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  1. AU="Ferreira, Laís Pereira"
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  1. Article ; Online: Congenital Zika Syndrome Is Associated With Interferon Alfa Receptor 1.

    Azamor, Tamiris / Cunha, Daniela Prado / da Silva, Andréa Marques Vieira / Bezerra, Ohanna Cavalcanti de Lima / Ribeiro-Alves, Marcelo / Calvo, Thyago Leal / Kehdy, Fernanda de Souza Gomes / Manta, Fernanda Saloum de Neves / Pinto, Thiago Gomes de Toledo / Ferreira, Laís Pereira / Portari, Elyzabeth Avvad / Guida, Letícia da Cunha / Gomes, Leonardo / Moreira, Maria Elisabeth Lopes / de Carvalho, Elizeu Fagundes / Cardoso, Cynthia Chester / Muller, Marcelo / Ano Bom, Ana Paula Dinis / Neves, Patrícia Cristina da Costa /
    Vasconcelos, Zilton / Moraes, Milton Ozório

    Frontiers in immunology

    2021  Volume 12, Page(s) 764746

    Abstract: Host factors that influence Congenital Zika Syndrome (CZS) outcome remain elusive. Interferons have been reported as the main antiviral factor in Zika and other flavivirus infections. Here, we accessed samples from 153 pregnant women (77 without and 76 ... ...

    Abstract Host factors that influence Congenital Zika Syndrome (CZS) outcome remain elusive. Interferons have been reported as the main antiviral factor in Zika and other flavivirus infections. Here, we accessed samples from 153 pregnant women (77 without and 76 with CZS) and 143 newborns (77 without and 66 with CZS) exposed to ZIKV conducted a case-control study to verify whether interferon alfa receptor 1 (
    MeSH term(s) Female ; Genotype ; Humans ; Infant, Newborn ; Interleukins/genetics ; Interleukins/immunology ; Polymorphism, Single Nucleotide/genetics ; Polymorphism, Single Nucleotide/immunology ; Pregnancy ; Pregnancy Complications, Infectious/genetics ; Pregnancy Complications, Infectious/immunology ; Receptor, Interferon alpha-beta/genetics ; Receptor, Interferon alpha-beta/immunology ; Zika Virus Infection/genetics ; Zika Virus Infection/immunology
    Chemical Substances IFNAR1 protein, human ; interferon-lambda, human ; IFNL4 protein, human ; Interleukins ; Receptor, Interferon alpha-beta (156986-95-7)
    Language English
    Publishing date 2021-11-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.764746
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Putative pathogen-selected polymorphisms in the PKLR gene are associated with mycobacterial susceptibility in Brazilian and African populations.

    Bezerra, Ohanna Cavalcanti de Lima / Alvarado-Arnez, Lucia Elena / Mabunda, Nédio / Salomé, Graça / de Sousa, Amina / Kehdy, Fernanda de Souza Gomes / Sales-Marques, Carolinne / Manta, Fernanda Saloum de Neves / Andrade, Rafaela Mota / Ferreira, Laís Pereira / Leal-Calvo, Thyago / Cardoso, Cynthia Chester / Nunes, Kelly / Gouveia, Mateus H / Mbulaiteve, Sam M / Yeboah, Edward D / Hsing, Ann / Latini, Ana Carla Pereira / Leturiondo, André Luiz /
    Rodrigues, Fabíola da Costa / Noronha, Ariani Batista / Ferreira, Cynthia de Oliveira / Talhari, Carolina / Rêgo, Jamile Leão / Castellucci, Léa Cristina de Carvalho / Tarazona-Santos, Eduardo / Carvalho, Elizeu Fagundes de / Meyer, Diogo / Pinheiro, Roberta Olmo / Jani, Ilesh V / Pacheco, Antonio Guilherme / Moraes, Milton Ozório

    PLoS neglected tropical diseases

    2021  Volume 15, Issue 8, Page(s) e0009434

    Abstract: Pyruvate kinase (PK), encoded by the PKLR gene, is a key player in glycolysis controlling the integrity of erythrocytes. Due to Plasmodium selection, mutations for PK deficiency, which leads to hemolytic anemia, are associated with resistance to malaria ... ...

