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Article ; Online: The challenging approach of a young patient with a primary intimal sarcoma of the heart: a case report.

Martinho, Mariana / Machado, Bárbara / Cruz, Inês / Fernandes, Isabel / Pereira, Hélder

European heart journal. Case reports

2024 Volume 8, Issue 2, Page(s) ytae071

Abstract: Background: Primary intimal sarcomas of the heart are extremely rare and have a dismal prognosis. Their management represents a complex clinical challenge since complete surgical resection is the only reliable possibility of cure but is only possible in ...

Abstract	Background: Primary intimal sarcomas of the heart are extremely rare and have a dismal prognosis. Their management represents a complex clinical challenge since complete surgical resection is the only reliable possibility of cure but is only possible in 50% of patients. In non-resectable disease, anthracycline-based therapy is the most effective treatment, but pazopanib may be used in patients unfit to receive anthracyclines. Case summary: A 38-year-old man presented with acute right heart failure symptoms due to a primary intimal sarcoma of the heart. A definite diagnosis was made after cardiac surgery. Multi-modality cardiac imaging showed early recurrence of disease with mitral valve and pulmonary veins' invasion, and the patient was deemed inoperable. Due to chronic kidney disease and previous heart failure symptoms, he was started on first-line pazopanib palliative treatment. After 11 months of chemotherapy, there was good clinical tolerance and no evidence of disease progression, which occurred after 13 months. Discussion: This case highlights the value of a multi-modality imaging approach for cardiac masses. Most importantly, it reports the successful treatment of a young patient with a primary intimal sarcoma of the heart who was started on palliative pazopanib, with a significantly higher progression-free survival than is reported in the literature. This finding may support pazopanib as a good alternative as first-line treatment when there is contraindication for anthracycline-based chemotherapy.
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytae071
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Thesis ; Online: Portefólio digital como instrumento privilegiado de avaliação de aprendizagens no 1.º Ciclo do Ensino Básico

Fernandes, Isabel Campos

2020

Abstract: O mundo educativo procura persistentemente inovação nas formas de ensinar, de aprender e de avaliar as aprendizagens dos alunos. Se antes da pandemia provocada pelo COVID-19 já se procurava inovação, agora isso é imperativo. O facto de um dia para o ... ...

Abstract	O mundo educativo procura persistentemente inovação nas formas de ensinar, de aprender e de avaliar as aprendizagens dos alunos. Se antes da pandemia provocada pelo COVID-19 já se procurava inovação, agora isso é imperativo. O facto de um dia para o outro nos termos visto em ensino à distância, fez com que todos os agentes de ensino tivessem que trabalhar com ferramentas digitais onde pudessem, não só contactar, mas também ensinar os conteúdos, motivar para a aprendizagem e avaliar o desenvolvimento das competências dos alunos. De repente, tudo mudou. Esta dissertação, que inicialmente tinha como propósito o portfólio físico, também mudou. Devido ao ensino à distância, o objeto de estudo passou a ser o portfólio digital, pois todo o trabalho de escola passou a ser realizado digitalmente. Quisemos saber se o portfólio digital pode ter um lugar priveligiado na avaliação das aprendizagens do aluno. Iniciamos com uma revisão narrativa de literatura sobre os portefólios para o nosso quadro teórico. Seguiu-se uma revisão sistemática, da qual resultaram estudos que utilizámos para confrontar com os nossos dados empíricos. A opção metodológica é qualitativa, pois pretendeu explorar dados recolhidos no ambiente do participante e compreender o significado e a importância da complexidade de uma situação. Os resultados permitiram concluir que o portfólio digital é um instrumento de avaliação completo, porque através dele conseguimos uma informação mais clara sobre o progresso dos alunos na sua aprendizagem. É, também, um instrumento contextualizado, pois está ligado às situações práticas do dia-a-dia onde decorrem as aprendizagens e a reflexão dos alunos sobre as suas próprias dificuldades, fazendo com que participem na construção de estratégias para as superar. The educational world persistently seeks innovation in the ways of lteaching, learning and evaluating how students learn. Before the pandemic caused by COVID-19, innovation was already sought on school. Now, this must happen. The fact that from one day to the next we saw ourselves in distance learning, all teaching agents had to work with digital tools, where they could, not only contact but also teach the contents, motivate for learning and assess the development os students’ skills. Suddenly, everything changed. This essay, which was initially on the physical portfolio, has also changed. Due to distance learning, the object of study became the digital portfolio, since all school work started to be performed at the digital level. We aimed to find out if the digital portfolio can have a privileged spot in the assessment of student learning. We started with a literature review on portfolios for our theoretical framework, followed by a systematic review on the ERIC database, which resulted in empirical studies that we used to compare the data collected in order to answer our research question. The methodological option is qualitative, as it intended to explore data collected in the participant's environment and understand the meaning and importance of the complexity of a situation. The results allowed us to conclude that the use of the digital portfolio is a complete assessment tool, because through it we get more precise information on the students' progress in their learning. It is also a more contextualized instrument, as it is linked to practical day-to-day situations where learning happens and where students reflect on their difficulties, allowing them to participate in the construction of strategies to overcome them.
Keywords	Portfólio digital ; Avaliação da aprendizagem ; 1º ciclo do Ensino Básico ; Digital portfolio ; Assessment ; Elementary School ; Domínio/Área Científica::Ciências Sociais::Ciências da Educação ; covid19
Language	Portuguese
Publishing country	pt
Document type	Thesis ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prognostication in Metastatic Solid Tumours: Medical Community General Knowledge.

