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  1. Article: Toxoplasma gondii Serotypes in Italian and Foreign Populations: A Cross-Sectional Study Using a Homemade ELISA Test

    Caldrer, Sara / Vola, Ambra / Ferrari, Guglielmo / Ursini, Tamara / Mazzi, Cristina / Meroni, Valeria / Beltrame, Anna

    Microorganisms. 2022 Aug. 05, v. 10, no. 8

    2022  

    Abstract: Toxoplasma gondii is a protozoan parasite responsible for human toxoplasmosis. The three major clonal lineages and different recombinant strains of T. gondii have a varied global distribution. This study aimed at evaluating the epidemiological ... ...

    Abstract Toxoplasma gondii is a protozoan parasite responsible for human toxoplasmosis. The three major clonal lineages and different recombinant strains of T. gondii have a varied global distribution. This study aimed at evaluating the epidemiological distribution of types II and I–III and recombinant or mixed T. gondii in Italians and foreigners residing in Italy, establishing an association between serotypes and demographic characteristics. We collected the sera of 188 subjects who had tested positive for specific T. gondii antibodies. The population was differentiated into groups based on sex, nationality, and place of birth (Italy, Africa, South America, Asia, or Europe (except Italy)). We then performed a homemade ELISA test that detected both the antibodies against the amino acid sequences of the three main genotype antigens (I–III) in human sera and discerned the T. gondii strains. Serotype II of T. gondii was the most prevalent in the Italian population, whereas type I–III was the most prevalent in the foreign group. Surprisingly, we observed a notable amount of recombinant or mixed serotypes in European and Italian subjects. Moreover, we showed a significant difference in the prevalence of T. gondii serotypes between men and women, Italians, and foreigners. This descriptive study is the first to investigate the epidemiological distribution of T. gondii serotypes in humans in Italy using a homemade ELISA. We considered this technique suitable for discriminating between serotypes II and I–III and, consequently, for an epidemiological study focusing on the observation of circulating T. gondii strains and clinical correlations.
    Keywords Protozoa ; Toxoplasma gondii ; amino acids ; cross-sectional studies ; descriptive studies ; epidemiological studies ; genotype ; geographical distribution ; humans ; nationalities and ethnic groups ; parasites ; serotypes ; toxoplasmosis ; Africa ; Asia ; Italy ; South America
    Language English
    Dates of publication 2022-0805
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10081577
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: Toxoplasma gondii

    Caldrer, Sara / Vola, Ambra / Ferrari, Guglielmo / Ursini, Tamara / Mazzi, Cristina / Meroni, Valeria / Beltrame, Anna

    Microorganisms

    2022  Volume 10, Issue 8

    Abstract: Toxoplasma ... ...

    Abstract Toxoplasma gondii
    Language English
    Publishing date 2022-08-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10081577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Molecular Epidemiology of Rhinovirus/Enterovirus and Their Role on Cause Severe and Prolonged Infection in Hospitalized Patients.

    Giardina, Federica A M / Piralla, Antonio / Ferrari, Guglielmo / Zavaglio, Federica / Cassaniti, Irene / Baldanti, Fausto

    Microorganisms

    2022  Volume 10, Issue 4

    Abstract: Rhinovirus is one of the most common respiratory viruses, causing both upper and lower respiratory tract infections. It affects mainly children and could cause prolonged infections, especially in immunocompromised patients. Here we report our data on a ... ...

