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Book ; Thesis: Antagonistische Wirkung von ausgewählten Antidepressiva, Neuroleptika und NMDA-Rezeptor-Antagonisten am serotoninergen Rezeptor des 5-HT3-Typs

Ferrari, Uta

2006

Author's details	vorgelegt von Uta Ferrari
Language	German
Size	82 S., Ill., graph. Darst., 21 cm
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	München, Univ., Diss., 2006
HBZ-ID	HT015930587
Database	Catalogue ZB MED Medicine, Health

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Book ; Online ; Thesis: Psychoneurologische und muskuläre Mechanismen in der Diabetesentstehung

Ferrari, Uta [Verfasser]

2021

Author's details	Uta Ferrari
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Universitätsbibliothek der Ludwig-Maximilians-Universität
Publishing place	München
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Die aktuelle Sarkopenie-Definition.

Ferrari, Uta / Drey, Michael

Deutsche medizinische Wochenschrift (1946)

2020 Volume 145, Issue 18, Page(s) 1315–1319

Abstract: Sarcopenia is characterized by a generalized loss of muscle function, strength and mass and is codable in Germany since 2018 in the ICD-10-GM (M62.50). For screening in primary care, it is possible to determine muscle function and strength by means of a ... ...

Title translation	The Actual Sarcopenia Definition 2019.
Abstract	Sarcopenia is characterized by a generalized loss of muscle function, strength and mass and is codable in Germany since 2018 in the ICD-10-GM (M62.50). For screening in primary care, it is possible to determine muscle function and strength by means of a sarcopenia questionnaire (SARC-F) as a self-filler with 5 questions of restrictions. With an increased score of 4 and higher, an examination of the musculature and a determination of the skeletal muscle mass index should be performed via dual energy X-ray absorption measurement (DXA) or bioelectric impedance analysis (BIA).If hand and/or leg strength is limited, the patient has probable sarcopenia and, according to the current revised version of the European consensus on sarcopenia, therapy can already be started and the cause clarified. A DXA or BIA examination confirms the diagnosis of sarcopenia by a lowered skeletal muscle index. A follow-up examination is recommended to differentiate between acute or chronic sarcopenia and to assess the progression of the disease. The severity of the disease is defined by additional examinations such as gait speed, timed up and go test (TUG) and/or short physical performance battery (SPPB). Patients with sarcopenia suffer from increasing immobility and disability and have an increased risk of falls, fractures and mortality. Frequently, co-morbidities should be clarified in all affected patients.
MeSH term(s)	Aged ; Aged, 80 and over ; Exercise Test ; Female ; Geriatric Assessment ; Germany ; Humans ; Male ; Physical Examination ; Sarcopenia/diagnosis ; Sarcopenia/physiopathology ; Surveys and Questionnaires
Language	German
Publishing date	2020-09-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	200446-x
ISSN	1439-4413 ; 0012-0472
ISSN (online)	1439-4413
ISSN	0012-0472
DOI	10.1055/a-0986-2818
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Article ; Online: Sarkopenie: Wie kommt der Patient wieder zu Kräften?

Ferrari, Uta / Drey, Michael

MMW Fortschritte der Medizin

2019 Volume 161, Issue 8, Page(s) 45–48

Title translation	Sarcopenia - how does the patient restore muscle strength again.
MeSH term(s)	Aged ; Aging/physiology ; Exercise Therapy ; Geriatric Assessment/methods ; Hand Strength ; Humans ; Muscle Strength/physiology ; Muscle, Skeletal/physiopathology ; Resistance Training ; Sarcopenia/diagnosis ; Sarcopenia/physiopathology ; Sarcopenia/therapy
Language	German
Publishing date	2019-04-29
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1478211-x
ISSN	1613-3560 ; 1438-3276
ISSN (online)	1613-3560
ISSN	1438-3276
DOI	10.1007/s15006-019-0455-2
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Article ; Online: Association of GLP-1 secretion with parameters of glycemic control in women after gestational diabetes mellitus.

Pappa, Eleni / Busygina, Kristina / Harada, Saori / Hermann, Hana / Then, Cornelia / Lechner, Andreas / Ferrari, Uta / Seissler, Jochen

BMJ open diabetes research & care

2024 Volume 12, Issue 1

Abstract: Introduction: Women with a history of gestational diabetes mellitus (GDM) are at high risk of developing type 2 diabetes, while the exact mechanisms underlying its pathophysiology are still unclear. We investigated the association of glucagon-like ... ...

