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  1. Article ; Online: Genetic Determinants of Surface Accessibility in

    Ferraro, Noel J / Pires, Marcos M

    Bioconjugate chemistry

    2022  Volume 33, Issue 5, Page(s) 767–772

    Abstract: Bacterial cell walls represent one of the most prominent targets of antibacterial agents. These agents include natural products (e.g., vancomycin) and proteins stemming from the innate immune system (e.g., peptidoglycan-recognition proteins and ... ...

    Abstract Bacterial cell walls represent one of the most prominent targets of antibacterial agents. These agents include natural products (e.g., vancomycin) and proteins stemming from the innate immune system (e.g., peptidoglycan-recognition proteins and lysostaphin). Among bacterial pathogens that infect humans,
    MeSH term(s) Anti-Bacterial Agents/metabolism ; Anti-Bacterial Agents/pharmacology ; Cell Wall/chemistry ; Humans ; Lysostaphin/chemistry ; Lysostaphin/metabolism ; Lysostaphin/pharmacology ; Peptidoglycan/chemistry ; Staphylococcus aureus ; Vancomycin/metabolism
    Chemical Substances Anti-Bacterial Agents ; Peptidoglycan ; Vancomycin (6Q205EH1VU) ; Lysostaphin (EC 3.4.24.75)
    Language English
    Publishing date 2022-05-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1024041-x
    ISSN 1520-4812 ; 1043-1802
    ISSN (online) 1520-4812
    ISSN 1043-1802
    DOI 10.1021/acs.bioconjchem.2c00173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3400: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Neisseria gonorrhoeae

    Cardenas, Amaris J / Thomas, Keena S / Broden, Mary W / Ferraro, Noel J / Pires, Marcos M / John, Constance M / Jarvis, Gary A / Criss, Alison K

    mBio

    2024  Volume 15, Issue 5, Page(s) e0011924

    Abstract: Gonorrhea, caused by the bacterium : Importance: Neisseria ... ...

    Abstract Gonorrhea, caused by the bacterium
    Importance: Neisseria gonorrhoeae
    MeSH term(s) Neisseria gonorrhoeae/immunology ; Neisseria gonorrhoeae/genetics ; Neisseria gonorrhoeae/metabolism ; Humans ; N-Acetylneuraminic Acid/metabolism ; Neutrophils/immunology ; Neutrophils/metabolism ; Neutrophils/microbiology ; Neutrophil Activation ; Sialic Acid Binding Immunoglobulin-like Lectins/metabolism ; Sialic Acid Binding Immunoglobulin-like Lectins/genetics ; Gonorrhea/immunology ; Gonorrhea/microbiology ; Complement System Proteins/immunology ; Complement System Proteins/metabolism ; Lipopolysaccharides/metabolism ; Bacterial Outer Membrane Proteins/metabolism ; Bacterial Outer Membrane Proteins/immunology ; Bacterial Outer Membrane Proteins/genetics ; Respiratory Burst ; Host-Pathogen Interactions/immunology ; Immune Evasion
    Chemical Substances N-Acetylneuraminic Acid (GZP2782OP0) ; Sialic Acid Binding Immunoglobulin-like Lectins ; Complement System Proteins (9007-36-7) ; lipid-linked oligosaccharides ; Lipopolysaccharides ; Bacterial Outer Membrane Proteins ; Opa protein, Neisseria (156319-92-5)
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.00119-24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Neisseria gonorrhoeae

    Cardenas, Amaris J / Thomas, Keena S / Broden, Mary W / Ferraro, Noel J / John, Constance M / Pires, Marcos M / Jarvis, Gary A / Criss, Alison K

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Gonorrhea, caused by the ... ...

    Abstract Gonorrhea, caused by the bacterium
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.17.576097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: SaccuFlow: A High-Throughput Analysis Platform to Investigate Bacterial Cell Wall Interactions.

