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  1. AU="Fernandes, Adriana Barrinha"
  2. AU="Goodwin, David G"
  3. AU="Hill, Jonathan C"
  4. AU="Chankasingh, Kyle"
  5. AU="Narayanasami, Uma"
  6. AU="Chen, Ruichao"
  7. AU=Li Xuefeng AU=Li Xuefeng
  8. AU="Stef J.F. Letteboer"
  9. AU="Gewurz, H"
  10. AU="Linares, Mauricio"
  11. AU="Gnesi, Marco"
  12. AU="Park, Jinny"
  13. AU="Hill, Benjamin D"
  14. AU=Huang Chunfa
  15. AU="Skonieczny, Paul"
  16. AU="LIVINGSTON, M S"
  17. AU="Lidia Gonzalez-Quereda"
  18. AU="Korkmaz, Asli"
  19. AU="Patel, Mrinal"
  20. AU="Louis Chauvel"
  21. AU="Jampen, Laurent"
  22. AU="Tan, Jiacheng"
  23. AU="Weiss, Jonathan D"

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  1. Artikel ; Online: Analytical performance of Raman spectroscopy in assaying biochemical components in human serum.

    Giansante, Stella / Giana, Hector Enrique / Fernandes, Adriana Barrinha / Silveira, Landulfo

    Lasers in medical science

    2021  Band 37, Heft 1, Seite(n) 287–298

    Abstract: Chronic non-infectious diseases are important to research as they are the main causes of death in Brazil and worldwide. One very important chronic non-infectious disease is cardiovascular disease, whose risk factors (diabetes, dyslipidemia, and renal ... ...

    Abstract Chronic non-infectious diseases are important to research as they are the main causes of death in Brazil and worldwide. One very important chronic non-infectious disease is cardiovascular disease, whose risk factors (diabetes, dyslipidemia, and renal failure) can be detected through assessments of serum biochemical components. The objective of this study was to evaluate the analytical performance of Raman spectroscopy for analysis of lipid profile (total cholesterol, triglycerides, and HDL cholesterol), non-protein nitrogenous compounds (urea and creatinine), and glucose in 242 human serum samples. Models to discriminate and quantify the samples were developed using the predicted concentration by quantitative regression model based on partial least squares (PLS). The analytical error for the "leave-one-out" cross-validation based on the predicted PLS concentration was 10.5 mg/dL for total cholesterol, 21.4 mg/dL for triglyceride, 13.0 mg/dL for HDL cholesterol, 4.9 mg/dL for urea, 0.21 mg/dL for creatinine, and 15.4 mg/dL for glucose. The Kappa coefficient indicate very good agreement for cholesterol (0.83), good for triglyceride (0.77), urea (0.70) and creatinine (0.66), and fair for HDL cholesterol (0.38) and glucose (0.30). The results of the analytical performance demonstrated that Raman spectroscopy can be considered an important methodology to screen the population, especially for serum triglycerides and cholesterol.
    Mesh-Begriff(e) Cholesterol ; Humans ; Least-Squares Analysis ; Serum ; Spectrum Analysis, Raman ; Triglycerides
    Chemische Substanzen Triglycerides ; Cholesterol (97C5T2UQ7J)
    Sprache Englisch
    Erscheinungsdatum 2021-02-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 632808-8
    ISSN 1435-604X ; 0268-8921
    ISSN (online) 1435-604X
    ISSN 0268-8921
    DOI 10.1007/s10103-021-03247-8
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  2. Artikel ; Online: Effectiveness of intravesical ozone in interstitial cystitis by the O'Leary-Sant symptom index.

    Pires, Maria Verônica / de Lima, Carlos José / Carvalho, Henrique Cunha / Moreira, Lívia Helena / Fernandes, Adriana Barrinha

    International urogynecology journal

    2022  Band 34, Heft 7, Seite(n) 1437–1446

    Abstract: Introduction and hypothesis: A prospective clinical, preliminary study was performed in patients with interstitial cystitis/bladder pain syndrome (IC/BPS) who were nonresponders to conventional treatment and received intravesical ozone as a therapeutic ... ...

