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Book ; Online ; E-Book: Nephrology and public health worldwide

Silva Junior, Geraldo B. / Ferreiro Fuentes, Alejandro / Nangaku, Masaomi / Remuzzi, Giuseppe / Ronco, Claudio

(Contributions to nephrology ; 199)

2021

Author's details	Editors: Silva Junior, Geraldo B. (Fortaleza) Ferreiro Fuentes, Alejandro (Montevideo) Nangaku, Masaomi (Tokyo ) Remuzzi, Giuseppe (Bergamo) Ronco, Claudio (Vicenza)
Series title	Contributions to nephrology ; 199
Collection
Keywords	Nephrology
Language	English
Size	1 Online-Ressource (viii, 359 Seiten), Illustrationen
Edition	1. Auflage
Publisher	S. Karger
Publishing place	Basel
Publishing country	Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT021374733
ISBN	978-3-318-06937-2 ; 9783318069365 ; 3-318-06937-X ; 3318069361
DOI	10.1159/isbn.978-3-318-06937-2
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Hybrid Therapies for Supporting Critically Ill Patients with Acute Kidney Injury: When, how, and for Whom?

Ferreiro-Fuentes, Alejandro / Guerisoli, Ana / Vega-Vega, Olynka

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

2023 Volume 75, Issue 6, Page(s) 337–347

Abstract: Unassigned: Acute kidney injury (AKI) is common in critically ill patients. There is no specific pharmacological treatment for established severe AKI. Therefore, the conventional therapeutic strategy is limited to the use of kidney replacement therapy ( ... ...

Abstract	Unassigned: Acute kidney injury (AKI) is common in critically ill patients. There is no specific pharmacological treatment for established severe AKI. Therefore, the conventional therapeutic strategy is limited to the use of kidney replacement therapy (KRT) to maintain homeostasis. Hybrid therapies optimize the advantages of intermittent and continuous modalities of KRT, combining lower hourly efficiency, longer application time, at lesser cost, but also adding different physicochemical principles of extracorporeal clearance. The sum of convection and diffusion, with or without adsorption or apheresis, and in different time combinations gives hybrid techniques great flexibility in prescribing a personalized treatment adapted to the needs of each patient at any given time. Hybrid therapies are increasingly being used due to their flexibility, which is determined by the combination of equipment, membranes, and available resources (machines and health-care personnel experience). The required technology is widely available in most intensive care units and uses low-cost consumables compared to other types of AKI treatment modalities, favoring its widespread use. Hybrid therapies are feasible and provide a viable form of KRT, either alone or as a transition therapy from continuous kidney replacement therapy to intermittent hemodialysis. (Rev Invest Clin. 2023;75(6):337-47).
MeSH term(s)	Humans ; Critical Illness/therapy ; Renal Replacement Therapy/methods ; Renal Dialysis/methods ; Intensive Care Units ; Acute Kidney Injury/therapy
Language	English
Publishing date	2023-12-28
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	138348-6
ISSN	0034-8376
ISSN	0034-8376
DOI	10.24875/RIC.23000230
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Article ; Online: Tobacco Use and the Kidney: A Review of Public Policies and Studies on Kidney Disease Progression.

Boggia, José / Silvariño, Ricardo / Ferreiro Fuentes, Alejandro

Contributions to nephrology

2021 Volume 199, Page(s) 188–200

Abstract: Clinical Background: Cigarette smoking is one of the leading causes of preventable deaths, including cardiovascular diseases and cancer. However, the effects of tobacco use on chronic kidney disease (CKD) are less widespread. Epidemiology: Smoking ... ...

Abstract	Clinical Background: Cigarette smoking is one of the leading causes of preventable deaths, including cardiovascular diseases and cancer. However, the effects of tobacco use on chronic kidney disease (CKD) are less widespread. Epidemiology: Smoking tobacco is associated with proteinuria and attenuation of glomerular filtration rate in the general population of different ethnicities. Smoking also accelerates the progression of established CKD and aggravates proteinuria along the wide spectrum of causes determining kidney disease. Furthermore, smoking worsens the survival of kidney transplant recipients and shortens graft survival. Most of the effects of tobacco exposure are dose and time dependent and could be ameliorated with smoking cessation. Challenges: In the last decades, tobacco use policies and regulations were implemented around the world obtaining a global 6% reduction in smoking prevalence. However, the reduction was not proportionally equal in all the geographical areas around the world. The region of Americas experimented the most positive result in reducing smoking prevalence. Smoking trends in South East Asian and Eastern Mediterranean regions show minor decrease or increased rates. The World Health Organization projected reaching a global target prevalence of 15% by 2025. Prevention and Treatment: The results showing smoking cessation slows the progression of kidney disease in smokers should drive our effort to help our patients quit smoking. Smoking prevention at the population level, and particularly in those at risk of CKD or with established CKD should be part of health policies and regulations all around the world.
MeSH term(s)	Disease Progression ; Humans ; Kidney ; Public Policy ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/etiology ; Tobacco Use
Language	English
Publishing date	2021-08-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	1662-2782 ; 0302-5144
ISSN (online)	1662-2782
ISSN	0302-5144
DOI	10.1159/000517726
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Step-by-step guide to setting up a kidney replacement therapy registry: the challenge of a national kidney replacement therapy registry.