    Abstract Pyruvate kinase (PK), encoded by the PKLR gene, is a key player in glycolysis controlling the integrity of erythrocytes. Due to Plasmodium selection, mutations for PK deficiency, which leads to hemolytic anemia, are associated with resistance to malaria in sub-Saharan Africa and with susceptibility to intracellular pathogens in experimental models. In this case-control study, we enrolled 4,555 individuals and investigated whether PKLR single nucleotide polymorphisms (SNPs) putatively selected for malaria resistance are associated with susceptibility to leprosy across Brazil (Manaus-North; Salvador-Northeast; Rondonópolis-Midwest and Rio de Janeiro-Southeast) and with tuberculosis in Mozambique. Haplotype T/G/G (rs1052176/rs4971072/rs11264359) was associated with leprosy susceptibility in Rio de Janeiro (OR = 2.46, p = 0.00001) and Salvador (OR = 1.57, p = 0.04), and with tuberculosis in Mozambique (OR = 1.52, p = 0.07). This haplotype downregulates PKLR expression in nerve and skin, accordingly to GTEx, and might subtly modulate ferritin and haptoglobin levels in serum. Furthermore, we observed genetic signatures of positive selection in the HCN3 gene (xpEHH>2 -recent selection) in Europe but not in Africa, involving 6 SNPs which are PKLR/HCN3 eQTLs. However, this evidence was not corroborated by the other tests (FST, Tajima's D and iHS). Altogether, we provide evidence that a common PKLR locus in Africans contribute to mycobacterial susceptibility in African descent populations and also highlight, for first, PKLR as a susceptibility gene for leprosy and TB.
    MeSH term(s) Adult ; Brazil ; Case-Control Studies ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Haplotypes ; Humans ; Linkage Disequilibrium ; Logistic Models ; Malaria/genetics ; Male ; Middle Aged ; Mozambique ; Polymorphism, Single Nucleotide ; Pyruvate Kinase/deficiency ; Pyruvate Kinase/genetics ; Young Adult
    Chemical Substances PKLR protein, human (EC 2.7.1.40) ; Pyruvate Kinase (EC 2.7.1.40)
    Language English
    Publishing date 2021-08-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0009434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A global metagenomic map of urban microbiomes and antimicrobial resistance

