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Article ; Online: Volumetric changes in post hemiglossectomy reconstruction with anterolateral thigh free flap versus radial forearm free flap.

Younis, P A / Davis, S / Sweedan, A O / ElSabbagh, A M / Fernandes, R P

International journal of oral and maxillofacial surgery

2023

Abstract: The volume of the reconstructed tongue is considered a critical factor for tongue function. Studies investigating the difference in volume loss between the anterolateral thigh free flap (ALTF) and radial forearm free flap (RFFF) used in reconstruction of ...

Abstract	The volume of the reconstructed tongue is considered a critical factor for tongue function. Studies investigating the difference in volume loss between the anterolateral thigh free flap (ALTF) and radial forearm free flap (RFFF) used in reconstruction of the tongue after hemiglossectomy are lacking. The aim of this study was to determine whether there is a significant difference in shrinkage between these two flaps. This was a retrospective study of all patients treated for tongue cancer by hemiglossectomy who underwent either ALTF or RFFF reconstruction at the University of Florida College of Medicine between January 2018 and April 2022. Computed tomography scans were used to measure the volumetric changes in the ALTF and RFFF at two time points over a 6-month period. Of the 85 patients assessed, 10 fulfilled the inclusion criteria: five were reconstructed with an ALTF and five with a RFFF. All underwent adjuvant radiotherapy. The mean ALTF percentage shrinkage was 39.6% ± 3.9%, while for the RFFF it was 51.1% ± 6.2% (P = 0.008). Therefore, it is recommended that the difference in volume loss between the two flaps is taken into consideration. It is suggested that in hemiglossectomy cases, the ALTF is made 1.4 times larger than the defect, while the RFFF is made 1.5 times larger.
Language	English
Publishing date	2023-12-18
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	353721-3
ISSN	1399-0020 ; 0901-5027
ISSN (online)	1399-0020
ISSN	0901-5027
DOI	10.1016/j.ijom.2023.12.003
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Article ; Online: Insights for Alzheimer's disease pharmacotherapy and current clinical trials.

Nascimento, A L C S / Fernandes, R P / Carvalho, A C S / Frigieri, I / Alves, R C / Chorilli, M

Neurochemistry international

2022 Volume 159, Page(s) 105401

Abstract: Over the years, the scientific community has sought improvements in the life quality of patients diagnosed with Alzheimer's disease (AD). Synaptic loss and neuronal death observed in the regions responsible for cognitive functions represent an ... ...

Abstract	Over the years, the scientific community has sought improvements in the life quality of patients diagnosed with Alzheimer's disease (AD). Synaptic loss and neuronal death observed in the regions responsible for cognitive functions represent an irreversible progressive disease that is clinically characterized by impaired cognitive and functional abilities, along with behavioral symptoms. Currently, image and body fluid biomarkers can provide early dementia diagnostic, being it the best way to slow the disease's progression. The first signs of AD development are still complex, the existence of individual genetic and phenotypic characteristics about the disease makes it difficult to standardize studies on the subject. The answer seems to be related between Aβ and tau proteins. Aβ deposition in the medial parietal cortex appears to be the initial stage of AD, but it does not have a strong correlation with neurodegeneration. The strongest link between symptoms occurs with tau aggregation, which antecede Aβ deposits in the medial temporal lobe, however, the protein can be found in cognitively healthy older people. The answer to the question may lie in some catalytic effect between both proteins. Amid so many doubts, Aducanumab was approved, which raised controversies and results intense debate in the scientific field. Abnormal singling of some blood biomarkers produced by adipocytes under high lipogenesis, such as TNFα, leptin, and interleukin-6, demonstrate to be linked to neuroinflammation worsens, diabetes, and also severe cases of COVID-19, howsoever, under higher lipolysis, seem to have therapeutic anti-inflammatory effects in the brain, which has increasingly contributed to the understanding of AD. In addition, the relationship of severe clinical complications caused by Sars-CoV-2 viral infection and AD, go beyond the term "risk group" and may be related to the development of dementia long-term. Thus, this review summarized the current emerging pharmacotherapies, alternative treatments, and nanotechnology applied in clinical trials, discussing relevant points that may contribute to a more accurate look.
MeSH term(s)	Aged ; Alzheimer Disease/genetics ; Amyloid beta-Peptides/metabolism ; Biomarkers ; COVID-19/drug therapy ; Humans ; Positron-Emission Tomography ; SARS-CoV-2 ; tau Proteins/metabolism
Chemical Substances	Amyloid beta-Peptides ; Biomarkers ; tau Proteins
Language	English
Publishing date	2022-07-13
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	283190-9
ISSN	1872-9754 ; 0197-0186
ISSN (online)	1872-9754
ISSN	0197-0186
DOI	10.1016/j.neuint.2022.105401
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Article ; Online: Response to "Major head and neck surgery as a risk factor for postoperative atrial fibrillation".