Gameiro-Santos, Rita / Fernandes, Isabel G / Luz, Paulo

BMJ supportive & palliative care

2022

Language	English
Publishing date	2022-03-24
Publishing country	England
Document type	Letter
ISSN	2045-4368
ISSN (online)	2045-4368
DOI	10.1136/spcare-2022-003577
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Article ; Online: Eco-physiological Responses of Aquatic Fungi to Three Global Change Stressors Highlight the Importance of Intraspecific Trait Variability.

Graça, Diana / Fernandes, Isabel / Cássio, Fernanda / Pascoal, Cláudia

Microbial ecology

2022 Volume 85, Issue 4, Page(s) 1215–1225

Abstract: Anthropogenic change at a global scale is affecting life on Earth with impacts on freshwaters. Aquatic hyphomycetes are fungi that drive organic matter decomposition in freshwaters and mediate energy transfer to higher trophic levels. Intraspecific trait ...

Abstract	Anthropogenic change at a global scale is affecting life on Earth with impacts on freshwaters. Aquatic hyphomycetes are fungi that drive organic matter decomposition in freshwaters and mediate energy transfer to higher trophic levels. Intraspecific trait variability affects ecological processes and can account for species adaptations to environmental change. To ascertain how aquatic hyphomycetes respond to global change related stressors, we selected 20 strains (7 species), based on their co-occurrence in streams and phylogenetic relatedness. We measured fungal growth rates at different temperatures (7 levels), nutrient concentrations (6 levels) and medium moisture (6 levels). Our results indicate that all stressors affected fungal growth, and responses to nutrient enrichment and moisture were strain specific. Fungal responses to the stressors were not explained by their phylogenetic relatedness. In the absence of stressors, interspecific diversity best explained the variance in fungal traits, while the increase in the stress gradient increased the importance of intraspecific diversity.
MeSH term(s)	Phylogeny ; Mitosporic Fungi/physiology ; Rivers/microbiology ; Fresh Water ; Phenotype ; Plant Leaves/microbiology ; Fungi/genetics ; Ecosystem
Language	English
Publishing date	2022-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1462065-0
ISSN	1432-184X ; 0095-3628
ISSN (online)	1432-184X
ISSN	0095-3628
DOI	10.1007/s00248-022-02007-7
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Article ; Online: Arteriovenous fistula cannulation in hemodialysis: A vascular access clinical practice guidelines narrative review.

