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  1. Book: Sex and gender differences in neurological disease

    Moro, Elena / Arabia, Gennarina / Tartaglia, Maria Carmela / Ferretti, Maria Teresa

    (International review of neurobiology ; volume 164)

    2022  

    Author's details edited by Elena Moro (Grenoble Alpes University, CHU of Grenoble, Division of Neurology, Grenoble Institute of Neurosciences, Grenoble, France), Gennarina Arabia (Magna Graecia University, Movement Disorders Center, Neurology Unit, Catanzaro, Italy), Maria Carmela Tartaglia (Memory Clinic, Krembil Brain Institute, University Health Network; Canadian Concussion Centre, Krembil Brain Institute, University Health Network; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada), Maria Teresa Ferretti (Women's Brain Project, Guntershausen, Switzerland)
    Series title International review of neurobiology ; volume 164
    Collection
    Keywords Nervenkrankheit ; Geschlechtsunterschied
    Subject Geschlechterdifferenz ; Geschlechtsdimorphismus ; Geschlechtsspezifisch ... ; Geschlechtsspezifische Differenz ; Sexualdimorphismus ; Geschlechterunterschied ; Geschlecht ; Geschlechtsunterschiede ; Gender Diversity ; Geschlechtsspezifische Diversität ; Nervenkrankheiten ; Neurologische Erkrankung ; Neurologische Krankheit ; Nervensystem ; Nervensystemkrankheit ; Nervous disease
    Language English
    Size xv, 375 Seiten, Illustrationen, Diagramme
    Edition First edition
    Publisher Academic Press, an imprint of Elsevier
    Publishing place Cambridge, MA ; San Diego, CA
    Publishing country United States
    Document type Book
    HBZ-ID HT021499272
    ISBN 978-0-323-91589-2 ; 9780323915908 ; 0-323-91589-2 ; 0323915906
    Database Catalogue ZB MED Medicine, Health

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  2. Book ; Online ; E-Book: Sex and gender differences in Alzheimer's disease

    Ferretti, Maria Teresa / Schumacher Dimech, Annemarie / Santuccione Chadha, Antonella

    the Women's Brain Project

    2021  

    Author's details edited by Maria Teresa Ferretti, Annemarie Schumacher Dimech, Antonella Santuccione Chadha
    Keywords Alzheimer's disease ; Brain/Sex differences ; Women's health services
    Subject code 616.83110082
    Language English
    Size 1 Online-Ressource (xxxiv, 479 Seiten), Illustrationen
    Publisher AP, Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021009914
    ISBN 978-0-128-19345-7 ; 9780128193440 ; 0-128-19345-X ; 0128193441
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Informant characteristics are associated with the Clinical Dementia Rating Sum of Boxes scores in the Alzheimer's Disease patients participating in the National Alzheimer's Coordinating Center Uniform Data Set.

    Vargas-Gonzalez, Juan-Camilo / Chadha, Antonella Santuccione / Castro-Aldrete, Laura / Ferretti, Maria Teresa / Tartaglia, Carmela

    Research square

    2024  

    Abstract: Background: The Clinical Dementia Rating: Methods: We included all participants from the NACC-UDS that had AD as diagnosis, and information about the Mini-Mental State Examination or Montreal Cognitive Assessment scores, informant sex, relationship ... ...

    Abstract Background: The Clinical Dementia Rating
    Methods: We included all participants from the NACC-UDS that had AD as diagnosis, and information about the Mini-Mental State Examination or Montreal Cognitive Assessment scores, informant sex, relationship to patient and frequency of contact; we also analyzed the possible interaction between these characteristics on the CDR
    Results: We included data from 20636 participants, totalling 47727 visits. Patients' age was 74.0 ± 9.4 years and 54.1% were females. Informant characteristics were mean age of 66.2 ± 13.2 years, 69.1% were females, and the relationship to patients was 60.5% spouse or partner, 26.7% children and 12.8% other relation. The CDR
    Conclusions: We found that the CDR
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3982448/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The missing X factor in Alzheimer disease.

    Ferretti, Maria Teresa / Santuccione Chadha, Antonella

    Nature reviews. Neurology

    2021  Volume 17, Issue 12, Page(s) 727–728

    MeSH term(s) Alzheimer Disease/genetics ; Humans
    Language English
    Publishing date 2021-10-11
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-021-00573-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 88: Show issues

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  5. Article: Gender medicine: Towards a gender-specific treatment of neuropsychiatric disorders.

    Biskup, Ewelina / Martinkova, Julie / Ferretti, Maria Teresa

    Handbook of clinical neurology

    2020  Volume 175, Page(s) 437–448

    Abstract: Sex and gender are increasingly recognized as major influencing factors in disorders across all medical specialties. Even though there is ample evidence of sex and gender differences in neuropsychiatric disorders, a sex and gender-differentiated approach ...

