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Article ; Online: Vibrato rate and extent in soprano voice: a survey on one century of singing.

Ferrante, Isidoro

The Journal of the Acoustical Society of America

2011 Volume 130, Issue 3, Page(s) 1683–1688

Abstract: This work presents a statistical study of vibrato parameters in soprano voices. More than one hundred recordings of the same tone sung by 75 artists have been analyzed. Vibrato rate and extent, tone length and intonation, together with their correlations ...

Abstract	This work presents a statistical study of vibrato parameters in soprano voices. More than one hundred recordings of the same tone sung by 75 artists have been analyzed. Vibrato rate and extent, tone length and intonation, together with their correlations are the main parameters under examination. The study shows a clear decrease of the mean vibrato rate during the last century (-1.8±0.3 Hz/century), together with an increase of vibrato extent (56.4±0.3cent/century). Vibrato rate and extent show a statistically significant negative correlation (r=-0.62). Vibrato rate increase near the end of the tone has been observed too, in agreement with previous measurements, together with a mean increase of the pitch of the tone. A small positive correlation has been also found among note duration and vibrato extent.
MeSH term(s)	Acoustics ; Algorithms ; Female ; History, 20th Century ; History, 21st Century ; Humans ; Models, Statistical ; Music ; Signal Processing, Computer-Assisted ; Sound Spectrography ; Time Factors ; Vibration ; Voice Quality
Language	English
Publishing date	2011-09
Publishing country	United States
Document type	Historical Article ; Journal Article
ZDB-ID	219231-7
ISSN	1520-8524 ; 0001-4966
ISSN (online)	1520-8524
ISSN	0001-4966
DOI	10.1121/1.3621017
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Article ; Online: Placenta Accreta Spectrum Disorders: How to reduce maternal transfusion? A center experience on extraperitoneal retrograde hysterectomy.

Simonetti, Francesca Maria / Algeri, Paola / Ferrante, Ilaria / Pirola, Serena / Carnelli, Marco / Patanè, Luisa / Fierro, Giulia / Frigerio, Luigi

European journal of obstetrics, gynecology, and reproductive biology

2023 Volume 287, Page(s) 148–154

Abstract: Objective: Placenta Accreta Spectrum disorders (PASd) refer to the range of pathologic adherence of placenta associated with high maternal morbidity and mortality due to severe and sometimes life-threatening hemorrhage at the time of delivery. The aim ... ...

Abstract	Objective: Placenta Accreta Spectrum disorders (PASd) refer to the range of pathologic adherence of placenta associated with high maternal morbidity and mortality due to severe and sometimes life-threatening hemorrhage at the time of delivery. The aim of this study is to describe the surgical technique of extraperitoneal retrograde hysterectomy, which has allowed a reduction of blood transfusions compared to patients who underwent classical post-partum hysterectomy. Study design: We collected data from twelve patients with antenatal diagnosis of PASd treated between 2018 and 2021 with an extra-peritoneal hysterectomy using a posterior retrograde approach and we compared them to patients who underwent classical hysterectomy for suspected PASd, treated between 2007 and 2017. Results: The classical hysterectomy group presented a higher frequency of blood and plasma transfusion compared to the extraperitoneal hysterectomy group. In particular, classical hysterectomy resulted in an independent risk factor for transfusion, with an increment of 6.6 times of risk. Conclusion: Even if future studies are required, we think that extraperitoneal hysterectomy could be a safe option in case of PASd, considering that classical hysterectomy compared to this approach increases, in our population, the risk of blood and plasma transfusion.
MeSH term(s)	Pregnancy ; Female ; Humans ; Cesarean Section/methods ; Blood Component Transfusion ; Placenta Accreta/surgery ; Placenta Accreta/diagnosis ; Plasma ; Hysterectomy/methods ; Retrospective Studies
Language	English
Publishing date	2023-06-14
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2023.06.012
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Article ; Online: High-resolution Volume Imaging of Neurons by the Use of Fluorescence eXclusion Method and Dedicated Microfluidic Devices.

Braïni, Céline / Mottolese, Angelo / Ferrante, Ivan / Monnier, Sylvain / Villard, Catherine

Journal of visualized experiments : JoVE

2018 , Issue 133

Abstract: Volume is an important parameter regarding physiological and pathological characteristics of neurons at different time scales. Neurons are quite unique cells regarding their extended ramified morphologies and consequently raise several methodological ... ...

