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Article ; Online: Immunometabolic and Vascular Health Responses among High Endurance Trained Subjects.

Fonseca, Henrique A R / Bittencourt, Celia Regina / Monteiro, Andrea Moreira / Fonseca, Francisco Antonio / Sanches, Lívia Rentas / Ferreira, Carlos Eduardo Dos Santos / Neto, Antonio Martins Figueiredo / Gidlund, Magnus / Izar, Maria Cristina

International journal of sports medicine

2023 Volume 45, Issue 3, Page(s) 245–252

Abstract: In this study, we aimed to examine the impact of high endurance training on vascular health parameters and immune-endocrine responses against modified low-density lipoprotein (LDL) particles. This observational, cross-sectional study included high ... ...

Abstract	In this study, we aimed to examine the impact of high endurance training on vascular health parameters and immune-endocrine responses against modified low-density lipoprotein (LDL) particles. This observational, cross-sectional study included high endurance-trained and healthy non-trained subjects. Vascular ultrasound was used to assess vascular health parameters based on carotid intima-media thickness and endothelial function (flow-mediated dilation). Enzyme-linked immunosorbent assays were used to measure interleukin (IL)-8 and IL-10, autoantibody isotypes anti-oxidized LDL (oxLDL) and anti-apolipoprotein B (ApoB-D) peptide. Plasma levels of the corticosterone and 17 α-hydroxyprogesterone hormones were analyzed by mass spectrometry. This study enrolled 96 subjects, of whom 44 were high endurance trained and 52 were healthy non-trained individuals. Smaller carotid intima-media thickness values were observed in the high-endurance trained than in the healthy non-trained males, while no differences were observed between female groups. Flow-mediated dilation measurements did not differ by training or sex. The humoral immune responses to IgG anti-oxLDL and IgM anti-ApoB-D autoantibodies showed an isotype imbalance between the high-endurance trained and the non-trained groups. Immunoendocrine parameters showed inverse correlations between 17 α-hydroxyprogesterone concentrations and carotid intima-media thickness measurements. Direct correlations were found between IL-10 concentrations and flow-mediated dilation measurements. Chronic high-endurance exercise modulates immune-endocrine and vascular health parameters, in a sex-dependent manner.
MeSH term(s)	Male ; Humans ; Female ; Carotid Intima-Media Thickness ; Interleukin-10 ; Endurance Training ; Cross-Sectional Studies ; 17-alpha-Hydroxyprogesterone
Chemical Substances	Interleukin-10 (130068-27-8) ; 17-alpha-Hydroxyprogesterone (68-96-2)
Language	English
Publishing date	2023-10-04
Publishing country	Germany
Document type	Observational Study ; Journal Article
ZDB-ID	603122-5
ISSN	1439-3964 ; 0172-4622 ; 0943-917X
ISSN (online)	1439-3964
ISSN	0172-4622 ; 0943-917X
DOI	10.1055/a-2186-2717
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Article: Lipid profile, the world needs to change.

Ferreira, Carlos Eduardo Dos Santos / Scartezini, Marileia / França, Carolina N

Journal of clinical lipidology

2017 Volume 11, Issue 3, Page(s) 769–770

MeSH term(s)	Blood Chemical Analysis/methods ; Fasting/blood ; Humans ; Lipids/blood ; Risk Factors
Chemical Substances	Lipids
Language	English
Publishing date	2017-02-10
Publishing country	United States
Document type	Letter
ZDB-ID	2365061-8
ISSN	1876-4789 ; 1933-2874
ISSN (online)	1876-4789
ISSN	1933-2874
DOI	10.1016/j.jacl.2017.01.019
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Article ; Online: Impact of COVID-19 Disease in Early Breast Cancer Management: A Summary of the Current Evidence.

