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  1. Book ; Online: Pediatric Central Nervous System Tumors: State-of-the-Art and Debated Aspects

    Mastronuzzi, Angela / Carai, Andrea / Ferretti, Elisabetta / Miele, Evelina

    2020  

    Keywords Medicine ; Paediatric medicine ; brain tumors ; pediatric neuro-oncology ; children ; central nervous system tumors ; pediatric oncology
    Size 1 electronic resource (84 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021229983
    ISBN 9782889636648 ; 288963664X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Derivation of Human Extraembryonic Mesoderm-like Cells from Primitive Endoderm.

    Farkas, Karin / Ferretti, Elisabetta

    International journal of molecular sciences

    2023  Volume 24, Issue 14

    Abstract: In vitro modeling of human peri-gastrulation development is a valuable tool for understanding embryogenetic mechanisms. The extraembryonic mesoderm (ExM) is crucial in supporting embryonic development by forming tissues such as the yolk sac, allantois, ... ...

    Abstract In vitro modeling of human peri-gastrulation development is a valuable tool for understanding embryogenetic mechanisms. The extraembryonic mesoderm (ExM) is crucial in supporting embryonic development by forming tissues such as the yolk sac, allantois, and chorionic villi. However, the origin of human ExM remains only partially understood. While evidence suggests a primitive endoderm (PrE) origin based on morphological findings, current in vitro models use epiblast-like cells. To address this gap, we developed a protocol to generate ExM-like cells from PrE-like cell line called naïve extraembryonic endoderm (nEnd). We identified the ExM-like cells by specific markers (
    MeSH term(s) Pregnancy ; Female ; Humans ; Endoderm/metabolism ; Mesoderm/metabolism ; Cell Differentiation/physiology ; Embryo, Mammalian ; Embryonic Development
    Language English
    Publishing date 2023-07-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241411366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Immunotherapy in melanoma: Can we predict response to treatment with circulating biomarkers?

    Splendiani, Elena / Besharat, Zein Mersini / Covre, Alessia / Maio, Michele / Di Giacomo, Anna Maria / Ferretti, Elisabetta

    Pharmacology & therapeutics

    2024  Volume 256, Page(s) 108613

    Abstract: Melanoma is the most aggressive form of skin cancer, representing approximately 4% of all cutaneous neoplasms and accounting for up to 80% of deaths. Advanced stages of melanoma involve metastatic processes and are associated with high mortality and ... ...

    Abstract Melanoma is the most aggressive form of skin cancer, representing approximately 4% of all cutaneous neoplasms and accounting for up to 80% of deaths. Advanced stages of melanoma involve metastatic processes and are associated with high mortality and morbidity, mainly due to the rapid dissemination and heterogeneous responses to current therapies, including immunotherapy. Immune checkpoint inhibitors (ICIs) are currently used in the treatment of metastatic melanoma (MM) and despite being linked to an increase in patient survival, a high percentage of them still do not benefit from it. Accordingly, the number of therapeutic regimens for MM patients using ICIs either alone or in combination with other therapies has increased, together with the need for reliable biomarkers that can both predict and monitor response to ICIs. In this context, circulating biomarkers, such as DNA, RNA, proteins, and cells, have emerged due to their ability to reflect disease status. Moreover, blood tests are minimally invasive and provide an attractive option to detect biomarkers, avoiding stressful medical procedures. This systematic review aims to evaluate the possibility of a non-invasive biomarker signature that can guide therapeutic decisions. The studies reported here offer valuable insight into how circulating biomarkers can have a role in personalized treatments for melanoma patients receiving ICIs therapy, emphasizing the need for rigorous clinical trials to confirm findings and establish standardized procedures.
    MeSH term(s) Humans ; Melanoma/drug therapy ; Melanoma/genetics ; Skin Neoplasms/drug therapy ; Immunotherapy/methods ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-02-16
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2024.108613
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1183: Show issues Location:
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  4. Article ; Online: Nephrogenic diabetes insipidus in a geriatric patient affected by SARS-CoV-2: complexity of a diagnosis, complexity of a virus.