Weyh, A M / Elayi, C S / Catanzaro, J N / Esmail, K / Yekikian, M / Bunnell, A M / Fernandes, R P

International journal of oral and maxillofacial surgery

2021 Volume 50, Issue 11, Page(s) 1530–1531

MeSH term(s)	Atrial Fibrillation/epidemiology ; Atrial Fibrillation/etiology ; Atrial Fibrillation/surgery ; Humans ; Incidence ; Postoperative Complications/etiology ; Risk Factors
Language	English
Publishing date	2021-03-07
Publishing country	Denmark
Document type	Letter ; Comment
ZDB-ID	353721-3
ISSN	1399-0020 ; 0901-5027
ISSN (online)	1399-0020
ISSN	0901-5027
DOI	10.1016/j.ijom.2021.02.017
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Article: Assessment of the stability of sheep sausages with the addition of different concentrations of Origanum vulgare extract during storage

Fernandes, R.P.P / M.A. Trindade / J.M. Lorenzo / M.P. de Melo

Meat science. 2018 Mar., v. 137

2018

Abstract: The aim of this study was to assess the stability of sheep sausages with the addition of different concentrations of Origanum vulgare extract during storage. Five treatments were prepared: without natural antioxidant (control), sodium erythorbate 500mg/ ... ...

Abstract	The aim of this study was to assess the stability of sheep sausages with the addition of different concentrations of Origanum vulgare extract during storage. Five treatments were prepared: without natural antioxidant (control), sodium erythorbate 500mg/kg (ER), and three amounts of extract (N1=4964.51mg/kg, N2=6630.98mg/kg and N3=8038.20mg/kg). From appearance sensory analysis, control treatment differed significantly compared to ER (P<0.05) and N3 (P<0.01) groups, with intense red color, agreeing with trend of a* values. On the other hand, oregano extract improved the lipid and protein stability of cooked sausages during the storage time. Regarding volatile compounds from lipid oxidation, the N2 group presented the lowest values at the end of chilled period. In conclusion, the oregano extract showed antioxidant potential equivalent to sodium erythorbate at intermediate and high levels, calculated by DPPH∙ and FRAP methods, and most of the parameters were not compromised, allowing synthetic antioxidants replaced while maintaining the nutritional and sensory quality of cooked sausages.
Keywords	Origanum vulgare ; antioxidant activity ; antioxidants ; color ; fluorescence recovery after photobleaching ; isoascorbic acid ; lipid peroxidation ; lipids ; oregano ; sausages ; sensory evaluation ; sensory properties ; sheep ; storage time ; volatile compounds
Language	English
Dates of publication	2018-03
Size	p. 244-257.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	753319-6
ISSN	1873-4138 ; 0309-1740
ISSN (online)	1873-4138
ISSN	0309-1740
DOI	10.1016/j.meatsci.2017.11.018
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Head and neck surgery is a risk factor for atrial fibrillation: incidence and outcomes.

Weyh, A M / Esmail, K / Yekikian, M / Catanzaro, J N / Bunnell, A M / Elayi, C S / Fernandes, R P

International journal of oral and maxillofacial surgery

2020 Volume 49, Issue 12, Page(s) 1535–1541

Abstract: Atrial fibrillation (AF) is the most common postoperative arrhythmia and can cause increased length of stay, costs, morbidity, and mortality. Little information exists about postoperative AF after major head and neck surgery, but it is thought to occur ... ...

