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  1. Article ; Online: In-situ acceleration-speed profile of an elite soccer academy: A cross-sectional study.

    Cardoso, Pedro / Tavares, Francisco / Loureiro, Nuno / Ferreira, Ruben / Araújo, João Pedro / Reis, Joana / Vaz, João R

    Journal of sports sciences

    2024  Volume 41, Issue 20, Page(s) 1868–1874

    Abstract: Speed is an essential skill in sports performance and an important performance metric in talent identification. This study aims to evaluate and compare the sprint acceleration characteristics across different age groups in an elite soccer academy. A ... ...

    Abstract Speed is an essential skill in sports performance and an important performance metric in talent identification. This study aims to evaluate and compare the sprint acceleration characteristics across different age groups in an elite soccer academy. A total of 141 elite academy soccer players were recruited to participate in the study, and they were assigned to their respective competitive age groups, ranging from under-14 to the B-team. An individual in-situ acceleration-speed (A-S) profile was assessed and derived from Global Position System (GPS) speed-acceleration raw data, from 10 consecutive football sessions, in the beginning of the season. The results showed that under-14 players exhibited significantly lower theoretical maximum speed (S0) (
    MeSH term(s) Humans ; Soccer ; Cross-Sectional Studies ; Running ; Acceleration ; Athletic Performance
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 995528-8
    ISSN 1466-447X ; 0264-0414
    ISSN (online) 1466-447X
    ISSN 0264-0414
    DOI 10.1080/02640414.2024.2305005
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2388: Show issues Location:
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  2. Article ; Online: peri

    Franceschini, Marco / Crosta, Martina / Ferreira, Rúben R / Poletto, Daniele / Demitri, Nicola / Zobel, J Patrick / González, Leticia / Bonifazi, Davide

    Journal of the American Chemical Society

    2022  Volume 144, Issue 47, Page(s) 21470–21484

    Abstract: Here, we report the synthesis of BN-doped graphenoid nanoribbons, in which peripheral carbon atoms at the zigzag edges have been selectively replaced by boron and nitrogen atoms as BN and NBN motifs. This includes high-yielding ring closure key steps ... ...

    Abstract Here, we report the synthesis of BN-doped graphenoid nanoribbons, in which peripheral carbon atoms at the zigzag edges have been selectively replaced by boron and nitrogen atoms as BN and NBN motifs. This includes high-yielding ring closure key steps that, through
    Language English
    Publishing date 2022-11-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.2c06803
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    In stock of ZB MED Bonn / Germany

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  3. Article ; Online: Contribution of

    Motta-Raymundo, Adriana / Rosmaninho, Pedro / Santos, Diana F / Ferreira, Ruben D / Silva, Sara P / Ferreira, Cristina / Sousa, Ana E / Silva, Susana L

    Frontiers in immunology

    2022  Volume 13, Page(s) 834137

    Abstract: Common Variable Immunodeficiency (CVID), the most prevalent symptomatic primary immunodeficiency, is frequently associated with severe inflammatory complications that determine its morbidity and mortality. We hypothesize ... ...

    Abstract Common Variable Immunodeficiency (CVID), the most prevalent symptomatic primary immunodeficiency, is frequently associated with severe inflammatory complications that determine its morbidity and mortality. We hypothesize that
    MeSH term(s) Common Variable Immunodeficiency ; Gastric Mucosa ; Helicobacter Infections/complications ; Helicobacter Infections/epidemiology ; Helicobacter pylori ; Humans ; Stomach Neoplasms/epidemiology
    Language English
    Publishing date 2022-05-31
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.834137
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  4. Article ; Online: Tweaking the Optoelectronic Properties of S-Doped Polycyclic Aromatic Hydrocarbons by Chemical Oxidation.