Pinto, Rui / Sousa, Clemente / Salgueiro, Anabela / Fernandes, Isabel

The journal of vascular access

2021 Volume 23, Issue 5, Page(s) 825–831

Abstract: The cannulation of an arteriovenous fistula (AVF) by the hemodialysis (HD) nurse is challenging. Despite it being the focus of extensive research, it is still one of the majors causes of damage making it prone to failure. A considerable number of ... ...

Abstract	The cannulation of an arteriovenous fistula (AVF) by the hemodialysis (HD) nurse is challenging. Despite it being the focus of extensive research, it is still one of the majors causes of damage making it prone to failure. A considerable number of Clinical Practice Guidelines (CPGs) for the management of vascular access (VA) have been published worldwide over the past two decades. This review aimed to assess all information available in the selected CPG regarding AVF cannulation for HD providing a comprehensive analysis in order to interpret possible future cannulation approaches. A total of seven CPGs were described in a coding table separated in seven subthemes: Initiation of cannulation, preparation, technique, needle selection, surveillance, pain, and education. Our analysis outlines current CPGs for HD VA cannulation with lack of good evidence support for the majority of the recommendations, showing that, there is an urgent need for international collaboration and coordination to ensure relevant and high-quality evidence. Future CPGs must consider recommendations with better grading of evidence aiming patient-centered care and nurse decision models that can potentially represent better AVF cannulation outcomes.
MeSH term(s)	Arteriovenous Fistula ; Arteriovenous Shunt, Surgical/adverse effects ; Catheterization/adverse effects ; Catheterization/methods ; Humans ; Renal Dialysis/methods
Language	English
Publishing date	2021-04-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2252820-9
ISSN	1724-6032 ; 1129-7298
ISSN (online)	1724-6032
ISSN	1129-7298
DOI	10.1177/11297298211006972
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Article: A Case of Success: Complete Response to Radium-223 in Metastatic Castration-Resistant Prostate Cancer.

Soares de Pinho, Inês / Esperança-Martins, Miguel / Machado, Bárbara / Dâmaso, Sara / Lopes Brás, Raquel / Cantinho, Guilhermina / Fernandes, Isabel / Costa, Luís

Cureus

2024 Volume 16, Issue 2, Page(s) e53637

Abstract: Radium-223 dichloride (Ra223) is the first targeted alpha agent approved for treating metastatic castration-resistant prostate cancer (mCRPC) with bone-exclusive disease. A benefit in overall survival and time to the first symptomatic skeletal-related ... ...

Abstract	Radium-223 dichloride (Ra223) is the first targeted alpha agent approved for treating metastatic castration-resistant prostate cancer (mCRPC) with bone-exclusive disease. A benefit in overall survival and time to the first symptomatic skeletal-related event was shown in the Alpharadin in Symptomatic Prostate Cancer Patients (ALSYMPCA) trial. However, this trial did not describe a bone scan response to Ra223, and there is no universal consensus about how it should be monitored. Furthermore, a scintigraphy flare phenomenon may lead to false-positive tracer uptake in responsive cases, thereby misleading the interpretation of imaging results. We present the case of a 67-year-old male with mCRPC and exclusive bone disease treated with Ra223. The bone scintigraphy after the end of the treatment showed an apparent aggravation of the lesions, corresponding to a flare phenomenon, with an almost complete resolution after three months. The patient maintained a scintigraphic response for seven months.
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.53637
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Article: Emerging role of liquid biopsy in rat sarcoma virus mutated metastatic colorectal cancer: A case report.

Gramaça, João / Fernandes, Isabel Gomes / Trabulo, Carolina / Gonçalves, Joana / Dos Santos, Rita Gameiro / Baptista, Adriano / Pina, Idília

World journal of gastrointestinal oncology

2024 Volume 16, Issue 1, Page(s) 234–243

Abstract: Background: In patients with metastatic colorectal cancer (mCRC), the treatment options are limited and have been proved to be affected by rat sarcoma virus (RAS) mutational status. In RAS wild-type (wt) patients, the combination of anti-epidermal ... ...

