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  1. Article: Polymeric Systems for the Controlled Release of Flavonoids.

    Pecorini, Gianni / Ferraro, Elisabetta / Puppi, Dario

    Pharmaceutics

    2023  Volume 15, Issue 2

    Abstract: Flavonoids are natural compounds that are attracting great interest in the biomedical field thanks to the wide spectrum of their biological properties. Their employment as anticancer, anti-inflammatory, and antidiabetic drugs, as well as for many other ... ...

    Abstract Flavonoids are natural compounds that are attracting great interest in the biomedical field thanks to the wide spectrum of their biological properties. Their employment as anticancer, anti-inflammatory, and antidiabetic drugs, as well as for many other pharmacological applications, is extensively investigated. One of the most successful ways to increase their therapeutic efficacy is to encapsulate them into a polymeric matrix in order to control their concentration in the physiological fluids for a prolonged time. The aim of this article is to provide an updated overview of scientific literature on the polymeric systems developed so far for the controlled release of flavonoids. The different classes of flavonoids are described together with the polymers most commonly employed for drug delivery applications. Representative drug delivery systems are discussed, highlighting the most common techniques for their preparation. The flavonoids investigated for polymer system encapsulation are then presented with their main source of extraction and biological properties. Relevant literature on their employment in this context is reviewed in relationship to the targeted pharmacological and biomedical applications.
    Language English
    Publishing date 2023-02-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15020628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Advance in the Diagnostics and Management of Musculoskeletal Diseases.

    de Sire, Alessandro / Ferraro, Elisabetta / Leigheb, Massimiliano

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 7

    Abstract: Musculoskeletal disorders are a broad spectrum of diseases, affecting muscles, bones, ligaments, and tendons worldwide [ ... ]. ...

    Abstract Musculoskeletal disorders are a broad spectrum of diseases, affecting muscles, bones, ligaments, and tendons worldwide [...].
    Language English
    Publishing date 2022-06-29
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12071588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COVID-19 in multiple sclerosis patients treated with dimethyl fumarate.

    Capone, Fioravante / Ferraro, Elisabetta / Motolese, Francesco / Di Lazzaro, Vincenzo

    Journal of neurology

    2021  Volume 268, Issue 9, Page(s) 3132–3134

    MeSH term(s) COVID-19 ; Dimethyl Fumarate/therapeutic use ; Fingolimod Hydrochloride ; Humans ; Immunosuppressive Agents/adverse effects ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis, Relapsing-Remitting/drug therapy ; SARS-CoV-2
    Chemical Substances Immunosuppressive Agents ; Dimethyl Fumarate (FO2303MNI2) ; Fingolimod Hydrochloride (G926EC510T)
    Language English
    Publishing date 2021-02-20
    Publishing country Germany
    Document type Letter
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-021-10446-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.40: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: HIF-1, the Warburg Effect, and Macrophage/Microglia Polarization Potential Role in COVID-19 Pathogenesis.

    Ferraro, Elisabetta / Germanò, Maria / Mollace, Rocco / Mollace, Vincenzo / Malara, Natalia

    Oxidative medicine and cellular longevity

    2021  Volume 2021, Page(s) 8841911

    Abstract: Despite the international scientific community's commitment to improve clinical knowledge about coronavirus disease 2019 (COVID-19), knowledge regarding molecular details remains limited. In this review, we discuss hypoxia's potential role in the ... ...

    Abstract Despite the international scientific community's commitment to improve clinical knowledge about coronavirus disease 2019 (COVID-19), knowledge regarding molecular details remains limited. In this review, we discuss hypoxia's potential role in the pathogenesis of the maladaptive immune reaction against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The state of infection, with serious respiratory dysfunction, causes tissues to become hypoxic due to a discrepancy between cellular O
    MeSH term(s) COVID-19/immunology ; COVID-19/metabolism ; COVID-19/pathology ; COVID-19/virology ; Cell Polarity ; Humans ; Hypoxia-Inducible Factor 1/metabolism ; Macrophages/metabolism ; Microglia/metabolism ; SARS-CoV-2/physiology ; Warburg Effect, Oncologic
    Chemical Substances Hypoxia-Inducible Factor 1
    Language English
    Publishing date 2021-03-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2455981-7
    ISSN 1942-0994 ; 1942-0994
    ISSN (online) 1942-0994
    ISSN 1942-0994
    DOI 10.1155/2021/8841911
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Assessment of lipolysis biomarkers in adipose tissue of patients with gastrointestinal cancer.

