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Article ; Online: Sclerosing mesenteritis: a rare disease involving the adipose tissue of the bowel mesentery.

Flor, Nicola / Ferretti, Francesca / Pellegrinelli, Alessandro / Tubazio, Igor / Colombo, Francesco

2024

Language	English
Publishing date	2024-01-09
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2454173-4
ISSN	1970-9366 ; 1828-0447
ISSN (online)	1970-9366
ISSN	1828-0447
DOI	10.1007/s11739-023-03510-6
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Zs.A 6673: Show issues

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Article: Therapeutic Management of Adults with Inflammatory Bowel Disease and Malignancies: A Clinical Challenge.

Ferretti, Francesca / Cannatelli, Rosanna / Maconi, Giovanni / Ardizzone, Sandro

Cancers

2023 Volume 15, Issue 2

Abstract: Patients with chronic inflammatory bowel diseases (IBD) have increased risk of developing intestinal and extraintestinal cancers. However, once a diagnosis of malignancy is made, the therapeutic management of Crohn's disease (CD) and ulcerative colitis ( ... ...

Abstract	Patients with chronic inflammatory bowel diseases (IBD) have increased risk of developing intestinal and extraintestinal cancers. However, once a diagnosis of malignancy is made, the therapeutic management of Crohn's disease (CD) and ulcerative colitis (UC) can be challenging as major guidelines suggest discontinuing the ongoing immunosuppressant and biological therapies for at least 2-5 years after the end of cancer treatment. Recently, new molecules such as vedolizumab and ustekinumab have been approved for IBD and limited data exist on the real risk of new or recurrent cancer in IBD patients with prior cancer, exposed to immunosuppressants and biologic agents. Thus, a multidisciplinary approach and case-by-case management is the preferred choice. The primary aim of our review was to summarize the current evidence about the safety of reintroducing an immunosuppressant or biologic agent in patients with a history of malignancy and to compare the different available therapies, including gut-selective agents. The secondary aim was to evaluate the clinical course of the IBD patients under cancer treatment who do not receive any specific immunosuppressant treatment after the diagnosis of cancer.
Language	English
Publishing date	2023-01-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15020542
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Article ; Online: Rilpivirine long-acting for the prevention and treatment of HIV infection.

Ferretti, Francesca / Boffito, Marta

Current opinion in HIV and AIDS

2018 Volume 13, Issue 4, Page(s) 300–307

Abstract: Purpose of review: Rilpivirine is a non-nucleoside reverse transcriptase inhibitor approved for the treatment of HIV in combination with other antiretrovirals (ARV). The development of the long-acting formulation of rilpivirine (RPV-LA) and its use in ... ...

Abstract	Purpose of review: Rilpivirine is a non-nucleoside reverse transcriptase inhibitor approved for the treatment of HIV in combination with other antiretrovirals (ARV). The development of the long-acting formulation of rilpivirine (RPV-LA) and its use in clinical settings is the subject of this review. Recent findings: In 2017, the results of the phase IIb study LATTE2 have been published. This study demonstrated that the combination of RPV-LA with a second long-acting agent (cabotegravir) administered intramuscularly every 4--8 weeks was similar in virologic suppression rates to standard of care ARV treatment. Summary: RPV-LA is an injectable nanoparticle suspension for intramuscular use. Phase I studies in healthy volunteers demonstrated that RPV-LA, administered at doses between 600 and 1200 mg, was well tolerated and effective in maintaining satisfactory drug concentrations in plasma, vaginal secretions and rectal tissue compartments for at least 4 weeks. RPV-LA efficacy was also shown in a phase II clinical trial in HIV infected patients and phase III studies are currently ongoing. Most study participants stated that they would use or continue using injectables, both in HIV treatment and prevention settings. Long-acting injectable ARVs have the potential to improve the convenience of HIV drug regimens.
MeSH term(s)	Anti-HIV Agents/administration & dosage ; Delayed-Action Preparations/administration & dosage ; Delayed-Action Preparations/chemistry ; HIV/drug effects ; HIV/physiology ; HIV Infections/drug therapy ; HIV Infections/prevention & control ; HIV Infections/virology ; Humans ; Randomized Controlled Trials as Topic ; Rilpivirine/administration & dosage ; Rilpivirine/chemistry
Chemical Substances	Anti-HIV Agents ; Delayed-Action Preparations ; Rilpivirine (FI96A8X663)
Language	English
Publishing date	2018-05-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2502511-9
ISSN	1746-6318 ; 1746-630X
ISSN (online)	1746-6318
ISSN	1746-630X
DOI	10.1097/COH.0000000000000474
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Article: An Update on Current Pharmacotherapeutic Options for the Treatment of Ulcerative Colitis.