    Danko, David / Bezdan, Daniela / Afshin, Evan E / Ahsanuddin, Sofia / Bhattacharya, Chandrima / Butler, Daniel J / Chng, Kern Rei / Donnellan, Daisy / Hecht, Jochen / Jackson, Katelyn / Kuchin, Katerina / Karasikov, Mikhail / Lyons, Abigail / Mak, Lauren / Meleshko, Dmitry / Mustafa, Harun / Mutai, Beth / Neches, Russell Y / Ng, Amanda /
    Nikolayeva, Olga / Nikolayeva, Tatyana / Png, Eileen / Ryon, Krista A / Sanchez, Jorge L / Shaaban, Heba / Sierra, Maria A / Thomas, Dominique / Young, Ben / Abudayyeh, Omar O / Alicea, Josue / Bhattacharyya, Malay / Blekhman, Ran / Castro-Nallar, Eduardo / Cañas, Ana M / Chatziefthimiou, Aspassia D / Crawford, Robert W / De Filippis, Francesca / Deng, Youping / Desnues, Christelle / Dias-Neto, Emmanuel / Dybwad, Marius / Elhaik, Eran / Ercolini, Danilo / Frolova, Alina / Gankin, Dennis / Gootenberg, Jonathan S / Graf, Alexandra B / Green, David C / Hajirasouliha, Iman / Hastings, Jaden J.A / Hernandez, Mark / Iraola, Gregorio / Jang, Soojin / Kahles, Andre / Kelly, Frank J / Knights, Kaymisha / Kyrpides, Nikos C / Łabaj, Paweł P / Lee, Patrick K.H / Leung, Marcus H.Y / Ljungdahl, Per O / Mason-Buck, Gabriella / McGrath, Ken / Meydan, Cem / Mongodin, Emmanuel F / Moraes, Milton Ozorio / Nagarajan, Niranjan / Nieto-Caballero, Marina / Noushmehr, Houtan / Oliveira, Manuela / Ossowski, Stephan / Osuolale, Olayinka O / Özcan, Orhan / Paez-Espino, David / Rascovan, Nicolás / Richard, Hugues / Rätsch, Gunnar / Schriml, Lynn M / Semmler, Torsten / Sezerman, Osman U / Shi, Leming / Shi, Tieliu / Siam, Rania / Song, Le Huu / Suzuki, Haruo / Court, Denise Syndercombe / Tighe, Scott W / Tong, Xinzhao / Udekwu, Klas I / Ugalde, Juan A / Valentine, Brandon / Vassilev, Dimitar I / Vayndorf, Elena M / Velavan, Thirumalaisamy P / Wu, Jun / Zambrano, María M / Zhu, Jifeng / Zhu, Sibo / Mason, Christopher E / Abdullah, Natasha / Abraao, Marcos / Adel, Ait-hamlat / Afaq, Muhammad / Al-Quaddoomi, Faisal S / Alam, Ireen / Albuquerque, Gabriela E / Alexiev, Alex / Ali, Kalyn / Alvarado-Arnez, Lucia E / Aly, Sarh / Amachee, Jennifer / Amorim, Maria G / Ampadu, Majelia / Amran, Muhammad Al-Fath / An, Nala / Andrew, Watson / Andrianjakarivony, Harilanto / Angelov, Michael / Antelo, Verónica / Aquino, Catharine / Aranguren, Álvaro / Araujo, Luiza F / Vasquez Arevalo, Hitler Francois / Arevalo, Jenny / Arnan, Carme / Alvarado Arnez, Lucia Elena / Arredondo, Fernanda / Arthur, Matthew / Asenjo, Freddy / Aung, Thomas Saw / Auvinet, Juliette / Aventin, Nuria / Ayaz, Sadaf / Baburyan, Silva / Bakere, Abd-Manaaf / Bakhl, Katrin / Bartelli, Thais F / Batdelger, Erdenetsetseg / Baudon, François / Becher, Kevin / Bello, Carla / Benchouaia, Médine / Benisty, Hannah / Benoiston, Anne-Sophie / Benson, Joseph / Benítez, Diego / Bernardes, Juliana / Bertrand, Denis / Beurmann, Silvia / Bitard-Feildel, Tristan / Bittner, Lucie / Black, Christina / Blanc, Guillaume / Blyther, Brittany / Bode, Toni / Boeri, Julia / Boldgiv, Bazartseren / Bolzli, Kevin / Bordigoni, Alexia / Borrelli, Ciro / Bouchard, Sonia / Bouly, Jean-Pierre / Boyd, Alicia / Branco, Gabriela P / Breschi, Alessandra / Brindefalk, Björn / Brion, Christian / Briones, Alan / Buczansla, Paulina / Burke, Catherine M / Burrell, Aszia / Butova, Alina / Buttar, Irvind / Bynoe, Jalia / Bönigk, Sven / Bøifot, Kari O / Caballero, Hiram / Cai, Xiao Wen / Calderon, Dayana / Cantillo, Angela / Carbajo, Miguel / Carbone, Alessandra / Cardenas, Anais / Carrillo, Katerine / Casalot, Laurie / Castro, Sofia / Castro, Ana V / Castro, Astred / Castro, Ana Valeria B / Cawthorne, Simone / Cedillo, Jonathan / Chaker, Salama / Chalangal, Jasna / Chan, Allison / Chasapi, Anastasia I / Chatziefthimiou, Starr / Chaudhuri, Sreya Ray / Chavan, Akash Keluth / Chavez, Francisco / Chem, Gregory / Chen, Xiaoqing / Chen, Michelle / Chen, Jenn-Wei / Chernomoretz, Ariel / Chettouh, Allaeddine / Cheung, Daisy / Chicas, Diana / Chiu, Shirley / Choudhry, Hira / Chrispin, Carl / Ciaramella, Kianna / Cifuentes, Erika / Cohen, Jake / Coil, David A / Collin, Sylvie / Conger, Colleen / Conte, Romain / Corsi, Flavia / Cossio, Cecilia N / Costa, Ana F / Cuebas, Delisia / D’Alessandro, Bruno / Dahlhausen, Katherine E / Darling, Aaron E / Das, Pujita / Davenport, Lucinda B / David, Laurent / Davidson, Natalie R / Dayama, Gargi / Delmas, Stéphane / Deng, Chris K / Dequeker, Chloé / Desert, Alexandre / Devi, Monika / Dezem, Felipe S / Dias, Clara N / Donahoe, Timothy Ryan / Dorado, Sonia / Dorsey, LaShonda / Dotsenko, Valeriia / Du, Steven / Dutan, Alexandra / Eady, Naya / Eisen, Jonathan A / Elaskandrany, Miar / Epping, Lennard / Escalera-Antezana, Juan P / Ettinger, Cassie L / Faiz, Iqra / Fan, Luice / Farhat, Nadine / Faure, Emile / Fauzi, Fazlina / Feigin, Charlie / Felice, Skye / Ferreira, Laís Pereira / Figueroa, Gabriel / Fleiss, Aubin / Flores, Denisse / Velasco Flores, Jhovana L / Fonseca, Marcos A.S / Foox, Jonathan / Forero, Juan Carlos / Francis, Aaishah / French, Kelly / Fresia, Pablo / Friedman, Jacob / Fuentes, Jaime J / Galipon, Josephine / Garcia, Mathilde / Garcia, Laura / García, Catalina / Geiger, Annie / Gerner, Samuel M / Ghose, Sonia L / Giang, Dao Phuong / Giménez, Matías / Giovannelli, Donato / Githae, Dedan / Gkotzis, Spyridon / Godoy, Liliana / Goldman, Samantha / Gonnet, Gaston H / Gonzalez, Juana / Gonzalez, Andrea / Gonzalez-Poblete, Camila / Gray, Andrew / Gregory, Tranette / Greselle, Charlotte / Guasco, Sophie / Guerra, Juan / Gurianova, Nika / Haehr, Wolfgang / Halary, Sebastien / Hartkopf, Felix / Hawkins-Zafarnia, Arya / Hazrin-Chong, Nur Hazlin / Helfrich, Eric / Hell, Eva / Henry, Tamera / Hernandez, Samuel / Hernandez, Pilar Lopez / Hess-Homeier, David / Hittle, Lauren E / Hoan, Nghiem Xuan / Holik, Aliaksei / Homma, Chiaki / Hoxie, Irene / Huber, Michael / Humphries, Elizabeth / Hyland, Stephanie / Hässig, Andrea / Häusler, Roland / Hüsser, Nathalie / Petit, Robert A / Iderzorig, Badamnyambuu / Igarashi, Mizuki / Iqbal, Shaikh B / Ishikawa, Shino / Ishizuka, Sakura / Islam, Sharah / Islam, Riham / Ito, Kohei / Ito, Sota / Ito, Takayuki / Ivankovic, Tomislav / Iwashiro, Tomoki / Jackson, Sarah / Jacobs, JoAnn / James, Marisano / Jaubert, Marianne / Jerier, Marie-Laure / Jiminez, Esmeralda / Jinfessa, Ayantu / De Jong, Ymke / Joo, Hyun Woo / Jospin, Guilllaume / Kajita, Takema / Ahmad Kassim, Affifah Saadah / Kato, Nao / Kaur, Amrit / Kaur, Inderjit / de Souza Gomes Kehdy, Fernanda / Khadka, Vedbar S / Khan, Shaira / Khavari, Mahshid / Ki, Michelle / Kim, Gina / Kim, Hyung Jun / Kim, Sangwan / King, Ryan J / KoLoMonaco, Giuseppe / Koag, Ellen / Kobko-Litskevitch, Nadezhda / Korshevniuk, Maryna / Kozhar, Michael / Krebs, Jonas / Kubota, Nanami / Kuklin, Andrii / Kumar, Sheelta S / Kwong, Rachel / Kwong, Lawrence / Lafontaine, Ingrid / Lago, Juliana / Lai, Tsoi Ying / Laine, Elodie / Laiola, Manolo / Lakhneko, Olha / Lamba, Isha / de Lamotte, Gerardo / Lannes, Romain / De Lazzari, Eleonora / Leahy, Madeline / Lee, Hyunjung / Lee, Yunmi / Lee, Lucy / Lemaire, Vincent / Leong, Emily / Lewandowska, Dagmara / Li, Chenhao / Liang, Weijun / Lin, Moses / Lisboa, Priscilla / Litskevitch, Anna / Liu, Eric Minwei / Liu, Tracy / Livia, Mayra Arauco / Lo, Yui Him / Losim, Sonia / Loubens, Manon / Lu, Jennifer / Lykhenko, Olexandr / Lysakova, Simona / Mahmoud, Salah / Majid, Sara Abdul / Makogon, Natalka / Maldonado, Denisse / Mallari, Krizzy / Malta, Tathiane M / Mamun, Maliha / Manoir, Dimitri / Marchandon, German / Marciniak, Natalia / Marinovic, Sonia / Marques, Brunna / Mathews, Nicole / Matsuzaki, Yuri / Matthys, Vincent / May, Madelyn / McComb, Elias / Meagher, Annabelle / Melamed, Adiell / Menary, Wayne / Mendez, Katterinne N / Mendez, Ambar / Mendy, Irène Mauricette / Meng, Irene / Menon, Ajay / Menor, Mark / Meoded, Roy / Merino, Nancy / Miah, Karishma / Mignotte, Mathilde / Miketic, Tanja / Miranda, Wilson / Mitsios, Athena / Miura, Ryusei / Miyake, Kunihiko / Moccia, Maria D / Mohan, Natasha / Mohsin, Mohammed / Moitra, Karobi / Moldes, Mauricio / Molina, Laura / Molinet, Jennifer / Molomjamts, Orgil-Erdene / Moniruzzaman, Eftar / Moon, Sookwon / de Oliveira Moraes, Isabelle / Moreno, Mario / Mosella, Maritza S / Moser, Josef W / Mozsary, Christopher / Muehlbauer, Amanda L / Muner, Oasima / Munia, Muntaha / Munim, Naimah / Muscat, Maureen / Mustac, Tatjana / Muñoz, Cristina / Nadalin, Francesca / Naeem, Areeg / Nagy-Szakal, Dorottya / Nakagawa, Mayuko / Narce, Ashanti / Nasu, Masaki / Navarrete, Irene González / Naveed, Hiba / Nazario, Bryan / Nedunuri, Narasimha Rao / Neff, Thomas / Nesimi, Aida / Ng, Wan Chiew / Ng, Synti / Nguyen, Gloria / Ngwa, Elsy / Nicolas, Agier / Nicolas, Pierre / Nika, Abdollahi / Noorzi, Hosna / Nosrati, Avigdor / Nunes, Diana N / O’Brien, Kathryn / O’Hara, Niamh B / Oken, Gabriella / Olawoyin, Rantimi A / Oliete, Javier Quilez / Olmeda, Kiara / Oluwadare, Tolulope / Oluwadare, Itunu A / Ordioni, Nils / Orpilla, Jenessa / Orrego, Jacqueline / Ortega, Melissa / Osma, Princess / Osuolale, Israel O / Osuolale, Oluwatosin M / Ota, Mitsuki / Oteri, Francesco / Oto, Yuya / Ounit, Rachid / Ouzounis, Christos A / Pakrashi, Subhamitra / Paras, Rachel / Pardo-Este, Coral / Park, Young-Ja / Pastuszek, Paulina / Patel, Suraj / Pathmanathan, Jananan / Patrignani, Andrea / Perez, Manuel / Peros, Ante / Persaud, Sabrina / Peters, Anisia / Phillips, Adam / Pineda, Lisbeth / Pizzi, Melissa P / Plaku, Alma / Plaku, Alketa / Pompa-Hogan, Brianna / Portilla, María Gabriela / Posada, Leonardo / Priestman, Max / Prithiviraj, Bharath / Priya, Sambhawa / Pugdeethosal, Phanthira / Pugh, Catherine E / Pulatov, Benjamin / Pupiec, Angelika / Pyrshev, Kyrylo / Qing, Tao / Rahiel, Saher / Rahmatulloev, Savlatjon / Rajendran, Kannan / Ramcharan, Aneisa / Ramirez-Rojas, Adan / Rana, Shahryar / Ratnanandan, Prashanthi / Read, Timothy D / Rehrauer, Hubert / Richer, Renee / Rivera, Alexis / Rivera, Michelle / Robertiello, Alessandro / Robinson, Courtney / Rodríguez, Paula / Rojas, Nayra Aguilar / Roldán, Paul / Rosario, Anyelic / Roth, Sandra / Ruiz, Maria / Boja Ruiz, Stephen Eduard / Russell, Kaitlan / Rybak, Mariia / Sabedot, Thais S / Sabina, Mahfuza / Saito, Ikuto / Saito, Yoshitaka / Malca Salas, Gustavo Adolfo / Salazar, Cecilia / San, Kaung Myat / Sanchez, Jorge / Sanchir, Khaliun / Sankar, Ryan / de Souza Santos, Paulo Thiago / Saravi, Zulena / Sasaki, Kai / Sato, Yuma / Sato, Masaki / Sato, Seisuke / Sato, Ryo / Sato, Kaisei / Sayara, Nowshin / Schaaf, Steffen / Schacher, Oli / Schinke, Anna-Lena M / Schlapbach, Ralph / Schori, Christian / Schriml, Jason R / Segato, Felipe / Sepulveda, Felipe / Serpa, Marianna S / De Sessions, Paola F / Severyn, Juan C / Shakil, Maheen / Shalaby, Sarah / Shari, Aliyah / Shim, Hyenah / Shirahata, Hikaru / Shiwa, Yuh / Da Silva, Ophélie / Silva, Jordana M / Simon, Gwenola / Singh, Shaleni K / Sluzek, Kasia / Smith, Rebecca / So, Eunice / Andreu Somavilla, Núria / Sonohara, Yuya / Rufino de Sousa, Nuno / Souza, Camila / Sperry, Jason / Sprinsky, Nicolas / Stark, Stefan G / La Storia, Antonietta / Suganuma, Kiyoshi / Suliman, Hamood / Sullivan, Jill / Supie, Arif Asyraf Md / Suzuki, Chisato / Takagi, Sora / Takahara, Fumie / Takahashi, Naoya / Takahashi, Kou / Takeda, Tomoki / Takenaka, Isabella K / Tanaka, Soma / Tang, Anyi / Man Tang, Yuk / Tarcitano, Emilio / Tassinari, Andrea / Taye, Mahdi / Terrero, Alexis / Thambiraja, Eunice / Thiébaut, Antonin / Thomas, Sade / Thomas, Andrew M / Togashi, Yuto / Togashi, Takumi / Tomaselli, Anna / Tomita, Masaru / Tomita, Itsuki / Toth, Oliver / Toussaint, Nora C / Tran, Jennifer M / Truong, Catalina / Tsonev, Stefan I / Tsuda, Kazutoshi / Tsurumaki, Takafumi / Tuz, Michelle / Tymoshenko, Yelyzaveta / Urgiles, Carmen / Usui, Mariko / Vacant, Sophie / Vann, Laura E / Velter, Fabienne / Ventorino, Valeria / Vera-Wolf, Patricia / Vicedomini, Riccardo / Suarez-Villamil, Michael A / Vincent, Sierra / Vivancos-Koopman, Renee / Wan, Andrew / Wang, Cindy / Warashina, Tomoro / Watanabe, Ayuki / Weekes, Samuel / Werner, Johannes / Westfall, David / Wieler, Lothar H / Williams, Michelle / Wolf, Silver A / Wong, Brian / Wong, Yan Ling / Wong, Tyler / Wright, Rasheena / Wunderlin, Tina / Yamanaka, Ryota / Yang, Jingcheng / Yano, Hirokazu / Yeh, George C / Yemets, Olena / Yeskova, Tetiana / Yoshikawa, Shusei / Zafar, Laraib / Zhang, Yang / Zhang, Shu / Zhang, Amy / Zheng, Yuanting / Zubenko, Stas

