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  1. Article ; Online: Metabolic Syndrome: A Predisposing Factor for Rheumatoid Arthritis.

    González-Gay, Miguel Á / Castañeda, Santos / Ferraz-Amaro, Iván

    The Journal of rheumatology

    2024  Volume 51, Issue 4, Page(s) 329–331

    MeSH term(s) Humans ; Metabolic Syndrome/complications ; Metabolic Syndrome/epidemiology ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/metabolism ; Causality
    Language English
    Publishing date 2024-04-01
    Publishing country Canada
    Document type Editorial
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.2023-1210
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  2. Article: Reply to comment on: Alpha-Klotho protein in systemic lupus erythematosus.

    Ferraz-Amaro, Ivan / Gonzalez-Gay, Miguel Angel

    Clinical and experimental rheumatology

    2023  Volume 41, Issue 7, Page(s) 1566

    MeSH term(s) Humans ; Klotho Proteins ; Lupus Erythematosus, Systemic/diagnosis
    Chemical Substances Klotho Proteins (EC 3.2.1.31)
    Language English
    Publishing date 2023-03-02
    Publishing country Italy
    Document type Letter ; Comment
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/okuim1
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  3. Article: SCORE2

    Quevedo-Abeledo, Juan Carlos / González-Gay, Miguel Á / Ferraz-Amaro, Iván

    Therapeutic advances in musculoskeletal disease

    2022  Volume 14, Page(s) 1759720X221092373

    Abstract: Introduction: Systemic lupus erythematosus (SLE) has been associated with an increased risk of cardiovascular (CV) disease. Recently, the Systematic Coronary Risk Assessment (SCORE), a well-known CV risk algorithm, has been updated to a new predictive ... ...

    Abstract Introduction: Systemic lupus erythematosus (SLE) has been associated with an increased risk of cardiovascular (CV) disease. Recently, the Systematic Coronary Risk Assessment (SCORE), a well-known CV risk algorithm, has been updated to a new predictive model (SCORE2). This new algorithm improves the identification of individuals at high risk of developing CV disease across Europe. Since carotid atherosclerosis is a predictor of future CV events and CV death, our objective was to compare the predictive capacity of SCORE2
    Methods: Two hundred and thirty-five individuals over 40 years of age diagnosed with SLE were consecutively recruited in this cross-sectional study. SCORE and SCORE2 were calculated. The relationship of SCORE and SCORE2 with each other, and with the presence of subclinical carotid atherosclerosis (both carotid plaque and carotid intima media thickness -cIMT-), was studied.
    Results: SCORE2 and SCORE did not correlate with each other (Spearman's Rho = 0.125,
    Conclusion: In SLE patients, the ability of SCORE2 to predict the presence of subclinical atherosclerosis is higher than that of SCORE. According to our results, SCORE2, rather than SCORE, should be used in the CV risk stratification of patients with SLE. Prospective studies are needed to confirm these findings.
    Language English
    Publishing date 2022-04-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2516075-8
    ISSN 1759-7218 ; 1759-720X
    ISSN (online) 1759-7218
    ISSN 1759-720X
    DOI 10.1177/1759720X221092373
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  4. Article ; Online: Comment on: Proprotein convertase subtilisin/kexin type 9 in the dyslipidaemia of patients with axial spondyloarthritis is related to disease activity: reply.

    González-Gay, Miguel Á / Ferraz-Amaro, Iván

    Rheumatology (Oxford, England)

    2021  Volume 60, Issue 7, Page(s) e268–e269

    MeSH term(s) Dyslipidemias ; Humans ; Spondylarthritis ; Subtilisins
    Chemical Substances Subtilisins (EC 3.4.21.-)
    Language English
    Publishing date 2021-02-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keab183
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    Zs.MO 497: Show issues

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  5. Article ; Online: Cardiovascular disease in the QUEST-RA study, 10 years later.

    Naranjo, Antonio / Ferraz-Amaro, Iván

    Arthritis research & therapy

    2019  Volume 21, Issue 1, Page(s) 242

    MeSH term(s) Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/epidemiology ; Arthritis, Rheumatoid/prevention & control ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Comorbidity ; Humans ; Methotrexate/therapeutic use ; Outcome Assessment, Health Care/methods ; Outcome Assessment, Health Care/statistics & numerical data ; Prevalence ; Risk Assessment/methods ; Risk Assessment/statistics & numerical data ; Risk Factors ; Surveys and Questionnaires ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Antirheumatic Agents ; Tumor Necrosis Factor-alpha ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2019-11-14
    Publishing country England
    Document type Editorial ; Multicenter Study
    ZDB-ID 2107602-9
    ISSN 1478-6362 ; 1478-6354
    ISSN (online) 1478-6362
    ISSN 1478-6354
    DOI 10.1186/s13075-019-2025-5
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  6. Article: Articular

    Ferraz-Amaro, Iván / Sheikh, Arif / Polack, Berna / Giles, Jon T / Bathon, Joan M

    The Journal of rheumatology

    2022  Volume 49, Issue 12, Page(s) 1315–1319

    Abstract: Objective: Examination and conventional radiography of joints are unable to precisely evaluate and measure disease activity in rheumatoid arthritis (RA). We quantified joint inflammation using : Methods: We cross-sectionally studied 34 patients with ... ...