    Abstract Introduction and hypothesis: A prospective clinical, preliminary study was performed in patients with interstitial cystitis/bladder pain syndrome (IC/BPS) who were nonresponders to conventional treatment and received intravesical ozone as a therapeutic alternative.
    Methods: Sixteen patients received six applications of intravesical ozone at a concentration of 41 μg/mL. We evaluated therapeutic efficacy by the percentage reduction of Interstitial Cystitis Symptom and Problem Index scores (ICSI/ICPI-the O'Leary-Sant symptom index), recurrence rate, nonresponse, and side effects in scores collected on admission (pre-treatment), at the end of the therapeutic protocol (post-treatment), and 180 days (follow-up) after the last ozone application.
    Results: The mean age of women was 52.9 years (SD: 15.5), and the duration of symptoms was 5.7 years (SD: 7.1). The median ICSI on admission was 17 (IQR: 14.25-19.5) and at follow-up was 0.5 (IQR: 0-2), with a reduction of 97.5% (CI: 85.7-100). The median ICSI/ICPI on admission was 31.5 (IQR: 29-35.2) and at follow-up was 2.0 (IQR: 0-3.75), with a reduction of 92.3% (CI: 88.8-100). The recurrence rate was only 6.25%, and no patients were nonresponders to the treatment.
    Conclusions: The application of intravesical ozone was effective in the treatment of patients with IC/BPS who were nonresponders to conventional therapy, showing a progressive and safe effect, at least in the short term.
    Mesh-Begriff(e) Humans ; Female ; Middle Aged ; Cystitis, Interstitial/drug therapy ; Cystitis, Interstitial/diagnosis ; Prospective Studies ; Administration, Intravesical ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2022-10-15
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1050631-7
    ISSN 1433-3023 ; 0937-3462
    ISSN (online) 1433-3023
    ISSN 0937-3462
    DOI 10.1007/s00192-022-05383-3
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  3. Artikel ; Online: Cardiopulmonary and hematological effects of infrared LED photobiomodulation in the treatment of SARS-COV2.

    Pereira, Pâmela Camila / de Lima, Carlos José / Fernandes, Adriana Barrinha / Zângaro, Renato Amaro / Villaverde, Antonio Balbin

    Journal of photochemistry and photobiology. B, Biology

    2022  Band 238, Seite(n) 112619

    Abstract: Background: COVID-19 disease is caused by SARS-CoV-2 which can trigger acute respiratory syndrome, which presents with dense alveolar and interstitial infiltrates and pulmonary edema, causing severe hypoxemia and significant alteration to pulmonary ... ...