    Abstract Sex and gender are increasingly recognized as major influencing factors in disorders across all medical specialties. Even though there is ample evidence of sex and gender differences in neuropsychiatric disorders, a sex and gender-differentiated approach has not yet been sufficiently applied to diagnostics and management. Therefore, there is an urgent need to establish general recommendations and guidelines toward precision and sex/gender medicine, with regard to dosage, tolerability, interactions and side effects, sensitivity of diagnostic tests, and distinct treatment strategies. This chapter illustrates the current knowledge about sex and gender aspects in neuropsychiatric disorders, providing a base not only to assist the clinician in the handling of specific pathologic entities, but also to sensitize medical practitioners to consider sex and gender in clinical decision-making. As such, the chapter is a call to action to physicians and researchers to produce more sex- and gender-stratified evidence, leading to an acceleration of guideline development. Such novel guidelines will provide a base for medical education, of both medical students and specialists, as well as a reference point for practitioners, toward precision medicine.
    MeSH term(s) Humans ; Precision Medicine ; Sex Factors
    Language English
    Publishing date 2020-06-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 0072-9752
    ISSN 0072-9752
    DOI 10.1016/B978-0-444-64123-6.00029-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Understanding COVID-19 new diagnostic guidelines - a message of reassurance from an internal medicine doctor in Shanghai.

    Bischof, Evelyne / Chen, Guoting / Ferretti, Maria Teresa

    Swiss medical weekly

    2020  Volume 150, Page(s) w20216

    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; COVID-19 Testing ; China/epidemiology ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Humans ; Internal Medicine ; Physicians ; Pneumonia, Viral/diagnosis ; Practice Guidelines as Topic ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-03-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2036179-8
    ISSN 1424-3997 ; 1424-7860
    ISSN (online) 1424-3997
    ISSN 1424-7860
    DOI 10.4414/smw.2020.20216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Sex and gender differences in dementia.

    Salwierz, Patrick / Davenport, Carly / Sumra, Vishaal / Iulita, M Florencia / Ferretti, Maria Teresa / Tartaglia, Maria Carmela

    International review of neurobiology

    2022  Volume 164, Page(s) 179–233

    Abstract: The dementia landscape has undergone a striking paradigm shift. The advances in understanding of neurodegeneration and proteinopathies has changed our approach to patients with cognitive impairment. Firstly, it has recently been shown that the various ... ...

    Abstract The dementia landscape has undergone a striking paradigm shift. The advances in understanding of neurodegeneration and proteinopathies has changed our approach to patients with cognitive impairment. Firstly, it has recently been shown that the various proteinopathies that are the cause of the dementia begin to build up long before the appearance of any obvious symptoms. This has cemented the idea that there is an urgency in diagnosis as it occurs very late in the pathophysiology of these diseases. Secondly, that accurate diagnosis is required to deliver targeted therapies, that is precision medicine. With this latter point, the realization that various factors of a person need to be considered as they may impact the presentation and progression of disease has risen to the forefront. Two of these factors aside from race and age are biological sex and gender (social construct), as both can have tremendous impact on manifestation of disease. This chapter will cover what is known and remains to be known on the interaction of sex and gender with some of the major causes of dementia.
    MeSH term(s) Alzheimer Disease ; Cognitive Dysfunction ; Dementia/diagnosis ; Dementia/epidemiology ; Dementia/etiology ; Female ; Humans ; Male ; Sex Factors
    Language English
    Publishing date 2022-08-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209876-3
    ISSN 2162-5514 ; 0074-7742
    ISSN (online) 2162-5514
    ISSN 0074-7742
    DOI 10.1016/bs.irn.2022.07.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Chromosomal and environmental contributions to sex differences in the vulnerability to neurological and neuropsychiatric disorders: Implications for therapeutic interventions.

    Pallier, Patrick N / Ferrara, Maria / Romagnolo, Francesca / Ferretti, Maria Teresa / Soreq, Hermona / Cerase, Andrea

    Progress in neurobiology

    2022  Volume 219, Page(s) 102353

    Abstract: Neurological and neuropsychiatric disorders affect men and women differently. Multiple sclerosis, Alzheimer's disease, anxiety disorders, depression, meningiomas and late-onset schizophrenia affect women more frequently than men. By contrast, Parkinson's ...