Cavalcante, Francisco Pimentel / Abdala, Edson / Weissmann, Leonardo / Ferreira, Carlos Eduardo Dos Santos / Amorim, Gilberto / de Oliveira, Vilmar Marques / Guilgen, Gisah / Landeiro, Luciana / Pinho, João Renato Rebello / Pulchinelli, Álvaro / Ribeiro, Heber / Souza, Rafael / Rosa, Daniela Dornelles

JCO global oncology

2022 Volume 8, Page(s) e2100357

Abstract: Purpose: An expert panel on breast cancer and COVID-19 disease was convened to address the impact of the COVID-19 pandemic for early breast cancer (eBC) management.: Methods: To ensure that the most clinically relevant information was addressed, ... ...

Abstract	Purpose: An expert panel on breast cancer and COVID-19 disease was convened to address the impact of the COVID-19 pandemic for early breast cancer (eBC) management. Methods: To ensure that the most clinically relevant information was addressed, essential information was drawn from several of the latest national and international guidelines and another technical document. The expert panel met in five virtual closed sessions from November 2020 to May 2021 to consult on the relevant data from evidence-based results. The data gathered were discussed on an online platform. Results: This article reports the expert panel's highlights of these meetings' discussions. In addition, it provides practical recommendations covering topics regarding diagnosis, treatment, and management of patients with eBC in clinical settings routinely encountered by health care professionals amid the COVID-19 pandemic. Conclusion: This article provided guidance on several topics regarding eBC management amid the COVID-19 pandemics to inform safer care practices.
MeSH term(s)	Breast Neoplasms/diagnosis ; Breast Neoplasms/therapy ; COVID-19 ; Female ; Humans ; Pandemics/prevention & control
Language	English
Publishing date	2022-05-20
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2687-8941
ISSN (online)	2687-8941
DOI	10.1200/GO.21.00357
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Fonseca, Henrique A.R. / Bittencourt, Celia Regina / Monteiro, Andrea Moreira / Fonseca, Francisco Antonio / Sanches, Lívia Rentas / Ferreira, Carlos Eduardo dos Santos / Neto, Antonio Martins Figueiredo / Gidlund, Magnus / Izar, Maria Cristina

International Journal of Sports Medicine

2023 Volume 45, Issue 03, Page(s) 245–252

Abstract	In this study, we aimed to examine the impact of high endurance training on vascular health parameters and immune-endocrine responses against modified low-density lipoprotein (LDL) particles. This observational, cross-sectional study included high endurance-trained and healthy non-trained subjects. Vascular ultrasound was used to assess vascular health parameters based on carotid intima-media thickness and endothelial function (flow-mediated dilation). Enzyme-linked immunosorbent assays were used to measure interleukin (IL)-8 and IL-10, autoantibody isotypes anti-oxidized LDL (oxLDL) and anti-apolipoprotein B (ApoB-D) peptide. Plasma levels of the corticosterone and 17 α-hydroxyprogesterone hormones were analyzed by mass spectrometry. This study enrolled 96 subjects, of whom 44 were high endurance trained and 52 were healthy non-trained individuals. Smaller carotid intima-media thickness values were observed in the high-endurance trained than in the healthy non-trained males, while no differences were observed between female groups. Flow-mediated dilation measurements did not differ by training or sex. The humoral immune responses to IgG anti-oxLDL and IgM anti-ApoB-D autoantibodies showed an isotype imbalance between the high-endurance trained and the non-trained groups. Immunoendocrine parameters showed inverse correlations between 17 α-hydroxyprogesterone concentrations and carotid intima-media thickness measurements. Direct correlations were found between IL-10 concentrations and flow-mediated dilation measurements. Chronic high-endurance exercise modulates immune-endocrine and vascular health parameters, in a sex-dependent manner.
Keywords	exercise ; humoral immunity ; oxidized LDL ; atherosclerosis ; endothelium
Language	English
Publishing date	2023-10-04
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	603122-5
ISSN	1439-3964 ; 0172-4622 ; 0943-917X
ISSN (online)	1439-3964
ISSN	0172-4622 ; 0943-917X
DOI	10.1055/a-2186-2717
Database	Thieme publisher's database

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Article ; Online: Rare Presentation of Dercum's Disease in a Child with Abnormalities in Lipoprotein Metabolism.