    Abstract Background: COVID-19 disease is caused by SARS-CoV-2 which can trigger acute respiratory syndrome, which presents with dense alveolar and interstitial infiltrates and pulmonary edema, causing severe hypoxemia and significant alteration to pulmonary mechanics with reduced pulmonary compliance. The photobiomodulation technique alters cellular and molecular metabolism, showing promising results regarding the reduction of acute pulmonary inflammation.
    Objective: To compare the photomodulation technique using near-infrared LED to conventional respiratory physiotherapy treatment in patients with COVID-19 in reversing acute conditions, reducing hospitalization time, and decreasing the need for oxygen therapy.
    Methodology: The cohort was comprised of 30 patients undergoing COVID-19 treatment who were divided and allocated into two equal groups randomly: the LED group (LED), treated with infrared LED at 940 nm and conventional therapy, and the control group (CON), who received conventional treatment (antibiotic therapy for preventing superimposed bacterial infections, and physiotherapy) with LED irradiation off. Phototherapy used a vest with an array of 300 LEDs (940 nm) mounted on a 36 cm × 58 cm area and positioned in the patient's anterior thoracic and abdominal regions. The total power was 6 W, with 15 min irradiation time. Cardiopulmonary functions and blood count were monitored before and after treatment. The patients were treated daily for 7 days. Statistical analysis was conducted using a two-tailed unpaired Student's t-test at a significance level of α = 0.05.
    Results: Post-treatment, the LED group showed a reduction in hospital discharge time and a statistically significant improvement for the following cardiopulmonary functions: Partial Oxygen Saturation, Tidal Volume, Maximum Inspiratory, and Expiratory Pressures, Respiratory Frequency, Heart Rate, and Systolic Blood Pressure (p < 0.05). Regarding blood count, it was observed that post-treatment, the LED group presented with significant differences in the count of leukocytes, neutrophils, and lymphocytes.
    Conclusion: Photobiomodulation therapy can be used as a complement to conventional treatment of COVID-19, promoting the improvement of cardiopulmonary functions, and minimization of respiratory symptoms.
    Mesh-Begriff(e) Humans ; COVID-19 ; SARS-CoV-2 ; RNA, Viral ; COVID-19 Drug Treatment ; Lung
    Chemische Substanzen RNA, Viral
    Sprache Englisch
    Erscheinungsdatum 2022-12-05
    Erscheinungsland Switzerland
    Dokumenttyp Randomized Controlled Trial ; Journal Article
    ZDB-ID 623022-2
    ISSN 1873-2682 ; 1011-1344
    ISSN (online) 1873-2682
    ISSN 1011-1344
    DOI 10.1016/j.jphotobiol.2022.112619
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  4. Artikel ; Online: Diagnosing sickle cell disease and iron deficiency anemia in human blood by Raman spectroscopy.

    da Silva, Wagner Rafael / Silveira, Landulfo / Fernandes, Adriana Barrinha

    Lasers in medical science

    2019  Band 35, Heft 5, Seite(n) 1065–1074

    Abstract: This work proposed the diagnosis of iron deficiency anemia (IDA) and sickle cell disease (SCD) in human blood caused by iron deficiency and hemoglobin S (HbS), which are among the most common anemias, by means of Raman spectroscopy. Whole blood samples ... ...

    Abstract This work proposed the diagnosis of iron deficiency anemia (IDA) and sickle cell disease (SCD) in human blood caused by iron deficiency and hemoglobin S (HbS), which are among the most common anemias, by means of Raman spectroscopy. Whole blood samples from patients diagnosed with IDA and HbS, as well as from normal subjects (HbA), were obtained and submitted to Raman spectroscopy (830 nm, 150 mW, 400-1800 cm
    Mesh-Begriff(e) Anemia, Iron-Deficiency/blood ; Anemia, Iron-Deficiency/diagnosis ; Anemia, Sickle Cell/blood ; Anemia, Sickle Cell/diagnosis ; Discriminant Analysis ; Female ; Humans ; Least-Squares Analysis ; Male ; Principal Component Analysis ; Spectrum Analysis, Raman
    Sprache Englisch
    Erscheinungsdatum 2019-10-22
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 632808-8
    ISSN 1435-604X ; 0268-8921
    ISSN (online) 1435-604X
    ISSN 0268-8921
    DOI 10.1007/s10103-019-02887-1
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  5. Artikel: Biochemical Analysis of Urine Samples from Diabetic and Hypertensive Patients without Renal Dysfunction Using Spectrophotometry and Raman Spectroscopy Techniques Aiming Classification and Diagnosis.

    de Sousa Vieira, Elzo Everton / Silveira, Landulfo / Carvalho, Henrique Cunha / Bispo, Jeyse Aliana Martins / Fernandes, Fernanda Barrinha / Fernandes, Adriana Barrinha

    Bioengineering (Basel, Switzerland)

    2022  Band 9, Heft 10

    Abstract: The purpose of this study was to perform a comparative biochemical analysis between conventional spectrophotometry and Raman spectroscopy, techniques used for diagnoses, on the urine of healthy (CT) and diabetic and hypertensive patients (DM&HBP). Urine ... ...

