LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 923

Search options

  1. Article: Wearable Technologies for Healthy Ageing: Prospects, Challenges, and Ethical Considerations.

    Canali, S / Ferretti, A / Schiaffonati, V / Blasimme, A

    The Journal of frailty & aging

    2023  Volume 13, Issue 2, Page(s) 149–156

    Abstract: Digital technologies hold promise to modernize healthcare. Such opportunity should be leveraged also to address the needs of rapidly ageing populations. Against this backdrop, this paper examines the use of wearable devices for promoting healthy ageing. ... ...

    Abstract Digital technologies hold promise to modernize healthcare. Such opportunity should be leveraged also to address the needs of rapidly ageing populations. Against this backdrop, this paper examines the use of wearable devices for promoting healthy ageing. Previous work has assessed the prospects of digital technologies for health promotion and disease prevention in older adults. However, to our knowledge, ours is one of the first attempts to specifically address the use of wearables for healthy ageing, and to offer ethical insights for assessing the prospects of leveraging wearable devices in this context. We provide an analysis of the considerable opportunities associated with the use of wearables for healthy ageing, with a focus on the five domains of intrinsic capacity: locomotion, sensory functions, psychological aspects, cognition, and vitality. We then highlight current limitations and ethical challenges of such approach to healthy ageing, including issues related to access, inclusion, privacy, surveillance, autonomy, and regulation. We conclude by discussing the implications of our analysis in light of current debates on the ethics of digital health, and suggest measures to address the identified challenges.
    MeSH term(s) Humans ; Aged ; Healthy Aging ; Wearable Electronic Devices ; Digital Health ; Aging ; Cognition
    Language English
    Publishing date 2023-12-26
    Publishing country France
    Document type Journal Article
    ZDB-ID 2856228-8
    ISSN 2273-4309 ; 2260-1341
    ISSN (online) 2273-4309
    ISSN 2260-1341
    DOI 10.14283/jfa.2024.19
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: To heal or not to heal: the ACL dilemma.

    Ferretti, Andrea

    Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology

    2020  Volume 21, Issue 1, Page(s) 11

    MeSH term(s) Anterior Cruciate Ligament ; Anterior Cruciate Ligament Injuries/surgery ; Humans ; Wound Healing
    Language English
    Publishing date 2020-08-29
    Publishing country Italy
    Document type Editorial
    ZDB-ID 2043336-0
    ISSN 1590-9999 ; 1590-9921
    ISSN (online) 1590-9999
    ISSN 1590-9921
    DOI 10.1186/s10195-020-00554-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6153: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Numerically Precise Benchmark of Many-Body Self-Energies on Spherical Atoms.

    Vacondio, S / Varsano, D / Ruini, A / Ferretti, A

    Journal of chemical theory and computation

    2022  Volume 18, Issue 6, Page(s) 3703–3717

    Abstract: We investigate the performance of beyond-GW approaches in many-body perturbation theory by addressing atoms described within the spherical approximation via a dedicated numerical treatment based on B-splines and spherical harmonics. We consider the GW, ... ...

    Abstract We investigate the performance of beyond-GW approaches in many-body perturbation theory by addressing atoms described within the spherical approximation via a dedicated numerical treatment based on B-splines and spherical harmonics. We consider the GW, second Born (2B), and GW + second order screened exchange (GW+SOSEX) self-energies and use them to obtain ionization potentials from the quasi-particle equation (QPE) solved perturbatively on top of independent-particle calculations. We also solve the linearized Sham-Schlüter equation (LSSE) and compare the resulting xc potentials against exact data. We find that the LSSE provides consistent starting points for the QPE but does not present any practical advantage in the present context. Still, the features of the xc potentials obtained with it shed light on possible strategies for the inclusion of beyond-GW diagrams in the many-body self-energy. Our findings show that solving the QPE with the GW+SOSEX self-energy on top of a PBE or PBE0 solution is a viable scheme to go beyond GW in finite systems, even in the atomic limit. However, GW shows a comparable performance if one agrees to use a hybrid starting point. We also obtain promising results with the 2B self-energy on top of Hartree-Fock, suggesting that the full time-dependent Hartree-Fock vertex may be another viable beyond-GW scheme for finite systems.
    Language English
    Publishing date 2022-05-13
    Publishing country United States
    Document type Journal Article
    ISSN 1549-9626
    ISSN (online) 1549-9626
    DOI 10.1021/acs.jctc.2c00048
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Thesis ; Online: Ethics and Governance of Big Data in Health Research and Digital Health Applications

    Ferretti, Agata

    2021  

    Abstract: The health sector is undergoing a digital revolution. Digital technologies monitor and capture data about people’s health and physiology. The widespread availability of digital technologies and powerful analytical tools - such as artificial intelligence ( ...