Rosa-Diez, Guillermo / González-Bedat, María Carlota / Luxardo, Rosario / Ceretta, María Laura / Ferreiro-Fuentes, Alejandro

Clinical kidney journal

2021 Volume 14, Issue 7, Page(s) 1731–1737

Abstract: Chronic kidney disease (CKD) has become one of the most important public health problems worldwide. Analysis, and understanding, of this global/national/regional reality would benefit from renal registry databases. The implementation of a CKD registry ( ... ...

Abstract	Chronic kidney disease (CKD) has become one of the most important public health problems worldwide. Analysis, and understanding, of this global/national/regional reality would benefit from renal registry databases. The implementation of a CKD registry (including all categories) is difficult to achieve, given its high cost. On the other hand, patients with end-stage kidney disease (ESKD) are easily accessible and constitute the most severe subgroup in terms of comorbidities and healthcare costs. A kidney replacement therapy registry (KRTR) is defined as the systematic and continuous collection of a population-based data set from ESKD patients treated by dialysis/kidney transplant. The lack of available data, particularly in emerging economies, leaves information gaps on healthcare and outcomes in these patients. The heterogeneity/absence of a KRTR in some countries is consistent with the inequities in access to KRT worldwide. In 2014, the Pan American Health Organization (PAHO) proposed to determine the prevalence of patients on dialysis for at least 700 patients per million inhabitants by 2019 in every Latin American (LA) country. Since then, PAHO and the Sociedad LatinoAmericana de Nefrología e Hipertensión have provided training courses and certification of KRTR in LA. The purpose of this manuscript is to provide guidance on how to set up a new KRTR in countries or regions that still lack one. Advice is provided on the sequential steps in the process of setting up a KRTR, personnel requirements, data set content and minimum quality indicators required.
Language	English
Publishing date	2021-01-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2655800-2
ISSN	2048-8513 ; 2048-8505
ISSN (online)	2048-8513
ISSN	2048-8505
DOI	10.1093/ckj/sfab015
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Article ; Online: The Future of Nephrology and Public Health.

Silva Junior, Geraldo / Gadonski, Giovani / Ferreiro Fuentes, Alejandro / Nangaku, Masaomi / Remuzzi, Giuseppe / Ronco, Claudio

Contributions to nephrology

2021 Volume 199, Page(s) 339–350

Abstract: The study of kidney diseases has been described since the Hippocratic era, but nephrology as a medical specialty dates from the mid-20th century. Despite all interesting aspects of nephrology, there is a lack of interest by young physicians for the ... ...

Abstract	The study of kidney diseases has been described since the Hippocratic era, but nephrology as a medical specialty dates from the mid-20th century. Despite all interesting aspects of nephrology, there is a lack of interest by young physicians for the specialty worldwide. Great discoveries have been made throughout the years, leading to great achievements in diagnosis, classification, and treatment of kidney diseases. There is a current interest in the search for novel biomarkers for early detection of kidney dysfunction, and, in the future, there will be novel diagnostic tests for kidney diseases. There have been significant improvements in dialysis and transplant techniques, and novel modalities are being studied, including new renal replacement therapy modalities, such as the wearable artificial kidney. Another trend in the contemporary world, and one that should increase in the future, is the increasing patient connectivity, using novel technologies that will allow access to healthcare and improve outcomes.
MeSH term(s)	Humans ; Kidney Diseases/diagnosis ; Kidney Diseases/therapy ; Nephrology/history ; Public Health ; Renal Dialysis ; Renal Replacement Therapy
Language	English
Publishing date	2021-08-03
Publishing country	Switzerland
Document type	Journal Article
ISSN	1662-2782 ; 0302-5144
ISSN (online)	1662-2782
ISSN	0302-5144
DOI	10.1159/000517714
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Article ; Online: Nephrologists' perspectives on the impact of COVID-19 on caring for patients undergoing dialysis in Latin America: a qualitative study.

