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Article: Special Issue "Drug Treatments for Inflammatory Bowel Diseases".

Luiz-Ferreira, Anderson / Stolfi, Carmine

2023 Volume 17, Issue 1

Abstract: Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic idiopathic, relapsing and remitting inflammatory diseases that affect the gastrointestinal tract, causing significant morbidity and loss of quality ...

Abstract	Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic idiopathic, relapsing and remitting inflammatory diseases that affect the gastrointestinal tract, causing significant morbidity and loss of quality of life in affected individuals [...].
Language	English
Publishing date	2023-12-29
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph17010059
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Evaluation of the Physical-chemical Characteristics and Biopharmaceutical Performance of Dilu-Cap: A Complete Line of Excipients for Hard-shell Capsules.

Ferreira, Anderson de Oliveira / Polonini, Hudson

International journal of pharmaceutical compounding

2022 Volume 26, Issue 4, Page(s) 283–291

Abstract: The development of an efficient formulation for hardshell capsules needs to consider pharmaceutical and biopharmaceutical aspects to assist in the careful selection of excipients, which are essential ingredients for the formulation's good performance. ... ...

Abstract	The development of an efficient formulation for hardshell capsules needs to consider pharmaceutical and biopharmaceutical aspects to assist in the careful selection of excipients, which are essential ingredients for the formulation's good performance. They ensure correct bioavailability, solubility, stability, dose accuracy (weight variation and content uniformity), and organoleptic characteristics. Given this, DiluCap was developed as a line of excipients so that the pharmacist can compound every capsule formulation with ease and trust in its final characteristics. The line is composed of six excipients: 1) Dilucap SLD, for soluble active pharmaceutical ingredients Class I and III from the Biopharmaceutical Classification System - it promotes disintegration without a negative impact on dissolution; 2) Dilucap PSD, for poorly soluble active pharmaceutical ingredients Class II and IV - it favors the disintegration and dissolution of the active pharmaceutical ingredients; 3) Dilucap SR, for active pharmaceutical ingredients requiring modified/ slow release - it reduces the disintegration and release rate of the active pharmaceutical ingredients, promoting its slow release, and, also, prevents plasma peaks responsible for adverse effects; 4) DiluCap Hygro, for hygroscopic or deliquescent active pharmaceutical ingredients - it reduces hygroscopicity, deliquescence, and eutectic mixture formation; 5) DiluCap Antioxi, for active pharmaceutical ingredients susceptible to oxidation - it provides chemical stabilization due to antioxidant ingredients and reduces water activity and chemical degradation; 6) DiluCap OD, for orodispersible active pharmaceutical ingredients that can be compounded as sprinkle capsules or sublingual capsules - it favors transmucosal permeation. The testing conducted for the DiluCap line of excipients showed that all products have suitable flow properties (angle of repose and Carr's compressibility index), hygroscopicity, biopharmaceutical performance (dissolution profiles), and stability. This corroborates the allegations that DiluCap provides a science based line of excipients to the compounding pharmacies with proven functionality that saves time (reduces the preprocessing and the number of items in stock) and guarantees efficacy and safety of hard-shell oral capsules formulations.
MeSH term(s)	Biological Products ; Capsules/chemistry ; Excipients/chemistry ; Solubility
Chemical Substances	Biological Products ; Capsules ; Excipients
Language	English
Publishing date	2022-07-12
Publishing country	United States
Document type	Journal Article
ISSN	1092-4221
ISSN	1092-4221
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Article ; Online: Critical exponents of master-node network model.

Mihara, Antonio / Ferreira, Anderson A / Martins, André C R / Ferreira, Fernando F

Physical review. E

2023 Volume 108, Issue 5-1, Page(s) 54303

Abstract: The dynamics of competing opinions in social network plays an important role in society, with many applications in diverse social contexts such as consensus, election, morality, and so on. Here, we study a model of interacting agents connected in ... ...

Abstract	The dynamics of competing opinions in social network plays an important role in society, with many applications in diverse social contexts such as consensus, election, morality, and so on. Here, we study a model of interacting agents connected in networks in order to analyze their decision stochastic process. We consider a first-neighbor interaction between agents in a one-dimensional network with the shape of ring topology. Moreover, some agents are also connected to a hub, or master node, who has preferential choice or bias. Such connections are quenched. As the main results, we observed a continuous nonequilibrium phase transition to an absorbing state as a function of control parameters. By using the finite-size scaling method we analyzed the static and dynamic critical exponents to show that this model probably cannot match any universality class already known.
Language	English
Publishing date	2023-12-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.108.054303
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Article: Compatibility of Gestrinone, Nimesulide, and Piroxicam in Pentravan for Transdermal and Transmucosal Application.

