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Article ; Online: Neonatal and infantile cholestasis: An overlooked health burden with unmet needs.

Fernando, Meranthi / Rajindrajith, Shaman

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

2021 Volume 39, Issue 6, Page(s) 531–538

MeSH term(s)	Cholestasis ; Cost of Illness ; Female ; Health Services Needs and Demand ; Humans ; Infant, Newborn ; Male
Language	English
Publishing date	2021-01-21
Publishing country	India
Document type	Journal Article
ZDB-ID	632595-6
ISSN	0975-0711 ; 0254-8860
ISSN (online)	0975-0711
ISSN	0254-8860
DOI	10.1007/s12664-020-01137-5
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Zs.A 2085: Show issues

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Article ; Online: Challenges faced in establishing a pediatric liver transplant program in a lower-middle-income country with free healthcare service.

Fernando, Meranthi / Tillakaratne, Suchintha / Gunetilleke, Bhagya / Liyanage, Chamila / Appuhamy, Chinthaka / Weerasuriya, Aruna / Uragoda, Buddhika / Welikala, Nadeeshya / Ranaweera, Liyanage / Ganewatte, Eranga / Dissanayake, Janaki / Mudalige, Anushka / Siriwardana, Rohan

Pediatric transplantation

2024 Volume 28, Issue 1, Page(s) e14681

Abstract: Background: Liver transplant is the cure for children with liver failure. Sri Lanka is a lower-middle-income country with a predominant free, state health system. Pediatric liver transplant program in Sri Lanka is still in the budding state where the ... ...

Abstract	Background: Liver transplant is the cure for children with liver failure. Sri Lanka is a lower-middle-income country with a predominant free, state health system. Pediatric liver transplant program in Sri Lanka is still in the budding state where the initial experience of the program is yet to be documented. Methods: A retrospective review was performed including the clinical characteristics of all pediatric liver transplant recipients of Colombo North Centre for Liver Diseases since the inception of the program from June 2020 to May 2023. Results: There were 14 PLT performed in 3 years. The median recipient age and weight were 8 years (6 months-15 years) and 23.3 kg (6.4-49.2), respectively. The majority were boys (64%). All were from low-income backgrounds. Indications for LT were acute liver failure (5/14), decompensated chronic liver disease (5/14), and acute on chronic liver failure (4/14). Underlying liver diseases were Wilson disease (6/14), autoimmune liver disease (3/14), biliary atresia (2/14) and progressive familial intrahepatic cholestasis type 3 (1/14), and unknown etiology (2/14). The majority were living donor liver transplants (86%). Of the living donors, 42% (5/12) were Buddhist priests. There were three immediate deaths and two late deaths. The 3-month survival was 78%, and overall survival was 64%. Living donor transplants carried a higher success rate (92%) compared to diseased donor transplants (0%; 2/2). Conclusions: Initial experience of pediatric liver transplant program of Sri Lanka is promising despite being established in a free healthcare system amidst the crisis circumstances.
MeSH term(s)	Male ; Child ; Humans ; Female ; Liver Transplantation ; Living Donors ; Developing Countries ; Postoperative Complications/etiology ; Hepatolenticular Degeneration ; Retrospective Studies ; Delivery of Health Care ; Graft Survival ; Treatment Outcome
Language	English
Publishing date	2024-02-05
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1390284-2
ISSN	1399-3046 ; 1397-3142
ISSN (online)	1399-3046
ISSN	1397-3142
DOI	10.1111/petr.14681
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Zs.A 4947: Show issues

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Article ; Online: Wilson disease in children and adolescents.

Fernando, Meranthi / van Mourik, Indra / Wassmer, Evangeline / Kelly, Deirdre

Archives of disease in childhood

2020 Volume 105, Issue 5, Page(s) 499–505

Abstract: Wilson disease (WD) is a rare, recessively inherited disorder of copper metabolism mainly affecting liver and brain. In childhood, it is known to have a predominant hepatic phenotype. It is likely that the low awareness for WD-associated neuropsychiatric ...