    Matuszewska, Oliwia / Battisti, Tommaso / Ferreira, Ruben R / Biot, Nicolas / Demitri, Nicola / Mézière, Cécile / Allain, Magali / Sallé, Marc / Mañas-Valero, Samuel / Coronado, Eugenio / Fresta, Elisa / Costa, Rubén D / Bonifazi, Davide

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 29, Issue 11, Page(s) e202203115

    Abstract: Peri-thiaxanthenothiaxanthene, an S-doped analog of peri-xanthenoxanthene, is used as a polycyclic aromatic hydrocarbon (PAH) scaffold to tune the molecular semiconductor properties by editing the oxidation state of the S-atoms. Chemical oxidation of ... ...

    Abstract Peri-thiaxanthenothiaxanthene, an S-doped analog of peri-xanthenoxanthene, is used as a polycyclic aromatic hydrocarbon (PAH) scaffold to tune the molecular semiconductor properties by editing the oxidation state of the S-atoms. Chemical oxidation of peri-thiaxanthenothiaxanthene with H
    Language English
    Publishing date 2023-01-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202203115
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  5. Article ; Online: Photoreduction of Anthracenes Catalyzed by peri-Xanthenoxanthene: a Scalable and Sustainable Birch-Type Alternative.

    De Luca, Cristian / Zanetti, Davide / Battisti, Tommaso / Ferreira, Rúben R / Lopez, Sofia / McMillan, Alexander H / Lesher-Pérez, Sasha Cai / Maggini, Laura / Bonifazi, Davide

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 29, Issue 63, Page(s) e202302129

    Abstract: The typical Birch reduction transforms arenes into cyclohexa-1,4-dienes by using alkali metals, an alcohol as a proton source, and an amine as solvent. Capitalizing on the strong photoreductive properties of peri-xanthenoxanthene (PXX), herein we report ... ...

    Abstract The typical Birch reduction transforms arenes into cyclohexa-1,4-dienes by using alkali metals, an alcohol as a proton source, and an amine as solvent. Capitalizing on the strong photoreductive properties of peri-xanthenoxanthene (PXX), herein we report the photocatalyzed "Birch-type" reduction of acenes by employing visible blue light irradiation at room temperature in the presence of air. Upon excitation at 405 or 460 nm in the presence of a mixture of N,N-diisopropylethylamine (DIPEA) and trifluoromethanesulfonimide (HNTf
    Language English
    Publishing date 2023-10-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202302129
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  6. Article ; Online: International multicenter experience of transjugular intrahepatic portosystemic shunt implantation in patients with common variable immunodeficiency.

    Globig, Anna-Maria / Heeg, Maximilian / Larsen, Carsten Schade / Ferreira, Ruben Duarte / Kindle, Gerhard / Goldacker, Sigune / Strohmeier, Valentina / Silva, Susana L / Cunningham-Rundles, Charlotte / Quinti, Isabella / Thimme, Robert / Bettinger, Dominik / Schultheiß, Michael / Warnatz, Klaus

    The journal of allergy and clinical immunology. In practice

    2021  Volume 9, Issue 7, Page(s) 2931–2935.e1

    MeSH term(s) Common Variable Immunodeficiency ; Humans ; Liver Cirrhosis ; Portasystemic Shunt, Transjugular Intrahepatic
    Language English
    Publishing date 2021-03-13
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.02.056
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7086: Show issues Location:
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  7. Article: Mass spectrometry and ion mobility spectrometry of G-quadruplexes. A study of solvent effects on dimer formation and structural transitions in the telomeric DNA sequence d(TAGGGTTAGGGT)

    Ferreira, Rubén / Marchand, Adrien / Gabelica, Valérie

    Methods. 2012 May, v. 57, no. 1

    2012  

    Abstract: We survey here state of the art mass spectrometry methodologies for investigating G-quadruplexes, and will illustrate them with a new study on a simple model system: the dimeric G-quadruplex of the 12-mer telomeric DNA sequence d(TAGGGTTAGGGT), which can ...