Ferretti, Francesca / Cannatelli, Rosanna / Monico, Maria Camilla / Maconi, Giovanni / Ardizzone, Sandro

Journal of clinical medicine

2022 Volume 11, Issue 9

Abstract: The main goals of Ulcerative Colitis (UC) treatment are to both induce and maintain the clinical and endoscopic remission of disease, reduce the incidence of complications such as dysplasia and colorectal carcinoma and improve quality of life. Although a ...

Abstract	The main goals of Ulcerative Colitis (UC) treatment are to both induce and maintain the clinical and endoscopic remission of disease, reduce the incidence of complications such as dysplasia and colorectal carcinoma and improve quality of life. Although a curative medical treatment for UC has not yet been found, new therapeutic strategies addressing specific pathogenetic mechanisms of disease are emerging. Notwithstanding these novel therapies, non-biological conventional drugs remain a mainstay of treatment. The aim of this review is to summarize current therapeutic strategies used as treatment for ulcerative colitis and to briefly focus on emerging therapeutic strategies, including novel biologic therapies and small molecules. To date, multiple therapeutic approaches can be adopted in UC and the range of available compounds is constantly increasing. In this era, the realization of well-designed comparative clinical trials, as well as the definition of specific therapeutic models, would be strongly suggested in order to achieve personalized management for UC patients.
Language	English
Publishing date	2022-04-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11092302
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Article ; Online: Relevance of sonographic parameters for inflammatory bowel disease in children.

Dell'Era, Alessandra / Cannatelli, Rosanna / Ferretti, Francesca / Manzotti, Cristina / Dilillo, Dario / Zuccotti, Gianvincenzo / Meneghin, Fabio / Ardizzone, Sandro / Maconi, Giovanni

Journal of ultrasound

2023 Volume 26, Issue 4, Page(s) 815–822

Abstract: Purpose: Intestinal ultrasound (IUS) is widely used as the first exam in patients with suspected inflammatory bowel disease (IBD). This study investigated the accuracy of several IUS parameters, including increased bowel wall thickening (BWT), in ... ...

Abstract	Purpose: Intestinal ultrasound (IUS) is widely used as the first exam in patients with suspected inflammatory bowel disease (IBD). This study investigated the accuracy of several IUS parameters, including increased bowel wall thickening (BWT), in detecting IBD in a paediatric population. Methods: The study included an unselected series of 113 patients aged 2-18 years (mean age 10.8 years, 65 male), referred for recurrent abdominal pain or altered bowel habits, without known organic diseases, to perform an IUS as first investigation of a diagnostic workup. Patients with full systematic IUS examination, clinical and biochemical exams, and ileocolonoscopy or an uneventful follow-up at least one year follow up were eligible. Results: 23 IBD patients (20.4%; 8 ulcerative colitis, 12 Crohn's disease and 3 indeterminate colitis) were diagnosed. We found that increased BWT > 3 mm (OR 5.4), altered IUS bowel pattern (IUS-BP, OR 9.8) and mesenteric hypertrophy (MH, OR 5.2) accurately identified IBD at the multivariate analysis. IUS-BP, MH and BWT > 3 mm had a sensitivity of 78.3%, 65.2% and 69.6% and a specificity of 93.3%, 92.2% and 96.7%, respectively. The combination of these three alterations increased the specificity up to 100%, whilst decreased sensitivity to 56.5%. Conclusion: Among several US parameters suggestive of IBD, the increased BWT, MH and altered echopattern are independent predictors of IBD. The ultrasonographic diagnosis of IBD could be more accurate if relied on combination of different sonographic parameters, than on the sole BWT evaluation.
MeSH term(s)	Humans ; Male ; Child ; Sensitivity and Specificity ; Inflammatory Bowel Diseases/diagnostic imaging ; Crohn Disease/diagnostic imaging ; Intestines ; Abdominal Pain
Language	English
Publishing date	2023-07-04
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2365426-0
ISSN	1876-7931 ; 1971-3495
ISSN (online)	1876-7931
ISSN	1971-3495
DOI	10.1007/s40477-023-00800-9
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Article ; Online: α-Synuclein Aggregation Inhibitory and Antiplasmodial Activity of Constituents from the Australian Tree