Izar, Maria Cristina de Oliveira / Fonseca, Henrique Andrade Rodrigues da / França, Carolina Nunes / Machado, Valéria Arruda / Ferreira, Carlos Eduardo Dos Santos / Fonseca, Francisco Antonio Helfenstein

Arquivos brasileiros de cardiologia

2018 Volume 111, Issue 5, Page(s) 755–757

MeSH term(s)	1-Alkyl-2-acetylglycerophosphocholine Esterase/blood ; Adiposis Dolorosa/complications ; Adiposis Dolorosa/diagnostic imaging ; Adiposis Dolorosa/metabolism ; C-Reactive Protein ; Child ; Cholesterol, HDL/blood ; Dyslipidemias/blood ; Female ; Humans ; Lipomatosis/diagnosis ; Lipomatosis/metabolism ; Lipoproteins/blood ; Pain/etiology ; Rare Diseases/complications ; Rare Diseases/diagnostic imaging ; Rare Diseases/metabolism
Chemical Substances	Cholesterol, HDL ; Lipoproteins ; C-Reactive Protein (9007-41-4) ; 1-Alkyl-2-acetylglycerophosphocholine Esterase (EC 3.1.1.47)
Language	Portuguese
Publishing date	2018-11-23
Publishing country	Brazil
Document type	Case Reports
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.5935/abc.20180191
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Article ; Online: PCSK9 and its clinical importance with the new therapeutic targets against dyslipidemia.

Ferreira, Carlos Eduardo dos Santos / Fonseca, Francisco Antônio Helfenstein / Mangueira, Cristóvão Luis Pitangueira

Einstein (Sao Paulo, Brazil)

2013 Volume 10, Issue 4, Page(s) 526–527

Abstract: This is a remarkable progress; since the finding of statins, there was no new way of reducing, significantly, cholesterol and LDL fraction. It is also clear that this decrease, by statins, is related to future cardiovascular lesions, being useful in its ... ...

Abstract	This is a remarkable progress; since the finding of statins, there was no new way of reducing, significantly, cholesterol and LDL fraction. It is also clear that this decrease, by statins, is related to future cardiovascular lesions, being useful in its primary and secondary prophylaxis. The authors presented studies on research to promote the falling of blood cholesterol by means of antibodies, which inhibit the pro-protein PCSK9, as well as agents that act performing the RNA interference. We had two advantages immediately: for patients with myopathy associated with statins, and the fact of being injected every 15 days, that may contribute to better treatment adherence.
MeSH term(s)	Antibodies, Monoclonal/administration & dosage ; Cholesterol, LDL/blood ; Clinical Trials as Topic ; Dyslipidemias/therapy ; Humans ; Proprotein Convertase 9 ; Proprotein Convertases/immunology ; RNA Interference ; Serine Endopeptidases/immunology
Chemical Substances	Antibodies, Monoclonal ; Cholesterol, LDL ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Proprotein Convertases (EC 3.4.21.-) ; Serine Endopeptidases (EC 3.4.21.-)
Language	Portuguese
Publishing date	2013-03-05
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2418293-X
ISSN	2317-6385 ; 1679-4508
ISSN (online)	2317-6385
ISSN	1679-4508
DOI	10.1590/s1679-45082012000400024
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Article ; Online: Study protocol: epidemiological and clinical characteristics of acute viral hepatitis in Brazilian health services.

Sitnik, Roberta / Maluf, Maira Marranghello / Oliveira, Ketti G / Siqueira, Ricardo Andreotti / Ferreira, Carlos Eduardo Dos Santos / Mangueira, Cristóvão Luis Pitangueira / Azevedo, Raymundo Soares / Ferraz, Maria Lucia Cardoso Gomes / Correa, Maria Cassia Jacintho Mendes / Ferreira, Paulo Roberto Abrão / Mendes Pereira, Gerson Fernando / de Souza, Flávia Moreno Alves / Pimenta, Cristina / Pinho, João Renato Rebello

BMJ open

2021 Volume 11, Issue 7, Page(s) e045852

Abstract: Introduction: Acute viral hepatitis is a disease of great clinical importance. This study proposes actions to better characterise cases of acute hepatitis in Brazil and to provide relevant information to institutionalised health policies within the ... ...

