Result 1 - 10 of total 75
2023
| Keywords | Text ; ddc:610 |
|---|---|
| Language | English |
| Publishing country | de |
| Document type | Book ; Audio / Video ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
2023
| Keywords | Text ; ddc:610 |
|---|---|
| Language | English |
| Publishing country | de |
| Document type | Book ; Audio / Video ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
2023 Volume 13, Issue 1, Page(s) 19340
Abstract: Purified diets (PD) increase standardization and repeatability in rodent studies but lead to differences in the phenotype of animals compared to grain-based "chow" diets. PD contain less fiber and are often devoid of soluble fiber, which can impact gut ... ...
| Abstract | Purified diets (PD) increase standardization and repeatability in rodent studies but lead to differences in the phenotype of animals compared to grain-based "chow" diets. PD contain less fiber and are often devoid of soluble fiber, which can impact gut health. Thus, the aim of the present study was to modify the PD AIN93G by addition of soluble fiber, to promote more natural gut development as seen with chow diets. One hundred twenty male C57BL/6J mice were fed over 12 weeks either a chow diet, AIN93G or one of three modified AIN93G with increased fiber content and different ratios of soluble fiber to cellulose. Gut health was assessed through histological and immunohistochemical parameters and gut barrier gene expression. Gut microbiota composition was analyzed and its activity characterized through short chain fatty acid (SCFA) quantification. Feeding AIN93G led to tissue atrophy, a less diverse microbiota and a lower production of SCFA compared to chow diet. The addition of soluble fiber mitigated these effects, leading to intermediate colon and caecum crypt lengths and microbiota composition compared to both control diets. In conclusion, the addition of soluble fibers in PDs seems essential for gut morphology as well as a diverse and functional gut microbiome. |
|---|---|
| MeSH term(s) | Mice ; Male ; Animals ; Dietary Fiber/metabolism ; Mice, Inbred C57BL ; Colon/metabolism ; Cecum/metabolism ; Diet ; Fatty Acids, Volatile/metabolism |
| Chemical Substances | Dietary Fiber ; Fatty Acids, Volatile |
| Language | English |
| Publishing date | 2023-11-07 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2615211-3 |
| ISSN | 2045-2322 ; 2045-2322 |
| ISSN (online) | 2045-2322 |
| ISSN | 2045-2322 |
| DOI | 10.1038/s41598-023-46331-5 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Ferrario, P.G.; Bub, A.; Frommherz, L.; Krüger, R.; Rist, M.J.; Watzl, B. “A new statistical workflow (R-packages based) to investigate associations between one variable of interest and the metabolome"
2023
Abstract: This dataset contains a part of the underlying research data for the paper: Ferrario PG, Bub A, Frommherz L, Krüger R, Rist MJ, Watzl B. “A new statistical workflow (R-packages based) to investigate associations between one variable of interest and the ... ...
| Abstract | This dataset contains a part of the underlying research data for the paper: Ferrario PG, Bub A, Frommherz L, Krüger R, Rist MJ, Watzl B. “A new statistical workflow (R-packages based) to investigate associations between one variable of interest and the metabolome". These research data consist in measurements of the participants from the Karlsruhe Metabolomics and Nutrition (KarMeN) Study. Specifically, the data concern Age, BMI and two plasma metabolites: glycoursodeoxycholic acid (GUDCA), and the plasma metabolite decanoic acid (C10:0). GUDCA is a bile acid, and this was quantified by LC-MS (Liquid chromatography-mass spectrometry). C10:0 is a saturated fatty acid, and it was quantified by GC-MS (Gas chromatography-mass spectrometry). |
|---|---|
| Keywords | database ; Dataset ; Text ; ddc:540 ; metabolomics -- statistical workflow -- fatty acid -- bile acid |
| Language | English |
| Publishing date | 2023-07-21 |
| Publishing country | de |
| Document type | Book ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
2019 Volume 39, Issue 4, Page(s) 1807–1812
Abstract: Background: Chlorophyllin is used in traditional Chinese medicine because of its anticancer properties. This article describes the preparation and cytotoxic activity of a reduced chlorophyllin derivative (RCD) on tumour cell lines.: Materials and ... ...