Prebble, Dale W / Holland, Darren C / Ferretti, Francesca / Hayton, Joshua B / Avery, Vicky M / Mellick, George D / Carroll, Anthony R

Journal of natural products

2023 Volume 86, Issue 9, Page(s) 2171–2184

Abstract: Amyloid protein aggregates are linked to the progression of neurodegenerative conditions and may play a role in life stages ... ...

Abstract	Amyloid protein aggregates are linked to the progression of neurodegenerative conditions and may play a role in life stages of
MeSH term(s)	Antimalarials/pharmacology ; Eucalyptus ; Trees ; alpha-Synuclein ; Plant Extracts/chemistry ; Australia ; Plasmodium falciparum
Chemical Substances	Antimalarials ; alpha-Synuclein ; Plant Extracts
Language	English
Publishing date	2023-08-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.3c00458
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Zs.A 1144: Show issues

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Article ; Online: Demystifying autoimmune small bowel enteropathy.

Elli, Luca / Ferretti, Francesca / Vaira, Valentina

Current opinion in gastroenterology

2019 Volume 35, Issue 3, Page(s) 243–249

Abstract: Purpose of review: We reviewed the current 'state of the art' on autoimmune enteropathy and small-bowel mucosal atrophy, with the aim of supporting clinicians in a frequently challenging diagnosis through different therapeutic options and prognosis.: ... ...

Abstract	Purpose of review: We reviewed the current 'state of the art' on autoimmune enteropathy and small-bowel mucosal atrophy, with the aim of supporting clinicians in a frequently challenging diagnosis through different therapeutic options and prognosis. Recent findings: The diagnosis of small-bowel diseases has radically changed over the last 10 years. The possibility to 'easily' obtain bioptic samples from the jejunum and ileum by means of the enteroscopic techniques (particularly, device-assisted enteroscopy) and the novel cross-sectional imaging studies have opened the window to new insights on intestinal disorders. Consequentially, the detection of small-bowel mucosal atrophy has become a frequent finding in patients undergoing endoscopic investigation and its differential diagnosis can be challenging at times. Among the 'typical' causes of mucosal atrophy, autoimmune enteropathy has become more frequent than previously thought. However, the final diagnosis of autoimmune enteropathy is a 'puzzle' composed by serological, endoscopic, histological and molecular markers, which should be correctly dealt with in order to reach a certain diagnosis. Summary: In conclusion, there is an emerging body of literature about autoimmune enteropathy and small-bowel atrophy. The herein presented practical review on autoimmune enteropathy can be of help to clinicians in their daily practice.
MeSH term(s)	Atrophy ; Autoantibodies/immunology ; Balloon Enteroscopy ; Enterocytes/immunology ; Forkhead Transcription Factors/genetics ; GTP-Binding Proteins/immunology ; Goblet Cells/immunology ; Humans ; Immunoglobulin A/immunology ; Immunosuppressive Agents/therapeutic use ; Interleukin-2 Receptor alpha Subunit/genetics ; Intestinal Mucosa/immunology ; Intestinal Mucosa/pathology ; Intestine, Small/immunology ; Intestine, Small/pathology ; Nutritional Support ; Polyendocrinopathies, Autoimmune/diagnosis ; Polyendocrinopathies, Autoimmune/immunology ; Polyendocrinopathies, Autoimmune/pathology ; Polyendocrinopathies, Autoimmune/therapy ; Serologic Tests ; Transglutaminases/immunology
Chemical Substances	Autoantibodies ; FOXP3 protein, human ; Forkhead Transcription Factors ; IL2RA protein, human ; Immunoglobulin A ; Immunosuppressive Agents ; Interleukin-2 Receptor alpha Subunit ; transglutaminase 2 (EC 2.3.2.-) ; Transglutaminases (EC 2.3.2.13) ; GTP-Binding Proteins (EC 3.6.1.-)
Language	English
Publishing date	2019-01-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	632571-3
ISSN	1531-7056 ; 0267-1379
ISSN (online)	1531-7056
ISSN	0267-1379
DOI	10.1097/MOG.0000000000000515
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Article ; Online: Impact of penicillin allergy records on antimicrobial prescribing in hospitalised patients.