Abstract	Atrial fibrillation (AF) is the most common postoperative arrhythmia and can cause increased length of stay, costs, morbidity, and mortality. Little information exists about postoperative AF after major head and neck surgery, but it is thought to occur more frequently than after surgery at other extra-thoracic sites. A retrospective cohort study was implemented, including patients who had undergone major head and neck surgery and who had follow-up records covering a minimum of 60 days postoperative. The main outcome was the incidence of new onset postoperative AF after major head and neck surgery; secondary outcomes were the incidence of any AF, the role of cardiology, predictors of AF postoperatively, and clinical outcomes. A total 337 patients were included. Twenty-four patients experienced AF postoperatively (7.1%), of whom 12 (3.6%) had new onset AF. New onset AF was associated with advanced age of ≥65 years (odds ratio 11.6, P=0.027) and having a laryngectomy (odds ratio 9.9, P=0.003). Postoperative AF following major head and neck surgery is not a rare phenomenon and can be associated with considerable morbidity and costs due to the need for intensive care, specialty consultations, additional testing and laboratory studies, and cardiology follow-up.
MeSH term(s)	Atrial Fibrillation/epidemiology ; Atrial Fibrillation/etiology ; Humans ; Incidence ; Odds Ratio ; Postoperative Complications/epidemiology ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2020-05-29
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	353721-3
ISSN	1399-0020 ; 0901-5027
ISSN (online)	1399-0020
ISSN	0901-5027
DOI	10.1016/j.ijom.2020.04.014
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Article ; Online: Assessment of the stability of sheep sausages with the addition of different concentrations of Origanum vulgare extract during storage.

Fernandes, R P P / Trindade, M A / Lorenzo, J M / de Melo, M P

Meat science

2017 Volume 137, Page(s) 244–257

Abstract	The aim of this study was to assess the stability of sheep sausages with the addition of different concentrations of Origanum vulgare extract during storage. Five treatments were prepared: without natural antioxidant (control), sodium erythorbate 500mg/kg (ER), and three amounts of extract (N1=4964.51mg/kg, N2=6630.98mg/kg and N3=8038.20mg/kg). From appearance sensory analysis, control treatment differed significantly compared to ER (P<0.05) and N3 (P<0.01) groups, with intense red color, agreeing with trend of a* values. On the other hand, oregano extract improved the lipid and protein stability of cooked sausages during the storage time. Regarding volatile compounds from lipid oxidation, the N2 group presented the lowest values at the end of chilled period. In conclusion, the oregano extract showed antioxidant potential equivalent to sodium erythorbate at intermediate and high levels, calculated by DPPH
MeSH term(s)	Animals ; Antioxidants ; Ascorbic Acid ; Color ; Cooking ; Food Storage/methods ; Lipid Peroxidation ; Meat Products/analysis ; Origanum ; Plant Extracts ; Sheep
Chemical Substances	Antioxidants ; Plant Extracts ; isoascorbic acid (311332OII1) ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2017-11-15
Publishing country	England
Document type	Journal Article
ZDB-ID	753319-6
ISSN	1873-4138 ; 0309-1740
ISSN (online)	1873-4138
ISSN	0309-1740
DOI	10.1016/j.meatsci.2017.11.018
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of free and dipeptide forms of methionine supplementation on oxidative metabolism of broilers under high temperature.

Santana, T P / Gasparino, E / de Sousa, F C B / Khatlab, A S / Zancanela, V / Brito, C O / Barbosa, L T / Fernandes, R P M / Del Vesco, A P

Animal : an international journal of animal bioscience

2021 Volume 15, Issue 3, Page(s) 100173

Abstract: Our previous studies have shown that methionine supplementation could help to attenuate the effects of heat stress on the metabolism of broiler chickens. Here we investigated for the first time the effects of methionine supplementation in the form of DL- ... ...