    Cell. 2021 June 24, v. 184, no. 13

    2021  

    Abstract: We present a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities over 3 years, representing the first systematic, worldwide catalog of the urban microbial ecosystem. This atlas provides an annotated, geospatial profile of ... ...

    Institution The International MetaSUB Consortium
    Abstract We present a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities over 3 years, representing the first systematic, worldwide catalog of the urban microbial ecosystem. This atlas provides an annotated, geospatial profile of microbial strains, functional characteristics, antimicrobial resistance (AMR) markers, and genetic elements, including 10,928 viruses, 1,302 bacteria, 2 archaea, and 838,532 CRISPR arrays not found in reference databases. We identified 4,246 known species of urban microorganisms and a consistent set of 31 species found in 97% of samples that were distinct from human commensal organisms. Profiles of AMR genes varied widely in type and density across cities. Cities showed distinct microbial taxonomic signatures that were driven by climate and geographic differences. These results constitute a high-resolution global metagenomic atlas that enables discovery of organisms and genes, highlights potential public health and forensic applications, and provides a culture-independent view of AMR burden in cities.
    Keywords Archaea ; antibiotic resistance ; climate ; forensic sciences ; humans ; metagenomics ; microbial ecology ; microbiome ; public health
    Language English
    Dates of publication 2021-0624
    Size p. 3376-3393.e17.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2021.05.002
    Database NAL-Catalogue (AGRICOLA)

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