    Abstract Rhinovirus is one of the most common respiratory viruses, causing both upper and lower respiratory tract infections. It affects mainly children and could cause prolonged infections, especially in immunocompromised patients. Here we report our data on a 15-month surveillance of Rhinovirus seasonality and circulation in Lombardy Region, Italy. All rhinovirus/enterovirus-positive samples were amplified with RT-PCR for the VP4-VP2 region to assign the correct genotype. The median age of RV/EV-positive patients is 9 years, with a range of 0-96. RV-A and RV-C were detected in the majority of cases, while RV-B accounted for less than 10% of cases. An enterovirus species was detected in 6.45% of the cases. A total of 7% of the patients included in this study had a prolonged infection with a median duration of 62 days. All these patients were immunocompromised and most of them were pediatric with an RV-A infection. Two outbreaks were identified, mainly in the neonatal intensive care unit (NICU) and Oncohematology Department, caused by RV A89 and C43, respectively. Nearly 4.5% of the patients were admitted to the ICU requiring mechanical ventilation; all of which had preexisting comorbidities.
    Language English
    Publishing date 2022-03-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10040755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: SARS-CoV-2 infections in pediatric patients: A comparison of three pandemic waves.

    Rovida, Francesca / Giardina, Federica / Ferrari, Guglielmo / Paolucci, Stefania / Piralla, Antonio / Baldanti, Fausto

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2022  Volume 33 Suppl 27, Page(s) 93–95

    Abstract: The pediatric population seems to be at a lower risk of developing severe clinical symptoms of COVID-19. However, the clinical and epidemiological characteristics of COVID-19 in children are yet to be fully clarified. This retrospective observational ... ...

    Abstract The pediatric population seems to be at a lower risk of developing severe clinical symptoms of COVID-19. However, the clinical and epidemiological characteristics of COVID-19 in children are yet to be fully clarified. This retrospective observational study aimed to evaluate the frequency of pediatric laboratory-confirmed COVID-19 patients from February 2020 to April 2021. A total of 740 (5.1% of total) pediatric COVID-19 cases were observed during the study period. The peak of pediatric cases was observed in November 2020, with 239 cases. During the first wave of pandemics, the frequency of pediatric cases was 0.89% (49/5877 cases), ranging from 0.6% in February 2020 to 1.3% in April 2020. On the contrary, after the beginning of the second wave, the frequency of pediatric cases raised from 5.3% in September 2020 to 9.4%in February 2021, with an overall frequency of 8.2% (690/8416 cases). A different rate of SARS-CoV-2 circulation was observed among the pediatric population between the pandemic waves. During the second wave, two peaks of cases were observed. The last peak was associated with the spread of a more transmissive SARS-CoV-2 strain (VOC 202012/01).
    MeSH term(s) COVID-19 ; Child ; Humans ; Pandemics ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2022-02-10
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13642
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reply to Letter to the Editor: A Pure Autologous Dermal Graft and Dermal Flap Pocket in Prepectoral Implant Reconstruction After Skin-Reducing Mastectomy: A One-Stage Autologous Reconstruction Alternative to Acellular Dermal Matrices.

    Castagnetti, Fabio / Coiro, Saverio / Foroni, Monica / Falco, Giuseppe / Mele, Simone / Cenini, Eugenio / Morando, Ljuba / Begnini, Evelina / Borgonovo, Giulia / Ferrari, Guglielmo

    Aesthetic plastic surgery

    2022  Volume 47, Issue Suppl 1, Page(s) 99–100

    MeSH term(s) Humans ; Female ; Mastectomy ; Acellular Dermis ; Breast Neoplasms/surgery ; Mammaplasty ; Breast Implantation
    Language English
    Publishing date 2022-08-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 532791-x
    ISSN 1432-5241 ; 0364-216X
    ISSN (online) 1432-5241
    ISSN 0364-216X
    DOI 10.1007/s00266-022-03056-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A Pure Autologous Dermal Graft and Dermal Flap Pocket in Prepectoral Implant Reconstruction After Skin-Reducing Mastectomy: A One-Stage Autologous Reconstruction Alternative to Acellular Dermal Matrices.

    Castagnetti, Fabio / Coiro, Saverio / Foroni, Monica / Falco, Giuseppe / Mele, Simone / Cenini, Eugenio / Begnini, Evelina / Borgonovo, Giulia / Ferrari, Guglielmo

    Aesthetic plastic surgery

    2022  Volume 46, Issue 4, Page(s) 1679–1685

    Abstract: Skin-reducing mastectomy (SRM) with subpectoral implant positioning represents a consolidated, oncologically safe and cosmetically effective method for the immediate reconstruction of large and ptotic breasts. Acellular dermal matrix (ADM) has been ... ...