    Abstract We survey here state of the art mass spectrometry methodologies for investigating G-quadruplexes, and will illustrate them with a new study on a simple model system: the dimeric G-quadruplex of the 12-mer telomeric DNA sequence d(TAGGGTTAGGGT), which can adopt either a parallel or an antiparallel structure. We will discuss the solution conditions compatible with electrospray ionisation, the quantification of complexes using ESI-MS, the interpretation of ammonium ion preservation in the complexes in the gas phase, and the use of ion mobility spectrometry to resolve ambiguities regarding the strand stoichiometry, or separate and characterise different structural isomers. We also describe that adding electrospray-compatible organic co-solvents (methanol, ethanol, isopropanol or acetonitrile) to aqueous ammonium acetate increases the stability and rate of formation of dimeric G-quadruplexes, and causes structural transitions to parallel structures. Structural changes were probed by circular dichroism and ion mobility spectrometry, and the excellent correlation between the two techniques validates the use of ion mobility to investigate G-quadruplex folding. We also demonstrate that parallel G-quadruplex structures are easier to preserve in the gas phase than antiparallel structures.
    Keywords DNA ; acetonitrile ; ammonium acetate ; electrospray ionization mass spectrometry ; ethanol ; gases ; ionization ; isomers ; isopropyl alcohol ; methanol ; nucleotide sequences ; solvents ; stoichiometry ; telomeres
    Language English
    Dates of publication 2012-05
    Size p. 56-63.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 1066584-5
    ISSN 1095-9130 ; 1046-2023
    ISSN (online) 1095-9130
    ISSN 1046-2023
    DOI 10.1016/j.ymeth.2012.03.021
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 3239: Show issues Location:
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  8. Article ; Online: Synthesis, DNA-binding and antiproliferative properties of acridine and 5-methylacridine derivatives.

    Ferreira, Rubén / Aviñó, Anna / Mazzini, Stefania / Eritja, Ramon

    Molecules (Basel, Switzerland)

    2012  Volume 17, Issue 6, Page(s) 7067–7082

    Abstract: Several acridine derivatives were synthesized and their anti-proliferative activity was determined. The most active molecules were derivatives of 5-methylacridine-4-carboxylic acid. The DNA binding properties of the synthesized acridines were analyzed by ...

    Abstract Several acridine derivatives were synthesized and their anti-proliferative activity was determined. The most active molecules were derivatives of 5-methylacridine-4-carboxylic acid. The DNA binding properties of the synthesized acridines were analyzed by competitive dialysis and compared with the anti-proliferative activities. While inactive acridine derivatives showed high selectivity for G-quadruplex structures, the most active 5-methylacridine-4-carboxamide derivatives had high affinity for DNA but showed poor specificity. An NMR titration study was performed with the most active 5-methylacridine-4-carboxamide, confirming the high affinity of this compound for both duplex and quadruplex DNAs.
    MeSH term(s) Acridines/chemical synthesis ; Acridines/chemistry ; Acridines/pharmacology ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; DNA/chemistry ; Humans ; Inhibitory Concentration 50 ; Nuclear Magnetic Resonance, Biomolecular
    Chemical Substances 5-methylacridine-4-carboxylic acid ; Acridines ; Antineoplastic Agents ; DNA (9007-49-2)
    Language English
    Publishing date 2012-06-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules17067067
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    Zs.MO 81: Show issues

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  9. Article ; Online: Mass spectrometry and ion mobility spectrometry of G-quadruplexes. A study of solvent effects on dimer formation and structural transitions in the telomeric DNA sequence d(TAGGGTTAGGGT).

    Ferreira, Rubén / Marchand, Adrien / Gabelica, Valérie

    Methods (San Diego, Calif.)

    2012  Volume 57, Issue 1, Page(s) 56–63

    Abstract: We survey here state of the art mass spectrometry methodologies for investigating G-quadruplexes, and will illustrate them with a new study on a simple model system: the dimeric G-quadruplex of the 12-mer telomeric DNA sequence d(TAGGGTTAGGGT), which can ...