    Corich, Maria Ada / Niero, Michele / Corich, Lucia / Ferretti, Elisabetta / De Colle, Paolo / Bernardi, Stella / Ceschia, Giuliano / Sanson, Gianfranco / Zanetti, Michela

    Access microbiology

    2024  Volume 6, Issue 1

    Abstract: Background: Coronavirus disease 2019 (COVID-19) has an important impact on the kidney through direct and indirect damage mechanisms. Most previous studies have highlighted lesions caused by this virus in the early segments of the nephron. However, due ... ...

    Abstract Background: Coronavirus disease 2019 (COVID-19) has an important impact on the kidney through direct and indirect damage mechanisms. Most previous studies have highlighted lesions caused by this virus in the early segments of the nephron. However, due to the antigenic characteristics of the virus, with almost ubiquitous receptors, and the molecular release it triggers, the distal segments of the nephron could also be affected.
    Methods: A 71 year-old-man with respiratory failure while suffering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia presented with typical symptoms of diabetes insipidus after ~20 days of hospitalization. The water deprivation test led to the diagnosis of nephrogenic diabetes insipidus. The aetiological study was complex, in particular because of the patient's previous lithium therapy.
    Results: The sequence of pathognomonic events typical of diabetes insipidus associated with anamnestic, clinical and laboratory evidence strongly supported the diagnosis of nephrogenic diabetes insipidus due to SARS-CoV-2 rather than other aetiologies.
    Conclusions: The collecting duct could represent a target for SARS-CoV-2 infection, directly or indirectly, as a result of lesions of upstream portions of the nephron, which would cascade into the distal segment. Other molecules, besides angiotensin 2 converting enzyme, might be involved in facilitating the viral aggression. The complexity of the geriatric patient shows the importance of a comprehensive approach that integrates careful monitoring of clinical signs and symptoms and laboratory and instrumental tests. This is especially important in the context of SARS-CoV-2 infection and in the management of its unexpected complications.
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Case Reports
    ISSN 2516-8290
    ISSN (online) 2516-8290
    DOI 10.1099/acmi.0.000598.v4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mesoderm specification and diversification: from single cells to emergent tissues.

    Ferretti, Elisabetta / Hadjantonakis, Anna-Katerina

    Current opinion in cell biology

    2019  Volume 61, Page(s) 110–116

    Abstract: The three germ layers - mesoderm, endoderm and ectoderm - constituting the cellular blueprint for the tissues and organs that will form during embryonic development, are specified at gastrulation. Cells of mesodermal origin are the most abundant in the ... ...

    Abstract The three germ layers - mesoderm, endoderm and ectoderm - constituting the cellular blueprint for the tissues and organs that will form during embryonic development, are specified at gastrulation. Cells of mesodermal origin are the most abundant in the human body, representing a great variety of cell types, including the musculoskeletal system (bone, cartilage and muscle), cardiovascular system (heart, blood and blood vessels), as well as the connective tissues found throughout our bodies. A long-standing question pertains how this panoply of mesodermal cell types arises in a stereotypical fashion in time and space. This review discusses the events associated with mesoderm specification, highlighting the reconstruction of putative developmental trajectories facilitated by recent single-cell 'omic' data. We will also discuss the potential of emergent organoid systems to emulate and interrogate the dynamics of lineage specification at cellular resolution.
    MeSH term(s) Animals ; Cell Differentiation/physiology ; Cell Lineage/physiology ; Ectoderm/cytology ; Embryonic Development/physiology ; Endoderm/cytology ; Gastrulation/physiology ; Humans ; Mesoderm/cytology
    Language English
    Publishing date 2019-08-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2019.07.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2963: Show issues Location:
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  6. Article ; Online: mTORC1/ERK1/2 Interplay Regulates Protein Synthesis and Survival in Acute Myeloid Leukemia Cell Lines

    Germano, Concetta Anna / Clemente, Giuseppe / Storniolo, Antonello / Romeo, Maria Anele / Ferretti, Elisabetta / Cirone, Mara / Di Renzo, Livia

    Biology (Basel). 2023 May 02, v. 12, no. 5

    2023  

    Abstract: mTOR is constitutively activated in acute myeloid leukemia (AML) cells, as indicated by the phosphorylation of its substrates, 4EBP1 and P70S6K. Here, we found that quercetin (Q) and rapamycin (Rap) inhibited P70S6K phosphorylation, partially ... ...