| Abstract | Background: Chlorophyllin is used in traditional Chinese medicine because of its anticancer properties. This article describes the preparation and cytotoxic activity of a reduced chlorophyllin derivative (RCD) on tumour cell lines. Materials and methods: RCD was prepared by reducing chlorophyllin with lithium aluminium hydride, and its solubility in the alkaline and organic phases are different from that of the parent compound chlorophyllin. Results: RCD also has different chromatographic behaviour from chlorophyllin on thin-layer chromatography and high-pressure liquid chromatography, and excitation and emission spectra. RCD has cytotoxic activity against ZR-75, MCF-7 and HT-29, human tumour cell lines. A clonogenic assay showed that the growth of tumour colonies on soft agar was reduced by RCD in a dose-dependent manner. Conclusion: RCD is a novel compound exhibiting anticancer activity. |
|---|---|
| MeSH term(s) | Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Cell Proliferation/drug effects ; Chlorophyllides/chemistry ; Chlorophyllides/pharmacology ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/pathology ; Dose-Response Relationship, Drug ; Female ; HT29 Cells ; Humans ; MCF-7 Cells ; Oxidation-Reduction ; Preliminary Data |
| Chemical Substances | Antineoplastic Agents ; Chlorophyllides ; chlorophyllin (EEM82VOY7C) |
| Language | English |
| Publishing date | 2019-04-23 |
| Publishing country | Greece |
| Document type | Journal Article |
| ZDB-ID | 604549-2 |
| ISSN | 1791-7530 ; 0250-7005 |
| ISSN (online) | 1791-7530 |
| ISSN | 0250-7005 |
| DOI | 10.21873/anticanres.13287 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1642: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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Theriogenology. 2020 June, v. 149
2020
Abstract: Because of the need to improve the knowledge about canine perinatology, and given the major role of fetal fluids in sustaining the course of pregnancy and fetal development, an in-depth analysis to better understand the role of some hormones in these ... ...
| Abstract | Because of the need to improve the knowledge about canine perinatology, and given the major role of fetal fluids in sustaining the course of pregnancy and fetal development, an in-depth analysis to better understand the role of some hormones in these compartments is essential. Among all, leptin is recognized to play a key role not only on the energetic homeostasis, but also at multiple levels, influencing the control of reproduction, food assumption and metabolism. Even if in humans and other species it is reported the presence of leptin receptors during fetal development, very little is known about the canine species, in which the role of leptin still needs to be fully understood. The present study aimed to assess the amniotic fluid leptin (AFL) concentrations at term pregnancy in healthy dogs, and to evaluate the possible influence played by breed body-size (after assessment of correlation with maternal bodyweight and placental weight), or other maternal (age, parity, and the so-called “litter effect”) and neonatal (gender, birth weight, litter size) parameters on AFL concentrations, analyzed by ELISA test. The study was performed on 90 healthy, viable and normal weighted puppies, 39 small-sized (adult body weight < 10 kg) and 51 large-sized (adult body weight > 25 kg), born by 29 purebred, healthy bitches, submitted to elective Caesarean section because of breed-related or individual high risk for dystocia. The results showed that the mean AFL concentration in the small-sized puppies was significantly (p < 0.05) higher in comparison to large-sized puppies (867.48 vs 698.42 pg/ml), while all the other studied parameters did not show to influence AFL concentrations. In conclusions, the present study showed significant higher at term AFL concentrations in small-sized as compared to large-sized breeds, suggesting an influence of breed body-size on fetal metabolism, as previously reported for NEFA and IGF-I. |
|---|---|
| Keywords | adults ; amniotic fluid ; birth weight ; bitches ; body size ; breeds ; cesarean section ; dystocia ; enzyme-linked immunosorbent assay ; fetal development ; free fatty acids ; homeostasis ; humans ; insulin-like growth factor I ; leptin ; leptin receptors ; litter size ; metabolism ; pregnancy ; puppies ; purebreds ; risk |
| Language | English |
| Dates of publication | 2020-06 |
| Size | p. 1-5. |
| Publishing place | Elsevier Inc. |
| Document type | Article |
| ZDB-ID | 189232-0 |
| ISSN | 1879-3231 ; 0093-691X |
| ISSN (online) | 1879-3231 |
| ISSN | 0093-691X |
| DOI | 10.1016/j.theriogenology.2020.03.021 |
| Database | NAL-Catalogue (AGRICOLA) |
| Zs.A 3929: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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2022 Volume 62, Issue 1, Page(s) 71–82
Abstract: Introduction: Selenium is important for human health. However, the selenium status and selenium intake of the German population has not been recorded in a representative study so far.: Material and methods: Thus, literature from the last 50 years was ...
| Abstract | Introduction: Selenium is important for human health. However, the selenium status and selenium intake of the German population has not been recorded in a representative study so far. Material and methods: Thus, literature from the last 50 years was screened in a systematic way and the results of various studies were pulled together to shed light on the selenium status of the German population. Moreover, the selenium content of selected food items that were either found on the German market or grown in Germany was researched and evaluated. Results: Of 3542 articles identified, 37 studies met the inclusion criteria. These 37 studies comprised a total of 8,010 healthy adults living in Germany with a weighted arithmetic mean of 82 μg/l selenium in plasma or serum. The results will form a basis for interpreting upcoming results from national food consumption surveys. Furthermore, 363 selenium values for 199 food items were identified out of 20 data sources-published or analysed between 2002 and 2019. An estimation of the selenium intake of the German population will be possible with this data in future nutrition surveys. |
|---|---|
| MeSH term(s) | Adult ; Humans ; Selenium ; Food ; Nutritional Status ; Germany ; Nutrition Surveys |
| Chemical Substances | Selenium (H6241UJ22B) |
| Language | English |
| Publishing date | 2022-09-09 |
| Publishing country | Germany |
| Document type | Journal Article ; Review |
| ZDB-ID | 1466536-0 |
| ISSN | 1436-6215 ; 1436-6207 |
| ISSN (online) | 1436-6215 |
| ISSN | 1436-6207 |
| DOI | 10.1007/s00394-022-02990-0 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Ue I Zs.262: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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2023
Abstract: Aim: Purified diets (PD) increase standardization and repeatability in rodent studies, but lead to differences in the phenotype of animals compared to grain-based “chow” diets. PD contain less fiber and are often devoid of soluble fiber, which can impact ...