Abstract	Our previous studies have shown that methionine supplementation could help to attenuate the effects of heat stress on the metabolism of broiler chickens. Here we investigated for the first time the effects of methionine supplementation in the form of DL-methionyl-DL-methionine on broilers subjected to heat stress during the growth phase. Broilers were divided into two groups; one group was reared under thermoneutral conditions and the other under continuous heat stress (30 ± 1 °C, 60% relative humidity). Both groups were subdivided into three dietary treatments: a methionine-deficient (MD) diet, a diet supplemented with free methionine (DL-M), and a diet supplemented with methionine dipeptide (DL-MM). Broilers raised under chronic heat stress had lower feed intake and weight gain than broilers raised under thermoneutral conditions (P < 0.05). There were no differences in animal performance between methionine-supplemented diets (DL-M and DL-MM). Heat-stressed birds had significantly higher heterophil/lymphocyte (H/L) ratio than thermoneutral birds. Under heat stress, broilers fed DL-M and DL-MM diets had lower H/L ratio than birds fed the MD diet. Higher concentrations of carbonylated proteins and lower concentration of reduced glutathione were observed in broilers raised under heat stress. In comparing heat-stressed broilers, we found that birds fed the DL-M diet had lower concentrations of thiobarbituric acid-reactive substances and carbonylated proteins than those fed the MD diet (P < 0.05). Higher expression of glutathione peroxidase (GPX) and glutathione synthetase (GSS) genes was observed in heat-stressed broilers (P < 0.05). Under heat stress, the MD diet increased GPX expression compared with other diets. Under thermoneutral conditions, the DL-M diet resulted in the highest GSS expression. There was a negative correlation between DNA methylation and GPX and GSS expression. Our results showed that supplementation of broiler diets with free methionine or methionine dipeptide may help attenuate the effects of heat stress through enhanced activation of genes related to the glutathione antioxidant system. Methionine effects were found for gene regulation, gene expression, and post-translational processing.
MeSH term(s)	Animal Feed/analysis ; Animals ; Chickens/metabolism ; Diet/veterinary ; Dietary Supplements/analysis ; Dipeptides ; Hot Temperature ; Methionine/metabolism ; Oxidative Stress ; Temperature
Chemical Substances	Dipeptides ; Methionine (AE28F7PNPL)
Language	English
Publishing date	2021-02-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2257920-5
ISSN	1751-732X ; 1751-7311
ISSN (online)	1751-732X
ISSN	1751-7311
DOI	10.1016/j.animal.2021.100173
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Article: Effects of free and dipeptide forms of methionine supplementation on oxidative metabolism of broilers under high temperature

Santana, T.P / Gasparino, E / de Sousa, F.C.B / Khatlab, A.S / Zancanela, V / Brito, C.O / Barbosa, L.T / Fernandes, R.P.M / Del Vesco, A.P

Animal. 2021 Mar., v. 15, no. 3

2021

Abstract	Our previous studies have shown that methionine supplementation could help to attenuate the effects of heat stress on the metabolism of broiler chickens. Here we investigated for the first time the effects of methionine supplementation in the form of DL-methionyl-DL-methionine on broilers subjected to heat stress during the growth phase. Broilers were divided into two groups; one group was reared under thermoneutral conditions and the other under continuous heat stress (30 ± 1 °C, 60% relative humidity). Both groups were subdivided into three dietary treatments: a methionine-deficient (MD) diet, a diet supplemented with free methionine (DL-M), and a diet supplemented with methionine dipeptide (DL-MM). Broilers raised under chronic heat stress had lower feed intake and weight gain than broilers raised under thermoneutral conditions (P < 0.05). There were no differences in animal performance between methionine-supplemented diets (DL-M and DL-MM). Heat-stressed birds had significantly higher heterophil/lymphocyte (H/L) ratio than thermoneutral birds. Under heat stress, broilers fed DL-M and DL-MM diets had lower H/L ratio than birds fed the MD diet. Higher concentrations of carbonylated proteins and lower concentration of reduced glutathione were observed in broilers raised under heat stress. In comparing heat-stressed broilers, we found that birds fed the DL-M diet had lower concentrations of thiobarbituric acid-reactive substances and carbonylated proteins than those fed the MD diet (P < 0.05). Higher expression of glutathione peroxidase (GPX) and glutathione synthetase (GSS) genes was observed in heat-stressed broilers (P < 0.05). Under heat stress, the MD diet increased GPX expression compared with other diets. Under thermoneutral conditions, the DL-M diet resulted in the highest GSS expression. There was a negative correlation between DNA methylation and GPX and GSS expression. Our results showed that supplementation of broiler diets with free methionine or methionine dipeptide may help attenuate the effects of heat stress through enhanced activation of genes related to the glutathione antioxidant system. Methionine effects were found for gene regulation, gene expression, and post-translational processing.
Keywords	DNA methylation ; aerobiosis ; animal performance ; antioxidants ; diet ; dipeptides ; feed intake ; gene expression ; genes ; glutathione ; glutathione peroxidase ; glutathione synthase ; heat stress ; heterophils ; methionine ; relative humidity ; temperature ; weight gain
Language	English
Dates of publication	2021-03
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2257920-5
ISSN	1751-732X ; 1751-7311
ISSN (online)	1751-732X
ISSN	1751-7311
DOI	10.1016/j.animal.2021.100173
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Article: Altruistic helping in young children with ASD

Manfredi, Mirella / Fernandes Rodrigues Pereira, Elisabete / Horta Tabosa do Egito, Júlia / Scarano de Mendonca, Julia / Caldas Osório, Ana Alexandra

Research in Developmental Disabilities

A preliminary study

2021

Abstract: Abstract not released by publisher. ...