    Abstract mTOR is constitutively activated in acute myeloid leukemia (AML) cells, as indicated by the phosphorylation of its substrates, 4EBP1 and P70S6K. Here, we found that quercetin (Q) and rapamycin (Rap) inhibited P70S6K phosphorylation, partially dephosphorylated 4EBP1, and activated ERK1/2 in U937 and THP1, two leukemia cell lines. ERK1/2 inhibition by U0126 induced a stronger dephosphorylation of mTORC1 substrates and activated AKT. The concomitant inhibition of ERK1/2 and AKT further dephosphorylated 4EBP1 and further increased Q- or Rap-mediated cytotoxicity, compared to the single ERK1/2 or AKT inhibition in cells undergoing Q- or Rap-treatments. Moreover, quercetin or rapamycin reduced autophagy, particularly when used in combination with the ERK1/2 inhibitor, U0126. This effect was not dependent on TFEB localization in nuclei or cytoplasm or on the transcription of different autophagy genes, but did correlate with the reduction in protein translation due to a strong eIF2α-Ser51 phosphorylation. Thus, ERK1/2, by limiting 4EBP1 de-phosphorylation and eIF2α phosphorylation, behaves as a paladin of protein synthesis. Based on these findings, the combined inhibition of mTORC1, ERK1/2, and AKT should be considered in treatment of AML.
    Keywords autophagy ; cytoplasm ; cytotoxicity ; dephosphorylation ; myeloid leukemia ; neoplasm cells ; non-specific serine/threonine protein kinase ; phosphorylation ; protein synthesis ; quercetin ; rapamycin
    Language English
    Dates of publication 2023-0502
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12050676
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Interrogating molecular data for medulloblastoma risk stratification.

    Ferretti, Elisabetta / Po, Agnese

    The Lancet. Oncology

    2018  Volume 19, Issue 12, Page(s) 1548–1549

    MeSH term(s) Cerebellar Neoplasms ; Chromosome Aberrations ; Hedgehog Proteins ; Humans ; Medulloblastoma ; Prognosis ; Retrospective Studies
    Chemical Substances Hedgehog Proteins ; SHH protein, human
    Language English
    Publishing date 2018-11-01
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(18)30585-0
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  8. Article ; Online: Progesterone Receptor Modulates Extraembryonic Mesoderm and Cardiac Progenitor Specification during Mouse Gastrulation.

    Drozd, Anna Maria / Mariani, Luca / Guo, Xiaogang / Goitea, Victor / Menezes, Niels Alvaro / Ferretti, Elisabetta

    International journal of molecular sciences

    2022  Volume 23, Issue 18

    Abstract: Progesterone treatment is commonly employed to promote and support pregnancy. While maternal tissues are the main progesterone targets in humans and mice, its receptor (PGR) is expressed in the murine embryo, questioning its function during embryonic ... ...