    Abstract Neurological and neuropsychiatric disorders affect men and women differently. Multiple sclerosis, Alzheimer's disease, anxiety disorders, depression, meningiomas and late-onset schizophrenia affect women more frequently than men. By contrast, Parkinson's disease, autism spectrum condition, attention-deficit hyperactivity disorder, Tourette's syndrome, amyotrophic lateral sclerosis and early-onset schizophrenia are more prevalent in men. Women have been historically under-recruited or excluded from clinical trials, and most basic research uses male rodent cells or animals as disease models, rarely studying both sexes and factoring sex as a potential source of variation, resulting in a poor understanding of the underlying biological reasons for sex and gender differences in the development of such diseases. Putative pathophysiological contributors include hormones and epigenetics regulators but additional biological and non-biological influences may be at play. We review here the evidence for the underpinning role of the sex chromosome complement, X chromosome inactivation, and environmental and epigenetic regulators in sex differences in the vulnerability to brain disease. We conclude that there is a pressing need for a better understanding of the genetic, epigenetic and environmental mechanisms sustaining sex differences in such diseases, which is critical for developing a precision medicine approach based on sex-tailored prevention and treatment.
    MeSH term(s) Animals ; Female ; Male ; Sex Factors ; Sex Characteristics ; Schizophrenia ; Brain Diseases ; Autism Spectrum Disorder
    Language English
    Publishing date 2022-09-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 185535-9
    ISSN 1873-5118 ; 0301-0082
    ISSN (online) 1873-5118
    ISSN 0301-0082
    DOI 10.1016/j.pneurobio.2022.102353
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    Se 205: Show issues Location:
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  9. Article: Sex and gender considerations in Alzheimer's disease: The Women's Brain Project contribution.

    Castro-Aldrete, Laura / Moser, Michele V / Putignano, Guido / Ferretti, Maria Teresa / Schumacher Dimech, Annemarie / Santuccione Chadha, Antonella

    Frontiers in aging neuroscience

    2023  Volume 15, Page(s) 1105620

    Abstract: The global population is expected to have about 131.5 million people living with Alzheimer's disease (AD) and other dementias by 2050, posing a severe health crisis. Dementia is a progressive neurodegenerative condition that gradually impairs physical ... ...

    Abstract The global population is expected to have about 131.5 million people living with Alzheimer's disease (AD) and other dementias by 2050, posing a severe health crisis. Dementia is a progressive neurodegenerative condition that gradually impairs physical and cognitive functions. Dementia has a variety of causes, symptoms, and heterogeneity concerning the influence of sex on prevalence, risk factors, and outcomes. The proportion of male-to-female prevalence varies based on the type of dementia. Despite some types of dementia being more common in men, women have a greater lifetime risk of developing dementia. AD is the most common form of dementia in which approximately two-thirds of the affected persons are women. Profound sex and gender differences in physiology and pharmacokinetic and pharmacodynamic interactions have increasingly been identified. As a result, new approaches to dementia diagnosis, care, and patient journeys should be considered. In the heart of a rapidly aging worldwide population, the Women's Brain Project (WBP) was born from the necessity to address the sex and gender gap in AD. WBP is now a well-established international non-profit organization with a global multidisciplinary team of experts studying sex and gender determinants in the brain and mental health. WBP works with different stakeholders worldwide to help change perceptions and reduce sex biases in clinical and preclinical research and policy frameworks. With its strong female leadership, WBP is an example of the importance of female professionals' work in the field of dementia research. WBP-led peer-reviewed papers, articles, books, lectures, and various initiatives in the policy and advocacy space have profoundly impacted the community and driven global discussion. WBP is now in the initial phases of establishing the world's first Sex and Gender Precision Medicine Institute. This review highlights the contributions of the WBP team to the field of AD. This review aims to increase awareness of potentially important aspects of basic science, clinical outcomes, digital health, policy framework and provide the research community with potential challenges and research suggestions to leverage sex and gender differences. Finally, at the end of the review, we briefly touch upon our progress and contribution toward sex and gender inclusion beyond Alzheimer's disease.
    Language English
    Publishing date 2023-03-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2023.1105620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Longitudinal progression of choroid plexus enlargement is associated with female sex, cognitive decline and ApoE E4 homozygote status.

    Novakova Martinkova, Julie / Ferretti, Maria Teresa / Ferrari, Alberto / Lerch, Ondrej / Matuskova, Veronika / Secnik, Juraj / Hort, Jakub

    Frontiers in psychiatry

    2023  Volume 14, Page(s) 1039239

    Abstract: Introduction: Choroid plexus (CP)-related mechanisms have been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease. In this pilot study, we aimed to elucidate the association between longitudinal changes in CP ... ...

    Abstract Introduction: Choroid plexus (CP)-related mechanisms have been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease. In this pilot study, we aimed to elucidate the association between longitudinal changes in CP volume, sex and cognitive impairment.
    Methods: We assessed longitudinal changes in CP volume in a cohort of
    Results: We found an overall significant increase of CP volume in time (14.92 mm
    Conclusion: Our results contribute to potential mechanisms for sex differences in cognitive impairment with a novel finding of twice the annual choroid plexus enlargement in females and provide putative support for CP-related mechanisms of cognitive deterioration and its relationship to ApoE E4.
    Language English
    Publishing date 2023-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1039239
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