    Tambaro, Federica / Imbimbo, Giovanni / Ferraro, Elisabetta / Andreini, Martina / Belli, Roberta / Amabile, Maria Ida / Ramaccini, Cesarina / Lauteri, Giulia / Nigri, Giuseppe / Muscaritoli, Maurizio / Molfino, Alessio

    Cancer & metabolism

    2024  Volume 12, Issue 1, Page(s) 1

    Abstract: Background: Adipose tissue metabolism may be impaired in patients with cancer. In particular, increased lipolysis was described in cancer-promoting adipose tissue atrophy. For this reason, we assessed the expression of the lipolysis-associated genes and ...

    Abstract Background: Adipose tissue metabolism may be impaired in patients with cancer. In particular, increased lipolysis was described in cancer-promoting adipose tissue atrophy. For this reason, we assessed the expression of the lipolysis-associated genes and proteins in subcutaneous adipose tissue (SAT) of gastrointestinal (GI) cancer patients compared to controls to verify their involvement in cancer, among different types of GI cancers, and in cachexia.
    Methods: We considered patients with GI cancer (gastric, pancreatic, and colorectal) at their first diagnosis, with/without cachexia, and controls with benign diseases. We collected SAT and total RNA was extracted and ATGL, HSL, PPARα, and MCP1 were analyzed by qRT-PCR. Western blot was performed to evaluate CGI-58, PLIN1 and PLIN5.
    Results: We found higher expression of ATGL and HSL in GI cancer patients with respect to controls (p ≤ 0.008) and a trend of increase for PPARα (p = 0.055). We found an upregulation of ATGL in GI cancer patients with cachexia (p = 0.033) and without cachexia (p = 0.017) vs controls. HSL was higher in patients with cachexia (p = 0.020) and without cachexia (p = 0.021), compared to controls. ATGL was upregulated in gastric cancer vs controls (p = 0.014) and higher HSL was found in gastric (p = 0.008) and in pancreatic cancer (p = 0.033) vs controls. At the protein level, we found higher CGI-58 in cancer vs controls (p = 0.019) and in cachectic vs controls (p = 0.029), as well as in gastric cancer vs controls (p = 0.027).
    Conclusion: In our cohort of GI cancer patients, we found a modulation in the expression of genes and proteins involved in lipolysis, and differences were interestingly detected according to cancer type.
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2700141-6
    ISSN 2049-3002
    ISSN 2049-3002
    DOI 10.1186/s40170-023-00329-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Liquid Biopsy for Cancer Cachexia: Focus on Muscle-Derived microRNAs.

    Belli, Roberta / Ferraro, Elisabetta / Molfino, Alessio / Carletti, Raffaella / Tambaro, Federica / Costelli, Paola / Muscaritoli, Maurizio

    International journal of molecular sciences

    2021  Volume 22, Issue 16

    Abstract: Cancer cachexia displays a complex nature in which systemic inflammation, impaired energy metabolism, loss of muscle and adipose tissues result in unintentional body weight loss. Cachectic patients have a poor prognosis and the presence of cachexia ... ...