Polonini, Hudson / Ferreira, Anderson de Oliveira / Dijkers, Eli

International journal of pharmaceutical compounding

2021 Volume 25, Issue 5, Page(s) 422–426

Abstract: Transdermal products are intended to be applied topically but to promote the biological effects systemically, while transmucosal products have the same final effect but are to be applied on mucosa (for example, vaginal mucosa). The extension and velocity ...

Abstract	Transdermal products are intended to be applied topically but to promote the biological effects systemically, while transmucosal products have the same final effect but are to be applied on mucosa (for example, vaginal mucosa). The extension and velocity in which absorption occurs vary depending on the vehicle used, the active pharmaceutical ingredient and a broad range of other factors related to the formulation, patient, and environmental characteristics. Ready-to-use vehicles, such as Pentravan, with proven penetration efficacy for various active pharmaceutical ingredients, are paramount. Pentravan, specially developed for compounding pharmacies, has been extensively studied. To date, most studies have focused on endocrinology (e.g., sexual hormones), anti-aging strategies, and gynecology (endometriosis and related conditions). In this work, we have determined the compatibility of Pentravan and three active pharmaceutical ingredients: gestrinone, a steroidal substance for vaginal use (endometriosis), and nimesulide and piroxicam, two nonsteroidal anti-inflammatory drugs used both for topical and vaginal application. This article shows an excellent beyond-use date of 180 days when stored at room temperature, which renders it suitable for daily practice.
MeSH term(s)	Administration, Cutaneous ; Female ; Gestrinone ; Humans ; Piroxicam ; Sulfonamides
Chemical Substances	Sulfonamides ; Piroxicam (13T4O6VMAM) ; Gestrinone (1421533RCM) ; nimesulide (V4TKW1454M)
Language	English
Publishing date	2021-10-08
Publishing country	United States
Document type	Journal Article
ISSN	1092-4221
ISSN	1092-4221
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Article ; Online: Anthelmintic Drugs as Emerging Immune Modulators in Cancer.

Stolfi, Carmine / Pacifico, Teresa / Luiz-Ferreira, Anderson / Monteleone, Giovanni / Laudisi, Federica

International journal of molecular sciences

2023 Volume 24, Issue 7

Abstract: Despite recent advances in treatment approaches, cancer is still one of the leading causes of death worldwide. Restoration of tumor immune surveillance represents a valid strategy to overcome the acquired resistance and cytotoxicity of conventional ... ...

Abstract	Despite recent advances in treatment approaches, cancer is still one of the leading causes of death worldwide. Restoration of tumor immune surveillance represents a valid strategy to overcome the acquired resistance and cytotoxicity of conventional therapies in oncology and immunotherapeutic drugs, such as immune checkpoint inhibitors and immunogenic cell death inducers, and has substantially progressed the treatment of several malignancies and improved the clinical management of advanced disease. Unfortunately, because of tumor-intrinsic and/or -extrinsic mechanisms for escaping immune surveillance, only a fraction of patients clinically respond to and benefit from cancer immunotherapy. Accumulating evidence derived from studies of drug repositioning, that is, the strategy to identify new uses for approved or investigational drugs that are outside the scope of the original medical indication, has suggested that some anthelmintic drugs, in addition to their antineoplastic effects, exert important immunomodulatory actions on specific subsets of immune cell and related pathways. In this review, we report and discuss current knowledge on the impact of anthelmintic drugs on host immunity and their potential implication in cancer immunotherapy.
MeSH term(s)	Humans ; Programmed Cell Death 1 Receptor ; Neoplasms/drug therapy ; Immunologic Factors/pharmacology ; Immunologic Factors/therapeutic use ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Anthelmintics/pharmacology ; Anthelmintics/therapeutic use ; Immunotherapy ; B7-H1 Antigen
Chemical Substances	Programmed Cell Death 1 Receptor ; Immunologic Factors ; Antineoplastic Agents ; Anthelmintics ; B7-H1 Antigen
Language	English
Publishing date	2023-03-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24076446
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Article ; Online: TRAIL-Sensitizing Effects of Flavonoids in Cancer.

Luiz-Ferreira, Anderson / Pacifico, Teresa / Cruz, Álefe Cardoso / Laudisi, Federica / Monteleone, Giovanni / Stolfi, Carmine

International journal of molecular sciences

2023 Volume 24, Issue 23

Abstract: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) represents a promising anticancer agent, as it selectively induces apoptosis in transformed cells without altering the cellular machinery of healthy cells. Unfortunately, the presence of ... ...