Anton-Vazquez, Vanesa / Ferretti, Francesca / Kaya, Deniz / Mishra, Shashwat / Kerneis, Sven / Eden, Charlotte / Doan, Hong / Leung, Hiu Fung / Baltazar, Jeanelli / Starkey, Sarah / Uwagwu, Juliet / Dall'Antonia, Martino / Cepeda, Jorge

Clinical medicine (London, England)

2024 Volume 24, Issue 2, Page(s) 100024

Abstract: Background: The overdiagnosis of penicillin allergy and misclassification of non-truly allergic reactions is a growing public health problem, associated with the overuse of broad-spectrum and restricted antimicrobials. We aimed to evaluate the impact of ...

Abstract	Background: The overdiagnosis of penicillin allergy and misclassification of non-truly allergic reactions is a growing public health problem, associated with the overuse of broad-spectrum and restricted antimicrobials. We aimed to evaluate the impact of penicillin allergy status on antimicrobial prescribing. Methods: A retrospective study of inpatients with a documented penicillin allergy receiving antimicrobials was conducted from 1 April to 1 July 2021. Antimicrobial prescribing and clinical characteristics were compared between patients with an active penicillin allergy label and those whose label was removed following antimicrobial stewardship team review. Antimicrobials were classified in two categories: i) 'Access' (recommended), ii) 'Watch and Reserve' (restricted) according to WHO AWaRe classification, a tool to guide appropriate antibiotic use. Results: 437 patients with a documented penicillin allergy receiving antimicrobials were included. 353 patients with an active penicillin allergy label, more frequently received antimicrobials from the 'Watch and Reserve list' (283;80% vs 30;37%; p<0.001). In contrast, 84 patients who were de-labelled received more often antimicrobials from the 'Access list' (53;63% vs 64;18%; p<0.001). Conclusions: Penicillin allergy reviews and de-labelling strategies may reduce the use of restricted antimicrobials under the 'Watch and Reserve list'. This practice should be encouraged and reinforced in all hospitals.
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2048646-7
ISSN	1473-4893 ; 1470-2118
ISSN (online)	1473-4893
ISSN	1470-2118
DOI	10.1016/j.clinme.2024.100024
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Article ; Online: "Quality of Life in Epidermolysis Bullosa" and "Epidermolysis Bullosa Burden of Disease": Italian translation, cultural adaptation, and pilot testing of two disease-specific questionnaires.

Hachem, May El / Diociaiuti, Andrea / Zambruno, Giovanna / Samela, Tonia / Ferretti, Francesca / Carnevale, Claudia / Linertová, Renata / Bodemer, Christine / Murrell, Dédée F / Abeni, Damiano

Italian journal of pediatrics

2024 Volume 50, Issue 1, Page(s) 76

Abstract: Background: Inherited epidermolysis bullosa (EB) is a clinically and genetically heterogeneous group of skin fragility disorders characterized by blister formation following minor trauma. Four major types are distinguished based on the level of cleavage ...