Title translation	Altruistisches Helfen bei jungen Kindern mit ASD: Eine vorläufige Studie
Abstract	Abstract not released by publisher.
Keywords	Altruism ; Altruismus ; Assistance (Social Behavior) ; Autism Spectrum Disorders ; Autismus-Spektrum-Störungen ; Down's Syndrome ; Down-Syndrom ; Hilfeverhalten ; Krankheitsschweregrad ; Prosocial Behavior ; Prosoziales Verhalten ; Severity (Disorders) ; Social Cognition ; Socioemotional Functioning ; Soziale Kognition ; Sozioemotionales Funktionsniveau
Language	English
Document type	Article
ZDB-ID	639175-8
ISSN	1873-3379 ; 0891-4222
ISSN (online)	1873-3379
ISSN	0891-4222
DOI	10.1016/j.ridd.2021.104067
Database	PSYNDEX

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Article: Novel solid-state compounds of heavy rare-earth (III) picolinates. A pyrolytic study using: TG-DSC-IR, HSM-MS and GC-MS

Nascimento, A.L.C.S / Ashton, G.P / Caires, F.J / Carvalho, A.C.S / Ekawa, B / Fernandes, R. P / Ionashiro, M / Parkes, G.M.B

Journal of analytical and applied pyrolysis. 2019 Nov., v. 144

2019

Abstract: Heavy trivalent lanthanides and yttrium picolinates were synthesized by complexation of basic rare-earth metal carbonates with an aqueous solution of picolinic acid. The novel compounds were obtained with the general formula Ln(L)3∙nH2O, where L is ... ...

Abstract	Heavy trivalent lanthanides and yttrium picolinates were synthesized by complexation of basic rare-earth metal carbonates with an aqueous solution of picolinic acid. The novel compounds were obtained with the general formula Ln(L)3∙nH2O, where L is picolinate and n = 1.5 H2O (Dy, Ho, Yb, Lu and Y), 2 H2O (Tb and Tm) and 2.5 H2O (Er). The stoichiometry of the complexes was calculated through mass losses found using thermogravimetry (TG), complexometry and elemental analysis (EA). The thermal behavior in oxidative and pyrolytic atmospheres of the compounds was analyzed by simultaneous thermogravimetry - differential scanning calorimetry (TG-DSC). The gaseous products of the pyrolysis were determined throughout by monitoring the evolved species using TG-DSC couple to Fourier transform infrared spectroscopy (TG-DSC-IR), hot-stage microscopy mass spectrometry (HSM-MS), and gas chromatography-mass spectrometry (GC-MS). The obtained results validated mass loss assignments made using the TG curves. However, gaseous product analysis indicates the degradation processes are more complex than the thermoanalytical techniques suggest alone. This study used a GC-MS technique to identify the condensed gaseous products obtained during the second step of thermal degradation of the picolinate complexes. The analysis of the symmetric and asymmetric stretching frequencies of the carboxylate group in the IR spectra showed a monodentate bonding mode. The compounds were obtained in the amorphous state, as indicated by the powder x-ray diffractometry (PXRD) data.
Keywords	aqueous solutions ; carbonates ; differential scanning calorimetry ; Fourier transform infrared spectroscopy ; gas chromatography-mass spectrometry ; lanthanides ; microscopy ; monitoring ; picolinic acid ; pyrolysis ; stoichiometry ; thermal properties ; thermogravimetry ; X-ray diffraction ; yttrium
Language	English
Dates of publication	2019-11
Publishing place	Elsevier B.V.
Document type	Article
ISSN	0165-2370
DOI	10.1016/j.jaap.2019.104709
Database	NAL-Catalogue (AGRICOLA)

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