Abstract	Volume is an important parameter regarding physiological and pathological characteristics of neurons at different time scales. Neurons are quite unique cells regarding their extended ramified morphologies and consequently raise several methodological challenges for volume measurement. In the particular case of in vitro neuronal growth, the chosen methodology should include sub-micrometric axial resolution combined with full-field observation on time scales from minutes to hours or days. Unlike other methods like cell shape reconstruction using confocal imaging, electrically-based measurements or Atomic Force Microscopy, the recently developed Fluorescence eXclusion method (FXm) has the potential to fulfill these challenges. However, although being simple in its principle, implementation of a high-resolution FXm for neurons requires multiple adjustments and a dedicated methodology. We present here a method based on the combination of fluorescence exclusion, low-roughness multi-compartments microfluidic devices, and finally micropatterning to achieve in vitro measurements of local neuronal volume. The high resolution provided by the device allowed us to measure the local volume of neuronal processes (neurites) and the volume of some specific structures involved in neuronal growth, such as growth cones (GCs).
MeSH term(s)	Animals ; Fluorescence ; Humans ; Lab-On-A-Chip Devices/utilization ; Mice ; Neurons/physiology
Language	English
Publishing date	2018--26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
ISSN	1940-087X
ISSN (online)	1940-087X
DOI	10.3791/56923
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Article ; Online: Use of Sotrovimab in a cohort of pregnant women with a high risk of COVID 19 progression: a single-center experience.

Frallonardo, Luisa / Vimercati, Antonella / Novara, Roberta / Lepera, Cherola / Ferrante, Ilaria / Chiarello, Giulia / Cicinelli, Rossana / Mongelli, Michele / Brindicci, Gaetano / Segala, Francesco Vladimiro / Santoro, Carmen Rita / Bavaro, Davide Fiore / Laforgia, Nicola / Cicinelli, Ettore / Saracino, Annalisa / Di Gennaro, Francesco

Pathogens and global health

2023 Volume 117, Issue 5, Page(s) 513–519

Abstract: Neutralizing monoclonal antibodies (mAbs) have been shown to reduce disease progression in patients with underlying predisposing conditions. Unfortunately, there is no evidence on the use of Sotrovimab in pregnant women. Herein we present a case series ... ...

Abstract	Neutralizing monoclonal antibodies (mAbs) have been shown to reduce disease progression in patients with underlying predisposing conditions. Unfortunately, there is no evidence on the use of Sotrovimab in pregnant women. Herein we present a case series of pregnant women who received mAbs with Sotrovimab following the Italian Drug Agency (AIFA) indications. Since February 1, 2022 all pregnant women - regardless of gestational age - admitted to Obstetrics & Gynaecology of Policlinico University of Bari, with positive nasopharyngeal NAAT for SARS-CoV-2 were screened according to the AIFA indications for Sotrovimab and, if eligible, were proposed for treatment. Data on COVID-19, pregnancy, delivery, newborn outcomes, and adverse events were collected. From February 1 to May 15, 2022, 58 pregnant women were screened. Fifty (86%) patients were eligible, 19 of them (32.7%) denied their consent, in 18 cases (31%), the drug was temporarily unavailable, and the remaining 13 (22%) were treated with Sotrovimab. Out of these 13 patients, 6 (46%) were in the 3rd and 7 (54%) in the 2nd trimester of pregnancy. None of the 13 patients experienced adverse reactions due to Sotrovimab and all had a good clinical outcome. Furthermore, evaluating pre- and post-infusion clinical status and hematochemical profile, a reduction in D-dimers and an increase in SARS-CoV-2 antibodies (p < 0.01) during the 72 h following the infusion were observed. Our data, the first on the use of Sotrovimab in pregnant women, showed the safety and efficacy drug profile and its potential crucial role in preventing COVID-19 disease progression.
MeSH term(s)	Pregnancy ; Infant, Newborn ; Humans ; Female ; COVID-19 ; SARS-CoV-2 ; Pregnant Women ; Antibodies, Monoclonal ; Disease Progression
Chemical Substances	sotrovimab (1MTK0BPN8V) ; Antibodies, Monoclonal
Language	English
Publishing date	2023-03-10
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2625162-0
ISSN	2047-7732 ; 2047-7724
ISSN (online)	2047-7732
ISSN	2047-7724
DOI	10.1080/20477724.2023.2188839
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Article ; Online: Separation and preconcentration of actinides from concentrated nitric acid by extraction chromatography in microsystems.

