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  1. Book ; Online: Emerging and Disruptive Next-Generation Technologies for POC: Sensors, Chemistry and Microfluidics for Diagnostics

    Chiriacò, Maria Serena / Ferrara, Francesco / Primiceri, Elisabetta

    2022  

    Keywords Research & information: general ; Biology, life sciences ; light-emitting e-textiles ; alternating current electroluminescent devices ; light emitting diodes ; light electrochemical cells ; polymeric optical fibers ; fetal stem cells ; amniotic epithelial cells ; isolation protocol ; quality control ; label-free sorting ; diagnostic tool ; glucose ; glucose oxidase ; amperometric biosensor ; body fluids ; sweat ; wearable sensor ; oral cancer ; circulating tumor cells ; micromixers ; 3D microfluidics ; biodetection ; plastic microfluidics ; microfabrication ; cornea regeneration ; tissue engineering ; nanotechnology ; molecular mechanisms ; n/a
    Language 0|e
    Size 1 electronic resource (104 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021608834
    ISBN 9783036534152 ; 3036534156
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Atopic dermatitis: treatment and innovations in immunotherapy.

    Ferrara, Francesco / Zovi, Andrea / Capuozzo, Maurizio / Langella, Roberto

    Inflammopharmacology

    2024  

    Abstract: Atopic dermatitis (AD) is a common inflammatory skin disease characterized by itching and skin barrier dysfunction. Moderate to severe AD is often refractory to first-line topical treatments, and systemic immunosuppressants have been shown to be ... ...

    Abstract Atopic dermatitis (AD) is a common inflammatory skin disease characterized by itching and skin barrier dysfunction. Moderate to severe AD is often refractory to first-line topical treatments, and systemic immunosuppressants have been shown to be effective but have significant adverse effects. The paucity of basic treatments has contributed to the development of targeted topical and systemic immunotherapies based on the use of small molecules and biologic drugs which can directly interact with AD pathogenetic pathways. They represent a new era of therapeutic innovation. Additional new treatments are desirable since AD is a heterogeneous disease marked by different immunological phenotypes. This manuscript will review the mechanism of action, safety profile, and efficacy of promising new systemic immunological treatments for AD. Since moderate to severe AD can result in poor quality of life, the development of targeted and well-tolerated immunomodulators is a crucial purpose. The introduction of new pharmacological agents may offer new therapeutic options. However, there is the need to evaluate how "narrow-acting" agents, such as individual interleukin inhibitors, will perform under the safety and efficacy profiles compared with "broad-acting" agents, such as JAK inhibitors.
    Language English
    Publishing date 2024-04-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1080058-x
    ISSN 1568-5608 ; 0925-4692
    ISSN (online) 1568-5608
    ISSN 0925-4692
    DOI 10.1007/s10787-024-01453-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3274: Show issues Location:
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  3. Article ; Online: Healthcare Systems and Artificial Intelligence: Focus on Challenges and the International Regulatory Framework.

    Romagnoli, Alessia / Ferrara, Francesco / Langella, Roberto / Zovi, Andrea

    Pharmaceutical research

    2024  Volume 41, Issue 4, Page(s) 721–730

    Abstract: Background: Nowadays, healthcare systems are coping with the challenge of countering the exponential growth of healthcare costs worldwide, to support sustainability and to guarantee access to treatment for all patients.: Methods: Artificial ... ...

    Abstract Background: Nowadays, healthcare systems are coping with the challenge of countering the exponential growth of healthcare costs worldwide, to support sustainability and to guarantee access to treatment for all patients.
    Methods: Artificial Intelligence (AI) is the technology able to perform human cognitive functions through the creation of algorithms. The value of AI in healthcare and its ability to address healthcare delivery issues has been a subject of discussion within the scientific community for several years.
    Results: The aim of this work is to provide an overview of the primary uses of AI in the healthcare system, to discuss its desirable future uses while shedding light on the major issues related to implications within international regulatory processes. In this manuscript, it will be described the main applications of AI in various aspects of health care, from clinical studies to ethical implications, focusing on the international regulatory framework in countries in which AI is used, to discuss and compare strengthens and weaknesses.
    Conclusions: The challenges in regulatory processes to facilitate the integration of AI in healthcare are significant. However, overcoming them is essential to ensure that AI-based technologies are adopted safely and effectively.
    MeSH term(s) Humans ; Artificial Intelligence ; Algorithms ; Coping Skills ; Delivery of Health Care
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 843063-9
    ISSN 1573-904X ; 0724-8741 ; 0739-0742
    ISSN (online) 1573-904X
    ISSN 0724-8741 ; 0739-0742
    DOI 10.1007/s11095-024-03685-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pharmacotherapy Based on ACE2 Targeting and COVID-19 Infection.

    Vitiello, Antonio / Ferrara, Francesco

    International journal of molecular sciences

    2022  Volume 23, Issue 12

    Abstract: The new SARS-CoV-2 coronavirus is responsible for the COVID-19 pandemic. A massive vaccination campaign, which is still ongoing, has averted most serious consequences worldwide; however, lines of research are continuing to identify the best drug ... ...