    Apostolos, Alexis J / Ferraro, Noel J / Dalesandro, Brianna E / Pires, Marcos M

    ACS infectious diseases

    2021  Volume 7, Issue 8, Page(s) 2483–2491

    Abstract: Bacterial cell walls are formidable barriers that protect bacterial cells against external insults and oppose internal turgor pressure. While cell wall composition is variable across species, peptidoglycan is the principal component of all cell walls. ... ...

    Abstract Bacterial cell walls are formidable barriers that protect bacterial cells against external insults and oppose internal turgor pressure. While cell wall composition is variable across species, peptidoglycan is the principal component of all cell walls. Peptidoglycan is a mesh-like scaffold composed of cross-linked strands that can be heavily decorated with anchored proteins. The biosynthesis and remodeling of peptidoglycan must be tightly regulated by cells because disruption to this biomacromolecule is lethal. This essentiality is exploited by the human innate immune system in resisting colonization and by a number of clinically relevant antibiotics that target peptidoglycan biosynthesis. Evaluation of molecules or proteins that interact with peptidoglycan can be a complicated and, typically, qualitative effort. We have developed a novel assay platform (SaccuFlow) that preserves the native structure of bacterial peptidoglycan and is compatible with high-throughput flow cytometry analysis. We show that the assay is facile and versatile as demonstrated by its compatibility with sacculi from Gram-positive bacteria, Gram-negative bacteria, and mycobacteria. Finally, we highlight the utility of this assay to assess the activity of sortase A from
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Cell Wall ; Humans ; Peptidoglycan ; Staphylococcal Infections ; Staphylococcus aureus
    Chemical Substances Anti-Bacterial Agents ; Peptidoglycan
    Language English
    Publishing date 2021-07-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.1c00255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Systematic Assessment of Accessibility to the Surface of

    Ferraro, Noel J / Kim, Seonghoon / Im, Wonpil / Pires, Marcos M

    ACS chemical biology

    2021  Volume 16, Issue 11, Page(s) 2527–2536

    Abstract: Proteins from bacterial foes, antimicrobial peptides, and host immune proteins must navigate past a dense layer of bacterial surface biomacromolecules to reach the peptidoglycan (PG) layer of Gram-positive bacteria. A subclass of molecules (e.g., ... ...

    Abstract Proteins from bacterial foes, antimicrobial peptides, and host immune proteins must navigate past a dense layer of bacterial surface biomacromolecules to reach the peptidoglycan (PG) layer of Gram-positive bacteria. A subclass of molecules (e.g., antibiotics with intracellular targets) also must permeate through the PG (in a molecular sieving manner) to reach the cytoplasmic membrane. Despite the biological and therapeutic importance of surface accessibility, systematic analyses in live bacterial cells have been lacking. We describe a live cell fluorescence assay that is robust, shows a high level of reproducibility, and reports on the permeability of molecules to and within the PG scaffold. Moreover, our study shows that teichoic acids impede the permeability of molecules of a wide range of sizes and chemical composition.
    MeSH term(s) Antimicrobial Peptides/metabolism ; Fluorescence ; Reproducibility of Results ; Staphylococcus aureus/metabolism ; Surface Properties
    Chemical Substances Antimicrobial Peptides
    Language English
    Publishing date 2021-10-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1554-8937
    ISSN (online) 1554-8937
    DOI 10.1021/acschembio.1c00604
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Selective Display of a Chemoattractant Agonist on Cancer Cells Activates the Formyl Peptide Receptor 1 on Immune Cells.

    Sikorski, Eden L / Wehr, Janessa / Ferraro, Noel J / Rizzo, Sophia M / Pires, Marcos M / Thévenin, Damien

    Chembiochem : a European journal of chemical biology

    2022  Volume 23, Issue 8, Page(s) e202100521

    Abstract: Current immunotherapeutics often work by directing components of the immune system to recognize biomarkers on the surface of cancer cells to generate an immune response. However, variable changes in biomarker distribution and expression can result in ... ...

