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  1. Article ; Online: What is a low low-molecular-weight heparin dose?

    Godier, Anne / Llau, Juan V / Ferrandis, Raquel / Langenecker, Sibylle

    European journal of anaesthesiology

    2024  Volume 41, Issue 5, Page(s) 393

    MeSH term(s) Humans ; Heparin, Low-Molecular-Weight/adverse effects ; Heparin/adverse effects ; Anticoagulants/adverse effects
    Chemical Substances Heparin, Low-Molecular-Weight ; Heparin (9005-49-6) ; Anticoagulants
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 605770-6
    ISSN 1365-2346 ; 0265-0215
    ISSN (online) 1365-2346
    ISSN 0265-0215
    DOI 10.1097/EJA.0000000000001962
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1955: Show issues Location:
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  2. Article ; Online: Periprocedural use of antithrombotic therapy in interventional cardiology in Spain: are we doing better than other specialties?

    Anguita-Gámez, María / Vivas, David / Ferrandis, Raquel / Esteve-Pastor, María Asunción / Marín, Francisco / Anguita Sánchez, Manuel

    Revista espanola de cardiologia (English ed.)

    2024  

    Language Spanish
    Publishing date 2024-04-03
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 2592481-3
    ISSN 1885-5857 ; 1885-5857
    ISSN (online) 1885-5857
    ISSN 1885-5857
    DOI 10.1016/j.rec.2024.02.017
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  3. Article ; Online: Letter by Llau and Ferrandis regarding article, "Bridging evidence-based practice and practice-based evidence in periprocedural anticoagulation".

    Llau, Juan V / Ferrandis, Raquel

    Circulation

    2013  Volume 127, Issue 19, Page(s) e616

    MeSH term(s) Hemorrhage/epidemiology ; Heparin/adverse effects ; Humans ; Perioperative Care ; Thromboembolism/prevention & control ; Vitamin K/antagonists & inhibitors
    Chemical Substances Vitamin K (12001-79-5) ; Heparin (9005-49-6)
    Language English
    Publishing date 2013-05-14
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.112.151506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Management of perioperative thromboprophylaxis for surgery following COVID-19: an expert-panel survey.

    Ferrandis, Raquel / Llau, Juan V / Afshari, Arash / Douketis, James D / Gómez-Luque, Aurelio / Samama, Charles-Marc

    British journal of anaesthesia

    2021  Volume 127, Issue 4, Page(s) e143–e145

    MeSH term(s) Anticoagulants/therapeutic use ; COVID-19/complications ; Humans ; Perioperative Care/methods ; SARS-CoV-2 ; Time ; Venous Thromboembolism/complications ; Venous Thromboembolism/prevention & control
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2021-07-09
    Publishing country England
    Document type Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2021.06.041
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  5. Article ; Online: COVID-19: opening a new paradigm in thromboprophylaxis for critically ill patients?

    Ferrandis, Raquel / Llau, Juan V / Quintana, Manuel / Sierra, Pilar / Hidalgo, Francisco / Cassinello, Concepción / Gómez-Luque, Aurelio

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 332

    MeSH term(s) Anticoagulants/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/therapy ; Critical Illness ; Heparin, Low-Molecular-Weight/therapeutic use ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/therapy ; Pulmonary Embolism/complications ; Pulmonary Embolism/prevention & control ; SARS-CoV-2 ; Venous Thromboembolism/prevention & control
    Chemical Substances Anticoagulants ; Heparin, Low-Molecular-Weight
    Keywords covid19
    Language English
    Publishing date 2020-06-11
    Publishing country England
    Document type Letter
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03052-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5517: Show issues Location:
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  6. Article ; Online: Observational study on fluid therapy management in surgical adult patients.

    Colomina, Maria J / Ripollés-Melchor, Javier / Guilabert, Patricia / Jover, José Luis / Basora, Misericordia / Cassinello, Concha / Ferrandis, Raquel / Llau, Juan V / Peñafiel, Judith

    BMC anesthesiology

    2021  Volume 21, Issue 1, Page(s) 316

    Abstract: Background: Perioperative fluid therapy management is changing due to the incorporation of different fluids, surgical techniques, and minimally invasive monitoring systems. The objective of this study was to explore fluid therapy management during the ... ...