    Abstract The new SARS-CoV-2 coronavirus is responsible for the COVID-19 pandemic. A massive vaccination campaign, which is still ongoing, has averted most serious consequences worldwide; however, lines of research are continuing to identify the best drug therapies to treat COVID-19 infection. SARS-CoV-2 penetrates the cells of the host organism through ACE2. The ACE2 protein plays a key role in the renin-angiotensin system (RAS) and undergoes changes in expression during different stages of COVID-19 infection. It appears that an unregulated RAS is responsible for the severe lung damage that occurs in some cases of COVID-19. Pharmacologically modifying the expression of ACE2 could be an interesting line of research to follow in order to avoid the severe complications of COVID-19.
    MeSH term(s) Angiotensin-Converting Enzyme 2 ; COVID-19/drug therapy ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Renin-Angiotensin System ; SARS-CoV-2
    Chemical Substances Peptidyl-Dipeptidase A (EC 3.4.15.1) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2022-06-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23126644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Comment on: The perfect stoma: tips from a stoma nurse.

    Pata, Francesco / Parini, Dario / Rizzo, Gianluca / Bondurri, Andrea / Ferrara, Francesco

    The British journal of surgery

    2024  Volume 111, Issue 1

    MeSH term(s) Humans ; Surgical Stomas ; Preoperative Care
    Language English
    Publishing date 2024-01-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znae011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Imaging Follow-up of Non-Severe Aortic Stenosis: "When the winds of change blow, some people build walls and others build windmills".

    Carbone, Andreina / Ferrara, Francesco / Baliga, Ragavendra R / Bossone, Eduardo

    European journal of preventive cardiology

    2024  

    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1093/eurjpc/zwae138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4686: Show issues Location:
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  8. Article: Perspectives of association Baricitinib/Remdesivir for adults with Covid-19 infection

    Vitiello, Antonio / Ferrara, Francesco

    Molecular biology reports. 2022 Jan., v. 49, no. 1

    2022  

    Abstract: BACKGROUND: The global COVID-19 pandemic is currently underway. A massive worldwide vaccination campaign is still underway, representing the most promising weapon available to stop the pandemic. METHODS AND RESULTS: However, research continues to ... ...

    Abstract BACKGROUND: The global COVID-19 pandemic is currently underway. A massive worldwide vaccination campaign is still underway, representing the most promising weapon available to stop the pandemic. METHODS AND RESULTS: However, research continues to investigate the most effective drug treatments to reduce and avoid the most serious complications caused by COVID-19 infection. Recently, new evidence of good therapeutic efficacy against COVID-19 has emerged for the antiviral Remdesivir and the immunomodulatory Baricitinib, also in combination. The first one showed SARS-CoV-2 antireplicative activity, the second one useful to reduce the hyperinflammatory state caused by cytokine storm in the most severe phases of the infection. CONCLUSIONS: In this short communication we describe the molecular pharmacological mechanisms and the latest evidence for the use of these therapeutic agents in the treatment of COVID-19 infection.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; cytokines ; drugs ; molecular biology ; pandemic ; vaccination
    Language English
    Dates of publication 2022-01
    Size p. 827-831.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-021-06888-8
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: The direct correlation between microbiota and SARS-CoV-2 infectious disease.

    Vitiello, Antonio / Ferrara, Francesco / Zovi, Andrea

    Inflammopharmacology

    2023  Volume 31, Issue 2, Page(s) 603–610

    Abstract: The human microbiota is the good part of the human organism and is a collection of symbiotic microorganisms which aid in human physiological functions. Diseases that can be generated by an altered microbiota are continuously being studied, but it is ... ...

    Abstract The human microbiota is the good part of the human organism and is a collection of symbiotic microorganisms which aid in human physiological functions. Diseases that can be generated by an altered microbiota are continuously being studied, but it is quite evident how a damaged microbiota is involved in chronic inflammatory diseases, psychiatric diseases, and some bacterial or viral infections. However, the role of the microbiota in the host immune response to bacterial and viral infections is still not entirely understood. Metabolites or components which are produced by the microbiota are useful in mediating microbiota-host interactions, thus influencing the host's immune capacity. Recent evidence shows that the microbiota is evidently altered in patients with viral infections such as post-acute COVID-19 syndrome (PACS). In this review, the associations between microbiota and COVID-19 infection are highlighted in terms of biological and clinical significance by emphasizing the mechanisms through which metabolites produced by the microbiota modulate immune responses to COVID-19 infection.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Microbiota ; Virus Diseases ; Communicable Diseases ; Bacteria
    Language English
    Publishing date 2023-02-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1080058-x
    ISSN 1568-5608 ; 0925-4692
    ISSN (online) 1568-5608
    ISSN 0925-4692
    DOI 10.1007/s10787-023-01145-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  10. Article: Renin Angiotensin System and COVID-19 Infection.

    Ferrara, Francesco / Vitiello, Antonio

    Advanced pharmaceutical bulletin

    2021  Volume 12, Issue 1, Page(s) 1–4

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2021-01-23
    Publishing country Iran
    Document type Editorial
    ZDB-ID 3018440-X
    ISSN 2251-7308 ; 2228-5881
    ISSN (online) 2251-7308
    ISSN 2228-5881
    DOI 10.34172/apb.2022.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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