    Abstract Cancer cachexia displays a complex nature in which systemic inflammation, impaired energy metabolism, loss of muscle and adipose tissues result in unintentional body weight loss. Cachectic patients have a poor prognosis and the presence of cachexia reduces the tolerability of chemo/radio-therapy treatments and it is frequently the primary cause of death in advanced cancer patients. Early detection of this condition could make treatments more effective. However, early diagnostic biomarkers of cachexia are currently lacking. In recent years, although solid biopsy still remains the "gold standard" for diagnosis of cancer, liquid biopsy is gaining increasing interest as a source of easily accessible potential biomarkers. Moreover, the growing interest in circulating microRNAs (miRNAs), has made these molecules attractive for the diagnosis of several diseases, including cancer. Some muscle-derived circulating miRNA might play a pivotal role in the onset/progression of cancer cachexia. This topic is of great interest since circulating miRNAs might be easily detectable by means of liquid biopsies and might allow an early diagnosis of this syndrome. We here summarize the current knowledge on circulating muscular miRNAs involved in muscle atrophy, since they might represent easily accessible and promising biomarkers of cachexia.
    MeSH term(s) Adipose Tissue/metabolism ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; Cachexia/diagnosis ; Cachexia/genetics ; Circulating MicroRNA/analysis ; Circulating MicroRNA/blood ; Circulating MicroRNA/genetics ; Energy Metabolism/physiology ; Humans ; Inflammation/pathology ; Liquid Biopsy/methods ; MicroRNAs/analysis ; MicroRNAs/blood ; MicroRNAs/genetics ; Muscle, Skeletal/metabolism ; Muscular Atrophy/pathology ; Neoplasms/complications ; Neoplasms/genetics ; Signal Transduction/genetics ; Weight Loss/genetics
    Chemical Substances Biomarkers, Tumor ; Circulating MicroRNA ; MicroRNAs
    Language English
    Publishing date 2021-08-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22169007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Microglia Morphological Changes in the Motor Cortex of hSOD1

    Migliarini, Sara / Scaricamazza, Silvia / Valle, Cristiana / Ferri, Alberto / Pasqualetti, Massimo / Ferraro, Elisabetta

    Brain sciences

    2021  Volume 11, Issue 6

    Abstract: Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of spinal motor neurons as well as corticospinal (CSN) large pyramidal neurons within cortex layer V. An intense microglia immune response has been associated with both ... ...

    Abstract Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of spinal motor neurons as well as corticospinal (CSN) large pyramidal neurons within cortex layer V. An intense microglia immune response has been associated with both upper and lower motor neuron degeneration in ALS patients, whereas microgliosis occurrence in the motor cortex of hSOD1
    Language English
    Publishing date 2021-06-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci11060807
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  8. Article: Disease-Modifying Drugs and Breastfeeding in Multiple Sclerosis: A Narrative Literature Review.

    Capone, Fioravante / Albanese, Angela / Quadri, Giorgia / Di Lazzaro, Vincenzo / Falato, Emma / Cortese, Antonio / De Giglio, Laura / Ferraro, Elisabetta

    Frontiers in neurology

    2022  Volume 13, Page(s) 851413

    Abstract: Pregnancy-related issues in women with multiple sclerosis (MS) have been receiving increasing attention, with particular interest for the use of disease-modifying therapies (DMTs) before conception, during pregnancy, and postpartum, including ... ...

    Abstract Pregnancy-related issues in women with multiple sclerosis (MS) have been receiving increasing attention, with particular interest for the use of disease-modifying therapies (DMTs) before conception, during pregnancy, and postpartum, including breastfeeding. The risk of relapse is higher in the early postpartum period, especially in cases of significant disease activity prior to pregnancy, and thus treatment resumption and/or switching strategies might be necessary. Moreover, breastfeeding provides unmatched health benefits for babies and mothers, and is recommended as the best source of nutrition for infants. Furthermore, a protective role of breastfeeding on MS disease course has not been fully demonstrated and it remains debatable. At the same time, a source of concern is the potential transfer of DMTs into breastmilk and the resulting infant exposure. The use of most DMTs is unlicensed during breastfeeding mainly due to the limited data available on the excretion in human milk and on the effects on infants' exposure. Consequently, women have to face the difficult challenge of choosing between breastfeeding and DMT resumption. The present narrative review summarizes and discusses the available evidence on the safety of DMTs during breastfeeding and the relative approved labels. At the time of diagnosis of MS, specific counseling should be offered to women of childbearing age, making them aware of the possible therapeutic options and their impact on pregnancy and breastfeeding. Women can be encouraged to breastfeed, if clinically feasible, following a review of their medications and clinical status, with a personalized approach.
    Language English
    Publishing date 2022-04-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.851413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Bridging Therapies With Injectable Immunomodulatory Drugs in the Management of Multiple Sclerosis: A Delphi Survey of an Italian Expert Panel of Neurologists.

