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Article: Pulmonary Rehabilitation Associated with Noninvasive Ventilation on Physical Capacity and Quality of Life in Post-COVID-19: A Randomized Controlled Double-Blinded Clinical Trial Protocol.

Arêas, Guilherme Peixoto Tinoco / Goulart, Cássia da Luz / Sant'Anna, Thaís / Fernandes, Tiótrefis Gomes / Alvim, Rafael de Oliveira / Borges, Fernanda Facioli Dos Reis / do Amaral, Camila Miriam Suemi Sato Barros / Rodrigues, Suzy Cristina França / Valente, Jefferson / Ferreira, João Marcos Bemfica Barbosa / Rezende, Anna Gabriela / de Oliveira Júnior, Edival Ferreira / de Lacerda, Marcus Vinícius Guimarães / de Almeida-Val, Fernando Fonseca

Journal of multidisciplinary healthcare

2024 Volume 17, Page(s) 1483–1490

Abstract: Background: The coronavirus disease-2019 (COVID-19) pulmonary rehabilitation (PR) seems to be a better choice to improve physical and functional capacity after acute infection. However, there is a lack of evidence regarding the effects of different ... ...

Abstract	Background: The coronavirus disease-2019 (COVID-19) pulmonary rehabilitation (PR) seems to be a better choice to improve physical and functional capacity after acute infection. However, there is a lack of evidence regarding the effects of different strategies to optimize post-acute phase rehabilitation and reduce long COVID-19 physical deteriorations. Objective: To compare the use of a noninvasive ventilation (NIV) plus aerobic exercise strategy during PR program with to a standard PR (without NIV) on physical capacity and quality of life outcomes in post-COVID-19. Methods: Double-blinded randomized controlled clinical trial. A total of 100 individuals discharged from hospital in a post-acute phase of severe COVID-19 will be randomized into two groups: PR + NIV (Group 1) and PR (Group 2). Inclusion criteria include participants who present symptomatic dyspnea II and III by the modified Medical Research Council, aged 18 years or older. Both groups will receive aerobic and resistance exercise, and inspiratory muscle training. However, group 1 will perform aerobic training with bilevel NIV. Cardiopulmonary exercise test will assess the O Clinical trial registration: RBR-3t9pkzt.
Language	English
Publishing date	2024-04-05
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2453343-9
ISSN	1178-2390
ISSN	1178-2390
DOI	10.2147/JMDH.S438120
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Article ; Online: Anodal transcranial direct current stimulation associated with aerobic exercise on the functional and physical capacity of patients with heart failure with reduced ejection fraction: ELETRIC study protocol.

da Silva, Vanessa Christina Costa / da Silva Arêas, Fernando Zanela / Lopes, Antônio Luiz Ribeiro Boechat / de Almeida E Val, Fernando Fonseca / da Costa, Allyson Guimarães / Dos Santos, Joana Colares Correa / Ferreira, João Marcos Bemfica Barbosa / Peixoto Tinoco Arêas, Guilherme

Trials

2023 Volume 24, Issue 1, Page(s) 738

Abstract: Background: The hallmark symptom of heart failure (HF) is severe exercise intolerance. Fortunately, accumulated evidence suggests that exercise programs improve physical performance, enhance autonomy in daily activities and quality of life, and reduce ... ...