Matus Gonzalez, Andrea / Lorca, Eduardo / Cabrera, Sebastian / Hernandez, Alejandra / Zúñiga-Sm, Carlos / Sola, Laura / Michea, Luis / Ferreiro Fuentes, Alejandro / Cervantes, Lilia / Madero, Magdalena / Teixeira-Pinto, Armando / Wong, Germaine / Craig, Jonathan / Jaure, Allison

BMJ open

2023 Volume 13, Issue 5, Page(s) e062321

Abstract: Objective: To describe the experiences of nephrologists on caring for patients undergoing in-centre haemodialysis during the COVID-19 pandemic in Latin America.: Design: Twenty-five semistructured interviews were conducted by Zoom videoconference in ... ...

Abstract	Objective: To describe the experiences of nephrologists on caring for patients undergoing in-centre haemodialysis during the COVID-19 pandemic in Latin America. Design: Twenty-five semistructured interviews were conducted by Zoom videoconference in English and Spanish languages during 2020 until data saturation. Using thematic analysis, we conducted line-by-line coding to inductively identify themes. Setting: 25 centres across nine countries in Latin America. Participants: Nephrologists (17 male and 8 female) were purposively sampled to include diverse demographic characteristics and clinical experience. Results: We identified five themes: shock and immediate mobilisation for preparedness (overwhelmed and distressed, expanding responsibilities to manage COVID-19 infection and united for workforce resilience); personal vulnerability (being infected with COVID-19 and fear of transmitting COVID-19 to family); infrastructural susceptibility of dialysis units (lacking resources and facilities for quarantine, struggling to prevent cross-contamination, and depletion of personal protective equipment and cleaning supplies); helplessness and moral distress (being forced to ration life-sustaining equipment and care, being concerned about delayed and shortened dialysis sessions, patient hesitancy to attend to dialysis sessions, being grieved by socioeconomic disparities, deterioration of patients with COVID-19, harms of isolation and inability to provide kidney replacement therapy); and fostering innovative delivery of care (expanding use of telehealth, increasing uptake of PD and shifting focus on preventing syndemics). Conclusion: Nephrologists felt personally and professionally vulnerable and reported feeling helpless and morally distressed because they doubted their capacity to provide safe care for patients undergoing dialysis. Better availability and mobilisation of resources and capacities to adapt models of care, including telehealth and home-based dialysis, are urgently needed.
MeSH term(s)	Humans ; Male ; Female ; Renal Dialysis ; Nephrologists ; Latin America/epidemiology ; Pandemics ; COVID-19/therapy ; Qualitative Research ; Patient Care
Language	English
Publishing date	2023-05-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-062321
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Article ; Online: Development of a prediction score for in-hospital mortality in COVID-19 patients with acute kidney injury: a machine learning approach.

Ponce, Daniela / de Andrade, Luís Gustavo Modelli / Claure-Del Granado, Rolando / Ferreiro-Fuentes, Alejandro / Lombardi, Raul

Scientific reports

2021 Volume 11, Issue 1, Page(s) 24439

Abstract: Acute kidney injury (AKI) is frequently associated with COVID-19 and it is considered an indicator of disease severity. This study aimed to develop a prognostic score for predicting in-hospital mortality in COVID-19 patients with AKI (AKI-COV score). ... ...

Abstract	Acute kidney injury (AKI) is frequently associated with COVID-19 and it is considered an indicator of disease severity. This study aimed to develop a prognostic score for predicting in-hospital mortality in COVID-19 patients with AKI (AKI-COV score). This was a cross-sectional multicentre prospective cohort study in the Latin America AKI COVID-19 Registry. A total of 870 COVID-19 patients with AKI defined according to the KDIGO were included between 1 May 2020 and 31 December 2020. We evaluated four categories of predictor variables that were available at the time of the diagnosis of AKI: (1) demographic data; (2) comorbidities and conditions at admission; (3) laboratory exams within 24 h; and (4) characteristics and causes of AKI. We used a machine learning approach to fit models in the training set using tenfold cross-validation and validated the accuracy using the area under the receiver operating characteristic curve (AUC-ROC). The coefficients of the best model (Elastic Net) were used to build the predictive AKI-COV score. The AKI-COV score had an AUC-ROC of 0.823 (95% CI 0.761-0.885) in the validation cohort. The use of the AKI-COV score may assist healthcare workers in identifying hospitalized COVID-19 patients with AKI that may require more intensive monitoring and can be used for resource allocation.
MeSH term(s)	Acute Kidney Injury/complications ; Aged ; Area Under Curve ; COVID-19/complications ; COVID-19/mortality ; COVID-19/pathology ; COVID-19/virology ; Comorbidity ; Female ; Hospital Mortality ; Humans ; Machine Learning ; Male ; Middle Aged ; Prospective Studies ; ROC Curve ; Registries ; Risk Factors ; SARS-CoV-2/isolation & purification
Language	English
Publishing date	2021-12-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-03894-5
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Article: Capacity for the management of kidney failure in the International Society of Nephrology Latin America region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA).