    Abstract The health sector is undergoing a digital revolution. Digital technologies monitor and capture data about people’s health and physiology. The widespread availability of digital technologies and powerful analytical tools - such as artificial intelligence (AI) algorithms – makes it possible to generate, store, share and analyze vast amounts of aggregated data – “big data”. Big data offers exciting opportunities to improve prevention, diagnostics and therapeutics. Despite its benefits however, big data and AI-enabled technologies come with a series of technical, legal and methodological challenges which have ethical implications including privacy, equity, fairness, accountability, risk assessment, and benefit distribution. Given these novel ethical implications, the existing ethical guidance and oversight mechanisms are inadequate to effectively regulate big data use and health technology development. The first part of this thesis aims to gain a deeper insight into the ethical implications of big data and AI-enabled technologies in the health sector – specifically in health research and digital health applications. This analysis informs the second part of the thesis, which aims to determine the current state of ethical oversight mechanisms in health research and health apps in respect to big data. This goal will be achieved by mapping gaps in the existing ethical guidelines to suggest key reforms and future recommendations. The findings of this thesis show that the ethical discourse is biased toward privacy and technical concerns, leaving other ethical considerations unexamined. This narrow perspective is also reflected in the lack of comprehensive governance and adequate oversight to ensure an ethically aligned use of data in health research and health app development. The focus on data security compliance may result in insufficient guidance for stakeholders to make ethical choices, and thus may cause individual and collective harms. To avoid this risk, this thesis recommends updating the existing data governance ...
    Keywords info:eu-repo/classification/ddc/610 ; info:eu-repo/classification/ddc/600 ; info:eu-repo/classification/ddc/100 ; Medical sciences ; medicine ; Technology (applied sciences) ; Philosophy
    Subject code 170
    Language English
    Publisher ETH Zurich
    Publishing country ch
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Editorial Commentary: When Biomechanics Apparently Conflicts With Clinical Practice: The Role of Translational Medicine Regarding Combined Anterior Cruciate Ligament and Lateral Knee Reconstruction.

    Ferretti, Andrea

    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

    2018  Volume 34, Issue 9, Page(s) 2696–2698

    Abstract: The role of the anterolateral ligament as a secondary restraint to the anterior cruciate ligament in controlling tibial internal rotation and pivot shift is greatly debated today because biomechanical studies lead to conflicting results. However, extra- ... ...

    Abstract The role of the anterolateral ligament as a secondary restraint to the anterior cruciate ligament in controlling tibial internal rotation and pivot shift is greatly debated today because biomechanical studies lead to conflicting results. However, extra-articular reconstructions used along with intra-articular reconstructions seem to be able to improve knee stability and reduce the rate of failure, especially when a graft other than bone-patellar tendon-bone is used as an anterior cruciate ligament substitute. For translational medicine, the task is to fill the gap between laboratory studies and clinical practice.
    MeSH term(s) Anterior Cruciate Ligament ; Anterior Cruciate Ligament Injuries ; Humans ; Joint Instability ; Knee Joint ; Robotic Surgical Procedures ; Translational Medical Research
    Language English
    Publishing date 2018-09-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 632528-2
    ISSN 1526-3231 ; 0749-8063
    ISSN (online) 1526-3231
    ISSN 0749-8063
    DOI 10.1016/j.arthro.2018.06.045
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2046: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Response to "Editorial Commentary: The Anterolateral Ligament: The Emperor's New Clothes?"

    Ferretti, Andrea

    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

    2018  Volume 34, Issue 8, Page(s) 2262–2266

    MeSH term(s) Cadaver ; Humans ; Lacerations ; Ligaments ; Translations
    Language English
    Publishing date 2018-08-03
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 632528-2
    ISSN 1526-3231 ; 0749-8063
    ISSN (online) 1526-3231
    ISSN 0749-8063
    DOI 10.1016/j.arthro.2018.05.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2046: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Complexes of Alkaline and Ammonium Cations with Dopamine and Eumelanin Precursors: Dissecting the Role of Noncovalent Cation-π and Cation-Lone Pair (σ-Type) Interactions.

    Ferretti, Alessandro / Prampolini, Giacomo

    The journal of physical chemistry. A

    2022  Volume 126, Issue 15, Page(s) 2330–2341

    Abstract: Cation-π interactions and their possible competition with other noncovalent interactions (NCI) might play a key role in both dopamine- and eumelanin-based bioinspired materials. In this contribution, to unravel the delicate interplay between cation-π ... ...