Abstract	Background: The hallmark symptom of heart failure (HF) is severe exercise intolerance. Fortunately, accumulated evidence suggests that exercise programs improve physical performance, enhance autonomy in daily activities and quality of life, and reduce cardiovascular and other hospitalizations. Recently, experimental studies have explored the application of non-invasive brain stimulation techniques, especially transcranial direct current stimulation (tDCS), aiming to improve physical performance due to its ability to modulate brain functioning. The primary objective of the present study is to evaluate the effects of anodal tDCS associated with aerobic exercise on the functional capacity of patients with HF with reduced ejection fraction (HFrEF). Secondary objectives are to compare the effects of tDCS associated with aerobic exercise vs. sham-tDCS associated with aerobic exercise on cardiopulmonary exercise capacity; inflammatory cytokines; and quality of life. Methods: This is a two-arm, prospectively registered, randomized trial with concealed allocation, double-blind, and intention-to-treat analysis. Forty-four patients with HFrEF will be recruited. The experimental group will undertake 25-30 min aerobic exercise training associated with tDCS, for 4 weeks. The control group will undergo the same aerobic exercise training, but with sham-tDCS. The primary outcome will be functional performance by the 6-min walk test. Secondary outcomes will include cardiopulmonary exercise capacity, inflammatory cytokines, and quality of life. Outcomes will be collected by a researcher blinded to group allocation at baseline (T0) and after 4 weeks of intervention (T1). Discussion: Although previous studies have investigated the combined effect of tDCS on T3 area and physical performance and have suggested that tDCS could have reduced ratings of perceived exertion by affecting the activity of the insular cortex, and therefore increase exercise tolerance, this study is the first to evaluate the effects of the addition of anodal tDCS to aerobic exercise training for improving physical and functional performance, decreasing the perceived exertion, altering the quantification of inflammatory cytokines, and improving the subclinical values of the cardiopulmonary test in patients with HFrEF, which could result in an important advance in cardiac rehabilitation for patients with chronic HF. Trial registration: Brazilian Registry of Clinical Trials (ReBEC) RBR-10w787j6. Registered on 25 April 2023. https://ensaiosclinicos.gov.br/pesquisador.
MeSH term(s)	Humans ; Transcranial Direct Current Stimulation/methods ; Heart Failure/diagnosis ; Heart Failure/therapy ; Quality of Life ; Stroke Volume ; Exercise ; Double-Blind Method ; Cytokines ; Randomized Controlled Trials as Topic
Chemical Substances	Cytokines
Language	English
Publishing date	2023-11-17
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-023-07694-2
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Article ; Online: Echocardiographic Findings in Patients with COVID-19 with and without Previous Cardiovascular Disease.

Barberato, Silvio Henrique / Borsoi, Rafael / Roston, Fabio / Miranda, Hudson Laerte Machado / Patriota, Pedro / Otto, Maria Estefania / Beck, Adenalva Lima de Souza / Armstrong, Anderson da Costa / Ferreira, João Marcos Bemfica Barbosa / Camarozano, Ana Cristina / Silva, Letícia Braga Paciello da / Resende, Marcos Valério Coimbra / Vieira, Marcelo Luiz Campos / Fernandes-Silva, Miguel Morita

Arquivos brasileiros de cardiologia

2022 Volume 117, Issue 6, Page(s) 1207–1211

Title translation	Achados Ecocardiográficos em Pacientes com COVID-19 com e sem Doença Cardiovascular Prévia.
MeSH term(s)	COVID-19 ; Cardiovascular Diseases/diagnostic imaging ; Echocardiography ; Humans ; SARS-CoV-2
Language	Portuguese
Publishing date	2022-05-25
Publishing country	Brazil
Document type	Letter
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.36660/abc.20201300
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Article ; Online: Acute Chagas disease associated with ingestion of contaminated food in Brazilian western Amazon.

de Sousa, Débora Raysa Teixeira / de Oliveira Guerra, Jorge Augusto / Ortiz, Jessica Vanina / do Nascimento Couceiro, Katia / da Silva E Silva, Monica Regina Hosanahh / Jorge Brandão, Alba Regina / Guevara, Elsa / Arcanjo, Ana Ruth Lima / de Oliveira Júnior, Edival Ferreira / Smith-Doria, Susan / Mwangi, Victor Irungu / Morais, Rômulo Freire / Silva, George Allan Villarouco / Molina, Israel / Silveira, Henrique / Ferreira, João Marcos Bemfica Barbosa / Guerra, Maria das Graças Vale Barbosa

Tropical medicine & international health : TM & IH

2023 Volume 28, Issue 7, Page(s) 541–550

Abstract: Objective: To describe clinical, epidemiological and management information on cases of acute Chagas disease (ACD) by oral transmission in the state of Amazonas in western Amazon.: Methods: Manual and electronic medical records of patients diagnosed ... ...