Abstract	Introduction: Acute viral hepatitis is a disease of great clinical importance. This study proposes actions to better characterise cases of acute hepatitis in Brazil and to provide relevant information to institutionalised health policies within the Unified Health System. Available data on acute hepatitis in Brazil need to be re-evaluated regarding the different hepatotropic agent (hepatitis A to E virus) frequencies, as well as other agents that can cause similar clinical conditions, such as Herpes Simplex Virus 1 and 2(HSV1, HSV2), Varicella Zoster Virus (VZV), Cytomegalovirus (CMV), Epstein Barr Virus (EBV), Human Herpes Virus 6 and 7 (HHV6, HHV7), arbovirus (yellow fever, dengue, chikungunya, Zika), parvovirus B19, adenovirus, parechovirus, enterovirus, HIV, leptospirosis, toxoplasmosis and syphilis, in addition to autoimmune hepatitis. In this context, the primary aim of this study is the clinical-epidemiological and molecular characterisation of acute viral hepatitis in Brazilian health services from all geographical regions of the country. The present article describes the study protocol. Methods and analysis: This study will evaluate 2280 patients with symptoms and/or signs suggestive of acute liver disease in Brazilian health institutions in all five geographic Brazilian regions. Demographic, epidemiological and clinical data will be collected, as well as blood samples to be analysed at Hospital Israelita Albert Einstein Clinical Laboratory. Ethics and dissemination: Ethics approval was obtained at the national research ethics committee (Conselho Nacional de Ética em Pesquisa- CONEP-CAAE 00952818.4.1001.0071) and at all participating sites. Results will be published in journals and presented at scientific meetings.
MeSH term(s)	Brazil/epidemiology ; Epstein-Barr Virus Infections ; Health Services ; Hepatitis, Viral, Human/epidemiology ; Herpesvirus 4, Human ; Humans ; Zika Virus ; Zika Virus Infection
Language	English
Publishing date	2021-07-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2020-045852
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Article ; Online: Potential performance of a 0 h/1 h algorithm and a single cut-off measure of high-sensitivity troponin T in a diverse population: main results of the IN-HOPE study.

de Barros E Silva, Pedro G M / Ferreira, Ana Amaral / Malafaia, Felipe / Tavares Reis, Antonielle Figueiredo Macedo / Sznejder, Henry / Lopes Junior, Augusto Celso De Araujo / Agostinho, Camila Anacleto / Fonseca, Luiz Henrique de Oliveira / Okitoi, Débora Vieira Donini / Correa, Celso Musa / Zincone, Eduardo / Cury, Marcelo Paiva / Rosa, Gustavo Augusto Lopes / Ribeiro, Henrique Barbosa / Soeiro, Alexandre de Matos / de Oliveira, Carlos Alexandre Lemes / Kuusberg, Guilherme Capelli / Ohe, Louis Nakayama / Souza, Douglas de Oliveira /

Manfredi, Adriana Bertolami / Martins, Amanda Francisco / Sampaio, Pedro Paulo Nogueres / Vaz, Thiago Baganha / Franco, Luciana Ferreira / Ferreira, Carlos Eduardo Dos Santos / Lopes, Renato Delascio

European heart journal. Acute cardiovascular care

2023 Volume 12, Issue 11, Page(s) 755–764

Abstract: Aims: Chest pain is a major cause of medical evaluation at emergency department (ED) and demands observation to exclude the diagnosis of acute myocardial infarction (AMI). High-sensitivity cardiac troponin assays used as isolated measure and by 0- and 1- ...

