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  1. Book ; Online ; E-Book: Clinical Management of Bowel Endometriosis

    Ferrero, Simone / Ceccaroni, Marcello

    From Diagnosis to Treatment

    2020  

    Abstract: This book exclusively focuses on the practical aspects of diagnosing and managing bowel endometriosis, and highlights the importance of pursuing a multidisciplinary approach. Collecting chapters written by international experts in the field, the book is ... ...

    Author's details edited by Simone Ferrero, Marcello Ceccaroni
    Abstract This book exclusively focuses on the practical aspects of diagnosing and managing bowel endometriosis, and highlights the importance of pursuing a multidisciplinary approach. Collecting chapters written by international experts in the field, the book is divided into two parts: the first presents all imaging techniques that are currently available and useful in diagnosing bowel endometriosis, while the second covers all available surgical techniques for treating this disorder, including the modern and lesser-invasive Nerve-Sparing radical approaches. Featuring a wealth of figures, sketches and videos, the book offers an essential guide for specialists, resident and subspecialty trainees in the fields of gynecology, colorectal surgery, radiology and gastroenterology.
    Keywords Gynecology  ; Surgery ; Urology ; Gynecology
    Subject code 616.34
    Language English
    Size 1 online resource (VII, 207 p. 104 illus., 75 illus. in color.)
    Edition 1st ed. 2020.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-50446-8 ; 3-030-50445-X ; 978-3-030-50446-5 ; 978-3-030-50445-8
    DOI 10.1007/978-3-030-50446-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Preface: Bowel endometriosis.

    Ferrero, Simone

    Best practice & research. Clinical obstetrics & gynaecology

    2021  Volume 71, Page(s) 1

    Language English
    Publishing date 2021-02-11
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2050090-7
    ISSN 1532-1932 ; 1521-6934
    ISSN (online) 1532-1932
    ISSN 1521-6934
    DOI 10.1016/j.bpobgyn.2021.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Endometriosis: pathogenesis, diagnosis and treatment, volume II.

    Ferrero, Simone / Dutta, Mainak

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1334596

    MeSH term(s) Female ; Humans ; Endometriosis/diagnosis ; Endometriosis/therapy ; Endometriosis/genetics ; Epigenesis, Genetic ; Gene Expression Regulation
    Language English
    Publishing date 2023-12-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1334596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Proteomics in the Diagnosis of Endometriosis: Opportunities and Challenges.

    Ferrero, Simone

    Proteomics. Clinical applications

    2019  Volume 13, Issue 3, Page(s) e1800183

    Abstract: The non-surgical diagnosis of endometriosis is still challenging for the clinician. Ultrasonography and magnetic resonance imaging can be used to diagnose ovarian endometriotic cysts and deep infiltrating endometriosis; but their performance is poor in ... ...

    Abstract The non-surgical diagnosis of endometriosis is still challenging for the clinician. Ultrasonography and magnetic resonance imaging can be used to diagnose ovarian endometriotic cysts and deep infiltrating endometriosis; but their performance is poor in the diagnosis of initial stages of endometriosis. CA-125 and other serum markers (such as CA 19-9, serum protein PP14, interleukins, and angiogenetic factors) have been measured in women with endometriosis but they are not reliable for the diagnosis of the disease. Although several studies used proteomics technologies to identify plasmatic markers of endometriosis, the non-invasive diagnosis of endometriosis is far from being achieved. In this issue, Manousopoulou et al. compare the integrated quantitative proteomic profile of eutopic endometrium and serum of women with endometriosis and controls. 1214 proteins are differentially expressed in the eutopic endometrium and 404 proteins in the serum of the two study groups. 21 proteins are aberrantly expressed in both eutopic endometrium and serum of women with endometriosis. More work is needed to assess if the differentially expressed proteins identified in this study can be used as clinical markers of endometriosis.
    MeSH term(s) Case-Control Studies ; Endometriosis/diagnosis ; Endometriosis/metabolism ; Female ; Humans ; Proteomics
    Language English
    Publishing date 2019-01-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2261788-7
    ISSN 1862-8354 ; 1862-8346
    ISSN (online) 1862-8354
    ISSN 1862-8346
    DOI 10.1002/prca.201800183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Looking for a needle in the haystack of CLL.