    Abstract Current immunotherapeutics often work by directing components of the immune system to recognize biomarkers on the surface of cancer cells to generate an immune response. However, variable changes in biomarker distribution and expression can result in inconsistent patient response. The development of a more universal tumor-homing strategy has the potential to improve selectivity and extend therapy to cancers with decreased expression or absence of specific biomarkers. Here, we designed a bifunctional agent that exploits the inherent acidic microenvironment of most solid tumors to selectively graft the surface of cancer cells with a formyl peptide receptor ligand (FPRL). Our approach is based on the pH(Low) insertion peptide (pHLIP), a unique peptide that selectively targets tumors in vivo by anchoring to cancer cells in a pH-dependent manner. We establish that selectively remodeling cancer cells with a pHLIP-based FPRL activates formyl peptide receptors on recruited immune cells, potentially initiating an immune response towards tumors.
    MeSH term(s) Cell Line, Tumor ; Chemotactic Factors ; Humans ; Ligands ; Neoplasms/drug therapy ; Peptides/metabolism ; Peptides/pharmacology ; Receptors, Formyl Peptide/metabolism
    Chemical Substances Chemotactic Factors ; Ligands ; Peptides ; Receptors, Formyl Peptide
    Language English
    Publishing date 2022-03-09
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020469-3
    ISSN 1439-7633 ; 1439-4227
    ISSN (online) 1439-7633
    ISSN 1439-4227
    DOI 10.1002/cbic.202100521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: pH-Dependent Grafting of Cancer Cells with Antigenic Epitopes Promotes Selective Antibody-Mediated Cytotoxicity.

    Wehr, Janessa / Sikorski, Eden L / Bloch, Elizabeth / Feigman, Mary S / Ferraro, Noel J / Baybutt, Trevor R / Snook, Adam E / Pires, Marcos M / Thévenin, Damien

    Journal of medicinal chemistry

    2020  Volume 63, Issue 7, Page(s) 3713–3722

    Abstract: A growing class of immunotherapeutics work by redirecting components of the immune system to recognize markers on the surface of cancer cells. However, such modalities will remain confined to a relatively small subgroup of patients because of the lack of ...

    Abstract A growing class of immunotherapeutics work by redirecting components of the immune system to recognize markers on the surface of cancer cells. However, such modalities will remain confined to a relatively small subgroup of patients because of the lack of universal targetable tumor biomarkers among all patients. Here, we designed a unique class of agents that exploit the inherent acidity of solid tumors to selectively graft cancer cells with immuno-engager epitopes. Our targeting approach is based on pHLIP, a unique peptide that selectively targets tumors
    MeSH term(s) 2,4-Dinitrophenol/chemistry ; 2,4-Dinitrophenol/immunology ; 2,4-Dinitrophenol/pharmacology ; Amino Acid Sequence ; Animals ; Antibodies, Monoclonal/immunology ; Cell Line, Tumor ; Epitopes/chemistry ; Epitopes/immunology ; Epitopes/pharmacology ; Fluorescein-5-isothiocyanate/chemistry ; Fluorescein-5-isothiocyanate/metabolism ; Fluorescein-5-isothiocyanate/pharmacology ; Humans ; Hydrogen-Ion Concentration ; Immunologic Factors/chemistry ; Immunologic Factors/metabolism ; Immunologic Factors/pharmacology ; Immunotherapy/methods ; Killer Cells, Natural/drug effects ; Membrane Proteins/chemistry ; Membrane Proteins/metabolism ; Membrane Proteins/pharmacology ; Mice ; Neoplasms/metabolism ; Neoplasms/therapy
    Chemical Substances Antibodies, Monoclonal ; Epitopes ; Immunologic Factors ; Membrane Proteins ; pHLIP protein ; Fluorescein-5-isothiocyanate (I223NX31W9) ; 2,4-Dinitrophenol (Q13SKS21MN)
    Language English
    Publishing date 2020-03-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.0c00016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 151: Show issues Location:
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    Zs.MB 1: Show issues

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