    Abstract We survey here state of the art mass spectrometry methodologies for investigating G-quadruplexes, and will illustrate them with a new study on a simple model system: the dimeric G-quadruplex of the 12-mer telomeric DNA sequence d(TAGGGTTAGGGT), which can adopt either a parallel or an antiparallel structure. We will discuss the solution conditions compatible with electrospray ionisation, the quantification of complexes using ESI-MS, the interpretation of ammonium ion preservation in the complexes in the gas phase, and the use of ion mobility spectrometry to resolve ambiguities regarding the strand stoichiometry, or separate and characterise different structural isomers. We also describe that adding electrospray-compatible organic co-solvents (methanol, ethanol, isopropanol or acetonitrile) to aqueous ammonium acetate increases the stability and rate of formation of dimeric G-quadruplexes, and causes structural transitions to parallel structures. Structural changes were probed by circular dichroism and ion mobility spectrometry, and the excellent correlation between the two techniques validates the use of ion mobility to investigate G-quadruplex folding. We also demonstrate that parallel G-quadruplex structures are easier to preserve in the gas phase than antiparallel structures.
    MeSH term(s) Base Sequence ; Circular Dichroism ; DNA/chemistry ; G-Quadruplexes ; Nucleic Acid Conformation ; Solvents/chemistry ; Spectrometry, Mass, Electrospray Ionization ; Telomere
    Chemical Substances Solvents ; DNA (9007-49-2)
    Language English
    Publishing date 2012-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1066584-5
    ISSN 1095-9130 ; 1046-2023
    ISSN (online) 1095-9130
    ISSN 1046-2023
    DOI 10.1016/j.ymeth.2012.03.021
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    Zs.A 3239: Show issues Location:
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  10. Article ; Online: Calf injuries in professional football: Treat the patient or the scan? - A case study.

    Barreira, Paulo / Kassarjian, Ara / Araújo, João Pedro / Ferreira, Ruben / Espregueira Mendes, João

    Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine

    2016  Volume 21, Page(s) 63–67

    Abstract: Objective: To describe a case of a professional football player with significant imaging findings despite a rather innocuous clinical presentation with gradual onset of calf pain and who was able to continue training and playing with minor medical ... ...

    Abstract Objective: To describe a case of a professional football player with significant imaging findings despite a rather innocuous clinical presentation with gradual onset of calf pain and who was able to continue training and playing with minor medical intervention. To discuss some of the limitations of existing muscle injury grading systems and their potential to cover the full range of injury presentations for calf injuries.
    Design: Case report.
    Setting: A professional football player was assessed by physical examination, clinical testing and imaging (MRI) after a gradual onset of a calf injury. After returning to training and competition, a follow-up of his symptoms was performed with regular ultrasound imaging assessments.
    Participant: A professional football player (35 years, 1.90 m, 88 kg) male, African, striker, playing in the Professional Arabian Gulf League.
    Conclusion: The discordance between the clinical presentation and the imaging findings resulted in a challenging situation regarding the decision of whether to allow the player to train and compete. In addition, existing muscle injury grading systems do not seem to cover the full range of injuries seen in clinical practice.
    MeSH term(s) Adult ; Athletic Injuries/diagnostic imaging ; Athletic Injuries/therapy ; Humans ; Leg Injuries/diagnostic imaging ; Leg Injuries/therapy ; Magnetic Resonance Imaging ; Male ; Muscle, Skeletal/diagnostic imaging ; Muscle, Skeletal/injuries ; Soccer/injuries ; Ultrasonography, Interventional
    Language English
    Publishing date 2016-09
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2008604-0
    ISSN 1873-1600 ; 1466-853X
    ISSN (online) 1873-1600
    ISSN 1466-853X
    DOI 10.1016/j.ptsp.2016.01.004
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    Zs.A 5218: Show issues Location:
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