Abstract	Objective: To describe clinical, epidemiological and management information on cases of acute Chagas disease (ACD) by oral transmission in the state of Amazonas in western Amazon. Methods: Manual and electronic medical records of patients diagnosed with ACD at the Fundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD) were included. Results: There were 147 cases of acute CD registered from 10 outbreaks that occurred in the state of Amazonas between 2004 and 2022. The transmission pathway was through oral route, with probable contaminated palm fruit juice (açaí and/or papatuá), and involved people from the same family, friends or neighbours. Of 147 identified cases, 87 (59%) were males; cases were aged 10 months to 82 years. The most common symptom was the febrile syndrome (123/147; 91.8%); cardiac alterations were present in 33/100 (33%), (2/147; 1.4%) had severe ACD with meningoencephalitis, and 12 (8.2%) were asymptomatic. Most cases were diagnosed through thick blood smear (132/147; 89.8%), a few (14/147; 9.5%) were diagnosed by serology and (1/147; 0.7%) by polymerase chain reaction (PCR) and blood culture. In all these outbreaks, 74.1% of the patients were analysed by PCR, and Trypanosoma cruzi TcIV was detected in all of them. No deaths were recorded. The incidence of these foci coincided with the fruit harvest period in the state of Amazonas. Conclusion: The occurrence of ACD outbreaks in the Amazon affected individuals of both sexes, young adults, living in rural and peri-urban areas and related to the consumption of regional foods. Early diagnosis is an important factor in surveillance. There was a low frequency of cardiac alterations. Continuous follow-up of most patients was not carried out due to difficulty in getting to specialised centres; therefore, little is known about post-treatment.
MeSH term(s)	Male ; Female ; Young Adult ; Humans ; Brazil/epidemiology ; Chagas Disease/epidemiology ; Trypanosoma cruzi ; Disease Outbreaks ; Eating
Language	English
Publishing date	2023-06-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1314080-2
ISSN	1365-3156 ; 1360-2276
ISSN (online)	1365-3156
ISSN	1360-2276
DOI	10.1111/tmi.13899
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Article ; Online: Implantable cardioverter-defibrillator prevents sudden death in patients with Chagas cardiomyopathy in the Brazilian Amazon.

Couceiro, Katia do Nascimento / Ortiz, Jessica Vanina / Silva, Mônica Regina Hosannah da Silva E / Sousa, Débora Raysa Teixeira de / Souza, Kenny Rodrigues de / Alencar, Gabriela Maciel / Magalhães, Laylah Kelre Costa / Guerra, Maria das Graças Vale Barbosa / Ferreira, João Marcos Bemfica Barbosa / Guerra, Jorge Augusto de Oliveira

Revista da Sociedade Brasileira de Medicina Tropical

2021 Volume 54, Page(s) e0480–2020

Abstract: Chagas disease (CD), with approximately 10,000 deaths annually, has become a worldwide health problem. Approximately 35% of cases may show cardiac manifestations such as arrhythmias and/or conduction disorders, heart failure, thromboembolic accidents, ... ...

Abstract	Chagas disease (CD), with approximately 10,000 deaths annually, has become a worldwide health problem. Approximately 35% of cases may show cardiac manifestations such as arrhythmias and/or conduction disorders, heart failure, thromboembolic accidents, and sudden death. The Amazon region has long been considered a non-endemic area for CD; however, in the last decades, with an increase in the number of acute and chronic cases, disease evolution has received greater attention. Here, we report the successful implementation of a cardioverter-defibrillator for the prevention of sudden death in a patient with autochthonous Chagas cardiomyopathy in the Brazilian Amazon.
MeSH term(s)	Brazil ; Chagas Cardiomyopathy/complications ; Death, Sudden, Cardiac/prevention & control ; Defibrillators, Implantable ; Electrocardiography ; Humans
Language	English
Publishing date	2021-03-22
Publishing country	Brazil
Document type	Case Reports
ZDB-ID	1038126-0
ISSN	1678-9849 ; 0037-8682
ISSN (online)	1678-9849
ISSN	0037-8682
DOI	10.1590/0037-8682-0480-2020
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Article ; Online: Myocardial Injury in Patients With Acute and Subacute Chagas Disease in the Brazilian Amazon Using Cardiovascular Magnetic Resonance.

Couceiro, Katia do Nascimento / Ortiz, Jessica Vanina / Hosannah da Silva E Silva, Mônica Regina / Teixeira de Sousa, Débora Raysa / Andrade, Rubens Celso / Brandão, Alba Regina Jorge / de Morais, Rômulo Freire / Smith Doria, Susan / Fonseca, Rafael Almeida / da Silva, Paula Rita Leite / Fernandes, Fabio / Guerra, Maria das Graças Vale Barbosa / Rochitte, Carlos Eduardo / Ferreira, João Marcos Bemfica Barbosa / Guerra, Jorge Augusto de Oliveira

Journal of the American Heart Association

2022 Volume 11, Issue 13, Page(s) e021806

Abstract: Background Chagas disease is a neglected tropical disease that is still considered a global health emergency. In the Amazon region, most of the reports are of acute cases that are associated with oral transmission. This study aimed to evaluate myocardial ...

