Article ; Online: Scalable generation of sensory neurons from human pluripotent stem cells.
2023 Volume 18, Issue 4, Page(s) 1030–1047
Abstract: Development of new non-addictive analgesics requires advanced strategies to differentiate human pluripotent stem cells (hPSCs) into relevant cell types. Following principles of developmental biology and translational applicability, here we developed an ... ...
| Abstract | Development of new non-addictive analgesics requires advanced strategies to differentiate human pluripotent stem cells (hPSCs) into relevant cell types. Following principles of developmental biology and translational applicability, here we developed an efficient stepwise differentiation method for peptidergic and non-peptidergic nociceptors. By modulating specific cell signaling pathways, hPSCs were first converted into SOX10 |
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| MeSH term(s) | Humans ; Neurons/metabolism ; Nociceptors ; Cell Differentiation ; Signal Transduction ; Pluripotent Stem Cells ; Ganglia, Spinal/metabolism ; Sensory Receptor Cells |
| Language | English |
| Publishing date | 2023-04-11 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. |
| ZDB-ID | 2720528-9 |
| ISSN | 2213-6711 ; 2213-6711 |
| ISSN (online) | 2213-6711 |
| ISSN | 2213-6711 |
| DOI | 10.1016/j.stemcr.2023.03.006 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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