arterial reperfusion, animals were randomly assigned to groups for treatment with SH or FH (target temperature: 32°C) for 4 or 24 hours. Lesion volume, edema, functional recovery, and histological markers of cellular injury were evaluated for 1 month after ischemic injury. Effects of SH and FH on cerebral temperature were also analyzed for the first time by magnetic resonance thermometry, an approach that combines spectroscopy with gradient-echo-based phase mapping. Results: Both therapeutic approaches reduced ischemic lesion volume (P<0.001), although a longer FH treatment (24 hours) was required to achieve similar protective effects to those induced by 4 hours of SH. In addition, magnetic resonance thermometry demonstrated that systemic hypothermia reduced whole-brain temperature, whereas FH primarily reduced the temperature of the ischemic region. Conclusions: Focal brain hypothermia requires longer cooling periods to achieve the same protective efficacy as SH. However, FH mainly affects the ischemic region, and therefore represents a promising and nonstressful alternative to SH.
MeSH term(s)	Animals ; Body Temperature/physiology ; Brain/diagnostic imaging ; Brain Ischemia/diagnostic imaging ; Brain Ischemia/therapy ; Cerebrovascular Circulation ; Hypothermia, Induced/methods ; Infarction, Middle Cerebral Artery/diagnostic imaging ; Infarction, Middle Cerebral Artery/therapy ; Magnetic Resonance Imaging/methods ; Male ; Rats ; Rats, Sprague-Dawley ; Recovery of Function
Language	English
Publishing date	2016-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.116.014067
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Article ; Online: Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting.

Capelo-Diz, Alba / Lachiondo-Ortega, Sofía / Fernández-Ramos, David / Cañas-Martín, Jorge / Goikoetxea-Usandizaga, Naroa / Serrano-Maciá, Marina / González-Rellan, Maria J / Mosca, Laura / Blazquez-Vicens, Joan / Tinahones-Ruano, Alberto / Fondevila, Marcos F / Buyan, Mason / Delgado, Teresa C / Gutierrez de Juan, Virginia / Ayuso-García, Paula / Sánchez-Rueda, Alejandro / Velasco-Avilés, Sergio / Fernández-Susavila, Héctor / Riobello-Suárez, Cristina /

Dziechciarz, Bartlomiej / Montiel-Duarte, Cristina / Lopitz-Otsoa, Fernando / Bizkarguenaga, Maider / Bilbao-García, Jon / Bernardo-Seisdedos, Ganeko / Senra, Ana / Soriano-Navarro, Mario / Millet, Oscar / Díaz-Lagares, Ángel / Crujeiras, Ana B / Bao-Caamano, Aida / Cabrera, Diana / van Liempd, Sebastiaan / Tamayo-Carro, Miguel / Borzacchiello, Luigi / Gomez-Santos, Beatriz / Buqué, Xabier / Sáenz de Urturi, Diego / González-Romero, Francisco / Simon, Jorge / Rodríguez-Agudo, Rubén / Ruiz, Asier / Matute, Carlos / Beiroa, Daniel / Falcon-Perez, Juan M / Aspichueta, Patricia / Rodríguez-Cuesta, Juan / Porcelli, Marina / Pajares, María A / Ameneiro, Cristina / Fidalgo, Miguel / Aransay, Ana M / Lama-Díaz, Tomas / Blanco, Miguel G / López, Miguel / Villa-Bellosta, Ricardo / Müller, Timo D / Nogueiras, Rubén / Woodhoo, Ashwin / Martínez-Chantar, María Luz / Varela-Rey, Marta

Cell metabolism

2023 Volume 35, Issue 8, Page(s) 1373–1389.e8

Abstract: There has been an intense focus to uncover the molecular mechanisms by which fasting triggers the adaptive cellular responses in the major organs of the body. Here, we show that in mice, hepatic S-adenosylmethionine (SAMe)-the principal methyl donor-acts ...

Abstract	There has been an intense focus to uncover the molecular mechanisms by which fasting triggers the adaptive cellular responses in the major organs of the body. Here, we show that in mice, hepatic S-adenosylmethionine (SAMe)-the principal methyl donor-acts as a metabolic sensor of nutrition to fine-tune the catabolic-fasting response by modulating phosphatidylethanolamine N-methyltransferase (PEMT) activity, endoplasmic reticulum-mitochondria contacts, β-oxidation, and ATP production in the liver, together with FGF21-mediated lipolysis and thermogenesis in adipose tissues. Notably, we show that glucagon induces the expression of the hepatic SAMe-synthesizing enzyme methionine adenosyltransferase α1 (MAT1A), which translocates to mitochondria-associated membranes. This leads to the production of this metabolite at these sites, which acts as a brake to prevent excessive β-oxidation and mitochondrial ATP synthesis and thereby endoplasmic reticulum stress and liver injury. This work provides important insights into the previously undescribed function of SAMe as a new arm of the metabolic adaptation to fasting.
MeSH term(s)	Mice ; Animals ; S-Adenosylmethionine/metabolism ; Liver/metabolism ; Liver Neoplasms/metabolism ; Fasting ; Adenosine Triphosphate/metabolism ; Methionine Adenosyltransferase/metabolism ; Phosphatidylethanolamine N-Methyltransferase/metabolism
Chemical Substances	S-Adenosylmethionine (7LP2MPO46S) ; Adenosine Triphosphate (8L70Q75FXE) ; Methionine Adenosyltransferase (EC 2.5.1.6) ; PEMT protein, mouse (EC 2.1.1.17) ; Phosphatidylethanolamine N-Methyltransferase (EC 2.1.1.17)
Language	English
Publishing date	2023-07-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2176834-1
ISSN	1932-7420 ; 1550-4131
ISSN (online)	1932-7420
ISSN	1550-4131
DOI	10.1016/j.cmet.2023.07.002
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Article ; Online: Blood glutamate EAAT

Pérez-Mato, María / Iglesias-Rey, Ramón / Vieites-Prado, Alba / Dopico-López, Antonio / Argibay, Bárbara / Fernández-Susavila, Héctor / da Silva-Candal, Andrés / Pérez-Díaz, Amparo / Correa-Paz, Clara / Günther, Anne / Ávila-Gómez, Paulo / Isabel Loza, M / Baumann, Arnd / Castillo, José / Sobrino, Tomás / Campos, Francisco

EBioMedicine

2018 Volume 39, Page(s) 118–131

Abstract: Background: Excitatory amino acid transporter 2 (EAAT: Methods: To address this hypothesis, EAAT: Findings: The expression of EAAT: Interpretation: Although the transfection procedure most likely interferes with some of the intrinsic protective ...

Abstract	Background: Excitatory amino acid transporter 2 (EAAT Methods: To address this hypothesis, EAAT Findings: The expression of EAAT Interpretation: Although the transfection procedure most likely interferes with some of the intrinsic protective mechanisms of mesenchymal cells, the results show that the induced expression of EAAT
MeSH term(s)	Animals ; Brain Ischemia/metabolism ; Brain Ischemia/therapy ; Cell Line ; Disease Models, Animal ; Glutamate Plasma Membrane Transport Proteins/genetics ; Glutamate Plasma Membrane Transport Proteins/metabolism ; Glutamic Acid/blood ; HEK293 Cells ; Humans ; Male ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Rats ; Transfection
Chemical Substances	Glutamate Plasma Membrane Transport Proteins ; SLC1A2 protein, human ; Glutamic Acid (3KX376GY7L)
Language	English
Publishing date	2018-12-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2018.11.024
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