Calice-Silva, Viviane / Neyra, Javier A / Ferreiro Fuentes, Alejandro / Singer Wallbach Massai, Krissia Kamile / Arruebo, Silvia / Bello, Aminu K / Caskey, Fergus J / Damster, Sandrine / Donner, Jo-Ann / Jha, Vivekanand / Johnson, David W / Levin, Adeera / Malik, Charu / Nangaku, Masaomi / Okpechi, Ikechi G / Tonelli, Marcello / Ye, Feng / Madero, Magdalena / Tzanno Martins, Carmen

Kidney international supplements

2024 Volume 13, Issue 1, Page(s) 43–56

Abstract: Successful management of chronic kidney disease (CKD) in Latin America (LA) continues to represent a challenge due to high disease burden and geographic disparities and difficulties in terms of capacity, accessibility, equity, and quality of kidney ... ...

Abstract	Successful management of chronic kidney disease (CKD) in Latin America (LA) continues to represent a challenge due to high disease burden and geographic disparities and difficulties in terms of capacity, accessibility, equity, and quality of kidney failure care. Although LA has experienced significant social and economic progress over the past decades, there are still important inequities in health care access. Through this third iteration of the International Society of Nephrology Global Kidney Health Atlas, the indicators regarding kidney failure care in LA are updated. Survey responses were received from 22 of 31 (71%) countries in LA representing 96.5% of its total population. Median CKD prevalence was 10.2% (interquartile range: 8.4%-12.3%), median CKD disability-adjusted life year was 753.4 days (interquartile range: 581.3-1072.5 days), and median CKD mortality was 5.5% (interquartile range: 3.2%-6.3%). Regarding dialysis modality, hemodialysis continued to be the most used therapy, whereas peritoneal dialysis reached a plateau and kidney transplantation increased steadily over the past 10 years. In 20 (91%) countries, >50% of people with kidney failure could access dialysis, and in only 2 (9%) countries, people who had access to dialysis could initiate dialysis with peritoneal dialysis. A mix of public and private systems collectively funded most aspects of kidney replacement therapy (dialysis and transplantation) with many people incurring up to 50% of out-of-pocket costs. Few LA countries had CKD/kidney replacement therapy registries, and almost no acute kidney injury registries were reported. There was large variability in the nature and extent of kidney failure care in LA mainly related to countries' funding structures and limited surveillance and management initiatives.
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	193442-9
ISSN	2157-1716 ; 2157-1724 ; 0098-6577
ISSN (online)	2157-1716
ISSN	2157-1724 ; 0098-6577
DOI	10.1016/j.kisu.2024.01.001
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Article ; Online: On the need to harmonize nephrological terminology in Ibero-American countries.

Sánchez-Alvarez, J Emilio / Ferreiro-Fuentes, Alejandro / González-Bedat, María Carlota / Rosa Díez, Guillermo Javier / Lombardi, Raúl / Lugón, Jocemir / Mira, Filipe / Mastroianni, Gianna

Nefrologia

2022 Volume 41, Issue 6, Page(s) 700–701

MeSH term(s)	Humans ; Nephrology ; Terminology as Topic
Language	English
Publishing date	2022-01-14
Publishing country	Spain
Document type	Letter
ZDB-ID	2837917-2
ISSN	2013-2514 ; 2013-2514
ISSN (online)	2013-2514
ISSN	2013-2514
DOI	10.1016/j.nefroe.2021.01.002
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Article ; Online: On the need to harmonize nephrological terminology in Ibero-American countries.

Sánchez, J E / Ferreiro-Fuentes, Alejandro / González-Bedat, María Carlota / Rosa Díez, Guillermo Javier / Lombardi, Raúl / Lugón, Jocemir / Mira, Filipe / Mastroianni, Gianna

Nefrologia

2021

Title translation	Sobre la necesidad de armonizar la terminología nefrológica en los países latinoamericanos.
Language	Spanish
Publishing date	2021-06-17
Publishing country	Spain
Document type	Letter
ZDB-ID	2837917-2
ISSN	2013-2514 ; 2013-2514
ISSN (online)	2013-2514
ISSN	2013-2514
DOI	10.1016/j.nefro.2021.01.013
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