    Abstract The purpose of this study was to perform a comparative biochemical analysis between conventional spectrophotometry and Raman spectroscopy, techniques used for diagnoses, on the urine of healthy (CT) and diabetic and hypertensive patients (DM&HBP). Urine from 40 subjects (20 in the CT group and 20 in the DM&HBP group) was examined in a dispersive Raman spectrometer (an 830 nm excitation and a 350 mW power). The mean Raman spectra between both groups showed a significant difference in peaks of glucose; exploratory analysis by principal component analysis (PCA) identified spectral differences between the groups, with higher peaks of glucose and proteins in the DM&HBP group. A partial least squares (PLS) regression model estimated by the Raman data indicated the concentrations of urea, creatinine, glucose, phosphate, and total protein; creatinine and glucose were the biomarkers that presented the best correlation coefficient (
    Sprache Englisch
    Erscheinungsdatum 2022-09-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering9100500
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  6. Artikel ; Online: Analysis of pain relief and functional recovery in patients with rotator cuff tendinopathy through therapeutic ultrasound and photobiomodulation therapy: a comparative study.

    Martins, João Pedro Scaldaferri / de Lima, Carlos José / Fernandes, Adriana Barrinha / Alves, Leandro Procópio / Neto, Osmar Pinto / Villaverde, Antonio Balbin

    Lasers in medical science

    2022  Band 37, Heft 8, Seite(n) 3155–3167

    Abstract: This study aimed to compare shoulder tendinopathy treatment with therapeutic ultrasound combined with LED photobiomodulation therapy using LED-infrared (850 nm) or LED-red (640 nm). The study assessed 75 patients, aged 45 to 70 years, distributed into ... ...

    Abstract This study aimed to compare shoulder tendinopathy treatment with therapeutic ultrasound combined with LED photobiomodulation therapy using LED-infrared (850 nm) or LED-red (640 nm). The study assessed 75 patients, aged 45 to 70 years, distributed into five experimental groups (15 patients each): therapeutic ultrasound (US), infrared light irradiation (IR), visible red light irradiation (VR), infrared light and ultrasound combined (IR-US), and red light in conjunction with ultrasound (VR-US). The ultrasound parameters are 1 MHz, 0.5 W/cm
    Mesh-Begriff(e) Humans ; Low-Level Light Therapy/adverse effects ; Quality of Life ; Range of Motion, Articular ; Rotator Cuff/diagnostic imaging ; Shoulder Pain/therapy ; Tendinopathy/diagnostic imaging ; Tendinopathy/radiotherapy ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2022-06-01
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 632808-8
    ISSN 1435-604X ; 0268-8921
    ISSN (online) 1435-604X
    ISSN 0268-8921
    DOI 10.1007/s10103-022-03584-2
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  7. Artikel ; Online: Systemic Effects of Photobiomodulation on Blood Components in the Treatment of Community-Acquired Pneumonia.

    Pereira, Pâmela Camila / de Lima, Carlos José / Fernandes, Adriana Barrinha / Fernandes, Fernanda Barrinha / Zângaro, Renato Amaro / Villaverde, Antonio Balbin

    Photobiomodulation, photomedicine, and laser surgery

    2021  Band 40, Heft 1, Seite(n) 51–58

    Abstract: Background: ...

    Abstract Background:
    Mesh-Begriff(e) Community-Acquired Infections/therapy ; Humans ; Longitudinal Studies ; Neutrophils ; Pneumonia ; Prospective Studies
    Sprache Englisch
    Erscheinungsdatum 2021-12-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2578-5478
    ISSN (online) 2578-5478
    DOI 10.1089/photob.2021.0050
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  8. Artikel ; Online: Photobiomodulation: Shining Light on COVID-19.

    Fernandes, Adriana Barrinha / de Lima, Carlos José / Villaverde, Antônio G J Balbin / Pereira, Pamela Camila / Carvalho, Henrique Cunha / Zângaro, Renato Amaro

    Photobiomodulation, photomedicine, and laser surgery

    2020  Band 38, Heft 7, Seite(n) 395–397

    Abstract: Objective: ...