Abstract	Background Chagas disease is a neglected tropical disease that is still considered a global health emergency. In the Amazon region, most of the reports are of acute cases that are associated with oral transmission. This study aimed to evaluate myocardial injury in patients with acute Chagas disease before and after treatment. Methods and Results We evaluated 23 patients with acute Chagas disease in 3 different stages of progression. Group 1 had 12 patients evaluated during the acute phase, at the time of diagnosis, and 1 year after treatment, and Group 2 had 11 patients in the late postacute phase who were evaluated 5.2 years on average after diagnosis and treatment. ECGs with the Selvester score, 24-hour Holter exam, and cardiovascular magnetic resonance imaging were performed. The mean age of the 23 patients was 44.3±18.9 years, and they were mostly men (15/65.24%) from Amazonas state (22/95.6%). In 69.6% (n=16) of the patients, some ECG alterations were found, the most frequent being left anterior fascicular block and ventricular repolarization. In Group 1, the 24-hour Holter exam showed atrial tachycardia in 3 (25%) patients and ventricular extrasystoles in 2 (16.7%) patients. In Group 2, 1 patient had ventricular extrasystoles. Myocardial injury was observed in 7 patients (58.3%) at the acute phase and in 5 (50%) patients at the 1-year follow-up in Group 1 and in 2 (18.2%) patients in Group 2. Conclusions This article describes, for the first time, myocardial injury shown by cardiovascular magnetic resonance imaging in a group of patients with acute Chagas disease and reveals the importance of early detection and follow-up of the cardiac impairment in these patients.
MeSH term(s)	Adult ; Brazil/epidemiology ; Chagas Cardiomyopathy/diagnostic imaging ; Chagas Cardiomyopathy/epidemiology ; Chagas Disease/complications ; Electrocardiography ; Female ; Heart Injuries ; Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Male ; Middle Aged ; Ventricular Premature Complexes/complications
Language	English
Publishing date	2022-06-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.121.021806
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Article ; Online: Acute micro-outbreak of Chagas disease in the southeastern Amazon: a report of five cases.

Brito, Andreza Karoline Souza Barros de / Sousa, Débora Raysa Teixeira de / Silva Junior, Edson Fidelis da / Ruiz, Helton Jardys da Silva / Arcanjo, Ana Ruth Lima / Ortiz, Jessica Vanina / Brito, Sabrina Silva de / Jesus, Denison Vital / Lima, Jorge Rubens Coelho de / Couceiro, Kátia do Nascimento / Silva, Mônica Regina Hosannah da Silva E / Ferreira, João Marcos Bemfica Barbosa / Guerra, Jorge Augusto Oliveira / Guerra, Maria das Graças Vale Barbosa

Revista da Sociedade Brasileira de Medicina Tropical

2022 Volume 55, Page(s) e0687

Abstract: Background: Chagas disease is gaining importance in the Brazilian Amazon region as a differential diagnosis of febrile syndrome. The most recent microoutbreak occurred in Ipixuna, in Amazonas state.: Methods: An epidemiological survey was conducted ... ...

Abstract	Background: Chagas disease is gaining importance in the Brazilian Amazon region as a differential diagnosis of febrile syndrome. The most recent microoutbreak occurred in Ipixuna, in Amazonas state. Methods: An epidemiological survey was conducted using parasitological and serological tests, and electrocardiographic analysis. Results: The patients belonged to one family and had ingested açaí acquired from Ipixuna. All patients reported fever and initially a thick blood smear test was done to identify Trypanosoma cruzi. Benznidazole treatment was administered to all patients. Conclusions: Knowledge of the epidemiological dynamics of Chagas disease allows us to improve control and management measures for this disease.
MeSH term(s)	Brazil/epidemiology ; Chagas Disease/diagnosis ; Chagas Disease/drug therapy ; Chagas Disease/epidemiology ; Disease Outbreaks ; Humans ; Trypanosoma cruzi
Language	English
Publishing date	2022-08-22
Publishing country	Brazil
Document type	Case Reports ; Journal Article
ZDB-ID	1038126-0
ISSN	1678-9849 ; 0037-8682
ISSN (online)	1678-9849
ISSN	0037-8682
DOI	10.1590/0037-8682-0687-2021
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Article ; Online: Chronic Heart Disease after Treatment of Oral Acute Chagas Disease.

