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  1. Article ; Online: Fatal severe persistent pulmonary hypertension with lung microvasculature parietal hyperplasia in a neonate with congenital cytomegalovirus infection treated in-utero with valacyclovir: A case report.

    Fernicola, Federica / Carli, Anna / Arienti, Francesca / Viola Vasarri, Maria / Lanteri, Laura / Scandella, Gaia / Poletti De Chaurand, Valeria / Zicoia, Marianna / Iozzi, Lucia / Gorla, Sonia / Luisa Ventura, Maria / Locatelli, Anna / Sinelli, Mariateresa / Ornaghi, Sara

    European journal of obstetrics, gynecology, and reproductive biology

    2024  Volume 294, Page(s) 245–246

    MeSH term(s) Infant, Newborn ; Humans ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/etiology ; Valacyclovir/therapeutic use ; Hyperplasia ; Cytomegalovirus Infections/complications ; Cytomegalovirus Infections/drug therapy ; Lung/diagnostic imaging ; Microvessels ; Antiviral Agents/therapeutic use
    Chemical Substances Valacyclovir (MZ1IW7Q79D) ; Antiviral Agents
    Language English
    Publishing date 2024-01-11
    Publishing country Ireland
    Document type Case Reports ; Letter
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2024.01.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Indirect impact of SARS-CoV-2 pandemic on incidence of maternal primary cytomegalovirus and Toxoplasma gondii infection in pregnancy.

    Vasarri, Maria Viola / Fernicola, Federica / Arienti, Francesca / Carli, Anna / Colciago, Elisabetta / Locatelli, Anna / Trotta, Michele / Procopio, Angelica / Zammarchi, Lorenzo / Ornaghi, Sara

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2024  

    Abstract: Objective: Public health interventions promoted during the SARS-CoV-2 pandemic to control viral spread have impacted the occurrence of other communicable disease. Yet no studies have focused on perinatal infections with the potential for neonatal ... ...

    Abstract Objective: Public health interventions promoted during the SARS-CoV-2 pandemic to control viral spread have impacted the occurrence of other communicable disease. Yet no studies have focused on perinatal infections with the potential for neonatal sequelae, including cytomegalovirus (CMV) and Toxoplasma gondii (TG). Here we investigate whether incidence rates of maternal primary CMV and TG infection in pregnancy were affected by the implementation of pandemic-related public health measures.
    Methods: A retrospective study including all pregnant women with confirmed primary CMV or TG infection in pregnancy, managed between 2018 and 2021 at two university centers. The incidence rate was calculated as the number of CMV and TG infections per 100 consultations with a 95% confidence interval (CI). Data were compared between pre-pandemic (2018-2019) and pandemic (2020 and 2021) years. The Newcombe Wilson with Continuity Correction method was employed to compare incidence rates.
    Results: The study population included 215 maternal primary CMV and 192 TG infections. Rate of maternal primary CMV infection decreased in 2021 compared with 2018-2019 (4.49% vs 6.40%, attributable risk [AR] 1.92, P = 0.019). By contrast, the rate of TG infection substantially increased in 2020 (6.95% vs 4.61%, AR 2.34, P = 0.006). Close contact with cats was more common among patients with TG infection in 2020 and 2021 than among pre-pandemic TG-infected women (26.3% and 24.4% vs 13.3%, P = 0.013).
    Conclusion: Pandemic-related public health interventions and associated behavioral and lifestyle changes exerted a divergent effect on the incidence of primary CMV and TG infection in pregnancy, likely due to modulation of exposure to risk factors for these infections.
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.15534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Acute spontaneous non-hemorrhagic adrenal infarction in pregnancy: case-report and literature review.

    Ornaghi, Sara / Fernicola, Federica / Marelli, Elisabetta / Perotti, Mario / Di Gennaro, Filiberto / Cameroni, Irene / Mariani, Eloisa M / Pincelli, Angela I / Colciago, Elisabetta / Cetin, Irene / Vergani, Patrizia

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

    2023  Volume 39, Issue 1, Page(s) 2234492

    Abstract: Unilateral non-hemorrhagic adrenal infarction (NHAI) is a very uncommon cause of acute abdomen in pregnancy. Diagnosis is highly challenging due to its rarity, heterogeneity of clinical presentation, and inconclusiveness of the initial workup. Timely ... ...

    Abstract Unilateral non-hemorrhagic adrenal infarction (NHAI) is a very uncommon cause of acute abdomen in pregnancy. Diagnosis is highly challenging due to its rarity, heterogeneity of clinical presentation, and inconclusiveness of the initial workup. Timely recognition is pivotal to ensuring optimal outcomes. Here we describe a case of spontaneous unilateral NHAI diagnosed in a singleton pregnant woman at 32 weeks' gestation at our centre and provide the findings of an extensive literature review on the topic. We identified 22 articles describing 31 NHAI cases in 30 obstetric patients: NHAI occurs more frequently on the right side and in the third trimester, and diagnosis is formulated more than 24 h after clinical presentation in 50% of cases; second-level imaging is always necessary to reach a definitive diagnosis and start appropriate treatment. A high degree of clinical suspicion is needed to promptly recognize NHAI in pregnancy, thus allowing appropriate multidisciplinary management and timely treatment initiation. Promotion of knowledge and awareness of NHAI as a potential cause of acute abdomen in pregnancy is mandatory to improve clinical practice and, ultimately, perinatal outcomes.
    MeSH term(s) Pregnancy ; Female ; Humans ; Abdomen, Acute/diagnosis ; Abdomen, Acute/etiology ; Adrenal Gland Diseases/diagnosis ; Pregnancy Trimester, Third ; Infarction/diagnostic imaging ; Infarction/etiology
    Language English
    Publishing date 2023-07-24
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 639237-4
    ISSN 1473-0766 ; 0951-3590
    ISSN (online) 1473-0766
    ISSN 0951-3590
    DOI 10.1080/09513590.2023.2234492
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Letter to Editor: Asymptomatic CMV infection at birth following maternal infection, valacyclovir treatment, and a subsequent negative amniocentesis.

    Fernicola, Federica / Carli, Anna / Arienti, Francesca / Vasarri, Maria Viola / Lanteri, Laura / Scandella, Gaia / De Chaurand, Valeria Poletti / Zicoia, Marianna / Iozzi, Lucia / Ventura, Maria Luisa / Sinelli, Mariateresa / Locatelli, Anna / Ornaghi, Sara

    European journal of obstetrics, gynecology, and reproductive biology

    2023  Volume 292, Page(s) 268–269

    MeSH term(s) Pregnancy ; Infant, Newborn ; Female ; Humans ; Valacyclovir/therapeutic use ; Amniocentesis ; Antiviral Agents/therapeutic use ; Cytomegalovirus Infections/diagnosis ; Cytomegalovirus Infections/drug therapy ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/drug therapy ; Infectious Disease Transmission, Vertical/prevention & control
    Chemical Substances Valacyclovir (MZ1IW7Q79D) ; Antiviral Agents
    Language English
    Publishing date 2023-11-21
    Publishing country Ireland
    Document type Letter ; Comment
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2023.11.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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