Abstract	Wilson disease (WD) is a rare, recessively inherited disorder of copper metabolism mainly affecting liver and brain. In childhood, it is known to have a predominant hepatic phenotype. It is likely that the low awareness for WD-associated neuropsychiatric signs and symptoms in this age group means that neurological Wilson's disease is underdiagnosed in children and young people. Practitioners should be alert for this complication in children with or without liver disease. Management of children with WD requires a dedicated multidisciplinary approach involving hepatologists, geneticists, neurologists and psychiatrists to ensure subtle neuropsychiatric symptoms are identified early and addressed appropriately. This review highlights recent advances in hepatic and neuropsychiatric symptoms of WD in childhood, specific diagnostic tools and pitfalls and summarises existing and potential future treatment options.
MeSH term(s)	Adolescent ; Child ; Hepatolenticular Degeneration/complications ; Hepatolenticular Degeneration/diagnosis ; Hepatolenticular Degeneration/therapy ; Humans
Language	English
Publishing date	2020-01-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	524-1
ISSN	1468-2044 ; 0003-9888 ; 1359-2998
ISSN (online)	1468-2044
ISSN	0003-9888 ; 1359-2998
DOI	10.1136/archdischild-2018-315705
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Article: A Case of Dapsone-Induced Severe Agranulocytosis Causing Life-Threatening Skin Sepsis in a Sri Lankan Child with Borderline Leprosy: A Success Story!

Fernando, Meranthi / Kankananarachchi, Imalke / Navabalasooriyar, Pratheep / Herath, Bhagya / Punchihewa, Pushpa

Case reports in medicine

2019 Volume 2019, Page(s) 2314379

Abstract: Leprosy is a common skin disease in Sri Lanka which is being increasingly diagnosed due to the existing successful public health programme. Dapsone is a drug which holds unique pharmacological properties where it serves as both anti-inflammatory and ... ...

Abstract	Leprosy is a common skin disease in Sri Lanka which is being increasingly diagnosed due to the existing successful public health programme. Dapsone is a drug which holds unique pharmacological properties where it serves as both anti-inflammatory and antimicrobial agents. Of its main adverse effects, agranulocytosis is a serious consequence which is reported mainly in adults and elderly. We report a 7-year-old child who sustained life-threatening skin and subcutaneous tissue sepsis because of dapsone-induced agranulocytosis. Besides, this case highlights the importance of meticulous monitoring of cell counts due to the risk of neutropenia and the natural history of cell recovery following occurrence of neutropenia. Though high mortality rate has been described in most of the similar cases reported, the child we describe made a complete recovery following severe neutropenic sepsis.
Language	English
Publishing date	2019-05-06
Publishing country	United States
Document type	Case Reports
ZDB-ID	2502642-2
ISSN	1687-9635 ; 1687-9627
ISSN (online)	1687-9635
ISSN	1687-9627
DOI	10.1155/2019/2314379
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Article: Spondylocostal Dysplasia in a 7-Year-Old Sri Lankan Girl Causing Restrictive Lung Disease: A Case Report and Review of the Literature.

Kamalanathan, Phirarthana / Fernando, Meranthi / Jayawardena, Rohan / Upasena, A / Rajindrajith, Shaman / Mettananda, Sachith

Case reports in medicine

2020 Volume 2020, Page(s) 9241207

Abstract: Spondylocostal dysplasia (SCD) is a rare costovertebral malformation characterised by short-trunk short stature. It is a recessively inherited disorder, and commonly identified disease-causing mutations are ... ...

Abstract	Spondylocostal dysplasia (SCD) is a rare costovertebral malformation characterised by short-trunk short stature. It is a recessively inherited disorder, and commonly identified disease-causing mutations are in
Language	English
Publishing date	2020-10-06
Publishing country	United States
Document type	Case Reports
ZDB-ID	2502642-2
ISSN	1687-9635 ; 1687-9627
ISSN (online)	1687-9635
ISSN	1687-9627
DOI	10.1155/2020/9241207
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Article: Wilson's Disease and Hyperornithinemia-hyperammonemia-homocitrullinuria Syndrome in a Child: A Case Report with Lessons Learned!

Fernando, Meranthi / Vijay, Suresh / Santra, Saikat / Preece, Mary A / Brown, Rachel / Rodrigues, Astor / Gupte, Girish L

Euroasian journal of hepato-gastroenterology

2021 Volume 11, Issue 2, Page(s) 100–102

Abstract: Background: Wilson's disease (WD) is a rare disorder of copper toxicosis. Hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome is even rarer. The coexistence of these two disorders and their clinical implications are not yet reported. We ... ...