    Abstract Cation-π interactions and their possible competition with other noncovalent interactions (NCI) might play a key role in both dopamine- and eumelanin-based bioinspired materials. In this contribution, to unravel the delicate interplay between cation-π interactions and other possible competing forces, the configurational space of noncovalent complexes formed by dopamine or eumelanin precursors (
    MeSH term(s) Ammonium Compounds ; Cations ; Dopamine ; Melanins ; Sodium ; Static Electricity
    Chemical Substances Ammonium Compounds ; Cations ; Melanins ; eumelanin (12627-86-0) ; Sodium (9NEZ333N27) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2022-04-08
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.2c00333
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: In the shadow of privacy: Overlooked ethical concerns in COVID-19 digital epidemiology.

    Ferretti, Agata / Vayena, Effy

    Epidemics

    2022  Volume 41, Page(s) 100652

    Abstract: The COVID-19 pandemic witnessed a surge in the use of health data to combat the public health threat. As a result, the use of digital technologies for epidemic surveillance showed great potential to collect vast volumes of data, and thereby respond more ... ...

    Abstract The COVID-19 pandemic witnessed a surge in the use of health data to combat the public health threat. As a result, the use of digital technologies for epidemic surveillance showed great potential to collect vast volumes of data, and thereby respond more effectively to the healthcare challenges. However, the deployment of these technologies raised legitimate concerns over risks to individual privacy. While the ethical and governance debate focused primarily on these concerns, other relevant issues remained in the shadows. Leveraging examples from the COVID-19 pandemic, this perspective article aims to investigate these overlooked issues and their ethical implications. Accordingly, we explore the problem of the digital divide, the role played by tech companies in the public health domain and their power dynamics with the government and public research sector, and the re-use of personal data, especially in the absence of adequate public involvement. Even if individual privacy is ensured, failure to properly engage with these other issues will result in digital epidemiology tools that undermine equity, fairness, public trust, just distribution of benefits, autonomy, and minimization of group harm. On the contrary, a better understanding of these issues, a broader ethical and data governance approach, and meaningful public engagement will encourage adoption of these technologies and the use of personal data for public health research, thus increasing their power to tackle epidemics.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Pandemics ; Privacy ; Delivery of Health Care ; Public Health
    Language English
    Publishing date 2022-11-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2467993-8
    ISSN 1878-0067 ; 1755-4365
    ISSN (online) 1878-0067
    ISSN 1755-4365
    DOI 10.1016/j.epidem.2022.100652
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Clinical Outcomes After Anterior Cruciate Ligament Reconstruction in Patients With a Concomitant Segond Fracture: Letter to the Editor.

    Ferretti, Andrea / Carrozzo, Alessandro / Mazza, Daniele / Monaco, Edoardo

    The American journal of sports medicine

    2023  Volume 51, Issue 12, Page(s) NP46–NP48

    MeSH term(s) Humans ; Anterior Cruciate Ligament Injuries/surgery ; Anterior Cruciate Ligament Injuries/complications ; Tibial Fractures/surgery ; Tibial Fractures/complications ; Anterior Cruciate Ligament Reconstruction
    Language English
    Publishing date 2023-09-30
    Publishing country United States
    Document type Letter
    ZDB-ID 197482-8
    ISSN 1552-3365 ; 0363-5465
    ISSN (online) 1552-3365
    ISSN 0363-5465
    DOI 10.1177/03635465231189231
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 1910: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Solvent effects on catechol's binding affinity: investigating the role of the intra-molecular hydrogen bond through a multi-level computational approach.

    Prampolini, Giacomo / Campetella, Marco / Ferretti, Alessandro

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 3, Page(s) 2523–2536

    Abstract: The subtle interplay between the inter-molecular interactions established by catechol with the surrounding solvent and the intra-molecular hydrogen bond (HB) characterizing its conformational dynamics is investigated through a multi-level computational ... ...

    Abstract The subtle interplay between the inter-molecular interactions established by catechol with the surrounding solvent and the intra-molecular hydrogen bond (HB) characterizing its conformational dynamics is investigated through a multi-level computational approach. First, quantum mechanical (QM) calculations are employed to accurately characterize both large portions of the catechol's potential energy surface and the interaction energy with neighboring solvent molecules. The acquired information is thereafter exploited to develop a QM derived force-field (QMD-FF), in turn employed in molecular dynamics (MD) simulations based on classical mechanics. The reliability of the QMD-FF is further validated through a comparison with the outcomes of
    MeSH term(s) Solvents/chemistry ; Hydrogen Bonding ; Reproducibility of Results ; Molecular Dynamics Simulation ; Water/chemistry ; Catechols
    Chemical Substances Solvents ; Water (059QF0KO0R) ; Catechols
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d2cp04500a
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top