Abstract	Introduction: Women with a history of gestational diabetes mellitus (GDM) are at high risk of developing type 2 diabetes, while the exact mechanisms underlying its pathophysiology are still unclear. We investigated the association of glucagon-like peptide-1 (GLP-1) response to oral glucose with parameters of glycemic control in women with previous GDM in the prospective PPSDiab (Prediction, Prevention, and Subclassification of Type 2 Diabetes) study. Research design and methods: Glucose metabolism parameters and GLP-1 secretion were analyzed during oral glucose tolerance test (OGTT) in women with previous GDM (n=129) and women with a history of normal glucose tolerance (n=67) during pregnancy (controls). First- and second-phase insulin and GLP-1 secretion in relation to plasma glucose (PG) levels were assessed, and development of pre-diabetes was analyzed after 5-year follow-up among women with previous GDM and a normal glycemic state at baseline (n=58). Results: The area under the curve (AUC during the OGTT 0-120 min) of PG and insulin but not GLP-1 differed significantly between post-GDM women and controls. However, women with previous GDM had a significantly decreased GLP-1 response in relation to PG and plasma insulin during the second phase of the OGTT. After a follow-up of 5 years, 19.0% post-GDM women with a normal glycemic state at the baseline visit developed abnormal glucose metabolism. The total, first- and second-phase AUC GLP-1/PG and GLP-1/insulin ratios were not associated with development of abnormal glucose tolerance. Conclusions: Women with previous GDM showed a reduced GLP-1 response in relation to PG and insulin concentrations indicating early abnormalities in glucose metabolism. However, the altered GLP-1 response to oral glucose did not predict progression to pre-diabetes and type 2 diabetes in the first 5 years after GDM.
MeSH term(s)	Pregnancy ; Humans ; Female ; Glycemic Control ; Diabetes Mellitus, Type 2 ; Diabetes, Gestational ; Prediabetic State ; Prospective Studies ; Insulin, Regular, Human ; Insulin ; Glucagon-Like Peptide 1 ; Glucose
Chemical Substances	Insulin, Regular, Human ; Insulin ; Glucagon-Like Peptide 1 (89750-14-1) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2024-01-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2732918-5
ISSN	2052-4897 ; 2052-4897
ISSN (online)	2052-4897
ISSN	2052-4897
DOI	10.1136/bmjdrc-2023-003706
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Article: Associations of gestational diabetes and proton density fat fraction of vertebral bone marrow and paraspinal musculature in premenopausal women.

Harada, Saori / Gersing, Alexandra S / Stohldreier, Yannick / Dietrich, Olaf / Lechner, Andreas / Seissler, Jochen / Ferrari, Uta / Pappa, Eleni / Hesse, Nina

Frontiers in endocrinology

2024 Volume 14, Page(s) 1303126

Abstract: Background and objective: Fat content in bones and muscles, quantified by magnetic resonance imaging (MRI) as a proton density fat fraction (PDFF) value, is an emerging non-invasive biomarker. PDFF has been proposed to indicate bone and metabolic health ...

Abstract	Background and objective: Fat content in bones and muscles, quantified by magnetic resonance imaging (MRI) as a proton density fat fraction (PDFF) value, is an emerging non-invasive biomarker. PDFF has been proposed to indicate bone and metabolic health among postmenopausal women. Premenopausal women with a history of gestational diabetes (GDM) carry an increased risk of developing type 2 diabetes and an increased risk of fractures. However, no studies have investigated the associations between a history of GDM and PDFF of bone or of paraspinal musculature (PSM), composed of autochthonous muscle (AM) and psoas muscle, which are responsible for moving and stabilizing the spine. This study aims to investigate whether PDFF of vertebral bone marrow and of PSM are associated with a history of GDM in premenopausal women. Methods: A total of 37 women (mean age 36.3 ± 3.8 years) who were 6 to 15 months postpartum with (n=19) and without (n=18) a history of GDM underwent whole-body 3T MRI, including a chemical shift encoding-based water-fat separation. The PDFF maps were calculated for the vertebral bodies and PSM. The cross-sectional area (CSA) of PSM was obtained. Associations between a history of GDM and PDFF were assessed using multivariable linear and logistic regression models. Results: The PDFF of the vertebral bodies was significantly higher in women with a history of GDM (GDM group) than in women without (thoracic: median 41.55 (interquartile range 32.21-49.48)% vs. 31.75 (30.03-34.97)%; p=0.02, lumbar: 47.84 (39.19-57.58)% vs. 36.93 (33.36-41.31)%; p=0.02). The results remained significant after adjustment for age and body mass index (BMI) (p=0.01-0.02). The receiver operating characteristic curves showed optimal thoracic and lumbar vertebral PDFF cutoffs at 38.10% and 44.18%, respectively, to differentiate GDM (AUC 0.72 and 0.73, respectively, sensitivity 0.58, specificity 0.89). The PDFF of the AM was significantly higher in the GDM group (12.99 (12.18-15.90)% vs. 10.83 (9.39-14.71)%; p=0.04) without adjustments, while the CSA was similar between the groups (p=0.34). Conclusion: A history of GDM is significantly associated with a higher PDFF of the vertebral bone marrow, independent of age and BMI. This statistical association between GDM and increased PDFF highlights vertebral bone marrow PDFF as a potential biomarker for the assessment of bone health in premenopausal women at risk of diabetes.
MeSH term(s)	Humans ; Female ; Pregnancy ; Adult ; Bone Marrow/diagnostic imaging ; Bone Marrow/pathology ; Diabetes, Gestational/pathology ; Protons ; Vertebral Body ; Diabetes Mellitus, Type 2/pathology ; Adipose Tissue/diagnostic imaging ; Adipose Tissue/pathology ; Lumbar Vertebrae/diagnostic imaging ; Biomarkers
Chemical Substances	Protons ; Biomarkers
Language	English
Publishing date	2024-01-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1303126
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Article: Sarkopenie: Eine Herausforderung im Alter