Abstract	Background: Wilson's disease (WD) is a rare disorder of copper toxicosis. Hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome is even rarer. The coexistence of these two disorders and their clinical implications are not yet reported. We report on a child who succumbed to death due to liver disease caused by both disorders, documenting their disease-causing mutations and highlighting the lessons learnt out of this case. Case description: A child who was diagnosed to have WD soon after birth due to known parental heterozygosity was later found to have developmental delay, seizures, and hyperammonemia. Subsequent evaluation confirmed hyperornithinemia-hyperammonamia-homocitrullinuria (HHH) syndrome as a comorbidity. Though this child was commenced on medical treatment for both the metabolic diseases since early life, his liver disease was rapidly progressive requiring a liver transplant (LTx) at 6-years. He died in the posttransplant period possibly due to sepsis and hidden metabolic consequences. Conclusion: This case highlights that co-occurrence of WD and HHH syndrome would cause progressive liver disease despite medical treatment. Hence, the close clinical follow-up and early LTx would be warranted. How to cite this article: Fernando M, Vijay S, Santra S,
Language	English
Publishing date	2021-10-25
Publishing country	India
Document type	Case Reports
ZDB-ID	2651614-7
ISSN	2231-5128 ; 2231-5047
ISSN (online)	2231-5128
ISSN	2231-5047
DOI	10.5005/jp-journals-10018-1351
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Article: A Novel Mutation in

Manawadu, Thivanka Vishwani / Jasinge, Eresha / Fernando, Meranthi / Gamage, Pradeep / Gunarathne, Anusha Varuni

Indian journal of clinical biochemistry : IJCB

2019 Volume 35, Issue 2, Page(s) 251–254

Abstract: Beta-ketothiolase (mitochondrial acetoacetyl-CoA thiolase, T2) deficiency is a rare genetic disorder of ketone utilization and isoleucine catabolism caused by mutations in ... ...

Abstract	Beta-ketothiolase (mitochondrial acetoacetyl-CoA thiolase, T2) deficiency is a rare genetic disorder of ketone utilization and isoleucine catabolism caused by mutations in the
Keywords	covid19
Language	English
Publishing date	2019-09-16
Publishing country	India
Document type	Case Reports
ZDB-ID	1033583-3
ISSN	0974-0422 ; 0970-1915
ISSN (online)	0974-0422
ISSN	0970-1915
DOI	10.1007/s12291-019-00851-y
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Zs.A 2949: Show issues

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Article: Effect of feeding practices on dental caries among preschool children: a hospital based analytical cross sectional study.

Perera, Priyantha Julian / Fernando, Meranthi Preethika / Warnakulasooriya, Tania Dayanthi / Ranathunga, Nayomi

Asia Pacific journal of clinical nutrition

2014 Volume 23, Issue 2, Page(s) 272–277

Abstract: Feeding practices during early childhood play an important aetiological role in early childhood caries (ECC). The role of feeding practices in causation of ECC is debated. The objective of this study was to assess the aetiological role of feeding ... ...

Abstract	Feeding practices during early childhood play an important aetiological role in early childhood caries (ECC). The role of feeding practices in causation of ECC is debated. The objective of this study was to assess the aetiological role of feeding practices on ECC. A descriptive cross sectional study was conducted at a paediatric unit in Sri Lanka. Two hundred and eighty-five children between 36 to 60 months, admitted to the unit were randomly selected for the study. An interviewer administered questionnaire asked about socio-demographic characteristics and feeding practices. The mouths of children were examined for dental caries. Out of 285 children, 61% had exclusive breast feeding up to six months, 69% continued breast feeding beyond two years and 82% had overnight feeding after two years of age. One hundred and thirty-six children (47.7%) had dental caries with a mean deft score of 1.81. Overnight feeding with any type of milk beyond two years significantly increased dental caries incidence and severity. Children exclusively breast fed for six months or had breast feeding beyond two years had a higher prevalence of caries than children not exclusively breast fed or who were not breast feed beyond two years, but the difference was not significant. Overnight feeding with any type of milk beyond two years should be discouraged.
MeSH term(s)	Bottle Feeding/methods ; Bottle Feeding/statistics & numerical data ; Breast Feeding/methods ; Breast Feeding/statistics & numerical data ; Causality ; Child, Preschool ; Cross-Sectional Studies ; Dental Caries/epidemiology ; Feeding Behavior/physiology ; Female ; Humans ; Male ; Pediatric Dentistry/methods ; Pediatric Dentistry/statistics & numerical data ; Prevalence
Language	English
Publishing date	2014
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1460012-2
ISSN	0964-7058
ISSN	0964-7058
DOI	10.6133/apjcn.2014.23.2.13
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Zs.A 5285: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Feeding practices among children attending child welfare clinics in Ragama MOH area

Perera Priyantha J / Fernando Meranthi / Warnakulasuria Tania / Ranathunga Nayomi

International Breastfeeding Journal, Vol 6, Iss 1, p

a descriptive cross-sectional study

2011 Volume 18

Abstract: Abstract Background Feeding during early childhood is important for normal physical and mental growth as well as for health in later life. Currently, Sri Lanka has adopted the WHO recommendation of exclusive breastfeeding for six months, followed by ... ...