Losno, Marion / Pellé, Julien / Marie, Mylène / Ferrante, Ivan / Brennetot, René / Descroix, Stéphanie / Mariet, Clarisse

Talanta

2018 Volume 185, Page(s) 586–591

Abstract: An original method of monolith impregnation in microsystem for the analysis of radionuclides in nitric acid is reported. Three microcolumns made of monolith poly(AMA-co-EDMA) were impregnated in COC microsystems. The robustness of the microsystems in ... ...

Abstract	An original method of monolith impregnation in microsystem for the analysis of radionuclides in nitric acid is reported. Three microcolumns made of monolith poly(AMA-co-EDMA) were impregnated in COC microsystems. The robustness of the microsystems in nitric acid media until 8 M was demonstrated. High exchange capacity and affinity for tetravalent and hexavalent actinides in concentrated nitric media were obtained. The retention characteristics of the microcolumns impregnated by TBP, TBP-CMPO and DAAP were compared with those of the equivalent commercial particulate resins TBP™, TRU™ and UTEVA™ respectively. The separation of U, Th and Eu was validated in a classical microsystem and a procedure is proposed in a centrifugal microsystem.
Language	English
Publishing date	2018-08-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2018.04.036
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Article ; Online: Effect of dalfampridine on information processing speed impairment in multiple sclerosis.

De Giglio, Laura / De Luca, Francesca / Gurreri, Flavia / Ferrante, Ilaria / Prosperini, Luca / Borriello, Giovanna / Quartuccio, Esmeralda / Gasperini, Claudio / Pozzilli, Carlo

Neurology

2019 Volume 93, Issue 8, Page(s) e733–e746

Abstract: Objective: To test a possible benefit of dalfampridine on information processing speed (IPS), a key function for cognitive impairment (CogIm) in multiple sclerosis (MS).: Methods: In this randomized, double-blind, placebo-controlled trial, we ... ...

Abstract	Objective: To test a possible benefit of dalfampridine on information processing speed (IPS), a key function for cognitive impairment (CogIm) in multiple sclerosis (MS). Methods: In this randomized, double-blind, placebo-controlled trial, we included patients with a score on the Symbol Digit Modalities Test (SDMT) under the 10th percentile of the reference value. Patients were randomized in a 2:1 ratio to receive dalfampridine 10 mg or placebo twice daily for 12 weeks. They underwent a comprehensive neuropsychological evaluation at screening (T0), at the end of treatment (T1), and after a 4-week follow-up (T2). The primary endpoint was improvement in SDMT. Results: Out of 208 patients screened, 120 were randomized to receive either dalfampridine (n = 80) or placebo (n = 40). At T1, the dalfampridine group presented an increase of SDMT scores vs placebo group (mean change 9.9 [95% confidence interval (CI) 8.5-11.4] vs 5.2 [95% CI 2.8-7.6], Conclusion: Dalfampridine could be considered as an effective treatment option for IPS impairment in MS. Trial registration: 2013-002558-64 EU Clinical Trials Register. Classification of evidence: This study provides Class I evidence that for patients with MS with low scores on the SDMT, dalfampridine improves IPS.
MeSH term(s)	4-Aminopyridine/therapeutic use ; Adolescent ; Adult ; Aged ; Cognition Disorders/complications ; Cognition Disorders/drug therapy ; Double-Blind Method ; Fatigue/complications ; Fatigue/drug therapy ; Female ; Humans ; Male ; Middle Aged ; Multiple Sclerosis/complications ; Multiple Sclerosis/drug therapy ; Neuropsychological Tests/statistics & numerical data ; Potassium Channel Blockers/therapeutic use ; Time Factors ; Treatment Outcome ; Young Adult
Chemical Substances	Potassium Channel Blockers ; 4-Aminopyridine (BH3B64OKL9)
Language	English
Publishing date	2019-07-22
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000007970
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Article ; Online: Task-dependent deterioration of balance underpinning cognitive-postural interference in MS.

Prosperini, Luca / Castelli, Letizia / De Luca, Francesca / Fabiano, Francesca / Ferrante, Ilaria / De Giglio, Laura

Neurology

2016 Volume 87, Issue 11, Page(s) 1085–1092

Abstract: Objective: To investigate which concurrent cognitive task (if any) had the most detrimental effect on balance control of patients with multiple sclerosis (MS).: Methods: In a dual-task experiment, we evaluated the reciprocal effect of simultaneously ... ...