Ferrari, Uta / Drey, Michael

Osteologie

2020 Volume 29, Issue 02, Page(s) 143–149

Abstract: Sarkopenie ist ein geriatrisches Syndrom, das durch einen generalisierten Verlust von Muskelmasse und Muskelfunktion gekennzeichnet ist. Damit verbunden ist eine erhöhte Wahrscheinlichkeit von Stürzen, Frakturen, Behinderung und Mortalität. Seit Oktober ... ...

Abstract	Sarkopenie ist ein geriatrisches Syndrom, das durch einen generalisierten Verlust von Muskelmasse und Muskelfunktion gekennzeichnet ist. Damit verbunden ist eine erhöhte Wahrscheinlichkeit von Stürzen, Frakturen, Behinderung und Mortalität. Seit Oktober 2016 gibt es in den USA einen ICD-10-CM-Kode (M62.84) für Sarkopenie. In Deutschland kann Sarkopenie seit 2018 im ICD-10-GM (M62.50) kodiert werden. Zur Selektion in der Primärversorgung besteht die Möglichkeit, mittels eines Sarkopenie-Fragebogens (SARC-F) gefährdete Patienten zu identifizieren. Diese können dann einer weiterführenden Diagnostik zugeführt werden. Gemäß der aktuellen revidierten Fassung des europäischen Sarkopeniekonsensus sind ein Therapiebeginn und eine weitere Ursachenabklärung bereits bei Vorliegen einer eingeschränkten Muskelkraft möglich. Gegenwärtig besteht die Therapie aus Kraft- und Balancetraining sowie einer Ernährungsberatung, mit dem Ziel einer proteinreichen Ernährung. Eine medikamentöse Behandlung der Sarkopenie ist noch nicht verfügbar. Einige Substanzen sind jedoch in der klinischen Prüfung. Am vielversprechendsten scheint die Gruppe der Myostatin-Antagonisten zu sein.
Keywords	Sarkopenie ; Geriatrie ; Muskel ; Stürze ; sarcopenia ; geriatrics ; muscle ; falls
Language	German
Publishing date	2020-05-01
Publisher	© Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2113634-8
ISSN	2567-5818 ; 1019-1291
ISSN (online)	2567-5818
ISSN	1019-1291
DOI	10.1055/a-1155-1461
Database	Thieme publisher's database

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Article: Sarkopenie: eine Herausforderung im Alter