| Abstract | Aim: Purified diets (PD) increase standardization and repeatability in rodent studies, but lead to differences in the phenotype of animals compared to grain-based “chow” diets. PD contain less fiber and are often devoid of soluble fiber, which can impact gut health. Thus, the aim of the present study was to modify the PD AIN93G by addition of soluble fiber, to promote more natural gut development as seen with chow diets. Methods: One hundred twenty male C57BL/6J mice (from Charles River, Sulzfeld, Germany) were randomly assigned to one of five feeding groups, immediately after arrival (24 mice/group, 8 cages/group with 3 mice/cage). They were fed either a chow diet, AIN93G or one of three modified AIN93G with increased fiber content and different ratios of soluble fiber to cellulose for 12 weeks (70% soluble fiber: 30% cellulose [70S], 50% soluble fiber: 50% cellulose [50S] or 30% soluble fiber: 70% cellulose [30S]). As soluble fibers a mixture of inulin and pectin (50:50) was used. During the 12 weeks of intervention, body weight and food intake was assessed four times a week, and feces was collected during week 0, week 5 and week 10. After the intervention gut tissue was collected for histology (HE and AB stains) and gene expression analysis (qPCR). Furthermore, gut content was collected for analysis of microbiota (16s sequencing) and short-chain fatty acids (GC-FID). |
|---|---|
| Keywords | Other ; database ; Dataset ; ddc:570 |
| Subject code | 590 |
| Language | English |
| Publishing date | 2023-08-21 |
| Publishing country | de |
| Document type | Book ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
2023
| Keywords | article ; Text ; ddc:570 |
|---|---|
| Language | English |
| Publishing date | 2023-11-07 |
| Publisher | Springer Science and Business Media LLC |
| Publishing country | de |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
2020 Volume 149, Page(s) 1–5
Abstract: Because of the need to improve the knowledge about canine perinatology, and given the major role of fetal fluids in sustaining the course of pregnancy and fetal development, an in-depth analysis to better understand the role of some hormones in these ... ...
| Abstract | Because of the need to improve the knowledge about canine perinatology, and given the major role of fetal fluids in sustaining the course of pregnancy and fetal development, an in-depth analysis to better understand the role of some hormones in these compartments is essential. Among all, leptin is recognized to play a key role not only on the energetic homeostasis, but also at multiple levels, influencing the control of reproduction, food assumption and metabolism. Even if in humans and other species it is reported the presence of leptin receptors during fetal development, very little is known about the canine species, in which the role of leptin still needs to be fully understood. The present study aimed to assess the amniotic fluid leptin (AFL) concentrations at term pregnancy in healthy dogs, and to evaluate the possible influence played by breed body-size (after assessment of correlation with maternal bodyweight and placental weight), or other maternal (age, parity, and the so-called "litter effect") and neonatal (gender, birth weight, litter size) parameters on AFL concentrations, analyzed by ELISA test. The study was performed on 90 healthy, viable and normal weighted puppies, 39 small-sized (adult body weight < 10 kg) and 51 large-sized (adult body weight > 25 kg), born by 29 purebred, healthy bitches, submitted to elective Caesarean section because of breed-related or individual high risk for dystocia. The results showed that the mean AFL concentration in the small-sized puppies was significantly (p < 0.05) higher in comparison to large-sized puppies (867.48 vs 698.42 pg/ml), while all the other studied parameters did not show to influence AFL concentrations. In conclusions, the present study showed significant higher at term AFL concentrations in small-sized as compared to large-sized breeds, suggesting an influence of breed body-size on fetal metabolism, as previously reported for NEFA and IGF-I. |
|---|---|
| MeSH term(s) | Amniotic Fluid/chemistry ; Animals ; Animals, Newborn/physiology ; Birth Weight ; Body Size/physiology ; Cesarean Section/veterinary ; Dogs/physiology ; Female ; Fetal Development ; Leptin/analysis ; Litter Size/physiology ; Male ; Organ Size ; Parturition ; Placenta/anatomy & histology ; Pregnancy ; Species Specificity |
| Chemical Substances | Leptin |
| Language | English |
| Publishing date | 2020-03-18 |
| Publishing country | United States |
| Document type | Comparative Study ; Journal Article |
| ZDB-ID | 189232-0 |
| ISSN | 1879-3231 ; 0093-691X |
| ISSN (online) | 1879-3231 |
| ISSN | 0093-691X |
| DOI | 10.1016/j.theriogenology.2020.03.021 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 3929: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.