    Abstract Skin-reducing mastectomy (SRM) with subpectoral implant positioning represents a consolidated, oncologically safe and cosmetically effective method for the immediate reconstruction of large and ptotic breasts. Acellular dermal matrix (ADM) has been proposed as a substitute for the pectoralis major muscle in this surgical approach; this technique led to a progressive evolution toward prepectoral reconstructions even in skin-reducing mastectomies. Obese patients with macromastia who are typical candidates for SRM with ADM are at increased risk of complications associated with ADMs. Therefore, we avoided ADMs and developed a novel autologous technique for immediate breast reconstruction in large and ptotic breasts eligible for SRM. Specifically, an autologous dermal graft is harvested from contralateral healthy breast reduction to cover the upper pole of the prepectoral implant.Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
    MeSH term(s) Acellular Dermis ; Breast Implantation/methods ; Breast Implants ; Breast Neoplasms/etiology ; Breast Neoplasms/surgery ; Esthetics ; Female ; Humans ; Mammaplasty/methods ; Mastectomy/methods ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2022-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 532791-x
    ISSN 1432-5241 ; 0364-216X
    ISSN (online) 1432-5241
    ISSN 0364-216X
    DOI 10.1007/s00266-022-02800-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1296: Show issues Location:
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  7. Article: Bifurcate inferior pedicle mammoplasty in large ptotic breast for tumor located at the upper outer quadrant with skin involvement-a novel technique allowing good cosmetic outcome: case report.

    Mele, Simone / Falco, Giuseppe / Borgonovo, Giulia / Castagnetti, Fabio / Cenini, Eugenio / Coiro, Saverio / Ferrari, Guglielmo

    Gland surgery

    2020  Volume 9, Issue 5, Page(s) 1590–1595

    Abstract: Breast oncoplastic techniques followed by radiotherapy represent nowadays the standard of care for breast cancer treatment. For tumours located at the upper outer quadrant in patients with large and ptotic breasts, the use of level II breast reduction ... ...

    Abstract Breast oncoplastic techniques followed by radiotherapy represent nowadays the standard of care for breast cancer treatment. For tumours located at the upper outer quadrant in patients with large and ptotic breasts, the use of level II breast reduction mammoplasty, allows large quadrantectomies without compromising the breast natural shape and reducing the breast volume to be irradiated. When the skin overlying the tumour in the upper outer quadrant is involved, the removal of the skin during mammoplasty could lead to an extreme reduction of the breast, resulting in a bad outcome. Different strategies have been adopted to avoid a poor cosmetic result including a Z plastic or latissimus dorsi (LD) mini flap. At our institution we developed a new technique utilizing an inferior bifurcated pedicle mammoplasty with the preservation of a skin island for a patient with a residual tumour following chemotherapy involving the skin in the upper outer quadrant of the right breast. The patient did show no complications, with no delay for adjuvant radiotherapy treatment. Our method is a novel technique to treat malignancies in this location for patients with large and ptotic breasts when skin removal is indicated and it may represent an effective strategy to prevent excessive gland reduction, thus avoiding poor cosmetic result.
    Language English
    Publishing date 2020-11-05
    Publishing country China (Republic : 1949- )
    Document type Case Reports
    ZDB-ID 3016969-0
    ISSN 2227-8575 ; 2227-684X
    ISSN (online) 2227-8575
    ISSN 2227-684X
    DOI 10.21037/gs-20-349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Applicability of a Proposed Italian Model for the treatment of B3 lesions.