Abstract	Objective: To investigate which concurrent cognitive task (if any) had the most detrimental effect on balance control of patients with multiple sclerosis (MS). Methods: In a dual-task experiment, we evaluated the reciprocal effect of simultaneously performing a postural and a cognitive task on balance and cognition in 52 patients and 26 sex- and age-matched controls. Balance was assessed by static posturography, while cognition was scored as number of correct items at 3 different neuropsychological tests, i.e., the Symbol Digit Modalities Test (SDMT), word list generation (WLG), and Stroop Color-Word Test (SCWT). Results: In both single and dual-task conditions, the patients had larger postural sway and worse scores at SDMT, WLG, and SCWT than the controls (p < 0.05). Test-retest reliability was excellent for all dual-task metrics (85%-94%). By means of 2-way analyses of the variance, we found significant main effects of dual task on balance, regardless of the concurrent cognitive task (p < 0.001). There was no main effect of dual task on cognitive performance across all the 3 task conditions (p ≥ 0.1). We observed a significant condition-by-group interaction effect on balance only when the SCWT was administered as concurrent task (p = 0.01), indicating a greater dual-task cost of balance for the patients than controls (53% vs 28%, p = 0.04). Conclusions: We suggest that tasks exploring executive functions involved in discriminating conflicting stimuli may be the most suitable to unmask the cognitive-postural interference phenomenon in patients with MS. This may support the hypothesis that MS-related damage constrains brain networks to subserve both postural control and executive functions.
MeSH term(s)	Attention ; Cognition ; Cross-Sectional Studies ; Executive Function ; Female ; Humans ; Male ; Middle Aged ; Motor Activity ; Multiple Sclerosis/physiopathology ; Multiple Sclerosis/psychology ; Neuropsychological Tests ; Postural Balance ; Reproducibility of Results
Language	English
Publishing date	2016-08-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000003090
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Article ; Online: Sliding walls: a new paradigm for fluidic actuation and protocol implementation in microfluidics.

Venzac, Bastien / Liu, Yang / Ferrante, Ivan / Vargas, Pablo / Yamada, Ayako / Courson, Rémi / Verhulsel, Marine / Malaquin, Laurent / Viovy, Jean-Louis / Descroix, Stéphanie

Microsystems & nanoengineering

2020 Volume 6, Page(s) 18

Abstract: Currently, fluidic control in microdevices is mainly achieved either by external pumps and valves, which are expensive and bulky, or by valves integrated in the chip. Numerous types of internal valves or actuation methods have been proposed, but they ... ...

Abstract	Currently, fluidic control in microdevices is mainly achieved either by external pumps and valves, which are expensive and bulky, or by valves integrated in the chip. Numerous types of internal valves or actuation methods have been proposed, but they generally impose difficult compromises between performance and fabrication complexity. We propose here a new paradigm for actuation in microfluidic devices based on rigid or semi-rigid walls with transversal dimensions of hundreds of micrometres that are able to slide within a microfluidic chip and to intersect microchannels with hand-driven or translation stage-based actuation. With this new concept for reconfigurable microfluidics, the implementation of a wide range of functionalities was facilitated and allowed for no or limited dead volume, low cost and low footprint. We demonstrate here several fluidic operations, including on/off or switch valving, where channels are blocked or reconfigured depending on the sliding wall geometry. The valves sustain pressures up to 30 kPa. Pumping and reversible compartmentalisation of large microfluidic chambers were also demonstrated. This last possibility was applied to a "4D" migration assay of dendritic cells in a collagen gel. Finally, sliding walls containing a hydrogel-based membrane were developed and used to concentrate, purify and transport biomolecules from one channel to another, such functionality involving complex fluidic transport patterns not possible in earlier microfluidic devices. Overall, this toolbox is compatible with "soft lithography" technology, allowing easy implementation within usual fabrication workflows for polydimethylsiloxane chips. This new technology opens the route to a variety of microfluidic applications, with a focus on simple, hand-driven devices for point-of-care or biological laboratories with low or limited equipment and resources.
Language	English
Publishing date	2020-04-06
Publishing country	England
Document type	Journal Article
ISSN	2055-7434
ISSN (online)	2055-7434
DOI	10.1038/s41378-019-0125-7
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Article ; Online: Validation of the Italian version of the Multiple Sclerosis Intimacy and Sexuality Questionnaire-19.

Carotenuto, Antonio / De Giglio, Laura / Chiodi, Alessandro / Petracca, Maria / Rosa, Laura / Bianchi, Maurizio / Ferrante, Ilaria / Lauro, Francesca / Moccia, Marcello / Ianniello, Antonio / Pozzilli, Carlo / Brescia Morra, Vincenzo / Lanzillo, Roberta

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2020 Volume 42, Issue 7, Page(s) 2903–2910

Abstract: Background: People with multiple sclerosis (MS) may experience sexual dysfunction throughout the disease course. Validated scales to assess sexual dysfunction in MS for Italian patients are lacking. Hence, we aimed at validating Multiple Sclerosis ... ...