    Abstract Background: Perioperative fluid therapy management is changing due to the incorporation of different fluids, surgical techniques, and minimally invasive monitoring systems. The objective of this study was to explore fluid therapy management during the perioperative period in our country.
    Methods: We designed the Fluid Day study as a cross-sectional, multicentre, observational study. The study was performed in 131 Spanish hospitals in February 2019. We included adult patients undergoing general anaesthesia for either elective or non-elective surgery. Demographic variables were recorded, as well as the type and total volume of fluid administered during the perioperative period and the monitorization used. To perform the analysis, patients were categorized by risk group.
    Results: We recruited 7291 patients, 6314 of which were included in the analysis; 1541 (24.4%) patients underwent high-risk surgery, 1497 (23. 7%) were high risk patients, and 554 (8.7%) were high-risk patients and underwent high-risk surgery; 98% patients received crystalloids (80% balanced solutions); intraoperative colloids were used in 466 patients (7.51%). The hourly intraoperative volume in mL/kg/h and the median [Q1; Q3] administered volume (mL/kg) were, respectively, 6.67 [3.83; 8.17] ml/Kg/h and 13.9 [9.52;5.20] ml/Kg in low-risk patients undergoing low- or intermediate-risk surgery, 6 [4.04; 9.08] ml/Kg/h and 15.7 [10.4;24.5] ml/Kg in high- risk patients undergoing low or intermediate-risk surgery, 6.41 [4.36; 9.33] ml/Kg/h and 20.2 [13.3;32.4] ml/Kg in low-risk patients undergoing high-risk surgery, and 5.46 [3.83; 8.17] ml/Kg/h and 22.7[14.1;40.9] ml/Kg in high-risk patients undergoing high- risk surgery . We used advanced fluid monitoring strategies in 5% of patients in the intraoperative period and in 10% in the postoperative period.
    Conclusions: The most widely used fluid was balanced crystalloids. Colloids were used in a small number of patients. Hourly surgery volume tended to be more restrictive in high-risk patients but confirms a high degree of variation in the perioperatively administered volume. Scarce monitorization was observed in fluid therapy management.
    Trial registration: Clinical Trials: NCT03630744.
    MeSH term(s) Aged ; Cross-Sectional Studies ; Female ; Fluid Therapy/methods ; Humans ; Male ; Middle Aged ; Perioperative Care/methods ; Spain
    Language English
    Publishing date 2021-12-13
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2091252-3
    ISSN 1471-2253 ; 1471-2253
    ISSN (online) 1471-2253
    ISSN 1471-2253
    DOI 10.1186/s12871-021-01518-z
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  7. Article ; Online: New anticoagulants and regional anesthesia.

    Llau, Juan V / Ferrandis, Raquel

    Current opinion in anaesthesiology

    2009  Volume 22, Issue 5, Page(s) 661–666

    Abstract: Purpose of review: The use of pharmacological thromboprophylaxis in the perioperative period may conflict with regional anesthetic techniques in which maintaining hemostatic integrity is essential. Recently, new anticoagulants have been developed with ... ...