    Abstract Objective: Examination and conventional radiography of joints are unable to precisely evaluate and measure disease activity in rheumatoid arthritis (RA). We quantified joint inflammation using
    Methods: We cross-sectionally studied 34 patients with RA in a substudy of the Rheumatoid Arthritis Study of the Myocardium (RHYTHM). All patients underwent
    Results: Calculated wj25SUV (Spearman ρ = 0.39,
    Conclusion: Articular FDG uptake in patients with RA was significantly correlated with the number of swollen joints but not with biochemical measures of inflammation.
    MeSH term(s) Humans ; Fluorodeoxyglucose F18 ; Arthritis, Rheumatoid/diagnostic imaging ; Arthritis, Rheumatoid/complications ; Joints/diagnostic imaging ; Positron Emission Tomography Computed Tomography/methods ; Positron-Emission Tomography/methods ; Inflammation/complications
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2022-08-15
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.220231
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  7. Article: Interleukin-6 serum levels are associated with disease features and cardiovascular risk in patients with systemic sclerosis.

    Ibrahim-Achi, Zeina / de Vera-González, Antonia / González-Delgado, Alejandra / López-Mejías, Raquel / González-Gay, Miguel Ángel / Ferraz-Amaro, Iván

    Clinical and experimental rheumatology

    2023  

    Abstract: Objectives: Systemic sclerosis (SSc) is a chronic multisystem disease characterised by microcirculatory vascular dysfunction and progressive fibrosis of the skin and internal organs. Interleukin-6 (IL-6) is a proinflammatory cytokine that has been ... ...

    Abstract Objectives: Systemic sclerosis (SSc) is a chronic multisystem disease characterised by microcirculatory vascular dysfunction and progressive fibrosis of the skin and internal organs. Interleukin-6 (IL-6) is a proinflammatory cytokine that has been implicated in the pathogenesis of several autoimmune diseases and in the initiation and progression of the cardiovascular disease. In the present work we aimed to study the relationship of IL-6 with clinical manifestations and the cardiovascular risk in patients with SSc.
    Methods: Cross-sectional study that included 53 individuals with SSc. A multivariate analysis was performed to study the relationship between IL-6 and disease characteristics and cardiovascular risk assessed by Systematic Coronary Risk Estimation (SCORE2) in SSc.
    Results: The presence of digital ulcers, calcinosis, and anti-Scl70 antibody was associated with higher levels of IL-6. This was also the case for functional respiratory parameters where this association was found to be significant and negative after correction for covariates. In addition, the SCORE2 cardiovascular risk algorithm showed a positive and significant association with circulating IL-6.
    Conclusions: IL-6 levels are associated with disease manifestations and cardiovascular risk in patients with SSc.
    Language English
    Publishing date 2023-12-04
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/3e8ufg
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  8. Article: Malondialdehyde Serum Levels in a Full Characterized Series of 430 Rheumatoid Arthritis Patients.

    Merino de Paz, Nayra / Quevedo-Abeledo, Juan Carlos / Gómez-Bernal, Fuensanta / de Vera-González, Antonia / Abreu-González, Pedro / Martín-González, Candelaria / González-Gay, Miguel Ángel / Ferraz-Amaro, Iván

    Journal of clinical medicine

    2024  Volume 13, Issue 3

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-02-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13030901
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  9. Article: Mean Platelet Volume Is Related to Cumulative Disease Damage in Patients with Systemic Lupus Erythematosus.

    Fernández-Cladera, Yolanda / Hernández-Díaz, Marta / García-González, María / Quevedo-Abeledo, Juan C / Quevedo-Rodríguez, Adrián / Gómez-Bernal, Fuensanta / Gómez-Moreno, Cristina / Martín-González, Candelaria / González-Gay, Miguel Á / Ferraz-Amaro, Iván

    Life (Basel, Switzerland)

    2024  Volume 14, Issue 4

    Abstract: Mean platelet volume (MPV), which represents the average platelet size in femtoliters, has emerged as a reliable biomarker in several systemic and chronic disorders. However, its relationship with disease characteristics in large series of patients with ... ...

    Abstract Mean platelet volume (MPV), which represents the average platelet size in femtoliters, has emerged as a reliable biomarker in several systemic and chronic disorders. However, its relationship with disease characteristics in large series of patients with systemic lupus erythematosus (SLE) has not been exhaustively studied to date. In the present work, we aimed to analyze how disease characteristics, including disease activity and cumulative damage, relate to MPV in a well-characterized series of SLE patients. In total, 179 patients with SLE and 181 age- and sex-matched healthy controls were recruited. Complete blood counts including MPV were assessed. Linear multivariable analysis was performed to evaluate the relationship between MPV and SLE disease characteristics, including composite scores of disease activity and damage. MPV was significantly lower in patients with SLE compared to controls after multivariable analysis (beta coefficient, -0.7 [95% confidence interval, -1.1 to -0.3)] fL,
    Language English
    Publishing date 2024-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14040428
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  10. Article: Reply to: Comment on: Reclassification into very-high cardiovascular risk in psoriatic arthritis as well as axial spondyloarthritis.

    Ferraz-Amaro, Iván / Rueda-Gotor, Javier / González-Gay, Miguel A

    Clinical and experimental rheumatology

    2020  Volume 38, Issue 6, Page(s) 1268

    MeSH term(s) Arthritis, Psoriatic/diagnosis ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Heart Disease Risk Factors ; Humans ; Risk Factors ; Spondylarthritis/complications ; Spondylarthritis/diagnosis
    Language English
    Publishing date 2020-06-23
    Publishing country Italy
    Document type Letter ; Comment
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
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