Ferrari, Uta / Drey, Michael

Aktuelle Ernährungsmedizin

2020 Volume 45, Issue 01, Page(s) 33–39

Abstract	Sarkopenie ist ein geriatrisches Syndrom, das durch einen generalisierten Verlust von Muskelmasse und Muskelfunktion gekennzeichnet ist. Damit verbunden ist eine erhöhte Wahrscheinlichkeit von Stürzen, Frakturen, Behinderung und Mortalität. Seit Oktober 2016 gibt es in den USA einen ICD-10-CM-Code (M62.84) für Sarkopenie. In Deutschland kann Sarkopenie seit 2018 im ICD-10-GM (M62.50) codiert werden. Zur Selektion in der Primärversorgung besteht die Möglichkeit mittels eines Sarkopeniefragebogens (SARC-F) gefährdete Patienten zu identifizieren. Diese können dann einer weiterführenden Diagnostik zugeführt werden. Gemäß der aktuellen revidierten Fassung des europäischen Sarkopeniekonsensus ist ein Therapiebeginn und eine weitere Ursachenabklärung bereits bei Vorliegen einer eingeschränkten Muskelkraft möglich. Gegenwärtig besteht die Therapie aus Kraft- und Balancetraining sowie einer Ernährungsberatung mit dem Ziel einer proteinreichen Ernährung. Eine medikamentöse Behandlung der Sarkopenie ist noch nicht verfügbar. Einige Substanzen sind jedoch in der klinischen Prüfung. Am vielversprechendsten scheint die Gruppe der Myostatinantagonisten zu sein.
Keywords	Sarkopenie ; Geriatrie ; Muskel ; Stürze ; sarcopenia ; geriatrics ; muscle ; falls
Language	German
Publishing date	2020-02-01
Publisher	© Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	131268-6
ISSN	1438-9916 ; 0341-0501
ISSN (online)	1438-9916
ISSN	0341-0501
DOI	10.1055/a-0965-9892
Database	Thieme publisher's database

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Article: Die aktuelle Sarkopenie-Definition

Ferrari, Uta / Drey, Michael

DMW - Deutsche Medizinische Wochenschrift

2020 Volume 145, Issue 18, Page(s) 1315–1319

Keywords	Sarkopenie ; Geriatrie ; Muskel ; Stürze ; geriatrisches Assessment ; sarcopenia ; geriatrics ; muscle ; falls ; geriatric assessment
Language	German
Publishing date	2020-09-01
Publisher	© Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	200446-x
ISSN	1439-4413 ; 0012-0472
ISSN (online)	1439-4413
ISSN	0012-0472
DOI	10.1055/a-0986-2818
Database	Thieme publisher's database

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Ua VI Zs.60/X: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Sarcopenia: investigation of metabolic changes and its associated mechanisms.

Marques, Jair / Shokry, Engy / Uhl, Olaf / Baber, Lisa / Hofmeister, Fabian / Jarmusch, Stefanie / Bidlingmaier, Martin / Ferrari, Uta / Koletzko, Berthold / Drey, Michael

Skeletal muscle

2023 Volume 13, Issue 1, Page(s) 2

Abstract: Background: Sarcopenia is one of the most predominant musculoskeletal diseases of the elderly, defined as age-related progressive and generalized loss of muscle mass with a simultaneous reduction in muscle strength and/or function. Using metabolomics, ... ...

Abstract	Background: Sarcopenia is one of the most predominant musculoskeletal diseases of the elderly, defined as age-related progressive and generalized loss of muscle mass with a simultaneous reduction in muscle strength and/or function. Using metabolomics, we aimed to examine the association between sarcopenia and the plasma metabolic profile of sarcopenic patients, measured using a targeted HPLC-MS/MS platform. Methods: Plasma samples from 22 (17 men) hip fracture patients undergoing surgery (8 sarcopenic, age 81.4+6.3, and 14 non-sarcopenic, age 78.4±8.1) were analyzed. T test, fold change, orthogonal partial least squares discriminant analysis, and sparse partial least squares discriminant analysis were used for mining significant features. Metabolite set enrichment analysis and mediation analysis by PLSSEM were thereafter performed. Results: Using a univariate analysis for sarcopenia z score, the amino acid citrulline was the only metabolite with a significant group difference after FDR correction. Positive trends were observed between the sarcopenia z score and very long-chain fatty acids as well as dicarboxylic acid carnitines. Multivariate analysis showed citrulline, non-esterified fatty acid 26:2, and decanedioyl carnitine as the top three metabolites according to the variable importance in projection using oPLS-DA and loadings weight by sPLS-DA. Metabolite set enrichment analysis showed carnitine palmitoyltransferase deficiency (II) as the highest condition related to the metabolome. Conclusions: We observed a difference in the plasma metabolic profile in association with different measures of sarcopenia, which identifies very long-chain fatty acids, Carn.DC and citrulline as key variables associated with the disease severity. These findings point to a potential link between sarcopenia and mitochondrial dysfunction and portraits a number of possible biochemical pathways which might be involved in the disease pathogenesis.
MeSH term(s)	Male ; Humans ; Aged ; Aged, 80 and over ; Sarcopenia ; Citrulline ; Tandem Mass Spectrometry ; Metabolomics ; Fatty Acids/metabolism
Chemical Substances	Citrulline (29VT07BGDA) ; Fatty Acids
Language	English
Publishing date	2023-01-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2595637-1
ISSN	2044-5040 ; 2044-5040
ISSN (online)	2044-5040
ISSN	2044-5040
DOI	10.1186/s13395-022-00312-w
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