Article ; Online: Escore eletrocardiográfico: aplicação em ergometria para avaliação do precondicionamento isquêmico.
Arquivos brasileiros de cardiologia
2010 Volume 95, Issue 4, Page(s) 486–492
Abstract: Background: the time for 1.0 mm ST-segment depression (T-1.0mm) adopted to characterize ischemic preconditioning (IPC) in sequential exercise tests is consistent and reproducible; however, it has several limitations.: Objective: to apply an ... ...
| Title translation | Electrocardiographic score: application in exercise test for the assessment of ischemic preconditioning. |
|---|---|
| Abstract | Background: the time for 1.0 mm ST-segment depression (T-1.0mm) adopted to characterize ischemic preconditioning (IPC) in sequential exercise tests is consistent and reproducible; however, it has several limitations. Objective: to apply an electrocardiographic score of myocardial ischemia in sequential exercise tests, comparing it to the conventional T-1.0 mm index. Methods: sixty one patients with mean age of 62.2 ± 7.5 years were evaluated; 86.9% were males. A total of 151 tests were analyzed, 116 of which were from patients who completed two assessment phases. The first phase comprised two sequential exercise tests for the documentation of IPC; the second phase, initiated one week later, comprised two more tests carried out under the effect of repaglinide. Two observers who were blind to the tests applied the score. Results: Perfect inter and intraobserver agreement was found (Kendall tau-b = 0.96, p < 0.0001, and Kendall tau-b = 0.98, p < 0.0001, respectively). Values of sensitivity and specificity, negative predictive value, positive predictive value and accuracy were 72.41%, 89.29%, 75.8%, 87.5% and 81.0%, respectively. Conclusion: the ischemic score is a consistent and reproducible method for the documentation of IPC, and is a feasible alternative to T-1.0 mm. |
| MeSH term(s) | Carbamates ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/physiopathology ; Double-Blind Method ; Electrocardiography/methods ; Electrocardiography/standards ; Ergometry ; Female ; Humans ; Hypoglycemic Agents/therapeutic use ; Ischemic Preconditioning ; Male ; Middle Aged ; Myocardial Ischemia/diagnosis ; Observer Variation ; Piperidines ; Predictive Value of Tests |
| Chemical Substances | Carbamates ; Hypoglycemic Agents ; Piperidines ; repaglinide (668Z8C33LU) |
| Language | Multiple languages |
| Publishing date | 2010-09-08 |
| Publishing country | Brazil |
| Document type | Comparative Study ; English Abstract ; Journal Article |
| ZDB-ID | 730261-7 |
| ISSN | 1678-4170 ; 0066-782X |
| ISSN (online) | 1678-4170 |
| ISSN | 0066-782X |
| DOI | 10.1590/s0066-782x2010005000122 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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