Abstract	Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) represents a promising anticancer agent, as it selectively induces apoptosis in transformed cells without altering the cellular machinery of healthy cells. Unfortunately, the presence of TRAIL resistance mechanisms in a variety of cancer types represents a major hurdle, thus limiting the use of TRAIL as a single agent. Accumulating studies have shown that TRAIL-mediated apoptosis can be facilitated in resistant tumors by combined treatment with antitumor agents, ranging from synthetic molecules to natural products. Among the latter, flavonoids, the most prevalent polyphenols in plants, have shown remarkable competence in improving TRAIL-driven apoptosis in resistant cell lines as well as tumor-bearing mice with minimal side effects. Here, we summarize the molecular mechanisms, such as the upregulation of death receptor (DR)4 and DR5 and downregulation of key anti-apoptotic proteins [e.g., cellular FLICE-inhibitory protein (c-FLIP), X-linked inhibitor of apoptosis protein (XIAP), survivin], underlying the TRAIL-sensitizing properties of different classes of flavonoids (e.g., flavones, flavonols, isoflavones, chalcones, prenylflavonoids). Finally, we discuss limitations, mainly related to bioavailability issues, and future perspectives regarding the clinical use of flavonoids as adjuvant agents in TRAIL-based therapies.
MeSH term(s)	Animals ; Mice ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis ; Cell Line, Tumor ; Flavonoids/pharmacology ; Flavonoids/therapeutic use ; Ligands ; Neoplasms/drug therapy ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism ; TNF-Related Apoptosis-Inducing Ligand/pharmacology ; TNF-Related Apoptosis-Inducing Ligand/metabolism ; Tumor Necrosis Factor-alpha/pharmacology
Chemical Substances	Antineoplastic Agents ; Flavonoids ; Ligands ; Receptors, TNF-Related Apoptosis-Inducing Ligand ; TNF-Related Apoptosis-Inducing Ligand ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2023-11-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242316596
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Article ; Online: Changes in bacterial communities induced by integrated production systems and the phenological stages of soybean.

Dos Santos, Jussane Antunes Fogaça / do Nascimento, Alexandre Ferreira / Rempel, Djovane Mikael / Ferreira, Anderson

The Science of the total environment

2023 Volume 912, Page(s) 168626

Abstract: Plant development and productivity depend on interactions with soil microorganisms for nutrient availability, promotion of growth and protection against phytopathogens. Although the influence of the phenological stages of soybean crops and their ... ...

Abstract	Plant development and productivity depend on interactions with soil microorganisms for nutrient availability, promotion of growth and protection against phytopathogens. Although the influence of the phenological stages of soybean crops and their environmental conditions on the soil bacterial communities have already been reported, no studies have focused on the influence of integrated agrosilvopastoral systems on bacterial consortia. In this study, we evaluated the influence of the phenological stages of soybean cultivated under conventional full sunlight (CFS) and integrated crop-livestock-forestry (ICLF) systems on bacterial communities in the rhizosphere and in bulk soil using high-throughput sequencing techniques. Proteobacteria, Actinobacteriota and Acidobacteriota were the most abundant phyla in both the rhizosphere and the bulk soil at all growth stages. The results support our hypotheses that the richness and diversity of soil bacterial communities are influenced by different cultivation systems, and that the structure of the bacterial communities in the rhizosphere and the bulk soil are modulated by the phenological stages of the soybean crop.
MeSH term(s)	Glycine max ; Soil Microbiology ; Bacteria ; Rhizosphere ; Soil/chemistry
Chemical Substances	Soil
Language	English
Publishing date	2023-11-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.168626
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Article: Postulated Adjuvant Therapeutic Strategies for COVID-19.

Ferreira, Anderson O / Polonini, Hudson C / Dijkers, Eli C F

Journal of personalized medicine

2020 Volume 10, Issue 3

Abstract: The number of COVID-19 patients is still growing exponentially worldwide due to the high transmissibility of the SARS-CoV-2 virus. Therapeutic agents currently under investigation are antiviral drugs, vaccines, and other adjuvants that could relieve ... ...