    Marfia, Girolama Alessandra / Centonze, Diego / Salvetti, Marco / Ferraro, Elisabetta / Panetta, Valentina / Gasperini, Claudio / Mirabella, Massimiliano / Conte, Antonella

    Frontiers in neurology

    2022  Volume 13, Page(s) 898741

    Abstract: Background: In multiple sclerosis (MS), bridging therapies are usually administered when switching from one therapy to another. Such treatments generally consist of injectable immunomodulatory drugs (interferon or glatiramer acetate), whose efficacy, ... ...

    Abstract Background: In multiple sclerosis (MS), bridging therapies are usually administered when switching from one therapy to another. Such treatments generally consist of injectable immunomodulatory drugs (interferon or glatiramer acetate), whose efficacy, safety, and tolerability data are consolidated for use even in fragile patients. We performed a nationwide survey to gather expert opinions regarding the most appropriate use of bridging therapies in MS.
    Methods: An independent steering committee of Italian neurologists with expertise in MS treatment identified critical issues in the use of bridging therapies and formulated a questionnaire. This questionnaire was used to conduct a Delphi web survey, involving a panel of Italian neurologists with experience in MS treatment. Their anonymous opinions were collected in three sequential rounds. Consensus was defined as an interquartile range (IQR) ≤2.
    Results: Responses were obtained from 38 experts (100%) in all three rounds. Injectable immunomodulatory drugs were considered first-line therapy in patients with mild-to-moderate disease activity and in women planning to become pregnant. In addition, the experts were confident about prescribing these drugs in patients at risk of cancer recurrence, while the panel agreed to discontinue any treatments in patients with uncontrolled cardiovascular or metabolic disorders. Moreover, bridging therapy with injectable immunomodulatory drugs was considered appropriate in order to protect the patient from disease reactivation when a prolonged washout was needed and also while waiting for the completion of the immunization schedule.
    Conclusion: The results of this nationwide survey confirm that, among Italian neurologists, there was wide agreement on the use of bridging therapies with injectable immunomodulatory drugs in several conditions in order to minimize the risk of disease reactivation when a prolonged washout was required or when the immunization schedule still needed to be completed in patients planning to become pregnant and in patients at risk of cancer recurrence.
    Language English
    Publishing date 2022-07-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.898741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Ranolazine Counteracts Strength Impairment and Oxidative Stress in Aged Sarcopenic Mice.

    Torcinaro, Alessio / Cappetta, Donato / De Santa, Francesca / Telesca, Marialucia / Leigheb, Massimiliano / Berrino, Liberato / Urbanek, Konrad / De Angelis, Antonella / Ferraro, Elisabetta

    Metabolites

    2022  Volume 12, Issue 7

    Abstract: Sarcopenia is defined as the loss of muscle mass associated with reduced strength leading to poor quality of life in elderly people. The decline of skeletal muscle performance is characterized by bioenergetic impairment and severe oxidative stress, and ... ...

    Abstract Sarcopenia is defined as the loss of muscle mass associated with reduced strength leading to poor quality of life in elderly people. The decline of skeletal muscle performance is characterized by bioenergetic impairment and severe oxidative stress, and does not always strictly correlate with muscle mass loss. We chose to investigate the ability of the metabolic modulator Ranolazine to counteract skeletal muscle dysfunctions that occur with aging. For this purpose, we treated aged C57BL/6 mice with Ranolazine/vehicle for 14 days and collected the
    Language English
    Publishing date 2022-07-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo12070663
    Database MEDical Literature Analysis and Retrieval System OnLINE

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