Abstract	Background: Inherited epidermolysis bullosa (EB) is a clinically and genetically heterogeneous group of skin fragility disorders characterized by blister formation following minor trauma. Four major types are distinguished based on the level of cleavage within the skin. Most EB forms present severely disabling cutaneous and systemic signs and symptoms. Management relies on daily time-consuming and distressing topical medications, and symptomatic treatment of systemic findings. Disease manifestations, symptoms, and daily care strongly affect patient and caregiver quality of life (QoL). To date, there are two validated EB-specific questionnaires, the "Quality of Life in Epidermolysis Bullosa" (QOLEB) and the "Epidermolysis Bullosa Burden of Disease" (EB-BoD) for the evaluation of patient and family disease burden, respectively. The aim of our study was to develop an Italian translation of the two questionnaires and to pilot-test them. Methods: The guidelines for translation and cross-cultural adaptation of health-related QoL measures were followed. Initially, two separate translations were generated for each questionnaire, and subsequently reconciled by an expert committee. This was followed by a back-translation process. The original texts and all translations underwent revision by the expert committee, resulting in definitive versions. The final versions were then tested in a pilot study involving cognitive debriefing in a group of 17 families, representative of all EB major types. Results: The translation and reconciliation process led to minor changes to obtain semantic/idiomatic/cultural equivalence of the Italian versions with the original ones and to reconcile the questions with the answer options. The cognitive debriefing process showed a good understanding and did not require text modifications. Conclusions: The Italian versions of the QOLEB and EB-BoD provide valuable tools in everyday clinical practice of reference centers, and they allow the participation in multicenter international real-life observational studies as well as in controlled clinical trials. They enable the identification of disease-specific psychological and socioeconomic challenges for EB patients and their families, guiding targeted interventions to ensure appropriate and timely care.
MeSH term(s)	Humans ; Quality of Life/psychology ; Pilot Projects ; Epidermolysis Bullosa/diagnosis ; Epidermolysis Bullosa/therapy ; Epidermolysis Bullosa/psychology ; Cost of Illness ; Surveys and Questionnaires ; Italy
Language	English
Publishing date	2024-04-19
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	2088556-8
ISSN	1824-7288 ; 1720-8424
ISSN (online)	1824-7288
ISSN	1720-8424
DOI	10.1186/s13052-024-01657-2
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Article: Ultrasonographic Evaluation of Intestinal Fibrosis and Inflammation in Crohn's Disease. The State of the Art.

Ferretti, Francesca / Cannatelli, Rosanna / Ardizzone, Sandro / Maier, Jeanette A / Maconi, Giovanni

Frontiers in pharmacology

2021 Volume 12, Page(s) 679924

Abstract: The evaluation of the degree of inflammation and fibrosis, intrinsic elements in intestinal wall damage of Crohn's disease, is essential to individuate the extent of the lesions and the presence of strictures. This information will contribute to the ... ...

Abstract	The evaluation of the degree of inflammation and fibrosis, intrinsic elements in intestinal wall damage of Crohn's disease, is essential to individuate the extent of the lesions and the presence of strictures. This information will contribute to the choice of the appropriate therapeutic approach, the prediction of the response to therapy and the course of the disease. The accurate evaluation of the extent and severity of inflammation and/or fibrosis in Crohn's disease currently requires histopathological analysis of the intestinal wall. However, in clinical practice and research, transmural assessment of the intestinal wall with cross sectional imaging is increasingly used for this purpose. The B-mode ultrasonograhic characteristics of the intestinal wall, the assessment of its vascularization by color Doppler and I.V. contrast agents, and the evaluation of the mechanical and elastic properties by sonoelastography, may provide useful and accurate information on the severity and extent of inflammation and intestinal fibrosis in Crohn's disease. The purpose of this review is to provide an update on current sonographic methods to discriminate inflammation and fibrosis in Crohn's disease.
Language	English
Publishing date	2021-04-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.679924
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