Abstract	Background: People with multiple sclerosis (MS) may experience sexual dysfunction throughout the disease course. Validated scales to assess sexual dysfunction in MS for Italian patients are lacking. Hence, we aimed at validating Multiple Sclerosis Intimacy and Sexuality Questionnaire (MSISQ-19) for Italian MS patients. Methods: We included both male and female MS patients. Each patient completed the Italian translation of the MSISQ-19. Construct validity was explored by the exploratory factor analysis and the Cronbach's alpha coefficient. Test-retest stability and concurrent internal and external validity were examined by Pearson' correlation coefficients. Results: We enrolled 369 MS patients (323 female and 46 male). Italian MSISQ-19 showed a Cronbach's alpha of 0.92. MSISQ-19 test and retest total scores correlated between each other (r = 0.48, p = 0.01). MSISQ-19 total score also correlated with primary, secondary and tertiary subscales (p < 0.001). Conclusion: The Italian Version of the MSISQ-19 showed satisfactory internal consistency and reliability with moderately adequate test-retest reproducibility, suggesting that it may be used as a valuable measure of sexual dysfunction in the Italian population.
Language	English
Publishing date	2020-11-21
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-020-04873-w
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Article: Can enzymatic antioxidant defences in liver discriminate between wild and sea cage-reared Bluefin Tuna quality

Ferrante, I / Ricci, R / Aleo, E / Passi, S / Cataudella, S

Aquaculture. 2008 July 2, v. 279, no. 1-4

2008

Abstract: Bluefin Tuna (Thunnus thynnus L.) is a fish species of high nutritional and commercial value that is increasingly farmed in the Mediterranean basin. Oxidative stress research in aquaculture is particularly important in the assessment of both the health ... ...

Abstract	Bluefin Tuna (Thunnus thynnus L.) is a fish species of high nutritional and commercial value that is increasingly farmed in the Mediterranean basin. Oxidative stress research in aquaculture is particularly important in the assessment of both the health of farmed fish and seafood quality. Reactive oxygen species (ROS) are able to start the lipid peroxidation process which is potentially dangerous in fish, since they contain a high percentage of n-3 polyunsaturated fatty acids, in particular C20:5 n-3 and C22:6 n-3, which account for most of seafood's nutritional quality. The study of the antioxidant system and how the various components interact to delay post-harvest lipid peroxidation covers both the improvement of quality and the extension of shelf life of the fresh tuna product. In this study, hepatic antioxidant enzymes (catalase--CAT, superoxide dismutase--SOD and glutathione peroxidase--GPx) and lipid peroxidation levels (TBARS) of wild and sea cage-reared tunas were investigated. The aim was to examine the possible oxidative stress state of wild tunas killed by different fishing methods, compared with reared specimens exposed to different periods of confinement but killed by the same method. No significant differences between wild specimens were found in relation to catching techniques. A significant depletion was observed in liver SOD activity in reared tunas (5.00 U/mg protein) in comparison with wild specimens (5.90 U/mg protein). No differences in liver CAT activity between wild and reared tunas were found. In reared specimens we observed an oxidative stress state indicated by an increase in GPx activity (104.70 U/mg protein and 0.83 U/mg protein in reared and wild tunas, respectively). A significantly higher liver lipid content was observed in reared tunas, but no significant differences between wild and reared tunas in terms of TBA reactive substances content were found (2.03 vs 2.02 micromol TBARS/mg lipid). Our results suggest that the increased GPx activity leads to the suppression of lipid peroxidation in liver of reared tunas. This is the first time that antioxidant enzyme activities have been assayed in Bluefin Tuna and the stress state seems to be related to the diet of reared specimens rather than to their confinement, as indicated by the absence of differences in the antioxidant activities related to the period of confinement.
Keywords	fish farms ; Thunnus thynnus ; tuna ; farmed fish ; liver ; catalase ; superoxide dismutase ; glutathione peroxidase ; antioxidant activity ; lipid peroxidation ; fish culture ; oxidative stress
Language	English
Dates of publication	2008-0702
Size	p. 182-187.
Publishing place	Amsterdam: Elsevier Science
Document type	Article
ZDB-ID	185380-6
ISSN	0044-8486 ; 0044-8516
ISSN	0044-8486 ; 0044-8516
DOI	10.1016/j.aquaculture.2008.03.035
Database	NAL-Catalogue (AGRICOLA)

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