    Ferrero, Simone / Genuardi, Elisa

    Blood

    2022  Volume 141, Issue 5, Page(s) 445–447

    MeSH term(s) Humans ; Leukemia, Lymphocytic, Chronic, B-Cell ; Prognosis
    Language English
    Publishing date 2022-12-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022018077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: MYD88 L265P Mutation Detection by ddPCR: Recommendations for Screening and Minimal Residual Disease Monitoring : ddPCR for Highly Sensitive Detection of MYD88 L265P Mutation.

    Drandi, Daniela / Ferrante, Martina / Borriero, Michela / Ferrero, Simone

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2621, Page(s) 57–72

    Abstract: ... ...

    Abstract MYD88
    MeSH term(s) Humans ; Myeloid Differentiation Factor 88 ; Neoplasm, Residual ; Prospective Studies ; Mutation ; Polymerase Chain Reaction/methods ; Immunoglobulin M/genetics
    Chemical Substances Myeloid Differentiation Factor 88 ; Immunoglobulin M
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2950-5_5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Endometrial receptivity in women with endometriosis.

    Racca, Annalisa / Bernabeu, Andrea / Bernabeu, Rafael / Ferrero, Simone

    Best practice & research. Clinical obstetrics & gynaecology

    2023  Volume 92, Page(s) 102438

    Abstract: As endometriosis is recognized as a contributing factor to infertility, prompting couples to embark on Assisted Reproductive Technology (ART) treatments, it becomes crucial to comprehend the extent and way this condition can affect success rates. Natural ...

    Abstract As endometriosis is recognized as a contributing factor to infertility, prompting couples to embark on Assisted Reproductive Technology (ART) treatments, it becomes crucial to comprehend the extent and way this condition can affect success rates. Natural conception data reveal lower success rates for women with endometriosis, yet the same cannot be extrapolated to the outcomes of in vitro fertilization (IVF). In recent years, advancements in the ART process, particularly the distinct stages of the IVF pathway and investigations into embryo quality have shown a comparable rate of embryonic quality and chromosomal normalcy (euploidy) between embryos obtained from individuals with or without endometriosis. Thus, the primary question that lingers relates to the functionality of the endometrium. This review addresses whether endometriosis can influence endometrial receptivity and implantation rates.
    MeSH term(s) Humans ; Female ; Pregnancy ; Endometriosis/complications ; Infertility, Female/etiology ; Infertility, Female/therapy ; Embryo Implantation ; Fertilization in Vitro ; Endometrium ; Pregnancy Rate
    Language English
    Publishing date 2023-11-29
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2050090-7
    ISSN 1532-1932 ; 1521-6934
    ISSN (online) 1532-1932
    ISSN 1521-6934
    DOI 10.1016/j.bpobgyn.2023.102438
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Endometriosis: Modern management of an ancient disease.

    Ferrero, Simone

    European journal of obstetrics, gynecology, and reproductive biology

    2017  Volume 209, Page(s) 1–2

    MeSH term(s) Disease Management ; Endometriosis/therapy ; Female ; Humans ; Pain Management
    Language English
    Publishing date 2017-02
    Publishing country Ireland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2016.12.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Dichotomic response to interleukin-6 blockade in idiopathic multicentric Castleman disease: two case reports.

    Ferrero, Simone / Ragaini, Simone

    Journal of medical case reports

    2021  Volume 15, Issue 1, Page(s) 105

    Abstract: Background: Human herpervirus-8/human immunodeficiency virus negative Idiopathic multicentric Castleman disease (iMCD) is a lymphoproliferative disorder sustained by a pro-inflammatory condition of hypercytokinemia mostly mediated by Interleukin-6 (IL-6) ...