Antunes, Andrei Fornanciari / Maduro, Simão Gonçalves / Pereira, Bruna Valessa Moutinho / Barbosa, Maria das Graças Vale / Guerra, Jorge Augusto de Oliveira / Ferreira, João Marcos Bemfica Barbosa

Arquivos brasileiros de cardiologia

2016 Volume 107, Issue 2, Page(s) 184–186

Abstract: We describe the recurrence of cardiac abnormalities in a patient treated during the acute phase of Chagas disease after outpatient follow-up of 5 years. ...

Abstract	We describe the recurrence of cardiac abnormalities in a patient treated during the acute phase of Chagas disease after outpatient follow-up of 5 years.
MeSH term(s)	Acute Disease ; Adolescent ; Arrhythmias, Cardiac/drug therapy ; Arrhythmias, Cardiac/etiology ; Chagas Cardiomyopathy/drug therapy ; Chagas Disease/drug therapy ; Electrocardiography ; Humans ; Male ; Nitroimidazoles/therapeutic use ; Recurrence ; Trypanocidal Agents/therapeutic use
Chemical Substances	Nitroimidazoles ; Trypanocidal Agents ; benzonidazole (YC42NRJ1ZD)
Language	Portuguese
Publishing date	2016-08
Publishing country	Brazil
Document type	Case Reports ; Journal Article
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.5935/abc.20160115
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Article ; Online: The Selvester QRS score as an estimative of myocardial injury in acute chagasic patients from the Brazilian Amazon.

do Nascimento Couceiro, Katia / Ortiz, Jessica Vanina / do Nascimento Correia, Michael / da Silva E Silva, Mônica Regina Hosannah / Brandão, Alba Regina / da Silva, Paula Rita Leite / Doria, Susan Smith / Bestetti, Reinaldo Bulgarelli / de Sousa, Débora Raysa Teixeira / da Silva Junior, Rubens Celso Andrade / das Graças Vale Barbosa Guerra, Maria / Ferreira, João Marcos Bemfica Barbosa / de Oliveira Guerra, Jorge Augusto

BMC infectious diseases

2021 Volume 21, Issue 1, Page(s) 396

Abstract: Background: In the Brazilian Amazon, a new epidemiological profile of Chagas disease transmission, the oral route, has been detected and cited as being responsible for the increase in acute cases in Brazil. The clinical evaluation of acute Chagas ... ...

Abstract	Background: In the Brazilian Amazon, a new epidemiological profile of Chagas disease transmission, the oral route, has been detected and cited as being responsible for the increase in acute cases in Brazil. The clinical evaluation of acute Chagas disease (ACD) has been a challenge since it can progress to a chronic phase with cardiac alterations, and the follow-up by modern diagnostic methods is very difficult due to the socio-geographical characteristics of the Brazilian Amazon. Thus, alternatives should be sought to alleviate this problem. We conducted a study to evaluate subjects with ACD using the 12-lead ECG QRS score (Selvester score) as an estimative of myocardial injury progression before and after ACD treatment. Methods: The study included indigenous subjects from the Amazon region with ACD in clinical follow-up at the Fundação de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD) Chagas Disease outpatient clinic in the state of Amazonas, Brazil. The control group consisted of 31 healthy volunteers with no history of heart disease and no reactive serology for Chagas disease. Baseline ECG was performed in all subjects. The Selvester scoring method was performed according to the standardized guide (< 3 points: no myocardial injury,> 3: points × 3% = % of the predicted LV infarction). Results: A total of 62 subjects were included, 31 as cases and 31 as controls. The mean follow-up of the case group was 17 months. The control group presented normal ECG. The case group presented 13 alterations before treatment and 11 after. Nineteen individuals presented scores > 3 points, 6 before and 13 after. In 19.36% of subjects, myocardial injury was found before treatment and in 41.94% after treatment. Conclusion: This is the first study that uses the Selvester score (SS) to predict myocardial injury in subjects with ACD. The results of this study suggest the significant presence of myocardial injury from the beginning of treatment to the period post treatment of ACD, which demonstrates that the SS can be applied for stratification and follow-up of Chagas disease in the Amazon region.
MeSH term(s)	Adult ; Brazil/ethnology ; Chagas Disease/complications ; Chagas Disease/drug therapy ; Chagas Disease/physiopathology ; Coronary Artery Disease/diagnostic imaging ; Electrocardiography/methods ; Female ; Heart/diagnostic imaging ; Heart/physiopathology ; Humans ; Indigenous Peoples ; Longitudinal Studies ; Male ; Middle Aged
Language	English
Publishing date	2021-04-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-021-06083-x
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Article ; Online: Cardiac Evaluation in the Acute Phase of Chagas' Disease with Post-Treatment Evolution in Patients Attended in the State of Amazonas, Brazil.