Abstract	The number of COVID-19 patients is still growing exponentially worldwide due to the high transmissibility of the SARS-CoV-2 virus. Therapeutic agents currently under investigation are antiviral drugs, vaccines, and other adjuvants that could relieve symptoms or improve the healing process. In this review, twelve therapeutic agents that could play a role in prophylaxis or improvement of the COVID-19-associated symptoms (as add-on substances) are discussed. Agents were identified based on their known pharmacologic mechanism of action in viral and/or nonviral fields and are postulated to interact with one or more of the seven known mechanisms associated with the SARS-CoV-2 virus: (i) regulation of the immune system; (ii) virus entrance in the cell; (iii) virus replication; (iv) hyperinflammation; (v) oxidative stress; (vi) thrombosis; and (vii) endotheliitis. Selected agents were immune transfer factor (oligo- and polypeptides from porcine spleen, ultrafiltered at <10 kDa; Imuno TF
Keywords	covid19
Language	English
Publishing date	2020-08-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm10030080
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Article: Always the Right Dose? Content Uniformity in Over 100 Different Formulations Tested.

Dijkers, Eli / Polonini, Hudson / Ferreira, Anderson de Oliveira

International journal of pharmaceutical compounding

2020 Volume 24, Issue 5, Page(s) 408–412

Abstract: There is still an evident need for nonsterile compounded medications for pediatric and elderly patients in cases where patients require dose adjustments or have swallowing difficulties. Pharmacists generally have the choice between compounding capsules ... ...

Abstract	There is still an evident need for nonsterile compounded medications for pediatric and elderly patients in cases where patients require dose adjustments or have swallowing difficulties. Pharmacists generally have the choice between compounding capsules or oral liquids. In daily pharmacy practice, extemporaneous capsules are from time to time seen as a better alternative to oral liquid medication, although various published studies indicate that weight variation and/or uniformity of content can be significantly out of specification for compounded capsules. In contrast, analyses with the ready-to-use oral liquid vehicle SyrSpend SF in 104 different formulations with 89 unique active pharmaceutical ingredients showed results that all 6.414 samples analyzed were within specification. It can, therefore, be argued that SyrSpend SF could be a better way to assure content uniformity compared to manually compounded, small-batch extemporaneous capsules.
MeSH term(s)	Aged ; Capsules/chemistry ; Child ; Drug Compounding ; Excipients/chemistry ; Humans ; Pharmacies
Chemical Substances	Capsules ; Excipients
Language	English
Publishing date	2020-09-04
Publishing country	United States
Document type	Journal Article
ISSN	1092-4221
ISSN	1092-4221
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Article ; Online: Mortality from neglected tropical diseases in the state of Piauí, Northeast Brazil: temporal trend and spatial patterns, 2001-2018.

Brito, Sheila Paloma de Sousa / Ferreira, Anderson Fuentes / Lima, Mauricélia da Silveira / Ramos, Alberto Novaes

Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil

2022 Volume 31, Issue 1, Page(s) e2021732

Abstract: Objetive: To analyze temporal trends and spatial patterns of mortality due to neglected tropical diseases (NTDs) in Piauí, Brazil, 2001-2018.: Methods: This was a mixed ecological study, with risk ratio (RR) calculation, spatiotemporal trend analysis, ...

Title translation	Mortalidade por doenças tropicais negligenciadas no Piauí, Nordeste do Brasil: tendência temporal e padrões espaciais, 2001-2018.
Abstract	Objetive: To analyze temporal trends and spatial patterns of mortality due to neglected tropical diseases (NTDs) in Piauí, Brazil, 2001-2018. Methods: This was a mixed ecological study, with risk ratio (RR) calculation, spatiotemporal trend analysis, Poisson joinpoint regression, using data from the Mortality Information System. Results: There were 2,609 deaths due to NTDs in the period (4.60/100,000 inhabitants), 55.2% were due to Chagas' disease. There was a higher risk of death in male (RR=1.76; 95%CI 1.25;2.46), being aged ≥60 years (RR=40.71; 95%CI 10.01;165.53), municipalities with medium vulnerability social (RR=1.76; 95%CI 1.09;2.84), smaller population size (RR=1.99; 95%CI 1.28;3.10) and the Cerrados macro-region (RR=4.51; 95%CI 2.51;8.11). There was an upward trend in mortality rates from 2001-2008 and a falling trend from 2009-2018. Conclusion: Mortality due to NTDs in Piauí remains high, particularly due to Chagas' disease, among groups with greater vulnerability, with concentration of higher rates in the southwest of the Semiarid macro-region and the northeast and south of the Cerrados macro-region.
MeSH term(s)	Brazil/epidemiology ; Chagas Disease/epidemiology ; Humans ; Male ; Neglected Diseases/epidemiology ; Odds Ratio ; Spatio-Temporal Analysis
Language	Portuguese
Publishing date	2022-04-15
Publishing country	Brazil
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2880588-4
ISSN	2237-9622 ; 1679-4974
ISSN (online)	2237-9622
ISSN	1679-4974
DOI	10.1590/S1679-49742022000100014
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