    Abstract Purpose of review: The use of pharmacological thromboprophylaxis in the perioperative period may conflict with regional anesthetic techniques in which maintaining hemostatic integrity is essential. Recently, new anticoagulants have been developed with more efficacy and a better safety profile. This article reviews the basis for the actual recommendations and the current status and management of these new drugs.
    Recent findings: Recent studies have outlined that the risk of epidural hematoma after neuraxial anesthesia may be higher than estimated. Therefore, it is imperative to follow the published recommendations. The use of new anticoagulant drugs may take into account the pharmacological profile of each one to safely perform regional anesthesia, mainly the time to reach peak plasma level and half-life.
    Summary: When new anticoagulant drugs are used for thromboprophylaxis in orthopedic surgery, the performance of neuraxial anesthetic techniques should be based on their pharmacology. If a peripheral blockade is chosen, these recommendations should be followed when a block is performed in a noncompressible area.
    MeSH term(s) Anesthesia, Epidural/methods ; Anesthesia, Spinal/methods ; Anticoagulants/therapeutic use ; Benzimidazoles/therapeutic use ; Dabigatran ; Hematoma, Epidural, Spinal/prevention & control ; Humans ; Morpholines/therapeutic use ; Nerve Block/methods ; Platelet Aggregation Inhibitors/therapeutic use ; Pyrazoles/therapeutic use ; Pyridines/therapeutic use ; Pyridones/therapeutic use ; Rivaroxaban ; Thiophenes/therapeutic use
    Chemical Substances Anticoagulants ; Benzimidazoles ; Morpholines ; Platelet Aggregation Inhibitors ; Pyrazoles ; Pyridines ; Pyridones ; Thiophenes ; apixaban (3Z9Y7UWC1J) ; Rivaroxaban (9NDF7JZ4M3) ; Dabigatran (I0VM4M70GC)
    Language English
    Publishing date 2009-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645203-6
    ISSN 1473-6500 ; 0952-7907
    ISSN (online) 1473-6500
    ISSN 0952-7907
    DOI 10.1097/ACO.0b013e32832eb8ab
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    Zs.A 2564: Show issues Location:
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  8. Article ; Online: Regional anaesthesia in patients on antithrombotic drugs: Joint ESAIC/ESRA guidelines.

    Kietaibl, Sibylle / Ferrandis, Raquel / Godier, Anne / Llau, Juan / Lobo, Clara / Macfarlane, Alan Jr / Schlimp, Christoph J / Vandermeulen, Erik / Volk, Thomas / von Heymann, Christian / Wolmarans, Morné / Afshari, Arash

    European journal of anaesthesiology

    2021  Volume 39, Issue 2, Page(s) 100–132

    Abstract: Background: Bleeding is a potential complication after neuraxial and peripheral nerve blocks. The risk is increased in patients on antiplatelet and anticoagulant drugs. This joint guideline from the European Society of Anaesthesiology and Intensive Care ...

    Abstract Background: Bleeding is a potential complication after neuraxial and peripheral nerve blocks. The risk is increased in patients on antiplatelet and anticoagulant drugs. This joint guideline from the European Society of Anaesthesiology and Intensive Care and the European Society of Regional Anaesthesia aims to provide an evidence-based set of recommendations and suggestions on how to reduce the risk of antithrombotic drug-induced haematoma formation related to the practice of regional anaesthesia and analgesia.
    Design: A systematic literature search was performed, examining seven drug comparators and 10 types of clinical intervention with the outcome being peripheral and neuraxial haematoma. Grading of Recommendations, Assessment, Development and Evaluation (GRADE) was used for assessing the methodological quality of the included studies and for formulating recommendations. A Delphi process was used to prepare a clinical practice guideline.
    Results: Clinical studies were limited in number and quality and the certainty of evidence was assessed to be GRADE C throughout. Forty clinical practice statements were formulated. Using the Delphi-process, strong consensus (>90% agreement) was achieved in 57.5% of recommendations and consensus (75 to 90% agreement) in 42.5%.
    Discussion: Specific time intervals should be observed concerning the adminstration of antithrombotic drugs both prior to, and after, neuraxial procedures or those peripheral nerve blocks with higher bleeding risk (deep, noncompressible). These time intervals vary according to the type and dose of anticoagulant drugs, renal function and whether a traumatic puncture has occured. Drug measurements may be used to guide certain time intervals, whilst specific reversal for vitamin K antagonists and dabigatran may also influence these. Ultrasound guidance, drug combinations and bleeding risk scores do not modify the time intervals. In peripheral nerve blocks with low bleeding risk (superficial, compressible), these time intervals do not apply.
    Conclusion: In patients taking antiplatelet or anticoagulant medications, practitioners must consider the bleeding risk both before and after nerve blockade and during insertion or removal of a catheter. Healthcare teams managing such patients must be aware of the risk and be competent in detecting and managing any possible haematomas.
    MeSH term(s) Anesthesia, Conduction ; Anticoagulants ; Fibrinolytic Agents/therapeutic use ; Hemorrhage/drug therapy ; Humans ; Pharmaceutical Preparations
    Chemical Substances Anticoagulants ; Fibrinolytic Agents ; Pharmaceutical Preparations
    Language English
    Publishing date 2021-03-05
    Publishing country England
    Document type Journal Article ; Practice Guideline
    ZDB-ID 605770-6
    ISSN 1365-2346 ; 0265-0215
    ISSN (online) 1365-2346
    ISSN 0265-0215
    DOI 10.1097/EJA.0000000000001600
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  9. Article ; Online: Prospective observational registry of perioperative and periprocedural management of antithrombotic therapy in "real world": the REQXAA study.