    Abstract Progesterone treatment is commonly employed to promote and support pregnancy. While maternal tissues are the main progesterone targets in humans and mice, its receptor (PGR) is expressed in the murine embryo, questioning its function during embryonic development. Progesterone has been previously associated with murine blastocyst development. Whether it contributes to lineage specification is largely unknown. Gastrulation initiates lineage specification and generation of the progenitors contributing to all organs. Cells passing through the primitive streak (PS) will give rise to the mesoderm and endoderm. Cells emerging posteriorly will form the extraembryonic mesodermal tissues supporting embryonic growth. Cells arising anteriorly will contribute to the embryonic heart in two sets of distinct progenitors, first (FHF) and second heart field (SHF). We found that PGR is expressed in a posterior-anterior gradient in the PS of gastrulating embryos. We established in vitro differentiation systems inducing posterior (extraembryonic) and anterior (cardiac) mesoderm to unravel PGR function. We discovered that PGR specifically modulates extraembryonic and cardiac mesoderm. Overexpression experiments revealed that PGR safeguards cardiac differentiation, blocking premature SHF progenitor specification and sustaining the FHF progenitor pool. This role of PGR in heart development indicates that progesterone administration should be closely monitored in potential early-pregnancy patients undergoing infertility treatment.
    MeSH term(s) Animals ; Cell Differentiation ; Female ; Gastrula/physiology ; Gastrulation ; Humans ; Mesoderm ; Mice ; Pregnancy ; Progesterone/metabolism ; Receptors, Progesterone/metabolism
    Chemical Substances Receptors, Progesterone ; Progesterone (4G7DS2Q64Y)
    Language English
    Publishing date 2022-09-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms231810307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: mTORC1/ERK1/2 Interplay Regulates Protein Synthesis and Survival in Acute Myeloid Leukemia Cell Lines.

    Germano, Concetta Anna / Clemente, Giuseppe / Storniolo, Antonello / Romeo, Maria Anele / Ferretti, Elisabetta / Cirone, Mara / Di Renzo, Livia

    Biology

    2023  Volume 12, Issue 5

    Abstract: mTOR is constitutively activated in acute myeloid leukemia (AML) cells, as indicated by the phosphorylation of its substrates, 4EBP1 and P70S6K. Here, we found that quercetin (Q) and rapamycin (Rap) inhibited P70S6K phosphorylation, partially ... ...

    Abstract mTOR is constitutively activated in acute myeloid leukemia (AML) cells, as indicated by the phosphorylation of its substrates, 4EBP1 and P70S6K. Here, we found that quercetin (Q) and rapamycin (Rap) inhibited P70S6K phosphorylation, partially dephosphorylated 4EBP1, and activated ERK1/2 in U937 and THP1, two leukemia cell lines. ERK1/2 inhibition by U0126 induced a stronger dephosphorylation of mTORC1 substrates and activated AKT. The concomitant inhibition of ERK1/2 and AKT further dephosphorylated 4EBP1 and further increased Q- or Rap-mediated cytotoxicity, compared to the single ERK1/2 or AKT inhibition in cells undergoing Q- or Rap-treatments. Moreover, quercetin or rapamycin reduced autophagy, particularly when used in combination with the ERK1/2 inhibitor, U0126. This effect was not dependent on TFEB localization in nuclei or cytoplasm or on the transcription of different autophagy genes, but did correlate with the reduction in protein translation due to a strong eIF2α-Ser51 phosphorylation. Thus, ERK1/2, by limiting 4EBP1 de-phosphorylation and eIF2α phosphorylation, behaves as a paladin of protein synthesis. Based on these findings, the combined inhibition of mTORC1, ERK1/2, and AKT should be considered in treatment of AML.
    Language English
    Publishing date 2023-05-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12050676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: 'Building a perfect body': control of vertebrate organogenesis by PBX-dependent regulatory networks.

    Selleri, Licia / Zappavigna, Vincenzo / Ferretti, Elisabetta

    Genes & development

    2019  Volume 33, Issue 5-6, Page(s) 258–275

    Abstract: ... ...

    Abstract Pbx
    MeSH term(s) Animals ; Gene Expression Regulation, Developmental ; Gene Regulatory Networks/genetics ; Genes, Homeobox/genetics ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Humans ; Organogenesis/genetics ; Vertebrates/embryology ; Vertebrates/genetics
    Chemical Substances Homeodomain Proteins
    Language English
    Publishing date 2019-01-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 806684-x
    ISSN 1549-5477 ; 0890-9369
    ISSN (online) 1549-5477
    ISSN 0890-9369
    DOI 10.1101/gad.318774.118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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