    Abstract Background: Human herpervirus-8/human immunodeficiency virus negative Idiopathic multicentric Castleman disease (iMCD) is a lymphoproliferative disorder sustained by a pro-inflammatory condition of hypercytokinemia mostly mediated by Interleukin-6 (IL-6). According to iMCD consensus guidelines, anti-IL-6 blockade should be the first-line therapy for iMCD. However, despite the existing therapeutic alternatives, a large proportion of iMCD patients still lacks an effective therapy.
    Case presentation: Here, we report two real-life iMCD cases with a different response to IL-6 blockade. The first presented patient obtained a prompt resolution of symptoms and a complete regression of adenopathies after IL-6 blockade therapy administration. Conversely, the second patient did not respond neither to Rituximab and Etoposide association nor to IL-6 blockade therapy (both Siltuximab and Tocilizumab). Furthermore, Intravenous immunoglobulin, Cyclosporine A, Sirolimus and anti-Interleukin-1 Anakinra were all attempted without any results. Since no treatment was successful, after a further confirmation of iMCD diagnosis by a second lymph node biopsy, patient has been candidate for thalidomide, cyclophosphamide and prednisone association therapy.
    Conclusions: The iMCD cases we reported are coherent with the evidences that IL-6 blockade is a safe and an effective therapy for iMCD. Despite this, more than half of patients do not respond to anti IL-6 drugs. In such cases, therapeutic alternatives could be represented by Sirolimus, targeting PI3K/AKT/mTOR signaling or by associations of conventional drugs such as thalidomide, cyclophosphamide and prednisone. However, the two reported iMCD cases, confirm the need to more deeply investigate iMCD pathogenesis and to better dissect the heterogeneity of the disease in order to develop novel, effective therapeutic strategies.
    MeSH term(s) Castleman Disease/drug therapy ; Humans ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-6 ; Phosphatidylinositol 3-Kinases ; Rituximab
    Chemical Substances Interleukin 1 Receptor Antagonist Protein ; Interleukin-6 ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2021-03-07
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-021-02726-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Experimental and new investigational drugs for the treatment of uterine fibroids.

    Evangelisti, Giulio / Ferrero, Simone / Perrone, Umberto / Gustavino, Claudio / Volpi, Eugenio / Izzotti, Alberto / Barra, Fabio

    Expert opinion on investigational drugs

    2024  , Page(s) 1–12

    Abstract: Introduction: Uterine fibroids, the most prevalent benign tumors among reproductive-age women, pose treatment challenges that range from surgical interventions to medical therapies for symptom control. Progestins and estroprogestins effectively manage ... ...

    Abstract Introduction: Uterine fibroids, the most prevalent benign tumors among reproductive-age women, pose treatment challenges that range from surgical interventions to medical therapies for symptom control. Progestins and estroprogestins effectively manage uterine bleeding by suppressing dysfunctional endometrium over fibroids. While GnRH agonists represent a crucial milestone in symptom treatment, their prolonged use results in menopausal-like symptoms and irreversible bone mineral density loss. Advancements in understanding fibroid pathophysiology have prompted the exploration of new compounds to overcome current therapy limitations.
    Areas covered: This manuscript offers an updated overview of investigational drugs for symptomatic uterine fibroids.
    Expert opinion: Despite ulipristal acetate's well-established efficacy as a selective progesterone receptor modulator (SPRM) in fibroid treatment, its prescription has declined due to the rare but severe risk of liver damage. Oral GnRH antagonists, like elagolix, relugolix, and linzagolix, with their novel pharmacodynamic properties, are gaining traction in fibroid management, inducing a dose-dependent reduction in circulating sex hormone levels. Ongoing research on natural compounds, such as vitamin D and epigallocatechin gallate (EGCG), presents emerging options for treating uterine fibroids. This evolving landscape reflects the ongoing efforts to improve therapeutic outcomes for individuals with symptomatic uterine fibroids.
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1080/13543784.2024.2343786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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