Abstract	Aims: Chest pain is a major cause of medical evaluation at emergency department (ED) and demands observation to exclude the diagnosis of acute myocardial infarction (AMI). High-sensitivity cardiac troponin assays used as isolated measure and by 0- and 1-h algorithms are accepted as a rule-in/rule-out strategy, but there is a lack of validation in specific populations. Methods and results: The IN-HOspital Program to systematizE Chest Pain Protocol (IN-HOPE study) is a multicentre study that prospectively included patients admitted to the ED due to suspected symptoms of AMI at 16 sites in Brazil. Medical decisions of all patients followed the standard approach of 0 h/3 h protocol, but, in addition, blood samples were also collected at 0 and 1 h and sent to a central laboratory (core lab) to measure high-sensitivity cardiac troponin T (hs-cTnT). To assess the theoretical performance of 0 h/1 h algorithm, troponin < 12 ng/L with a delta < 3 was considered rule-out while a value ≥ 52 or a delta ≥ 5 was considered a rule-in criterion (the remaining were considered as observation group). The main objective of the study was to assess, in a population managed by the 0 h/3 h protocol, the accuracy of 0 h/1 h algorithm overall and in groups with a higher probability of AMI. All patients were followed up for 30 days, and potential events were adjudicated. In addition to the prospective cohort, a retrospective analysis was performed assessing all patients with hs-cTnT measured during the year of 2021 but not included in the prospective cohort, regardless of the indication of the test. A total of 5.497 patients were included (583 in the prospective and 4.914 in the retrospective analysis). The prospective cohort had a mean age of 57.3 (± 14.8) and 45.6% of females with a mean HEART score of 4.0 ± 2.2. By the core lab analysis, 74.4% would be eligible for a rule-out approach (45.3% of them with a HEART score > 3) while 7.3% would fit the rule-in criteria. In this rule-out group, the negative predictive value for index AMI was 100% (99.1-100) overall and regardless of clinical scores. At 30 days, no death or AMI occurred in the rule-out group of both 0/1 and 0/3 h algorithms while 52.4% of the patients in the rule-in group (0 h/1 h) were considered as AMI by adjudication. In the observation group (grey zone) of 0 h/1 h algorithm, GRACE discriminated the risk of these patients better than HEART score. In the retrospective analysis, 1.091 patients had a troponin value of <5 ng/L and there were no cardiovascular deaths at 30 days in this group. Among all 4.914 patients, the 30-day risk of AMI or cardiovascular death increased according to the level of troponin: 0% in the group < 5 ng/L, 0.6% between 5 and 14 ng/L, 2.2% between 14 and 42 ng/L, 6.3% between 42 and 90 ng/L, and 7.7% in the level ≥ 90 ng/L. Conclusion: In this large multicentre study, a 0 h/1 h algorithm had the potential to classify as rule-in or rule-out in almost 80% of the patients. The rule-out protocol had high negative predictive value regardless of clinical risk scores. Categories of levels of hs-cTn T also showed good accuracy in discriminating risk of the patients with a very favourable prognosis for cardiovascular death in the group with value < 5 ng/L. Clinicaltrials.gov: NCT04756362.
MeSH term(s)	Female ; Humans ; Middle Aged ; Algorithms ; Biomarkers ; Chest Pain/diagnosis ; Chest Pain/etiology ; Emergency Service, Hospital ; Myocardial Infarction/diagnosis ; Myocardial Infarction/epidemiology ; Prospective Studies ; Retrospective Studies ; Troponin I ; Troponin T ; Male ; Adult ; Aged
Chemical Substances	Biomarkers ; Troponin I ; Troponin T
Language	English
Publishing date	2023-07-14
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	2663340-1
ISSN	2048-8734 ; 2048-8726
ISSN (online)	2048-8734
ISSN	2048-8726
DOI	10.1093/ehjacc/zuad082
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Article ; Online: Brazilian Position Statement for Familial Chylomicronemia Syndrome - 2023.