Ortiz, Jessica Vanina / Pereira, Bruna Valessa Moutinho / Couceiro, Katia do Nascimento / Silva, Monica Regina Hosannah da Silva E / Doria, Susan Smith / Silva, Paula Rita Leite da / Lira, Edson da Fonseca de / Guerra, Maria das Graças Vale Barbosa / Guerra, Jorge Augusto de Oliveira / Ferreira, João Marcos Bemfica Barbosa

Arquivos brasileiros de cardiologia

2019 Volume 112, Issue 3, Page(s) 240–246

Abstract: Background: In the past two decades, a new epidemiological profile of Chagas' disease (CD) has been registered in the Brazilian Amazon where oral transmission has been indicated as responsible for the increase of acute cases. In the Amazonas state, five ...

Abstract	Background: In the past two decades, a new epidemiological profile of Chagas' disease (CD) has been registered in the Brazilian Amazon where oral transmission has been indicated as responsible for the increase of acute cases. In the Amazonas state, five outbreaks of acute CD have been registered since 2004. The cardiac manifestations in these cases may be characterized by diffuse myocarditis, with alteration in the electrocardiogram (ECG) and transthoracic echocardiogram (TTE). Objective: To perform a cardiac evaluation in autochthonous patients in the acute phase and at least one year after submitted to treatment for acute CD and evaluate the demographic variables associated with the presence of cardiac alterations. Methods: We evaluated patients diagnosed with acute CD through direct parasitological or serological (IgM) methods from 2007 to 2015. These patients were treated with benznidazole and underwent ECG and TTE before and after treatment. We assumed a confidence interval of 95% (CI 95%, p < 0.05) for all variables analyzed. Results: We observed 63 cases of an acute CD in which oral transmission corresponded to 75%. Cardiac alterations were found in 33% of the cases, with a greater frequency of ventricular repolarization alteration (13%), followed by pericardial effusion (10%) and right bundle branch block and left anterior fascicular block (2%). The follow-up occurred in 48 patients with ECG and 25 with TTE for a mean period of 15.5 ± 4.1 months after treatment. Of these, 8% presented normalization of the cardiac alterations in ECG, 62.5% remained with the normal exams. All of the patients presented normal results in TTE in the post-treatment period. As for the demographic variables, isolated cases presented more cardiac alterations than outbreaks (p = 0.044) as well as cases from Central Amazonas mesoregion (p = 0.020). Conclusions: Although cardiac alterations have not been frequent in most of the studied population, a continuous evaluation of the clinical-epidemiological dynamics of the disease in the region is necessary in order to establish preventive measures.
MeSH term(s)	Adolescent ; Adult ; Brazil/epidemiology ; Chagas Cardiomyopathy/diagnostic imaging ; Chagas Cardiomyopathy/parasitology ; Chagas Disease/complications ; Chagas Disease/drug therapy ; Chagas Disease/epidemiology ; Echocardiography ; Electrocardiography ; Female ; Follow-Up Studies ; Humans ; Male ; Nitroimidazoles/therapeutic use ; Trypanocidal Agents/therapeutic use ; Trypanosoma cruzi/isolation & purification ; Young Adult
Chemical Substances	Nitroimidazoles ; Trypanocidal Agents ; benzonidazole (YC42NRJ1ZD)
Language	Portuguese
Publishing date	2019-01-07
Publishing country	Brazil
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.5935/abc.20190007
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