Abstract	Background: In patients with metastatic colorectal cancer (mCRC), the treatment options are limited and have been proved to be affected by rat sarcoma virus (RAS) mutational status. In RAS wild-type (wt) patients, the combination of anti-epidermal growth factor receptor (EGFR) monoclonal antibodies with chemotherapy (CT) is more effective than CT alone. On the other hand, RAS-mutated patients are not eligible for treatment with anti-EGFR antibodies. Case summary: Eleven patients with initially RAS-mutated mCRC were followed from diagnosis to May 2022. At the time of cell-free DNA determination, five patients had undergone one CT line, five patients had undergone two CT lines, and one patient had undergone three CT lines (all in combination with bevacizumab). At the second and third treatment lines [second line (2L), third line (3L)], patients with neo-RAS wt received a combination of CT and cetuximab. In neo-RAS wt patients treated with anti-EGFR, our findings indicated an increase in progression-free survival for both 2L and 3L (14.5 mo, Conclusion: Our case series demonstrated that monitoring RAS mutations in mCRC by liquid biopsy may provide an additional treatment line for neo-RAS wt patients.
Language	English
Publishing date	2024-01-16
Publishing country	China
Document type	Case Reports
ZDB-ID	2573696-6
ISSN	1948-5204
ISSN	1948-5204
DOI	10.4251/wjgo.v16.i1.234
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Article ; Online: Ovule Transcriptome Analysis Discloses Deregulation of Genes and Pathways in Sexual and Apomictic Limonium Species (Plumbaginaceae)

Caperta, Ana D. / Fernandes, Isabel / Conceição, Sofia I. R. / Marquès, Isabel / Róis, Ana S. / Paulo, Octávio S.

Genes (Basel). 2023 Apr. 12, v. 14, no. 4

2023

Abstract: The genus Limonium Mill. (sea lavenders) includes species with sexual and apomixis reproductive strategies, although the genes involved in these processes are unknown. To explore the mechanisms beyond these reproduction modes, transcriptome profiling of ... ...

Abstract	The genus Limonium Mill. (sea lavenders) includes species with sexual and apomixis reproductive strategies, although the genes involved in these processes are unknown. To explore the mechanisms beyond these reproduction modes, transcriptome profiling of sexual, male sterile, and facultative apomictic species was carried out using ovules from different developmental stages. In total, 15,166 unigenes were found to be differentially expressed with apomictic vs. sexual reproduction, of which 4275 were uniquely annotated using an Arabidopsis thaliana database, with different regulations according to each stage and/or species compared. Gene ontology (GO) enrichment analysis indicated that genes related to tubulin, actin, the ubiquitin degradation process, reactive oxygen species scavenging, hormone signaling such as the ethylene signaling pathway and gibberellic acid-dependent signal, and transcription factors were found among differentially expressed genes (DEGs) between apomictic and sexual plants. We found that 24% of uniquely annotated DEGs were likely to be implicated in flower development, male sterility, pollen formation, pollen-stigma interactions, and pollen tube formation. The present study identifies candidate genes that are highly associated with distinct reproductive modes and sheds light on the molecular mechanisms of apomixis expression in Limonium sp.
Keywords	Arabidopsis thaliana ; Limonium ; actin ; apomixis ; ethylene ; flowering ; gene expression regulation ; gene ontology ; male sterility ; males ; ovules ; pollen ; pollen tubes ; reactive oxygen species ; sexual reproduction ; transcriptome ; transcriptomics ; tubulin ; ubiquitin ; unigenes
Language	English
Dates of publication	2023-0412
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14040901
Database	NAL-Catalogue (AGRICOLA)

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Article: ITS rDNA Barcodes Clarify Molecular Diversity of Aquatic Hyphomycetes

Franco-Duarte, Ricardo / Fernandes, Isabel / Gulis, Vladislav / Cássio, Fernanda / Pascoal, Cláudia

Microorganisms. 2022 Aug. 04, v. 10, no. 8

2022

Abstract: Aquatic hyphomycetes are key microbial decomposers of allochthonous organic matter in freshwater ecosystems. Although their importance in carbon flow and food webs in streams is widely recognized, there are still gaps in our understanding of their ... ...