Abstract	Abstract Background Feeding during early childhood is important for normal physical and mental growth as well as for health in later life. Currently, Sri Lanka has adopted the WHO recommendation of exclusive breastfeeding for six months, followed by addition of complementary feeds thereafter, with continuation of breastfeeding up to or beyond two years. This study was conducted to evaluate the current feeding practices among Sri Lankan children during early childhood. Methods This study was a descriptive cross-sectional study conducted in the Ragama Medical Officer of Health (MOH) area. It was conducted between 10 August 2010 and 30 October 2010. Children between the ages of 24 and 60 months, attending child welfare clinics, were included in the study on consecutive basis. An interviewer-administered questionnaire was used to collect data regarding sociodemographic characteristics and feeding practices. Results There were 208 boys and 202 girls in the study population. Of them, 255 (62.2%) were exclusively breastfed up to 6 months. Younger children had a statistically significant, higher rate of exclusive breastfeeding compared to older children. Three hundred and fifty one (85.6%) children had received infant formula, and it was started before the age of 6 months in 61 children, and in 212 before one year. Sugar was added to infant formula in 330 (80.4%) children, and out of them 144 had sugar added within first year of life. Complementary foods were started before 4 months in 29 (7%) children. Of the 410 children, 294 (71.7%) were breastfed beyond 2 years and 41.6% of them were breastfed at regular intervals throughout the day. Three hundred and thirty eight (82.6%) children were receiving overnight feeding of either breast milk or infant formula even after 2 years. Conclusions Though a high rate of exclusive breastfeeding was observed in this study population, there are many other issues related to feeding during the early years of life that need immediate intervention. Too early introduction of complementary ...
Keywords	Pediatrics ; RJ1-570 ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2011-11-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: Prevalence of dental caries among a cohort of preschool children living in Gampaha district, Sri Lanka

Perera Priyantha J / Abeyweera Nishadhi T / Fernando Meranthi P / Warnakulasuriya Tania D / Ranathunga Nayomi

BMC Oral Health, Vol 12, Iss 1, p

A descriptive cross sectional study

2012 Volume 49

Abstract: Abstract Background Dental caries among young children are a global problem. Scant attention is paid towards primary teeth, leading to high prevalence of dental caries. There are only few studies done in Sri Lanka, addressing oral hygiene among preschool ...

Abstract	Abstract Background Dental caries among young children are a global problem. Scant attention is paid towards primary teeth, leading to high prevalence of dental caries. There are only few studies done in Sri Lanka, addressing oral hygiene among preschool children. Scientific evidence is in need to persuade authorities to establish a programme promoting oral hygiene among preschool children. Methods A descriptive cross sectional study was conducted in Ragama Medical officer of Health area. Consecutive children between 2 – 5 years of age, attending child welfare clinics were recruited for the study. Practices related to dental hygiene and socio-economic characteristics were obtained using an interviewer administered questionnaire. Mouth was examined for evidence of dental caries. Data collection and examination were done by two doctors who were trained for this purpose. The data were analysed using SSPS version 16. Results Total of 410 children were included. None had a routine visits to a dentist. Practices related to tooth brushing were satisfactory. Prevalence of dental caries gradually increased with age to reach 68.8% by 5 years. Mean total decayed-extracted-filled (deft) score for the whole sample was 1.41 and Significant caries index (SIC) was 4.09. Decayed tooth were the main contributor for the deft score and Care index was only 1.55. Girls had a significantly higher prevalence of caries than boys. Conclusions Dental care provided for Sri Lankan preschool children appears to be unsatisfactory as prevalence of dental caries among this cohort of preschool children was very high. There is an urgent need to improve dental care facilities for Sri Lankan preschool children.
Keywords	Dental caries ; Deft score ; SIC index ; Care index ; Dentistry ; RK1-715 ; Medicine ; R ; DOAJ:Dentistry ; DOAJ:Health Sciences
Subject code	360
Language	English
Publishing date	2012-11-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
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