    Vivas, David / Anguita-Gámez, María / Ferrandis, Raquel / Esteve-Pastor, María Asunción / Echeverri, Marysol / Igualada, Jesús / Anguita, Manuel / Egocheaga, Isabel / Nozal-Mateo, Beatriz / Abad-Motos, Ane / Figuero, Elena / Bouzó-Molina, Nuria / Lozano, Teresa / Álvarez-Ortega, Carlos / Torres, Javier / Descalzo, María José / Catalá, Juan Carlos / Martín-Rioboo, Enrique / Molines, Alejandra /
    Rodríguez-Contreras, Rocío / Carnero-Alcázar, Manuel / Marín, Francisco

    Revista espanola de cardiologia (English ed.)

    2023  Volume 76, Issue 9, Page(s) 729–738

    Abstract: Introduction and objectives: There is scarce real-world evidence on the management of perioperative antithrombotic treatment according to current recommendations. The aim of this study was to analyze the management of antithrombotic treatment in ... ...

    Abstract Introduction and objectives: There is scarce real-world evidence on the management of perioperative antithrombotic treatment according to current recommendations. The aim of this study was to analyze the management of antithrombotic treatment in patients undergoing surgery or another invasive intervention and to assess the consequences of this management on the occurrence thrombotic or bleeding events.
    Methods: This prospective, observational, multicenter and multispecialty study analyzed patients receiving antithrombotic therapy who underwent surgery or another invasive intervention. The primary endpoint was defined as the incidence of adverse (thrombotic and/or hemorrhagic) events after 30 days of follow-up with respect to management of perioperative antithrombotic drugs.
    Results: We included 1266 patients (male: 63.5%; mean age 72.6 years). Nearly half of the patients (48.6%) were under chronic anticoagulation therapy (mainly for atrial fibrillation; CHA
    Conclusions: The implementation of recommendations on the perioperative/periprocedural management of antithrombotic therapy in real-world patients is poor. Inappropriate management of antithrombotic treatment is associated with an increase in both thrombotic and hemorrhagic events.
    MeSH term(s) Humans ; Male ; Aged ; Anticoagulants/therapeutic use ; Fibrinolytic Agents/therapeutic use ; Fibrinolytic Agents/adverse effects ; Prospective Studies ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Hemorrhage/complications ; Risk Factors ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Registries ; Platelet Aggregation Inhibitors/adverse effects
    Chemical Substances Anticoagulants ; Fibrinolytic Agents ; Platelet Aggregation Inhibitors
    Language Spanish
    Publishing date 2023-03-11
    Publishing country Spain
    Document type Observational Study ; Multicenter Study ; Journal Article
    ZDB-ID 2592481-3
    ISSN 1885-5857 ; 1885-5857
    ISSN (online) 1885-5857
    ISSN 1885-5857
    DOI 10.1016/j.rec.2023.03.003
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  10. Article: COVID-19: opening a new paradigm in thromboprophylaxis for critically ill patients?

    Ferrandis, Raquel / Llau, Juan V / Quintana, Manuel / Sierra, Pilar / Hidalgo, Francisco / Cassinello, Concepción / Gómez-Luque, Aurelio

    Crit Care

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #593537
    Database COVID19

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