Izar, Maria Cristina de Oliveira / Santos Filho, Raul Dias Dos / Assad, Marcelo Heitor Vieira / Chagas, Antonio Carlos Palandri / Toledo Júnior, Alceu de Oliveira / Nogueira, Ana Cláudia Cavalcante / Souto, Ana Cristina Carneiro Fernandes / Lottenberg, Ana Maria Pitta / Chacra, Ana Paula Marte / Ferreira, Carlos Eduardo Dos Santos / Lourenço, Charles Marques / Valerio, Cynthia Melissa / Cintra, Dennys Esper / Fonseca, Francisco Antonio Helfenstein / Campana, Gustavo Aguiar / Bianco, Henrique Tria / Lima, Josivan Gomes de / Castelo, Maria Helane Costa Gurgel / Scartezini, Marileia /

Moretti, Miguel Antonio / Barreto, Natasha Slhessarenko Fraife / Maia, Rayana Elias / Montenegro Junior, Renan Magalhães / Alves, Renato Jorge / Figueiredo, Roberta Marcondes Machado / Fock, Rodrigo Ambrosio / Martinez, Tânia Leme da Rocha

Arquivos brasileiros de cardiologia

2023 Volume 120, Issue 4, Page(s) e20230203

Title translation	Posicionamento Brasileiro sobre Síndrome da Quilomicronemia Familiar – 2023.
MeSH term(s)	Humans ; Hyperlipoproteinemia Type I/diagnosis ; Hyperlipoproteinemia Type I/genetics ; Hyperlipoproteinemia Type I/therapy ; Brazil ; Hypertriglyceridemia ; Triglycerides
Chemical Substances	Triglycerides
Language	Portuguese
Publishing date	2023-04-18
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.36660/abc.20230203
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Article ; Online: Clinical correlation between a point-of-care testing system and laboratory automation for lipid profile.

Ferreira, Carlos Eduardo dos Santos / França, Carolina Nunes / Correr, Cassyano Januário / Zucker, Márcia L / Andriolo, Adagmar / Scartezini, Marileia

Clinica chimica acta; international journal of clinical chemistry

2015 Volume 446, Page(s) 263–266

Abstract: Background: We evaluated the clinical correlation between the CardioChek PA analyzer and a clinical laboratory reference method to use for screening program purposes.: Methods: Fasting blood samples were collected on 516 patients (age 20-85 y). One ... ...

Abstract	Background: We evaluated the clinical correlation between the CardioChek PA analyzer and a clinical laboratory reference method to use for screening program purposes. Methods: Fasting blood samples were collected on 516 patients (age 20-85 y). One venous sample was collected using a serum tube for the evaluation on a COBAS reference analyzer. A second venous sample was collected in a lithium heparin tube and was evaluated on the CardioChek PA analyzer (CCPA venous). A fingerstick sample (CCPA fingerstick) was evaluated only on the CardioChek PA analyzer. Linear regression analyses were performed for each measured analyte, total cholesterol, HDL-cholesterol and triglycerides. Results: The correlation between the CCPA fingerstick and CCPA venous was extremely high for HDL-C and triglycerides, and good for total cholesterol. Our results demonstrated a good clinical agreement for total cholesterol, HDL-C and triglycerides between 97.7% and 94.6% in the comparison of the CCPA to the reference analyzer. Conclusions: We identified the pre-analytic phase as an important step to guarantee the quality of results and indicate that the CardioChek PA is a reliable lipid point-of-care testing system that can be used for the application of clinical screening anywhere.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Automation, Laboratory/standards ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/diagnosis ; Cholesterol, HDL/blood ; Fasting/blood ; Female ; Humans ; Linear Models ; Male ; Middle Aged ; Point-of-Care Testing/standards ; Practice Guidelines as Topic ; Triglycerides/blood
Chemical Substances	Cholesterol, HDL ; Triglycerides
Language	English
Publishing date	2015-06-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80228-1
ISSN	1873-3492 ; 0009-8981
ISSN (online)	1873-3492
ISSN	0009-8981
DOI	10.1016/j.cca.2015.04.036
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