    Falco, Giuseppe / Capalbo, Emanuela / Marchesi, Vanessa / Ragazzi, Moira / Scaperrotta, Gianfranco / Ferrari, Guglielmo

    The breast journal

    2020  Volume 26, Issue 11, Page(s) 2320–2322

    MeSH term(s) Breast/diagnostic imaging ; Breast Neoplasms ; Female ; Humans ; Italy ; Mammography
    Language English
    Publishing date 2020-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1289960-4
    ISSN 1524-4741 ; 1075-122X
    ISSN (online) 1524-4741
    ISSN 1075-122X
    DOI 10.1111/tbj.14087
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    Zs.A 4483: Show issues Location:
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  9. Article ; Online: Spatial Distribution of Immune Cells Drives Resistance to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer.

    Donati, Benedetta / Reggiani, Francesca / Torricelli, Federica / Santandrea, Giacomo / Rossi, Teresa / Bisagni, Alessandra / Gasparini, Elisa / Neri, Antonino / Cortesi, Laura / Ferrari, Guglielmo / Bisagni, Giancarlo / Ragazzi, Moira / Ciarrocchi, Alessia

    Cancer immunology research

    2023  Volume 12, Issue 1, Page(s) 120–134

    Abstract: Neoadjuvant chemotherapy (NAC) alone or combined with target therapies represents the standard of care for localized triple-negative breast cancer (TNBC). However, only a fraction of patients have a response, necessitating better understanding of the ... ...

    Abstract Neoadjuvant chemotherapy (NAC) alone or combined with target therapies represents the standard of care for localized triple-negative breast cancer (TNBC). However, only a fraction of patients have a response, necessitating better understanding of the complex elements in the TNBC ecosystem that establish continuous and multidimensional interactions. Resolving such complexity requires new spatially-defined approaches. Here, we used spatial transcriptomics to investigate the multidimensional organization of TNBC at diagnosis and explore the contribution of each cell component to response to NAC. Starting from a consecutive retrospective series of TNBC cases, we designed a case-control study including 24 patients with TNBC of which 12 experienced a pathologic complete response (pCR) and 12 no-response or progression (pNR) after NAC. Over 200 regions of interest (ROI) were profiled. Our computational approaches described a model that recapitulates clinical response to therapy. The data were validated in an independent cohort of patients. Differences in the transcriptional program were detected in the tumor, stroma, and immune infiltrate comparing patients with a pCR with those with pNR. In pCR, spatial contamination between the tumor mass and the infiltrating lymphocytes was observed, sustained by a massive activation of IFN-signaling. Conversely, pNR lesions displayed increased pro-angiogenetic signaling and oxygen-based metabolism. Only modest differences were observed in the stroma, revealing a topology-based functional heterogeneity of the immune infiltrate. Thus, spatial transcriptomics provides fundamental information on the multidimensionality of TNBC and allows an effective prediction of tumor behavior. These results open new perspectives for the improvement and personalization of therapeutic approaches to TNBCs.
    MeSH term(s) Humans ; Case-Control Studies ; Neoadjuvant Therapy/methods ; Prognosis ; Retrospective Studies ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/genetics ; Female
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2732489-8
    ISSN 2326-6074 ; 2326-6066
    ISSN (online) 2326-6074
    ISSN 2326-6066
    DOI 10.1158/2326-6066.CIR-23-0076
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  10. Article ; Online: Reply To Invited Discussion On: The Bovine Pericardium Matrix In Immediate Implant-Based Breast Reconstruction.

    Castagnetti, Fabio / Bertani, Chiara / Foroni, Monica / Falco, Giuseppe / Cenini, Eugenio / De Bonis, Filomena / Ferrari, Guglielmo

    Aesthetic plastic surgery

    2021  Volume 45, Issue 3, Page(s) 1380–1381

    MeSH term(s) Animals ; Breast Implantation/adverse effects ; Cattle ; Humans ; Mammaplasty ; Pericardium/surgery
    Language English
    Publishing date 2021-01-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 532791-x
    ISSN 1432-5241 ; 0364-216X
    ISSN (online) 1432-5241
    ISSN 0364-216X
    DOI 10.1007/s00266-020-02114-1
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