    Abstract Objective:
    Mesh-Begriff(e) Betacoronavirus ; COVID-19 ; Coronavirus Infections/radiotherapy ; Humans ; Infrared Rays/therapeutic use ; Low-Level Light Therapy ; Pandemics ; Pneumonia, Viral/radiotherapy ; SARS-CoV-2 ; Ultraviolet Rays ; Ultraviolet Therapy
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-06-09
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2578-5478
    ISSN (online) 2578-5478
    DOI 10.1089/photob.2020.4882
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  9. Artikel ; Online: Discrimination model applied to urinalysis of patients with diabetes and hypertension aiming at diagnosis of chronic kidney disease by Raman spectroscopy.

    de Souza Vieira, Elzo Everton / Bispo, Jeyse Aliana Martins / Silveira, Landulfo / Fernandes, Adriana Barrinha

    Lasers in medical science

    2017  Band 32, Heft 7, Seite(n) 1605–1613

    Abstract: Higher blood pressure level and poor glycemic control in diabetic patients are considered progression factors that cause faster decline in kidney functions leading to kidney damage. The present study aimed to develop a quantification model of biomarkers ... ...

    Abstract Higher blood pressure level and poor glycemic control in diabetic patients are considered progression factors that cause faster decline in kidney functions leading to kidney damage. The present study aimed to develop a quantification model of biomarkers creatinine, urea, and glucose by means of selected peaks of these compounds, measured by Raman spectroscopy, and to estimate the concentration of these analytes in the urine of normal subjects (G_N), diabetic patients with hypertension (G_WOL) patients with chronic renal failure doing dialysis (G_D). Raman peak intensities at 680 cm
    Sprache Englisch
    Erscheinungsdatum 2017-09
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 632808-8
    ISSN 1435-604X ; 0268-8921
    ISSN (online) 1435-604X
    ISSN 0268-8921
    DOI 10.1007/s10103-017-2288-5
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  10. Artikel ; Online: Association of Ang-(1-7) and des-Arg

    Fernandes, Fernanda Barrinha / Fernandes, Adriana Barrinha / Febba, Andreia Cristina Silva / Leite, Ana Paula Oliveira / Leite, Cleber Aparecido / Vitalle, Maria Sylvia Souza / Jung, Flavia Fernandes / Casarini, Dulce Elena

    Hypertension research : official journal of the Japanese Society of Hypertension

    2021  Band 44, Heft 8, Seite(n) 969–977

    Abstract: Children with obesity have a high risk of developing cardiovascular disease and hypertension, which is associated with the renin-angiotensin system (RAS) activation and kallikrein-kinin system (KKS) inactivation. Although recent studies have identified ... ...

    Abstract Children with obesity have a high risk of developing cardiovascular disease and hypertension, which is associated with the renin-angiotensin system (RAS) activation and kallikrein-kinin system (KKS) inactivation. Although recent studies have identified several peptide-based biomarkers for obesity, circulating peptides from the RAS and KKS in adolescents with obesity have not been described. The aim of this study was to examine circulating levels of RAS and KKS peptides in adolescents with obesity to investigate the turnover of these peptides and their relationship to metabolic disorders resulting from weight gain. The subjects (n = 104) were divided into normal weight (NW), overweight (OW), obese (OB), and morbidly obese (MO) groups. Anthropometric profiles were created by measuring height, weight, blood pressure, and skinfolds. Plasma levels of Ang I, II, (1-7), BK, and des-Arg
    Mesh-Begriff(e) Adolescent ; Biomarkers ; Bradykinin ; Cardiometabolic Risk Factors ; Child ; Humans ; Obesity, Morbid ; Pediatric Obesity
    Chemische Substanzen Biomarkers ; Bradykinin (S8TIM42R2W)
    Sprache Englisch
    Erscheinungsdatum 2021-02-10
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-021-00618-0
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