Abstract	Aquatic hyphomycetes are key microbial decomposers of allochthonous organic matter in freshwater ecosystems. Although their importance in carbon flow and food webs in streams is widely recognized, there are still gaps in our understanding of their molecular diversity and distribution patterns. Our study utilized the growing database of ITS rDNA barcodes of aquatic hyphomycetes (1252 sequences) and aimed to (i) produce new barcodes for some lesser-known taxa; (ii) clarify the taxonomic placement of some taxa at the class or order level, based on molecular data; and (iii) provide insights into the biogeographical origins of some taxa. This study increased the number of aquatic hyphomycete species with available ITS barcodes from 119 (out of ~300 species described) to 136. Phylogenetically, the 136 species were distributed between 2 phyla, 6 classes, and 10 orders of fungi. Future studies should strive to increase the database of ITS sequences, especially focusing on species with unclear phylogenetic relationships (incertae sedis) and with few sequences available. The geographical distribution of species with available ITS sequences included 50 countries from five continents, but 6 countries had more than 20 species associated, showing a bias toward the northern hemisphere, likely due to sampling bias.
Keywords	Hyphomycetes ; carbon ; databases ; freshwater ; geographical distribution ; organic matter ; phylogeny
Language	English
Dates of publication	2022-0804
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10081569
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Caveolin proteins electrochemical oxidation and interaction with cholesterol.

Fernandes, Isabel P G / Oliveira-Brett, Ana Maria

Bioelectrochemistry (Amsterdam, Netherlands)

2020 Volume 133, Page(s) 107451

Abstract: Caveolae consist in lipid raft domains composed of caveolin proteins, cholesterol, glycosphingolipids, and GPI-anchored proteins. Caveolin proteins present three different types, caveolin 1 (CAV-1), caveolin 2 (CAV-2) and caveolin 3 (CAV-3), with a very ... ...

Abstract	Caveolae consist in lipid raft domains composed of caveolin proteins, cholesterol, glycosphingolipids, and GPI-anchored proteins. Caveolin proteins present three different types, caveolin 1 (CAV-1), caveolin 2 (CAV-2) and caveolin 3 (CAV-3), with a very similar structure and amino acid composition. The native caveolin proteins oxidation mechanism was investigated for the first time, at a glassy carbon electrode, using cyclic, square wave and differential pulse voltammetry. The three native caveolin proteins oxidation mechanism presented only one tyrosine and tryptophan amino acid residues oxidation peak. Denatured caveolin proteins presented also the tyrosine, tryptophan and cysteine amino acid residues oxidation peaks. The reverse cholesterol transport is related to caveolae and caveolin proteins, and CAV-1 is directly connected to cholesterol transport. The influence of cholesterol on the three caveolin proteins electrochemical behaviour was evaluated. In the absence and in the presence of cholesterol, significant differences in the CAV-1 oxidation peak current were observed.
MeSH term(s)	Caveolae/metabolism ; Caveolin 1/chemistry ; Caveolin 1/metabolism ; Caveolin 2/chemistry ; Caveolin 2/metabolism ; Caveolin 3/chemistry ; Caveolin 3/metabolism ; Cholesterol/metabolism ; Electrochemical Techniques ; Humans ; Oxidation-Reduction ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism
Chemical Substances	CAV1 protein, human ; CAV2 protein, human ; CAV3 protein, human ; Caveolin 1 ; Caveolin 2 ; Caveolin 3 ; Recombinant Proteins ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2020-01-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2010650-6
ISSN	1878-562X ; 0302-4598 ; 1567-5394
ISSN (online)	1878-562X
ISSN	0302-4598 ; 1567-5394
DOI	10.1016/j.bioelechem.2019.107451
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